Drug Week

Diagnostics - Adding a bile acid sequestrant to statin therapy reported to reduce median hs-CRP levels

Drug Development - New drug application submitted for Toprol-XL and thiazide combination tablets for hypertension

Drug Development - U.S. FDA accepts supplemental application for Tysabri in multiple sclerosis

HIV/AIDS Therapy - U.S. FDA grants approval for new Kaletra tablet formulation for HIV patients

Pancreatic Cancer - Favorable 2-year survival data from phase II clinical trial of GVAX vaccine for pancreatic cancer

Acute Coronary Syndrome - AZD6140 plus aspirin assessed for safety, tolerability as antiplatelet therapy

Acute Coronary Syndrome - New study finds enoxaparin to be at least as effective as unfractionated heparin in treating ACS

Acute Coronary Syndrome - Phase IIa trial identifies maximum safe dosage of rNAPc2

Acute Myeloid Leukemia - Phase I trials of humanized monoclonal antibody for AML or MDS initiated

Addiction Medicine - Research suggests that bupropion is promising as treatment of methamphetamine addiction

Adverse Drug Reaction - Anabolic steroid use in each athlete involves multiple drugs and supplements

Cancer Therapy - Reports describe recent advances in cancer therapy research

Alcoholism - Acamprosate is effective in treatment of alcohol dependence

Alzheimer Disease - New findings in the area of Alzheimer disease detailed

Alzheimer Disease - PRX-03140 effective and well-tolerated in 14-day phase Ib clinical trial

Alzheimer Disease - Pre-fibrils, thought to be implicated in Alzheimer disease, are imaged at the molecular level

Alzheimer Disease - Study shows Ginkgo biloba extract improves cognitive functions

Anemia - First long-term phase II study of CERA in renal patients shows control of anemia

Cancer Therapy - Researchers' data advance cancer therapy research

Anesthesia - Org 25969 safely and effectively reverses rocuronium neuromuscular block in humans

Angina - ERICA data presented at American Heart Association scientific sessions; Ranexa met endpoint

Angina - Procoralan to be marketed in 27 European countries; expanded study underway

Angiology - Researchers detail new studies and findings in the area of angiology

Anti-Infectives - Antimicrobial armamentarium reviewed

Antipsychotics - Psychopharmacology discovery was slanted toward industry in the 1990s

Cancer Therapy - Researchers' findings advance cancer therapy research

Apoptosis - 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) induced apoptosis in pancreatic cancer

Apoptosis - Micromolar taxol induced cell necrosis in HeLa cells

Apoptosis - Programmed cell death pathways targeted with experimental therapeutics

Apoptosis - Role of gangliosides in fenretinide-induced apoptosis of neuroblastoma examined

Aspergillosis - Abelcet prolongs survival and reduces organ fungal load in CNS aspergillosis

Asthma - Philadelphia asthma organization wins $2 million grant to combat pediatric asthma

Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge

Asthma - Study looks at steroid-sparing effect of Zyflo in patients with severe asthma

Asthma - Vagonixen development moves forward with newly published study on ATP effects in asthmatic patients

Asthma Therapy - Patent issued for eFlow electronic nebulizer technology

Atherosclerosis - Atorvastatin reduced serum leptin levels in hypercholesterolemic rabbit model

Atherosclerosis - Transdermal hormone replacement therapy reduces carotid artery wall thickness

Autism - ADHD medication may be useful for treating hyperactivity symptoms in autism

Cardiology - Researchers provide details of new studies and findings in the area of cardiology

Avian Influenza - Alliance with Novavax focuses on expediting development of vaccines

Avian Influenza - Bird flu threat creates demand for cold and flu products

Avian Influenza - New technology delivers medication supplies without human risk

Avian Influenza - Remel's Xpect Flu A&B test kit detects selected avian influenza strains

Bacteriology - Drug manufacturer expands agreement with Eli Lilly for Vancocin

Biomedical Engineering - Ceramic substrate anchors vascular bundles for bone grafts

Diabetes Therapy - New research in the area of diabetes therapy detailed

Biomedical Engineering - Endothelial progenitor cells give rise to engineered blood vessels

