Drug Week

Age-Related Macular Degeneration - Positive preliminary clinical results presented on EVIZON for treatment of AMD

Drug Development - ALTU-135 well tolerated in cystic fibrosis patients with pancreatic insufficiency

Obesity Therapy - Phase IIa trial data indicate statistically significant weight loss in obese patients taking APD356

Pharmaceutical Research - Antibiotic daunomycin binds to human serum albumin at nonclassical drug binding site

Rhinitis - PreHistin significantly reduces allergy symptoms in 714-patient phase III clinical trial

Adverse Drug Reaction - Patients develop acute liver failure after receiving amoxicillin/clavulanate

Allergy & Immunology - Donor HLA alleles may control hepatitis C virus spread to liver grafts

Allergy & Immunology - Low-dose fluticasone propionate more effective and less costly than montelukast

Allergy & Immunology - Oral alternative to allergy shots raises concerns in the U.S

Alzheimer Disease - Acute gamma-secretase inhibition improves contextual fear conditioning in mice

Alzheimer Disease - New scrapbooking approach to help families affected by Alzheimer disease

Breast Cancer - New research in the area of breast cancer detailed

Anesthesia - Anesthesia with pentobarbital rather than ketamine/xylazine may be preferred for echocardiography

Angiology - Cilostazol reduces risk of restenosis after percutaneous transluminal angioplasty

Angiology - Gene transfer stimulates neoangiogenesis in rabbit peripheral ischemia models

Angiology - Low protein Z levels may be a risk factor in central retinal vein or artery occlusion

Angiology - The JAK2/STAT5 pathway maintains neovascular growth during oxygen deprivation

Angioplasty - Ischemic preconditioning may attenuate regional release of inflammatory markers

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Anti-infectives - Antimicrobial use common in U.S. neonatal and pediatric intensive care patients

Anti-inflammatories - Lipoxin pathyways offer treatment options for diseases involving inflammation

Antibacterial Agents - Antibacterial products don't appear to heighten household risk of drug-resistant infection

Antimicrobials - Keratinocyte cathelicidin production acts directly against skin pathogens

Antimicrobials - LaeA regulates morphogenetic fungal virulence factors

Cancer Therapy - Reports add new data to cancer therapy research

Antimicrobials - Post-translational modification of therapeutic peptides by NisB investigated

Antioxidants - Constituents of triphala show individual antioxidant activity

Antioxidants - Protection efficacy is higher for inclusion complexes than for free drugs

Apoptosis - Activator protein 2 alpha status determines chemosensitivity of cancer cells

Apoptosis - Bile acids affected cell growth and death in human colonic adenocarcinoma cells

Apoptosis - Eicosapentenoic acid induced apoptosis in human pancreatic cancer cells

Cancer Therapy - Studies advance knowledge in cancer therapy research

Apoptosis - Full-length p73 alpha repressed drug-induced apoptosis in lung carcinoma cells

Apoptosis - Immunosuppression by morphine-induced lymphocyte apoptosis did not occur

Apoptosis - Interleukin-6-soluble receptor complex reduces infarct size via inhibiting myocardial apoptosis

Asthma - Hormone fluctuations are a factor in higher asthma rates in women

Asthma Therapy - Long-term budesonide inhalation well tolerated in children with asthma

Atherosclerosis - Neovessel instability may cause intraplaque hemorrhage in atherosclerotic lesions

Cancer Vaccines - Recent findings in cancer vaccines provide new insights

Atherosclerosis - Researchers' data advance atherosclerosis research

Atherosclerosis - Serum amyloid A-derived peptides resolve aortic lipid lesions in apoE^-/- mice

Atopic Dermatitis - MimyX Cream cleared for sales and marketing in the United States

Attention Deficit Hyperactivity Disorder - SPARLON, for treatment of ADHD in children and adolescents, receives approvable letter

Attention-Deficit Hyperactivity Disorder - Medication patch shown effective for attention-deficit hyperactivity disorder

Avian Influenza - Studies on combinational treatments against Avian influenza are extended

Cancer Vaccines - Research add new data to cancer vaccines body of knowledge

Avian Influenza - The right drugs and a good response plan will make a life-or-death difference if avian flu strikes

