Drug Week
Susan Hasty, Publisher
Table of Contents . . . January 27th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Cancer Therapy - Cervical cancer vaccine candidate induced a higher immune response in young girls
Cancer Therapy - Supplemental BLA submitted for Avastin in relapsed metastatic colorectal cancer
Drug Development - High response rates reported in use of single agent Treanda in non-Hodgkin lymphoma
Pain Management - U.S. FDA accepts investigational new drug application for Sativex
Rotavirus - Vaccine candidate shown effective against rotavirus disease in infants
Abortion - Studies evaluate misoprostol use to terminate pregnancies in Latin America
Actinic Keratoses - Diclofenac in 2.5% hyaluronan gel is effective for actinic keratoses
Addiction Medicine - Adolescent research animals are more sensitive to handling experience than adults
Addiction Medicine - Agency issues approvable letter for Vivitrol for treatment of alcohol dependence
Addiction Medicine - Alcohol-deterrent drugs help patients achieve high rates of long-term abstinence
Addiction Medicine - Binge cocaine treatment alters endothelial function and impairs the adrenergic pathway
Addiction Medicine - CYP2A6 and CYP2B6 are involved in nornicotine formation from nicotine in humans
Addiction Medicine - Cocaine- and amphetamine-regulated transcript peptides play a role in psychostimulant addiction
Addiction Medicine - Different drugs produce attention and motivation deficits in rats
Addiction Medicine - MRI findings are key to a leukoencephalopathy diagnosis caused by drug use
Addiction Medicine - Persons addicted to heroin maintain mimetic conditioned response
Adolescent Health - Psychotropic drug prescriptions for U.S. teens surge 250% over 7-year period
Adverse Drug Reaction - Everolimus disrupts angiogenic factors in glomerular tissues
Adverse Drug Reaction - QT prolongation and torsades de pointes occur in methadone users
Allergy & Immunology - Article reviews desloratadine for treating allergic inflammatory disorders
Allergy & Immunology - Danish biotech company to lead in evaluation of animal-free testing of allergy products
Allergy Vaccine - Vaccine with reduced IgE binding and preserved T cell epitopes prevents allergy attacks
Alzheimer Disease - Drugmaker applies for a new indication of severe Alzheimer disease for Aricept in Japan
Anesthesia - Clonidine reduces post-anesthesia agitation in children
Anesthesia - Lidocaine and mexiletine were safe and relieved neuropathic pain better than placebo
Angiology - Adenosine prevents neutrophil adhesion to endothelial cells
Angiology - Blood vessel/epicardial substance plays a role in maintaining epithelial cell integrity
Angiology - Sufentanil has direct vasodilatory effect on vascular tissue
Angiology - Urocortin reduces viability of vascular smooth muscle cells
Angiotensin - Angiotensin II plays a role postexercise proteinuria in rats
Antibacterial Agents - CSA antibiotic more active against bacterial infections than common therapies, studies show
Antimicrobials - Campylobacter coli strains exhibit resistance to ciprofloxacin and erythromycin
Antimicrobials - Public health measures and new microbial agents can reduce the risk of travel-related diarrhea
Antisense Technology - Cell surface conjugates can be antisense blocked in Entamoeba histolytica
Antisense Technology - Nuclear receptor 5a2 functions in skeletal muscle organization
Antisense Technology - Smad-interacting protein regulates chordin expression in the Xenopus embryo
Apoptosis - 1-(3,4-dimethoxyphenyl)-3,5-dodecenedione induced apoptosis in leukemia
Apoptosis - Abrogation of hsp70 induction increased antileukemia activity of 17-AAG
Apoptosis - Artemisinin and sodium butyrate showed cytotoxic effect on human cancer cells
Apoptosis - Bcl-xL , of the Bcl-2 family, is a link between apoptosis DNA damage response
Apoptosis - LAQ824 and roscovitine induced apoptosis in human leukemia cells
Apoptosis - Reports add new data to apoptosis research
Apoptosis - Researchers describe findings in apoptosis studies
Apoptosis - Researchers provide details of new studies and findings in the area of apoptosis
Apoptosis - Tumor suppressive effects of tocotrienol showed potential
Arthritis - Stepwise autoantibody testing can be used to distinguish RA patients at risk for poor outcome
Asthma - Hydrofluoroalkane metered-dose inhaler available by prescription for asthma, COPD
Asthma - Pharma company announces changes to product label for Singulair
Asthma - Trial shows MN-001 significantly improves measures of respiratory function in asthma
Atherosclerosis - Polygonum multiflorum derivative reduces atherosclerotic lesions in rabbits
Atopic Dermatitis - Antigen-specific immunotherapy using CpG ODN was developed in new mouse model
Atrial Fibrillation - Flec S-L Trial tests targeted pharmacological reversal of electrical remodeling
Attention Deficit Hyperactivity Disorder - U.S. FDA issues approvable letter for Daytrana methylphenidate transdermal system
Autism - Senate bill grants drug companies immunity from liability for injuries caused by vaccines