Biomedical Engineering - Scaffolds yield dermal constructs with minimal contraction

Birth Defects - Fruit fly research may revolutionize the study of birth defects secondary to methotrexate use

Botulinum Toxin - Visual side effects are reported after botulinum toxin type B injections

Breast Camcer - First patients enrolled in three breast cancer studies for Modrenal

Breast Cancer - Decoy chimera prevents urokinase receptor expression and breast cancer migration

Diabetes Therapy - Recent findings in diabetes therapy provide new insights

Breast Cancer - Researchers report details of new studies and findings in the area of breast cancer

Breast Cancer Risk Factors - Estrogen-progestin combination increases breast cancer risk

Breast Cancer Risk Factors - Further study is needed to assess toremifene for chemoprevention

Breast Cancer Therapy - Anastrozole decreases plasma lipids during neoadjuvant therapy

Breast Cancer Therapy - Medicinal herb induces cell growth arrest and apoptosis in breast cancer cells

Breast Cancer Therapy - Women switched to anastrozole treatment have improved event-free survival

Diabetes Therapy - Researchers' findings advance diabetes therapy research

Business & Finance - Biotech company announces contracts, adds to biodefense and vaccine development activities

Business & Finance - Immunotherapy-focused firm adopts mandatory board retirement policy

Business & Finance - Investment firm initiates coverage of four biotech companies

Business & Finance - Merck makes milestone $1 million payment for bacterial vaccine candidate

Business & Finance - Microparticle drug developer reports on operational progress

Business & Finance - Ohio entrepreneurial funding organization invests in Synapse Biomedical

Diabetes Therapy - Studies advance knowledge in diabetes therapy research

Business & Finance - Pharmaceutical distribution provider highlights 2005 performance

Business & Finance - RNAi-focused company provides 3Q update; arimoclomol moves forward, company reports $3.5M loss

Business & Finance - Survey indicates pharmaceutical firms cautious of investing in China and India

Business Updates - Pharma company moving from development stage to commercial organization

Cancer Gene Therapy - HER-2 protein expression can be inhibited in ovarian cancer cells

Diagnostics - Researchers report details of new studies and findings in the area of diagnostics

Cancer Gene Therapy - Papillary thyroid carcinoma after recombinant GH therapy for Turner syndrome

Cancer Gene Therapy - Zebularine has antimitogenic and chemosensitizing effects in ovarian cancer

Cancer Invasion - Runx2 transcription factor regulates cancer cell metastasis and invasion

Cancer Prevention - Reports add new data to cancer prevention research

Cancer Research - AmpliMed research shows preliminary evidence of antitumor activity

Cancer Research - Pediatric cancer research launches new research infastructure initiative

Hypertension - Reports advance knowledge in hypertension research

Cancer Research - Plant gene research may lead to the development of new oncology drugs

Cancer Research - Study demonstrates XL880 is generally well tolerated

Cancer Research - Vascular disrupting agents combined with antiangiogenics offer tumor strategy

Cancer Therapy - Advantages and disadvantages of management strategies for stage I seminoma discussed

Cancer Therapy - Anti-Helicobacter pylori therapy used to treat MALT lymphoma

Cancer Therapy - Breast cancer drug may help combat weight loss during radiation therapy

Neurology - Researchers provide details of new studies and findings in the area of neurology

Cancer Therapy - Chemoradiotherapy improved tumor control of nasopharyngeal carcinoma

Cancer Therapy - Continuous endostatin infusions stabilize advanced cancer cases

Cancer Therapy - Data from phase I trial of XL999 establishing MTD presented at cancer conference

Cancer Therapy - Epigallocatechin-3-gallate blocks photocarcinogenesis by thwarting proangiogenic activity

Cancer Therapy - High dose 3DCRT when combined with long-term androgen deprivation benefited unfavorable prostate cancer

Cancer Therapy - High dose L-asparaginase therapy evaluated for standard risk acute lymphoblastic leukemia

Oncology - Research in oncology provides new insights

Cancer Therapy - High-content screening of cytotoxic agents achieved

Cancer Therapy - Interferon treatment increases virotherapy for advanced hepatocellular carcinoma

