Enzymology
Ubiquitin ligase inhibitors are focus of two articles
Published in Drug Week, December 2nd, 2005
Ubiquitin ligases are enzymes that regulate protein degradation within the cell, affecting many important cellular functions, including cell division. Targeting ligases represents a novel approach to treating diseases where normal cellular processes are out of balance.
The first publication highlights a fluorescence resonance energy transfer (FRET)-based assay that can monitor the kinetics of enzymatic activity across a wide range of ligases to give more detail about how the...
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Source: Drug Week (2005-12-02)
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