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Adverse Drug Reaction

Patients develop acute liver failure after receiving amoxicillin/clavulanate

Published in Drug Week, November 25th, 2005

Patients develop acute liver failure (ALF) after receiving amoxicillin/clavulanate.

According to a study from the United States, "the aim of our study is to report upon the presentation of two patients with life-threatening ALF due to amoxicillin and amoxicillin/clavulanate. A 59-year-old, Caucasian male presented with ALF 34 days after receiving amoxicillin/clavulanate."

"Despite aggressive supportive care, he died on hospital day 10. A 42-year-old, Caucasian female presented with ALF 21 days after receiving amoxicillin. She underwent successful liver transplantation on hospital day 19," wrote R.J. Fontana and colleagues, University of Michigan...

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