Avian Influenza - U.S. agency announces rapid response team to combat avian flu

Awards - LSU researcher receives $485,000 U.S.NIH grant to study Friedreich's ataxia

Bacteriology - Antibacterial action of unsaturated fatty acids related to fatty acid synthesis inhibition

Bacteriology - Antimicrobial silver dressing introduced for wound care therapy

Biofilms - Protective antibodies prevent fungal biofilm formation

Cancer Vaccines - Research in cancer vaccines provides new insights

Biomaterial - Osteogenic protein 1 putty may improve bone autograft outcome in lumbar fusion

Biomedical Engineering - Fluorometric investigation reveals methylene blue changes HSA molecule conformation

Biomedical Engineering - Gradient-filtered NMR method is more reproducible and robust than CPMG method

Biomedical Engineering - Nonaqueous capillary electrophoresis separates four cold medicine ingredients

Biomedical Engineering - Novel voltammetric methods characterize zafirlukast in pharmaceutical formulations

Biomedical Engineering - One-step SPME-based approach shows enantiomeric selectivity of amphetamines

Cancer Vaccines - Researchers' work adds to cancer vaccines body of knowledge

Biomedicine - Medicinal components in Schisandra chinensis Baill. were identified

Biosynthesis - Candida DPMS may be regulated by phosphorylation-dephosphorylation

Bioterrorism - CEO discusses Project BioShield legislation and treatment strategies for biological weapons

Bioterrorism - U.S. grants $20 million for developing compounds to treat radiation damage

Bioterrorism - Vaccine maker reports $3.3M grant to develop smallpox vaccine

Bipolar Depression - Development agreement to fund drug trial for bipolar depression

Cancer Vaccines - Studies describe new findings in cancer vaccines research

Bladder Cancer - Research in bladder cancer provides new insights

Brain Cancer Therapy - Pemetrexed has limited distribution to brain

Breast Cancer - Findings advance knowledge in breast cancer research

Breast Cancer - Herceptin plus chemotherapy shown to reduce risk of breast cancer recurrence

Breast Cancer - Phase II trial of combination therapy for advanced breast cancer underway

Cardiology - Researchers' findings advance cardiology research

Breast Cancer Treatment - Chemotherapy-related bone loss is attenuated by tamoxifen treatment

Business & Finance - Antibody therapy maker selected to Dow Jones Sustainability Index for seventh consecutive year

Business & Finance - Biotechnology company requests reconsideration pending delisting from Nasdaq

Business & Finance - Genomics company reports first quarter net loss of $16.7 million

Business & Finance - GlaxoSmithKline improves efficiencies in their sourcing strategy using "Factory Model"

Diabetes Therapy - New research in the area of diabetes therapy detailed

Business & Finance - Mucotrol maker reports 103% increase in second-quarter 2006 revenues, EPS of $0.06

Business & Finance - Pharmaceutical company raises $70 million

Business & Finance - Respiratory disease drug developer completes reorganization and restructuring

Cancer Clinical Trials - Recommended phase II dose for T900607 determined

Cancer Pain Management - Age and tumor type significantly influence transdermal fentanyl absorption

Cancer Prevention - Long-term interferon therapy for chronic hepatitis C prevents liver cancer

Diabetes Therapy - Reports advance knowledge in diabetes therapy research

Cancer Prevention - New strides are being made in cancer chemoprevention

Cancer Prevention - Researchers provide details of new studies and findings in the area of cancer prevention

Cancer Research - New European legislation impacts both cancer trials and drug approval

Cancer Research - Patient enrollment begins in phase I trial of Tarvacin anticancer

Cancer Therapy - Administering dendritic cells in cancer nodules in hepatocellular carcinoma appears safe

Cancer Therapy - Anticancer drug gets fast track for elderly with acute myelogenous leukemia

Diabetes Therapy - Researchers detail new studies and findings in the area of diabetes therapy

Cancer Therapy - Anticoagulant treatment improved survival in cancer patients

Cancer Therapy - Antitumor activity of 3-chlorodeoxylapachol demonstrated

Cancer Therapy - Antitumor agent JNJ-7706621 inhibits cyclin-dependent kinases and aurora kinases

Cancer Therapy - Central nervous system chemoprophylaxis in non-Hodgkin lymphoma requires standardization

Cancer Therapy - Chemophase phase I trial initiated for superficial bladder cancer