Cancer Therapy - Late effects of pelvic rhabdomyosarcoma in female survivors analyzed

Cancer Therapy - Lower dose of hyperfractionated whole brain radiation delayed neurotoxicity from chemoradiation in lymphoma patients

Cancer Therapy - Macrophage migration inhibitory factor marks hypoxia-dependent chemosensitivity

Cancer Therapy - Magnesium depletion enhanced cisplatin-induced nephrotoxicity

Oncology - Researchers detail new studies and findings in the area of oncology

Cancer Therapy - Management strategies of non-seminomatous germ cell tumors discussed

Cancer Therapy - Meningoceles are induced by an antitumor agent in rat fetuses

Cancer Therapy - Oncolytic viral therapy approved for head and neck cancer

Cancer Therapy - Positive Panzem NCD phase Ib clinical trial results reported

Cancer Therapy - Promising results presented for tubulin binding agent, ENMD-1198

Statins - Researchers report details of new studies and findings in the area of statins

Cancer Therapy - Recent studies add new data to cancer therapy research

Cancer Therapy - Thrombospondin-1 helps cyclooxygenase inhibitors fight cancer invasion

Transplant Medicine - Research add new data to transplant medicine body of knowledge

Cancer Therapy - Use of imatinib mesylate in malignant mesothelioma demonstrated limited efficacy

Cancer Therapy - Valproate activates bovine leukemia virus gene expression and induces leukemia/lymphoma regression

Cancer Therapy - [I-131]MIBG and topotecan combination therapy evaluated for neuroblastoma

Cardiology - Angiomax recommended for use in percutaneous coronary interventions in updated guidelines

Cardiology - Enrollment is complete in trial of drug eluting graft for coronary artery bypass

Cardiology - New findings in cardiology described

Transplant Medicine - Researchers' work adds to transplant medicine body of knowledge

Cardiology - Treating ACS patients with aggressive antiplatelet therapy may increase bleeding

Cardiomyocytes - New data illuminates research in cardiomyocytes

Cardiovascular Disease - Study shows rimonabant improves cardiometabolic risk factors in obese patients

Celiac Disease - New book offers tips on dining and traveling gluten and allergy-free

Cervical Cancer - Researchers report new drug could change management options for cervical cancer

Virology - Recent findings illuminate research in virology

Chemotherapy - Clinical and nonclinical ispinesib results reported at AACR-NCI-EORTC meeting

Chemotherapy - Efficacy of cisplatin and platinum(IV) complexes unaffected by tumor microenvironmental factors

Chemotherapy - Etoposide, cisplatin, and irinotecan triplet used to treat advanced-stage small-cell lung cancer

Chemotherapy - First-line doxorubicin and docetaxel deemed effective in patients with metastatic breast cancer

Chemotherapy - Gemcitabine and treosulfan used to treat patients with metastatic uveal melanoma

Chemotherapy - Methylene blue considered for possible use in chemotherapy

Virology - Researchers describe findings in virology studies

Chemotherapy - Pemetrexed plus gemcitabine did not improve overall survival in pancreatic cancer patients

Cholesterol - Data shows Crestor plus ezetimibe reduces LDL cholesterol levels by 65%

Cholesterol - Study shows patients on Lipitor have fewer cardiovascular events than with Zocor

Cholesterol - Torcetrapib plus atorvastatin has positive effects on cholesterol levels

Clinical Trials - BlAsp 30 plus pioglitazone provides an effective treatment option for type 2 diabetes

Clinical Trials - Carotid stenting pilot trial begins in Europe using embolic protection system

Clinical Trials - Clinical research organization reports $0.02 per share net loss

Clinical Trials - Company ahead of schedule in phase III clinical trial of Actimmune

Clinical Trials - Drugmaker plans filing strategy for orBec

Clinical Trials - Human enzyme replacement therapy yields positive results for Hunter syndrome

Clinical Trials - Merck makes $1 million payment on start of DNA cancer vaccine trial

Clinical Trials - Metformin plus glimepiride, but not rosiglitazone, improved blood pressure control in DM-2

Clinical Trials - Phase I clinical trial begins for anticancer small molecule drug for leukemias