Autism - Variations in the serotonin transporter are associated with autism
Avian Influenza - Ingestible avian influenza formulation eradicates virus strain in independent lab tests
Avian Influenza - U.S. Congressional bill includes $3 billion for development and purchase of vaccines
Awards - Diabetes drug developer recognized for leadership and product innovation
Bacteriology - Data from phase 2 safety trial of monoclonal antibody for staph infections presented
Behavioral Medicine - Florida behavioral healthcare provider licenses physiological substance abuse protocols
Biomedical Engineering - New low-nickel austenitic stainless steel implants yield good results in animal tissues
Biomedical Engineering - Research add new data to Biomedical Engineering body of knowledge
Biomedical Engineering - Transfected stromal cells improve the fate of healing bone grafts
Bioterrorism - Biodefense support agreement inked with GE Healthcare
Bladder Cancer - Urine ThinPrep specimens reveal disease stage in patients with bladder cancer
Bloodstream Infections - BSI is leading cause of morbidity/mortality in pediatric patients
Bone Cancer - Phase 1 preliminary findings in multiple myeloma study presented at hematology meeting
Bone Formation - Calcineurin appears to regulate bone formation through an effect on osteoblast differentiation
Brain Cancer - Reports describe recent advances in Brain Cancer research
Breast Cancer - Adjuvant systemic therapy used to treat male breast carcinoma
Breast Cancer - Alpha6beta4 integrin depends on VEGF to maintain malignant breast tumor growth
Breast Cancer - Angiogenic induction may be a key feature of hormone-dependent breast cancer
Breast Cancer - Breast cancer resistance protein may not be primarily involved in multiple myeloma
Breast Cancer - Cell stress protein linked to aggressive breast cancer disease
Breast Cancer - Femara receives U.S. approval for new treatment indication
Breast Cancer - Findings in Breast Cancer provide new insights
Breast Cancer - Letrozole as post-operative breast cancer therapy reduces recurrence, large study shows
Breast Cancer - Lobular breast cancer metastasized to the colon
Breast Cancer - New findings in Breast Cancer described
Breast Cancer - Overexpressed Twist alters angiogenesis and chromosomal stability in breast tumors
Breast Cancer - Studies describe new findings in Breast Cancer research
Breast Cancer - The MCT-1 oncogene promotes tumor angiogenesis and blocks apoptosis
Breast Cancer - Use of light therapy for breast-cancer-related fatigue evaluated
Breast Cancer Prevention - Prophylactic endocrine treatment is not recommended outside clinical trial setting
Breast Cancer Survival - Benefits of longer tamoxifen therapy were seen in younger estrogen receptor-positive women vs. older women
Breast Cancer Therapy - Mental health plays strong role in chemotherapy-related fatigue in breast cancer patients
Breast Cancer Therapy - Time to progression may be valuable surrogate marker in predicting breast cancer survival
Business & Finance - American Stock Exchange lists common stock of biotech company making cancer drugs
Business & Finance - Biopharma regains full compliance with Nasdaq listing requirements
Business & Finance - Biopharmaceutical company adopts stockholder rights plan to address takeover tactics
Business & Finance - Biopharmaceutical company announces plans to refocus resources
Business & Finance - Drug discovery company announces reorganization of research business, job losses expected
Business & Finance - Drug distribution company announces sale of its wholesale drug-distribution business
Business & Finance - ECG services company signs $12.4 million in cardiac monitoring contracts since last update
Business & Finance - Immune system-focused biopharmaceutical company listed on OTC Bulletin Board
Business & Finance - Japanese biopharmaceutical company updates financial forecast after acquiring Arakis
Business & Finance - Previously announced sale of myoblast cell therapy program complete
Business & Finance - TSX Venture Exchange halts trading of diabetes drug developer
Business Ethics - Pharma firms top annual ethical ranking of multinational companies
Business Update - Genomics company spins off CoGenesys division as an independent company
Business Update - Prescription drug card program reports first-decade savings of $1 billion
Business Update - Software maker reports expanding use of DMX
Cancer Epidemiology - ErbB2 mutations are rare in Japanese patients with lung cancer
Cancer Immunotherapy - Antibody-based drugs may be more effective when combined with IL-2 or IL-12
Cancer Research - Advances reported in development of oncolytic viruses for cancer treatment
Cancer Research - Study examined metabolic deviations related to weight loss during chemoirradiation
Cancer Research - U.S. DOD awards $1.5 million in research funding to Nebraska cancer center
Cancer Therapy - Angiogenesis inhibitor ZD6474 helps control central nervous system tumors in mice
Cancer Therapy - Anticancer activity is displayed by light-induced ruthenium complexes