Cancer Therapy - CoFactor, in combination with 5-FU and oxaliplatin, may be effective against colorectal cancer

Diagnostics - Findings in diagnostics provide new insights

Cancer Therapy - Cost of epoetin alfa and darbepoetin alfa treatment in Sweden evaluated

Cancer Therapy - Emesis adversely affected clinical and economic outcomes of cancer therapy

Cancer Therapy - Gemcitabine plus Apo2L/TRAIL resulted in a greater antitumor effect

Cancer Therapy - IRFAPA recommended over PRFA therapy if patients' conditions permit laparotomy

Cancer Therapy - Interleukin-21 enhances tumor rejection through a NKG2D-dependent mechanism

Cancer Therapy - Intraperitoneal hyperthermic chemotherapy used for peritoneal surface malignancy

Diagnostics - New data illuminates research in diagnostics

Cancer Therapy - New studies highlight promising potential of cancer immunotherapy

Cancer Therapy - Nonsteroidal inhibitors of 17beta-HSD317 were identified for prostate cancer treatment

Cancer Therapy - Paclitaxel was well tolerated but showed limited efficacy in bronchioloalveolar carcinoma

Cancer Therapy - Porphyrin superoxide dismutase mimetic enhanced tumor radio-responsiveness

Cancer Therapy - Progressive muscle relaxation training reduced chemotherapy side effects

Cancer Therapy - Quality of life considerations impact choice of cancer treatment

HIV/AIDS Vaccines Development - Studies add new findings to HIV/AIDS vaccines development body of knowledge

Cancer Therapy - Recent studies add new data to cancer therapy research

Cancer Therapy - Second-line chemotherapy showed modest activity in patients with hormone-refractory prostate cancer

Cancer Therapy - Sentinel node biopsy recommended before neoadjuvant chemotherapy

Cancer Therapy - Tarceva now available in Europe to tackle growing lung cancer epidemic

Hematology - Researchers' findings advance hematology research

Cancer Therapy - Tumor types selected for phase II trials of Coramsine

Cancer Vaccine - Bacterial mimic under study as cancer vaccine may also help protect tumors

Cancer Vaccines - Findings in cancer vaccines provide new insights

Hypertension - Researchers describe findings in hypertension studies

Canine Distemper Virus Outbreaks - Canine distemper virus outbreak occurs in Asian clawless otter littermates in captivity

Cardiology - Antibodies to heparin pose a risk of adverse events following cardiac surgery

Cardiology - Flow mediated dilation is associated with changes in coronary diameter and coronary blood flow

Cardiology - Natural history atherosclerosis study to examine vulnerable plaques

Hypertension - Studies advance knowledge in hypertension research

Cardiology - New data illuminates research in cardiology

Cardiomyopathy - Valsartan decreases type I collagen synthesis in patients with hypertrophic cardiomyopathy

Cardiovascular Research - Agent delivery mode influences cardiomyocyte injury induced by myocardial contrast echocardiography

Cardiovascular Research - Atorvastatin prevents downregulation in lipopolysaccharide-stimulated cells

Leukemia - Studies describe new findings in leukemia research

Cardiovascular Research - Mouse myocardium displays unique excitation-contraction characteristics

Cardiovascular Research - Propranolol inhibits the human ether-a-go-go-related gene potassium channels

Cardiovascular Research - Zinc deficiency influences arterial BP vascular NO pathway in growing rats

Carpal Tunnel Syndrome - Topical analgesic patch effective in reducing pain of carpal tunnel syndrome

Cervical Cancer - Similar outcome seen in pregnant and non-pregnant women treated with neo-adjuvant chemotherapy

Chemotherapy - 5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines

Neuroscience - Researchers publish new studies and findings in the area of neuroscience

Chemotherapy - Cardiac toxicity in breast cancer treated with doxorubicin and paclitaxel

Chemotherapy - Chemotherapy induced toxic myelopathy

Chemotherapy - Cisplatin plus epirubicin deemed effective regimen in malignant mesothelioma

Chemotherapy - Delayed onset bleomycin-induced pneumonitis observed

Chemotherapy - Dose-dense chemotherapy may be superior to CHOP for primary mediastinal large B-cell lymphoma