Clinical Trials - Phase II cancer trials designed using total and complete response endpoints

Clinical Trials - Phase II study of antisense drug in cardiovascular disease underway

Clinical Trials - Phase III psoriasis drug trial achieves safety, efficacy endpoints

Clinical Trials - Preclinical data demonstrate potential of prodrug technology

Clinical Trials - Study data on forodesine in leukemia treatment presented at hematology meeting

Clostridium Difficile - Fluoroquinolones are predominant risk factor for C. difficile-associated diarrhea

Collaborations - Advanced transdermal delivery gel development agreement signed with dermatology firm

Collaborations - Agreement signed with Pharmacuro to market StriantSR in the Nordic region

Collaborations - Baxter gains rights to commercialize hard and soft tissue-repair products

Collaborations - Cell analysis tools maker enters joint venture for clinical microbiology system

Collaborations - Cell therapy manufacturing firm announces agreement with BD Biosciences

Collaborations - Companies announce license, collaboration agreement for assay technology

Collaborations - Companies to collaborate on investigational antibiotic for infections

Collaborations - Exclusive distribution agreement for PhaSeal is ending

Collaborations - Licensing deal signed to develop intranasal insulin spray in 85 countries

Collaborations - MS research center and Schering AG to develop treatment assessment guidelines

Collaborations - Maker of image analysis tools renews collaboration with Pfizer

Collaborations - Partnership formed to expand sales force for Zanaflex capsules

Collaborations - Partnership with Duke spinout company focuses on cardiovascular stent coatings

Collaborations - South Korean firm to commercialize humanized monoclonal antibody in Asia

Collaborations - Stem cell focused company, Wayne State collaborate on prostate cancer research

Colon Cancer - Vegetables affect the expression of genes involved in anticarcinogenic processes

Complementary & Alternative Medicine - Antitumor-promoting effects of triterpene acids from Eriobotrya japonica leaves evaluated

Complementary & Alternative Medicine - Ayurvedic herbs may be an effective treatment option for diabetes mellitus

Complementary & Alternative Medicine - Glucosamine and chondroitin sulfate proven to protect joint health

Complementary & Alternative Medicine - Milk thistle used in treatment and prophylaxis of cancer

Complementary & Alternative Medicine - Parents often use CAM in their healthy, asthmatic, or HIV-infected children

Congenital Muscular Torticollis - Botulinum toxin type A shows promise for pediatric treatment

Contraception - New prescribing information announced for Ortho Evra birth control patch

Coronary Artery Disease - New class of plaque inhibiting drugs found ineffective

Coronary Artery Disease - Study investigates use of patient's own stem cells for coronary artery disease

DNA Research - First DNA test for response to schizophrenia treatment offered in England

DNA Research - Long QT syndrome-related mutations and single nucleotide polymorphisms identified

DNA Research - STAT5 activation protects insulin-producing cells against induced apoptosis

Dermatology - Daily topical applications of dobesilate may improve rosacea

Dermatology - Normal human fibroblasts bolster melanoma-induced angiogenesis

Developmental Biology - Cytokine-dependent regulation of anion transporter gene transactivators shown

Diabetes Complications - Diabetes severity, not antidiabetic regimen, raises congestive heart failure risk

Diabetes Complications - Fluvastatin is cost-effective and prevents MACE during percutaneous coronary intervention

Diabetes Complications - U.S. FDA approves INVANZ for treatment complicated foot infection in diabetic patients

Diabetes Control - Antimetabolic syndrome effect of puerarin attributed to multiple mechanisms

Diabetes Control - Metformin and thiazolidinediones combination reduces vascular risk in diabetics

Diabetes Control - Ten steps are presented to help more type 2 diabetics reach their glycemic goal

Diabetes Pathogenesis - Brazilin raises fructose-2,6-bisphosphate levels, thus inhibiting hepatic gluconeogenesis

Diabetes Pathogenesis - Tegaserod activates 5-HT₄ receptor agonist, improving gastric emptying rates

Diabetes Technology - DexCom selects semiconductor company for turnkey SoC Design and fabrication

Diabetes Therapy - Findings advance knowledge in diabetes therapy research

Diabetes Therapy - Novel aryl indole-2-carboxylic acid analogs reduced hyperglycemia