Cancer Therapy - Antisense/radiation therapy effectively treats nasopharyngeal cancer
Cancer Therapy - Breast cancer drugs may slow growth of lung cancer
Cancer Therapy - Concurrent growth factor inhibition and gemcitabine staunch pancreatic cancer growth
Cancer Therapy - Cytochrome modulation triggers apoptosis in tumor cells
Cancer Therapy - Data advance knowledge in Cancer Therapy research
Cancer Therapy - Findings describe new data in Cancer Therapy research
Cancer Therapy - Gefitinib with weekly epirubicin controls disease in patients with metastatic breast cancer
Cancer Therapy - HuMax-CD38 proves effective in preclinical studies in multiple myeloma
Cancer Therapy - Maximum tolerated dose of continuous mitomycin-C infusion determined
Cancer Therapy - Neoadjuvant chemotherapy used to treat liver metastases from colorectal cancer
Cancer Therapy - New platinum-based, anti-cancer agent overcomes drug resistance
Cancer Therapy - Paclitaxel decreased uptake of gemcitabine in human leukemia cells
Cancer Therapy - Pegamotecan exhibited antitumor activity in solid tumors and lymphomas
Cancer Therapy - Recent findings illuminate research in Cancer Therapy
Cancer Therapy - Reports describe recent advances in Cancer Therapy research
Cancer Therapy - Researchers describe findings in Cancer Therapy studies
Cancer Therapy - Researchers provide details of new studies and findings in the area of Cancer Therapy
Cancer Therapy - Soluble FLT-1 receptor thwarts vascular endothelial growth factor and angiogenesis
Cancer Therapy - Spectroscopic signatures for different forms of topotecan studied
Cancer Therapy - Study suggests a new prophylactic approach in the field of radioprotection of salivary glands
Cancer Vaccines - Researchers' data advance Cancer Vaccines research
Cancer Vaccines - Studies add new findings to Cancer Vaccines body of knowledge
Cardiology - Dexamethasone inhibits neointima formation but is linked to adverse vascular changes
Cardiology - Fenofibrate did not significantly reduce coronary event risk in type 2 diabetics
Cardiology - Global measurements of inflammatory markers forecast heart disease risk in women
Cardiology - Impact of new targets on lipid treatment and cardiovascular risk reduction was reviewed
Cardiology - Low-dose granulocyte-colony stimulating factor renews vascularity in ischemic tissue
Cardiology - Published study reports link between tooth loss and coronary heart disease
Cardiology - Review discusses cardiovascular safety of antiobesity drug sibutramine
Cardiology - Sibutramine Cardiovascular Outcome Trial study is introduced
Cardiology - Sympathetic stimulation can reveal congenital long-QT syndrome
Cardiomyocytes - Calcitonin gene-related peptide localization is similar to sarcolemmal L-type calcium channel
Cardiovascular Disease - CRP-lowering with atorvastatin eliminates paroxysmal AF
Cardiovascular Disease - Calcium antagonists are useful in lowering cardio-renal risk
Cardiovascular Disease - Carvedilol was superior to nebivolol in improving LV function
Cardiovascular Disease - Countries consider challenges and benefits of Rx-to-OTC switches for cholesterol reducers
Cardiovascular Disease - Post-CV event anticoagulation therapy improves long-term outcome
Cardiovascular Research - Aldosterone induces negative inotropic response in human trabeculae
Cardiovascular Research - Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction
Cell Therapy - Autologous cells from fat tissue revive new vessel growth in ischemic limbs
Chagas Disease - Optimal strategy to combat Chagas disease is a combination of vector control and potential new drug
Chemotherapy - Antiangiogenic chemotherapy in pediatric cancer patients deemed feasible
Chemotherapy - Chemotherapeutic cisplatin dosage can be reduced by ZD 1839
Chemotherapy - Vitamin C enhanced chemosensitization of esophageal cancer cells
Chronic Lymphocytic Leukemia - NDA filed for Genasense Injection
Chronic Pain - Positive preliminary results reported from transdur-sufentanil patch study
Chronic Pain - Studies suggest potential for acceptance-based clinical methods for chronic pain management
Cirrhosis - Rapid-onset primary biliary cirrhosis resembles drug-induced liver injury
Clinical Trials - Analysis recommends phase 3 trial of tifacogin for community-acquired pneumonia continue
Clinical Trials - Cancer cell-inhibiting drug shows significant activity in elderly leukemia patients
Clinical Trials - Drugmaker files responses to FDA's approvable letters on NDAs for oxymorphone ER and IR tablets
Clinical Trials - Enrollment begins in Japan arm of SPIRIT III drug-eluting stent trial
Clinical Trials - Enrollment complete in phase 3 trial of drug treatment of advanced ovarian cancer
Clinical Trials - Enrollment completed in phase 2b/3 study of cancer pain drug
Clinical Trials - Enrollment full in first phase 3 trial of oregovomab therapy in advanced ovarian cancer
Clinical Trials - Human clinical trials for pandemic flu vaccine initiated in Beijing, China
Clinical Trials - Merck starts phase 1 clinical trial for S. aureus vaccine