Chemotherapy - Dosimetry of docetaxel plus estramustine performed for prostate cancer

Oncology - Findings in oncology provide new insights

Chemotherapy - Early efficacy of epoetin alfa superior to darbepoetin alfa

Chemotherapy - Etoposide, leucovorin, and 5-fluorouracil used to treat resected gastric cancer

Chemotherapy - Intracavitary chemotherapy used to treat recurrent glioblastoma

Chemotherapy - Razoxane was combined with radiotherapy for treatment of melanoma brain metastases

Chronic Liver Disease - Serum hyaluronic acid relays the progression of non-alcoholic steatohepatitis

Clinical Trials - Authorization granted for U.K. trial of hemoglobin glutamer in cardiac surgery

Oncology - New data illuminates research in oncology

Clinical Trials - Dolastatin-10 ineffective in phase II clinical trials

Clinical Trials - HIV drug maker posts loss of $0.36 per share

Clinical Trials - Interim clinical trial results demonstrate safety and efficacy of coronary stent

Clinical Trials - OROS MPH safe and effective for up to 2 years in children

Clinical Trials - Phase I dose-escalation trials in healthy volunteers overviewed

Clinical Trials - Phase I study begins of triple reuptake inhibitor for major depression

Oncology - Recent findings in oncology described

Clinical Trials - Positive preliminary results reported from trial of inhaled narcotic analgesics

Clinical Trials - Positive results reported from trial of entry inhibitor to treat HIV

Clinical Trials - Stent system shows reduction of restenosis in trial with diabetic patients

Collaborations - Agreement signed to distribute BrachySil throughout the People's Republic of China

Collaborations - Alliance signed with the U.S. CDC for research and development of a Pneumococcus vaccine

Collaborations - Alliance to focus on production of a novel protein targeting cancer

Physiology - Researchers detail new studies and findings in the area of physiology

Collaborations - Collaboration to develop therapeutic peptide candidates for inhalation therapy

Collaborations - Development and license agreement signed for anti-thrombosis drug

Collaborations - Development, commercialization agreement targets pulmonary hypertension

Collaborations - Distribution agreement signed for Sotradecol injection

Collaborations - Drug-discovery company announces discovery collaboration with Ono Pharmaceutical

Collaborations - Medical alert company partners with Seryx to offer pharmacogenetic test

Physiology - Researchers publish new studies and findings in the area of physiology

Collaborations - Nutritional product maker enters manufacturing agreement

Collaborations - Strategic alliances announced for pandemic influenza vaccine production

Colon Cancer - Findings in colon cancer provide new insights

Complementary & Alternative Medicine - Benzyl isothiocyanate inhibits jejunal function at levels needed to kill intestinal worms

Complementary & Alternative Medicine - Gamma-linolenic acid boosts effectiveness of Herceptin on cancer cells

Complementary & Alternative Medicine - Green tea extract cocktail blocks angiogenesis

Proteomics - New findings in the area of proteomics detailed

Complementary & Alternative Medicine - Kava herb may cause adverse reactions by disrupting drug metabolism

Complementary & Alternative Medicine - Laminin receptor mediated suppressive effect of EGCG on Fc epsilon RI expression

Complementary & Alternative Medicine - Workers on daily probiotics are less likely to take sick time

Compliance - National action plan to improve consumer use of prescription medication

Contraceptives - Duramed and Paladin sign SEASONALE product Canadian license and distribution agreement

Coronary Artery Disease - Bradycardia preserves perfusion by stimulating collateral vessel growth

Proteomics - Recent findings in proteomics described

Coronary Artery Disease - Recent findings illuminate research in coronary artery disease

Crohn Disease - Remicade data show promise for children afflicted with Crohn disease

Cystic Fibrosis - Reports add new data to cystic fibrosis research

Cytotoxicity - Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of acute myeloid leukemia

DNA Research - Kyushu University, DNA company identify haplotypes in Japanese population

Vaccines Vector - Researchers' findings advance vaccines vector research

DNA Vaccines - Recent studies add new data to DNA vaccines research

Dental Care - Clinical pediatric study supports benefits of CompuDent in administering anesthetic injections to children

Dental Research - Cavity-fighting CaviStat technology incorporated in confections

Dermatology - Skin of color requires unique care and treatment

Dermatology - Three studies show investigational psoriasis therapy may be effective option