Diabetes Therapy - Novel pyrimidine derivatives with thiazolidinedione unit show antidiabetic activity

Diabetes Therapy - Synthesis of type 2 diabetes drug acarbose was identified in Actinoplanes bacterium

Diabetes Therapy - TORCs increase gluconeogenesis and may be a diabetes mellitus therapeutic target

Diagnostics - Activated Factor XII TypeA predicts all-cause mortality in patients admitted with chest pain

Diagnostics - Dynex Technologies to introduce clinical-diagnostic workstation for near-patient labs

Diagnostics - L-[methyl-C-11] methionine-positron emission tomography used to monitor treatment of glioma

Diagnostics - MR imaging used to assess leukoencephalopathy in children treated for acute lymphoblastic leukemia

Diagnostics - New data illuminates research in diagnostics

Diagnostics - Schizophrenia paper outlines study of gene expression profiles for disease

Diet & Nutrition - Dietary regime for older obese should include essential nutrients and reduce fat

Diet & Nutrition - Environmental factors impact insulin-like growth factor activity

Diet & Nutrition - Low-fat diet with omega-3 fatty acid supplements can improve treatment efficacy

Diet & Nutrition - Rats fed high-fat diet developed hyperphagia and reduced sensitivity to cholecystokinin

Diet & Nutrition - Treatment with a-MSH enhances activity-based anorexia in animal model

Diet & Nutrition - Vitamin A supplementation regulates adipose tissue mass in lean and obese phenotypes

Digestive Tract Cancer - Higher heme iron intake is associated with risk of upper digestive tract cancer

Disease Associations - A single-nucleotide substitution is associated with allergic diseases

Disease Associations - Interaction with blood components is crucial in gene transfer

Disease Associations - Risk of malignant mesothelioma increased in testicular cancer survivors

Distribution Agreement - Software company signs distribution agreement with Fujifilm

Drug Abuse - New advertising campaign targets illicit use of methamphetamine

Drug Delivery - Amended recombinant cells are a good delivery vehicle for interferon-gamma

Drug Delivery - Coformulated N-octanoyl-glucosylceramide improves liposomal doxorubicin efficacy

Drug Delivery - Combined PLGA+PCL microspheres may be useful in the delivery of rifampicin and other agents

Drug Delivery - Magnesium aluminum silicate can improve alginate coating for drug release tablets

Drug Delivery - Next-phase clinical trial of insulin patch drug-delivery system begins

Drug Development - AEG35156 phase I oncology trial demonstrates target response in cancer patients

Drug Development - ANA975 phase I data indicates oral therapy of chronic hepatitis C virus is well tolerated

Drug Development - ATP-sensitive potassium channel opener protects kidneys in spontaneously hypertensive rats

Drug Development - Actilon for hepatitis C demonstrates antiviral activity in early clinical evaluation

Drug Development - Alagebrium demonstrates cardiac benefits in diastolic dysfunction and endothelial function studies

Drug Development - All follow-up visits completed in phase III trial of Rheopheresis

Drug Development - Anti-angiogenic compounds may have applications in cancer, other diseases

Drug Development - Apo A-I mimetic peptide inhibits atherosclerosis in preclinical animal study

Drug Development - Avian flu vaccine in development uses proprietary bacterial vectoring technologies

Drug Development - Boronic acid bioisostere of combretastatin A-4 synthesized

Drug Development - Bronchitol granted orphan drug status in Europe

Drug Development - Byetta reduces blood sugar levels when combined with TZDs in diabetics

Drug Development - Collaboration to develop, market antithrombin in Europe, Canada, Middle East

Drug Development - Commercialization rights for almogran in Switzerland granted to Merz

Drug Development - Data from phase I trial of XL647 presented at cancer conference; therapy generally well tolerated.

