Leukemia

Gastrin-gastrin receptor axis appears to be a potential target for leukemia therapies

Published in Drug Week, December 2nd, 2005

The gastrin-gastrin receptor axis appears to be a potential target for new therapeutic approaches to leukemia.

"The gastrin CCK2 pathway has been implicated in the development of various cancers including leukemia. An autocrine or intracrine pathway may exist in the leukemia cell that is involved in stimulating proliferation," scientists writing in the journal Oncology Reports reported.

"We tested four leukemia cell lines, KU812, ML-1, MOLT-4, and U937 for the existence of the CCK2 receptor and gastrin precursor protein using immunoblotting. We also assessed the effect of CCK2 antagonist PD 135 and both gastrin 17 and glycine-extended gastrin...

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Source: Drug Week (2005-12-02)

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