Dermatology - Unclogged pores are what's new in the treatment of acne

Vaccines Vector - Researchers' work adds to vaccines vector body of knowledge

Diabetes Pathogenesis - Pancreatic epithelial cells can be converted into insulin-producing cells

Diabetes Therapy - Antioxidants alleviate diabetic complications

Diabetes Therapy - Findings in diabetes therapy provide new insights

Diabetes Therapy - Glucokinase activator modulates pancreatic islet and hepatocyte function

Diabetes Therapy - Metformin restores microvascular reactivity in diabetic rats

Diabetes Therapy - Muraglitazar is new peroxisome proliferator-activated receptor agonist

Virology - Recent findings in virology provide new insights

Diabetes Therapy - Patients with nonalcoholic steatohepatitis and type 2 diabetes benefit from nateglinide

Diabetes Therapy - Vanadyl sulfate exacerbates nephrotoxicity in diabetic rats

Diabetic Retinopathy - Membrane-type 1 matrix metalloproteinase signals in retinal glial cells increase with hypoxia

Virology - Researchers report details of new studies and findings in the area of virology

Diagnostics - Benzodiazepines detected in human plasma and oral fluid using novel method

Diagnostics - Biomarkers help researchers stage fibrosis in patients infected with hepatitis C

Diagnostics - CT and FDG-PET image fusion impacted treatment planning and management of esophageal carcinoma

Diagnostics - Findings advance knowledge in diagnostics research

Diagnostics - HPLC method simultaneously detects four antiepiletic drugs in human serum

Diagnostics - High-throughput assay detects down to 1.25 ng/ml piperaquine in plasma

Diagnostics - Hypersil C8 BDS column offers best separation of chlortetracycline from impurities

Diagnostics - MEKC simultaneously detects HIV-protease inhibitors lamivudine and zidovudine

Diagnostics - Novel voltammetric method detects sertraline in flow at reduced cost

Diagnostics - Radiation resistance in cervical cancer was associated with increased ICAM-3 expression

Diagnostics - Skin tests and serum-specific IgE assays useful in diagnosing cephalosporin reactions

Diagnostics - UPLC and exact mass oa-TOF MS developed for detection of human metabolites of acetaminophen

Diet & Nutrition - Benefits of tea flavonoids reported at American Dietetic Association meeting

Diet & Nutrition - Corn bran fiber averts liver injury in rodent models

Diet & Nutrition - Genetic toxicology study finds chromium picolinate is safe

Diet & Nutrition - Marginal, prolonged copper intake is deleterious to cardiac health

Disease Association - Salmeterol and formoterol have no short-term adverse effects on HRV

Disease Associations - Lung cancer metastasis induced acute pancreatitis

Disease Associations - Overweight patients bear a higher risk for developing acute liver failure

Drug Abuse - 4'-methyl-alpha-pyrrolidinobutyrophenone metabolites are detectable in rat urine using GC-MS

Drug Abuse - Study of Prometa initiated for alcohol addiction

Drug Delivery - Intramuscular administration of antimalarial drug arteether appears to be most potent

Drug Delivery - Multivesicular liposomes are useful for the sustained delivery of breviscapine

Drug Delivery - NIR diffuse reflectance spectroscopy predicts drug dissolution profiles effectively

Drug Delivery - New device launched to help combat bioterrorism

Drug Delivery - Novel microemulsion system shows promise for transdermal aceclofenac delivery

Drug Delivery - Rifampicin-loaded PLGA microspheres deliver drug into MTB-residing alveolar macrophages

Drug Development - 5-caffeoylquinic acid identified as matrix metalloproteinase-9 inhibitor

Drug Development - Anti-HIV dibenzylbutyrolactone-type lignans isolated from Phenax rugosus

Drug Development - Aryloxyphenyl cyclopropyl methanones active against multidrug resistant Mycobacterium tuberculosis

Drug Development - Atypical antipsychotics based on 8-substituted 3,4-dihydroquinolinones show promise

Drug Development - CEO details progress on development of cancer drugs

Drug Development - Chemogenomics database developed to improve drug candidate selection

Drug Development - Drug-discovery company announces collaboration with Mitsubishi Pharma Corp.