Drug Development - Data suggests EOquin as a radiation sensitizer slows tumor growth

Drug Development - Data support the initiation of a phase II program with VX-950 for hepatitis C

Drug Development - Disease modification in rheumatoid arthritis: New DMARDs to compete for anti-TNF failure patients

Drug Development - Drug companies form alliance to develop abuse-resistant opioid painkillers

Drug Development - E.U. marketing authorization application for Daxas withdrawn

Drug Development - Endothelial cell lactosylceramide is an upstream mediator of angiogenesis

Drug Development - Entecavir 2-year data analysis did not detect emergence of resistance in hepatitis B

Drug Development - Expression of recombinant human MEPE in a mammalian expression system reported

Drug Development - Life sciences company introduces modified RNAi human kinase collection

Drug Development - Mapatumumab may be the first apoptosis modulator to live up to its potential

Drug Development - Mechanism of action of multi-functional class of defense proteins discussed

Drug Development - Peptide-based drug stimulates production of red blood cells

Drug Development - Phase I trial of temozolomide plus O-6-benzylguanine conducted for patients with malignant glioma

Drug Development - Phase III PROVIDENCE-1 study of antibiotic treatment in peripheral arterial disease is expanded

Drug Development - Pivotal amoxicillin PULSYS phase III trial begins

Drug Development - Pivotal phase III trial of vaccine against Japanese encephalitis begins

Drug Development - Positive preclinical data on camptothecin compound presented

Drug Development - Significant neuroprotective effects of Miraxion reported

Drug Development - Study shows INGN 241 and celecoxib combination kills breast cancer cells

Drug Development - Study to define the prevalence of the molecular marker N-cadherin among a variety of tumor types

Drug Development - Technology to assemble therapeutic protein avimers described in publication

Drug Development - Thought leaders drive success from early-stage drug development to post-launch

Drug Resistance - Compounds transported by MRP1 could be predicted

Drug Resistance - Disrupting thrombin-PAR1 interaction may reduce tumor drug resistance

Drug Resistance - MBL-producing P. aeruginosa associated with higher case-fatality rate and invasive disease

Drug Resistance - Rapid community-acquired MRSA emergence in children has reached epidemic proportions

Drug Resistance - Researchers describe findings in drug resistance studies

Drug Resistance - The associations between MRSA infection and HIV severity indicators merit examination

Drug Safety - Diabetisource AC 1.5 Liter bottles lot 2135L recalled due to incorrect labeling

Drug Safety - GenTeal products recalled in U.S. due to product sterility

Drug Safety - Isotope ratio mass spectrometry allows screening for manufacturer of pharmaceutical ingredients

Drug Safety - New campaign warns of risks of counterfeit medicines on Internet

Drug Safety - Study shows that people are unaware of the possible harmful effects of painkillers

Drug Toxicity - Polymorphisms in cytochrome P450 2B6 may account for efavirenz toxicity during HIV/TB treatment

Drug Toxicity - Study demonstrates importance of monitoring drugs with toxicity risk

Endocrinology - Gonadotropin-releasing hormone analogs resensitize breast cancer cells to tamoxifen

Endocrinology - Thyroid hormone has tissue-specific effects on P-glycoprotein expression

Environmental Health - Novel HPLC-MS/MS assay reveals low general exposure to bisphenol A in humans

Epidemiology - HIV seropositivity is increasing among tuberculosis cases in India

Epilepsy - Internet poll indicates women with epilepsy not getting enough information

Facilities - Aspirin maker increases visibility with new sign

Facilities - Pharmaceutical packaging company building new factory in China

Finance - Beacon Equity Research researching painless drug delivery technology

Finance - Bioscience company sells $19.5 million of common stock to investors

Finance - Biotech company reports product sales increased by 31%

Finance - Blood plasma volume expander developer reports loss of $0.02 per share

Finance - Cancer drug maker reports loss of $0.10 per share

Finance - Cancer-focused biotech reports third-quarter revenues of $58,000

Finance - Cancer-focused company reports revenue of $3.2 million for quarter

Finance - Carbohydrate compound developer reports net loss of $1.68 million

Finance - Cell therapy developer reports no revenue for 3 and 9 months

Finance - Chemically derived drug maker reports $5.4M decline in sales

Finance - Chinese pharmaceutical firm reports that revenues increase 81.9%

Finance - Cognitive disorders-focused company reports loss of $0.11 per share

Finance - ComfortScan maker announces third-quarter 2005 results, revenue of $65,000