Clinical Trials - Phase 3 clinical trial for oral cancer detection drug began with investigators' meeting
Clinical Trials - Positive results reported from study of treatment for pulmonary arterial hypertension
Clinical Trials - Progress enrolling subjects to study implantable drug for Alzheimer reported
Clinical Trials - Promising interim phase 2 results in advanced stage malignant melanoma trial reported
Clinical Trials - Researcher presents argument for using new method in clinical trials
Clinical Trials - Results from Zadaxin proof-of-concept liver cancer trial indicate positive survival trend
Clinical Trials - U.S. phase 3 trial of mannitol in people with suspected asthma begins patient enrollment
Collaborations - Agreement to develop, market seven generic pharmaceutical products for U.S. market signed
Collaborations - All rights to Reloxin recovered subject to the completion of Allergan's acquisition of Inamed
Collaborations - Alliance to focus on cell-line development
Collaborations - AstraZeneca and collaborator announce license, research agreement for Alzheimer compound
Collaborations - Bayer has access to HuCAL Gold antibody library for drug discovery for an additional 5 years
Collaborations - Codevelopment agreement signed for system to deliver antimicrobial drugs
Collaborations - Collaboration on vascular endothelial growth factor trap extended to include Japan
Collaborations - Collaboration to pursue plant-made vaccine solution to avian influenza
Collaborations - Company developing blood substitute engages Regulus for U.S. FDA services
Collaborations - Deal to integrate human antibody drug development pipeline and operations
Collaborations - Drug company initiates $54 million drug discovery collaboration with Boehringer Ingelheim
Collaborations - Licensing and commercialization deal signed for atherosclerosis drug AGI-1067
Collaborations - Merck enters into broad strategic alliance for research and development
Collaborations - Online diet and fitness company announces collaboration with Mayo Clinic
Collaborations - Partnership renewed with France's Institut Pasteur
Collaborations - Pfizer and biotech company form collaboration for whole genome and replication studies
Collaborations - Pharma companies to collaborate on modeling of p38 kinase inhibitors
Collaborations - Pharma company and Boston Scientific complete research collaboration
Collaborations - Pharmaceutical companies discuss terminating collaborative deal for oral type 2 diabetes therapy
Collaborations - Research and licensing agreement signed with Tel Hashomer for oncology drug development
Collaborations - University, MMV, DNDi to collaborate on anti-parasitic drugs for malaria and leishmaniasis
Colorectal Cancer - Cholesterol-lowering drugs not associated with reduced disease risk
Colorectal Cancer - Colon cancer organization releases updated guidelines incorporating new technologies
Colorectal Cancer - Early chemotherapy in asymptomatic colorectal cancer did not improve survival
Complementary & Alternative Medicine - Chiropractic activator methods used in unretractable temporomandibular disorder pain
Complementary & Alternative Medicine - Personalized medicine's goal is to match right drug to right person, report says
Conjunctivitis - Prostaglandin D-2 may induce ocular inflammation in allergic conjunctivitis
Constipation Therapy - Report reviews the role of serotonergic agents for primary chronic constipation
Coxsackievirus Vaccine - Immunization-derived antibody protects cells from coxsackievirus
Cytokines - Modulation of cytokine production inhibits pro-inflammatory cytokines and augments interleukin
DNA Research - Loss of a splicing factor induces cell cycle arrest and apoptosis
DNA Research - Rfx1 plays a role in the DNA damage response
Depression - Gene linked with serotonin could help determine risk for depression
Depression - Income level may predict response to treatment
Depression - Maier and Bech scales are equivalent measures of depression
Dermatitis - Two Ser proteinases abundant in human skin are inhibited in atopic dermatitis
Dermatology - Drug-induced hypersensitivity syndrome shows transient immunosuppression before viral reactivation
Developmental Biology - Slow muscle regulates the pattern of trunk neural crest migration in zebrafish
Diabetes Complications - Gremlin gene expression prompts the formation of diabetic retinopathy
Diabetes Complications - Microangiopathy may influence normocytic normochromic anemia
Diabetes Complications - Topical tretinoin was safe effective therapy for foot ulcers in diabetics
Diabetes Pathogenesis - Findings describe new data in Diabetes Pathogenesis research
Diabetes Pathogenesis - PPAR gamma agonists do not directly enhance Na+ transport via the epithelial Na+ channel
Diabetes Pathogenesis - Study of thioacetamide-treated diabetic rats showed NF-kappaB regulated cyclin D1 signaling
Diabetes Research - Methylamine but not mafenide mimics insulin-like activity and shows antidiabetic properties
Diabetes Therapy - Experts suggest to prescribe orlistat only in conjunction with lifestyle modifications