Drug Development - First human trial for AT-1001 completed; U.S. FDA grants fast-track designation

Drug Development - Imidazole-4,5-dicarboxamide derivatives showed antiproliferative activity

Drug Development - Isoniazid derivatives inhibit Mycobacterium tuberculosis

Drug Development - Letter issued from U.S. FDA on Dapoxetine application

Drug Development - Lilly to support study of antagonist to curb weight gain from antipsychotic drugs

Drug Development - Metabolic profiling company develops new eicosanoid platform for drug discovery

Drug Development - Microtubule targeting agents sway tumor angiogenesis through hypoxia inducible factor-1

Drug Development - Partnership to launch clinical trial for moxifloxacin in tuberculosis therapy

Drug Development - Patient enrollment completed in a phase IIb trial of Albuferon in combination with ribavirin

Drug Development - Pharma companies report regulatory status of decitabine injection for MDS

Drug Development - Phase I study results of BLX-883 in hepatitis patients support continued development

Drug Development - Phase III clinical trial initiated in U.S. of treatment for head lice

Drug Development - Preliminary results suggest drug may prevent breast cancer, treat vaginal atrophy

Drug Development - Regulatory approval sought in Europe for Junovan as osteosarcoma therapy

Drug Development - Small compound inhibited matrix metalloproteinase-9 upregulation

Drug Development - Study confirms therapeutic potential of drug for bipolar depression

Drug Development - Study offers potential new targets for antibiotics

Drug Development - Threshold of toxicological concern applied to drug manufacturing

Drug Development - Xibrom receives award for best new branded pharmaceutical introduction in 2005

Drug Research - Gelucire stabilizes amorphous etoricoxib, improves its pharmaceutical performance

Drug Resistance - Drug-resistant pulmonary TB in western Turkey is higher in patients with treatment failure

Drug Safety - High doses of ibuprofen can cause significant GI bleeding despite its safety profile

Drug Stability - Piperacillin and tazobactam show comparable stability in PVC and non-PVC bags

Drug Toxicity - Intracameral Vigamox safely prevents endophthalmitis in rabbit model

Echocardiography - Recent findings in echocardiography described

Echocardiography - Strain rate provides accurate quantitation of regional contractile function

Eczema - Enrollment complete for phase I/II trial of Avrina, new drug candidate for eczema

Endocrinology - Travelers can avoid jet lag by resetting their body clocks

Enzymology - Biosynthesis of the antibiotic fosfomycin by a mononuclear iron enzyme is investigated

Enzymology - Docosahexaenoic acid enhances cyclooxygenase-2 induction in vascular smooth muscle cells

Epilepsy - Application filed for treatment of myclonic seizures in juveniles

Finance - Antibody focused company reports loss of $0.41 per share

Finance - Antibody-based drug developer reports net loss; initiates clinical trial

Finance - Bioengineered microspheres developer reports that revenues grew 27%

Finance - Biopharma company announces revenue of $2.7 million for third quarter

Finance - Biopharma company reports third quarter net income of $26.2 million

Finance - Biotech company announces $20.0 million common stock purchase agreement with Fusion Capital

Finance - Biotechnology company announces third quarter revenues of $2.1 million

Finance - Biotechnology company reports net loss of $7.6 million

Finance - Blood-related protein therapeutics developer lays off employees

Finance - California biosciences company completes previously announced private placement

Finance - Cancer drug developer incurs loss of $0.38 per share

Finance - Cancer vaccine maker records loss of $0.60 per share

Finance - Chinese pharmaceutical firm raises $6.3M in private placement

Finance - Clinical development organization announces service revenue of $75.6 million

Finance - Developer of monoclonal antibody therapies reports third quarter revenues

Finance - Diabetes care company sales up by 15% this year; trauma study planned

Finance - Direct selling company reports third-quarter revenue of $290.8 million

Finance - Drug abuse testing company announces third quarter revenue of $5,353,168

Finance - Drug delivery company reports record year-end revenue of $62.4 million

Finance - Drug delivery firm reports earnings of $0.04 per share

Finance - Drug developer raises $29.4 million in series A financing

Finance - Drug development services company records 15.2% revenue growth

Finance - Fertility product maker records 25% increase in revenues

Finance - Generic drug maker reports third quarter revenues of $118.7 million