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Apoptosis

Ceramide activates a mitochondrial p38 mitogen-activated protein kinase

"This study examined the impact of ceramide, an intracellular mediator of apoptosis, on the mitochondria to test the hypothesis that ceramide utilized p38 MAPK in the mitochondria to alter mitochondrial potential and induce apoptosis," wrote J.Y. Kong and colleagues, University of British Columbia.

"The capacity of ceramide to adversely affect mitochondria was demonstrated by the significant loss of mitochondrial potential (Delta psi_m ), indicated by a J-aggregate fluorescent probe, after embryonic chick cardiomyocytes were...

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