Diabetes Therapy - New data illuminates research in Diabetes Therapy
Diabetes Therapy - One year course of oral sulodexide delays the progression of diabetic nephropathy
Diabetes Therapy - Pioglitazone reduced oxidative stress in diabetic rats but not blood pressure
Diabetes Therapy - Research in Diabetes Therapy provides new insights
Diabetes Therapy - Review examines pramlintide for treatment of type 1 and type 2 diabetes
Diabetes Therapy - Simvastatin may maintain antioxidant activity and structural organization in diabetic lung
Diabetes Therapy Complications - Review assesses prevalence of complications related to metformin use in diabetes treatment
Diagnostics - Molecular imaging of apoptosis in cancer discussed
Diagnostics - New monoclonal antibodies discern hypoxia regulatory factors in human tissues
Diagnostics - Repetitive sequence-based PCR rapid and reproducible for MRSA outbreak analysis
Diagnostics - Reports describe recent advances in diagnostics research
Diagnostics - Scanning electron microscopy helps quantify keratin networks in cancer cells
Diet & Nutrition - Low-birth-weight infants show raised glutamine synthesis after parenteral amino acid infusion
Diet & Nutrition - Orlistat improved weight loss and Eating Disorder Inventory score in obese
Disease Associations - Associations between the kidney, renal cancers, and the eye reviewed
Disease Associations - Elevated anti-smooth muscle antibody is detected in HCV-HIV co-infection
Disease Associations - Portal vein gas developed after chemoradiotherapy for esophageal carcinoma
Disease Associations - Tuberculin reactivity rates lower and anergy rates higher in Indian ESRD patients
Drug Delivery - Agreement signed to develop controlled release product for distribution in Canada
Drug Delivery - Developer of human vaccines licenses micro-delivery technology from BD Medical
Drug Delivery - Guidelines for the use of continuous subcutaneous insulin infusion therapy are developed
Drug Delivery - New microcapsules could provide timed release drugs, vaccines
Drug Delivery - Polyion complex micelles steer drugs to corneal neovascularization
Drug Development - 10f-TDAF identified as target for antineoplastic intervention
Drug Development - A modeling study determines the molecular inhibitors of AChE
Drug Development - A new RNA aptamer targeting alphavbeta3 integrin hinders endothelial cell growth and survival
Drug Development - Anti-thrombosis program to be advanced into preclinical development
Drug Development - Approval granted from U.S. FDA for Zonisamide capsules, 25 mg, 50 mg & 100 mg
Drug Development - Biopharma company pursues parallel efforts in U.S. and Europe for its NE-180 program
Drug Development - Bronchitol European cystic fibrosis study commences
Drug Development - Cancer drug developer sums up pipeline progress
Drug Development - Ceftobiprole achieves potent activity in MRSA.
Drug Development - Chinese Food and Drug Administration grants approval to market treatment for diabetes
Drug Development - Depakote ER approved for acute manic or mixed episodes associated with bipolar disorder
Drug Development - Drug permeability in human 16HBE14o-airway cell layers is useful to predict lung permeability
Drug Development - Favorable toxicity profile of tasidotin warrants further study of the drug
Drug Development - Five new dermatological therapies launched
Drug Development - Flavonoids represent novel drug development leads because of antimicrobial activity
Drug Development - Humanized anti-CD74 antibody has shown therapeutic activity in lymphoma and myeloma transplants
Drug Development - INDA filed with U.S. FDA for monoclonal antibody treatment of Hodgkin lymphoma
Drug Development - Investigational new drug application submitted to U.S. FDA for Delta opioid agonist compound
Drug Development - Lancell, LLC granted $75,000 development award for vaccine acceleration technology
Drug Development - Marketing and sales of Hemopure initiated in South Africa
Drug Development - NDA filed with U.S. FDA for mesalamine treatment of ulcerative colitis
Drug Development - New drug application submitted to U.S. FDA for dasatinib
Drug Development - Organometallic compounds induce cytostatic and cytotoxic effects on cancer cells
Drug Development - PBT-3 caused long-term growth inhibition of K562 solid tumors in vivo
Drug Development - Pharmaceutical company to initiate 28-day trial of ANA975 in patients with chronic hepatitis C
Drug Development - Pharmacogenomics of human ABC transporter ABCG2 described
Drug Development - Phase III trial of AI-700 in patients with cardiovascular disease enrolls 700 patients
Drug Development - Pivotal phase III trial of drug for Huntington disease commences
Drug Development - Proof of feasibility phase for manufacture of congenital emphysema drug completed
Drug Development - Researchers describe findings in Drug Development studies
Drug Development - Review focused on regulatory issues for plant-made pharmaceuticals and vaccines
Drug Development - Rights to anticancer compound acquired from Mitsubishi Pharma Corp.
