Published in Drug Week, December 2nd, 2005
Ubiquitin ligases are enzymes that regulate protein degradation within the cell, affecting many important cellular functions, including cell division. Targeting ligases represents a novel approach to treating diseases where normal cellular processes are out of balance.
The first publication highlights a fluorescence resonance energy transfer (FRET)-based assay that can monitor the kinetics of enzymatic activity across a wide range of ligases to give more detail about how the...
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