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Acute Coronary Syndrome

AZD6140 plus aspirin assessed for safety, tolerability as antiplatelet therapy

Published in Drug Week, December 16th, 2005

New phase IIb data from the Disperse2 Study presented at the American Heart Association's Scientific Sessions, assessed the safety and tolerability of the AstraZeneca investigational drug AZD6140 plus aspirin compared with clopidogrel plus aspirin as antiplatelet therapy in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

The primary end point of the study was the incidence of total (major plus minor) bleeding events seen in patients taking AZD6140 or clopidogrel, which overall was 10.2% for the AZD6140 90 mg twice daily (BID) group, 10.2% for the AZD6140 180 mg BID group, and 9.2% for the clopidogrel 75 mg once daily (QD) group. Within these figures,...

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