Drug Development - Sale of Keflex brand of cephalexin not completed in December
Drug Development - Swiss agency approves Erbituxfor for the treatment of head and neck cancer
Drug Development - Thorough understanding of drug development is needed for clinical testing
Drug Development - Trials set to begin for Celiac disease therapy
Drug Development - Two milestones totaling $20 million in payments reached in Genentech alliance
Drug Development - U.S. FDA grants approval for zonisamide capsules for epilepsy
Drug Development - U.S. FDA grants fast track designation for esterase inhibitor for hereditary angioedema
Drug Development - U.S. FDA grants orphan drug designation for CellCept in myasthenia gravis
Drug Development - U.S. FDA issues approval for orally disintegrating drug for depression
Drug Development - U.S. FDA issues final approval for clozapine ANDA
Drug Development - Update provided on atrial fibrillation program
Drug Development - Worldwide ownership interest in antibiotic oritavancin sold
Drug Resistance - Studies advance knowledge in Drug Resistance research
Drug Safety - Agency to strengthen research and communication with AHRQ
Drug Safety - Healthcare disposable products manufacturer introduces medication labeling system
Drug Safety - Leftover drugs need special care in disposal, according to Harvard newsletter
Dyslipidemia - Eicosapentaenoic acid supplements have beneficial effects on arterial stiffness, data suggest
Endocrinology - Cytoglobin induction may protect islet cells following transplantation
Endocrinology - Recombinant growth factor replacement therapy released in U.S.
Endocrinology - Research add new data to endocrinology body of knowledge
Epitope Presentation - Hemagglutinin epitope presentation elicits strong antibody binding
Epstein-Barr Virus - Proliferation of EBV-positive Burkitt lymphoma cells is inhibited by RNA interference
Erectile Dysfunction - Psychosocial satisfaction is important in evaluation men treated for erective dysfunction
Esophageal Cancer Vaccine - Drugs can promote effect of cancer/testis antigen-specific cancer vaccines
Euvolemic Hyponatremia - U.S. FDA approves VAPRISOL for the treatment of euvolemic hyponatremia
Facilities - HIV/AIDS-focused drugmaker moves into new offices
Facilities - Pharmaceutical company selects West Chester, Ohio as site for new manufacturing plant
Fertility - Benefits and risks of ovarian tissue cryopreservation reviewed
Fibromyalgia - Characterization and consequences of pain variability studied in individuals with fibromyalgia
Finance - Alzheimer-focused drug developer receives notice related to Nasdaq minimum bid price rule
Finance - Biological technologies company announces 8% increase in sales over last year
Finance - Biological technologies company names Dr. Peter M. Blecher to board of directors
Finance - Biopharma company receives $8 million cash payment on Estrasorb
Finance - Biopharma to repatriate funds to the United States
Finance - Biopharmaceutical company announces removal of common stock from Nasdaq SmallCap Market
Finance - Biosciences company announces revenues of $56 million for fourth quarter 2005
Finance - Biotech greenhouse portfolio companies announce major developments
Finance - Biotech venture capital company first closing of its life sciences capital fund
Finance - Blood plasma volume expander maker raises $1,787,145 in rights offer
Finance - Cancer drug maker reports loss of $0.09 per share, provides clinical pipeline progress report
Finance - Cancer therapeutics company reports net loss of $5.9 million
Finance - Drug delivery company announces $2.5 million private placement with institutional investors
Finance - Drug discovery company enters bought deal financing to issue 6.5 million shares
Finance - Fibrin sealant developer reports significant decrease in sales revenue
Finance - International research grants given to 28 scientists
Finance - Investment company closes $550M life sciences fund
Finance - Investor Growth Capital is new principal owner of biomaterials producer
Finance - Kadian developer declares regular quarterly cash dividend
Finance - Nanobiotechnology company closes $4M private placement to fund ongoing operations
Finance - Neuroscience company announces $26.4M private placement
Finance - Neuroscience company raises $20.1M in extended series B financing
Finance - Neuroscience-focused company reports loss of $0.49 per share
Finance - Over-the-counter healthcare company revises guidance upward for fiscal 2005
Finance - Pfizer invests $50 million in private biotech company
Finance - Pharma company announces new North American credit facilities of US$290 million
Finance - Pharma company finalizes negotiations with unsecured convertible debenture holders
