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Apoptosis
Cyclosporine A and its nonimmunosuppressive derivative induce apoptosis of malignant melanoma cells
November 18th, 2005
Cyclosporine A and its nonimmunosuppressive derivative induce apoptosis of malignant melanoma cells. According to recently published research from Poland, "Advanced melanoma is a highly malignant tumor with an increasing incidence that has a poor prognosis due to resistance to common therapeutic strategies. "We have demonstrated previously that cyclosporine A (CsA) induces apoptosis of rat glioma cells, reactive astrocytes, and fibroblasts. In our present study, we investigated effects of CsA and its nonimmunosuppressive derivative NIM811 on survival of human and murine melanoma cells." "We demonstrated that CsA and NIM811 affect...
Source: Drug Week (2005-11-18)
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