Finance - Pharmaceuticals firm that enhances existing brands announces timing of financial disclosures
Finance - Revenue guidance increased for pharma firm focused on less common diseases
Finance - Shelf registration statement filed for overactive bladder drug maker
Finance - Stroke-focused biopharmaceutical company completes $15 million private placement
Fitness & Wellness - Statins alter the muscle's response to exercise stress
Flavivirus Vaccine - CRADA inked to evaluate PER.C6 technology for development of flavivirus vaccines
Fungal Infections - Antifungal therapy can prevent relapse in organ transplant recipients
Galantamine - Age-related memory deficits were reversed by galantamine treatment in murine model
Gastric Cancer - Postoperative oral fluoropyrimidine compared to paclitaxel/oral fluoropyrimidine
Gastric Cancer - Risk factors for gastrointestinal malignancy delineated
Gastroenterology - Notch signal blockade halts pancreatic cancer neurovascular progression
Gastrointestinal Stromal Tumors - Multidrug resistance proteins did not impair initial response of GIST to imatinib
Gene Expression - A novel survival-related gene controls apoptosis and tumorigenesis
Gene Research - Small RNA regulates endothelial nitric oxide synthase
Gene Research - Stanford University evolution research with stickleback fish cited by Science
Gene Therapy - Effect of epidermal growth factor receptor inhibitors on gliomas studied
Gene Therapy - Recombinant antibodies deliver peptides for deletion of antigen-specific CD4+8+ thymocytes
Generic Drugs - Pharma company announces final U.S. FDA approval for generic seizure medication
Generic Drugs - Pharma company receives approval to market generic Dostinex
Generic Drugs - U.S. FDA grants approval for generic muscle relaxant baclofen tablet
Genetics & Genomics - Additional human genome-wide siRNA libraries provided
Genetics & Genomics - Mutations associated with isoniazid resistance detected in MTB isolates from China
Geriatrics - Survey shows most Americans hope to live past 85, over half believe they will
Glioblastoma - Independent monitoring committee recommends that the PRECISE trial continue as planned
Glioblastoma - Virus-drug combination may have synergistic effect against brain cancer
Graves Disease - TSAb and TBII measurements are valuable in diagnosis, management of children with Graves disease
Group A Streptococcus - Streptococcal surface protein peptidase prevents infection of nasal tissue
Gynecology - Cytokines trigger angiogenic protein in murine ovaries
HIV/AIDS Drug Adherence - Efavirenz associated with lower drug adherence in HIV-infected children in Africa
HIV/AIDS Drug Adherence - Obtaining refills via pill organizers dispensed by pharmacist improves HAART adherence
HIV/AIDS Drug Interaction - Didenosine EC AUC is increased when dosed along with tenofovir DF
HIV/AIDS Drug Mutation - Biochemical basis explains evolutionary pathway of T215 mutations in HIV-1 RT
HIV/AIDS HAART - Article reviews advantages and drawbacks of non-thymidine NRTI backbones
HIV/AIDS HAART - New data illuminates research in HIV/AIDS HAART
HIV/AIDS HAART - Recent findings illuminate research in HIV/AIDS HAART
HIV/AIDS Healthcare - Mexico allocates HIV/AIDS expenditures between prevention and treatment
HIV/AIDS Mortality - Early mortality is associated with antiretroviral therapy started during advanced disease
HIV/AIDS Pathogenesis - Primer removal not a necessary component of HIV-1 reverse transcription
HIV/AIDS Research - Bioscience company presents data demonstrating cost-effectiveness of PhenoSense GT
HIV/AIDS Research - Indinavir impaired endothelial function in healthy HIV-negative men
HIV/AIDS Research - Pharma company submits new drug application to U.S. FDA for HIV-1 treatment
HIV/AIDS Therapy - Enrollment completed in trial of AIDS vaccine
HIV/AIDS Therapy - Kenyan government on track to exceed anti-retroviral treatment target
HIV/AIDS Therapy - Tentative approval granted by U.S. FDA for Stavudine Oral solution 1 mg/ml
HIV/AIDS Vaccines - New findings in the area of HIV/AIDS Vaccines detailed
Head & Neck Cancer - Antibody choice impacts vessel detection in oral mucosal tissues
Head & Neck Cancer - Weekly docetaxel and radiation therapy was deemed feasible
Healthcare Costs - Prometa protocol for alcoholism to be evaluated toward third-party reimbursement
Healthcare Costs - Reduced atrial fibrillation incidence with enalapril yields cost and health benefits
Healthcare Economics - International research reveals proven ways to reduce drug costs
Heart Failure - Arginine vasopressin may be new therapy target in heart failure
Heart Failure - Nicorandil revitalizes neovascular growth in failing rodent hearts
Heart Failure - Sildenafil improves cardiac performance by LV load decrease
Helicobacter Pylori - H. pylori conjugative transfer is mediated by relaxase and traG-like proteins
Hemangioma - Transgenic rabbits model the features of Kasabach-Merritt syndrome
Hematology - Recommended guidelines for molecular hematology outlined
Hematology - Research in hematology provides new insights
Hematology - Researchers detail new studies and findings in the area of hematology
Hematology - Sickle cell disease corrected in human models using stem cell-based gene therapy
Hematology - Therapeutic monitoring based on plastic-tube INRs could result in higher doses of warfarin
Hepatitis A Virus - Mass vaccination with live attenuated hepatitis A vaccine is effective
Hepatitis C Therapy - Cyclosporine inhibits hepatitis C virus in vitro
Hepatitis C Therapy - Older patients experience more adverse events from combination therapy
Hepatitis C Virus - Combination treatment for chronic hepatitis C granted marketing approval in Japan
Hepatitis C Virus - First phase 3 results in hepatitis C trial with thymalfasin combination reported
Hepatitis C Virus - Hepatitis C virus infection is prevalent in a safer injection facility
Hepatitis C Virus - Modified siRNA compuund selected for development in hepatitis C antiviral program
Herpes - BCS appears to be associated with primary HHV-6, but more research is needed
Herpes Simplex Virus - Heparin sulfate isoforms assist HSV-1 entry and spread
Hormonal Cancer - Enhanced hormone glucuronidation may be protective against hormonal cancer
Human Genome - Tandem transcripts team up to form single RNA transcript
Hyperadrenocorticoid - No effect in survival time seen between dogs treated with mitotane or trilostane
Hypertension - Pharma companies sign agreement for development of modified-release lercanidipine
Hypertension - Relaxin increases cardiac output and reduces systemic arterial load
Hypertension - Shift work is a significant and independent risk factor for the progression of hypertension
Immunology - 2005 was a year of accelerated momentum for lupus research
Immunotherapy - Clinical efficacy of cancer immunotherapy targeting WT1 protein should be clarified
Infectious Diseases - Host immune response is impeded by Taenia crassiceps secreted enzymes
Infectious Diseases - Induced expression of melittin suppresses Chlamydia and Mycoplasma infections
Infectious Diseases - Legionella acquires type IV secretion substrates via horizontal gene transfer
Influenza - Agency approves Tamiflu for prevention of influenza in children aged 1-12
Influenza - Evidence exists for future H5N1 influenza virus transmission among humans
Influenza - Medical consulting company to assist with the California Influenza Surveillance Project
Influenza - Roche grants sub-license to Hetero Drugs for production of Tamiflu in India
Influenza - Strategy developed for stockpiling oseltamivir in preparation for influenza pandemic
Influenza - U.S. FDA approves influenza vaccine manufacturing facility
Influenza - U.S. FDA extends prophylaxis indication for Tamiflu to children 1-12 years of age
Influenza - U.S. FDA grants approval to initiate human testing of intravenous Peramivir for influenza
Informatics - World's largest interactive drug database unveiled
Information Technology - Study finds growth rates and regulatory compliance force life science companies to outsource
Insomnia - Diagnosis and treatment of insomnia of interest to general practitioners
Kidney Cancer - Carboxyamidotriazole has an insignificant impact on advanced renal cell carcinoma progression
Legal Issues - Antitrust lawsuit filed against Bristol-Meyers Squibb in 2003 settled for $4.2 million
Legal Issues - Spanish court rules against Ratiopharm in cholesterol-lowering drug patent challenge
Legislative Issues - Greenwood praises passage of pandemic influenza plan
Leishmaniasis - Sitamaquine is efficacious for visceral leishmaniasis treatment in Kenya
Leukemia - Cloretazine and ara-C chemotherapy regimen showed strong antileukemic activity
Leukemia - Hematopoietic cell transplantation followed reduced-intensity conditioning for leukemia therapy
Leukemia - Leukemia mortality related to ionizing radiation at Portsmouth Naval Shipyard
Leukemia - Positive Dacogen injection data presented
Leukemia - Quantification of AML1-ETO fusion transcript used to prognosticate leukemia
Lipid Research - Liposome uptake by cardiomyocytes is influenced by electrical charge
Liver Injury - TLR ligand attenuates liver injury by down-regulating macrophage TLR expression
Lung Cancer - Low-dose gemcitabine infusion and cisplatin used to treat lung cancer
Lung Cancer - Nedaplatin and paclitaxel deemed effective for non-small cell lung cancer
Lung Cancer - Slug transcription factor promotes the invasion of lung adenocarcinoma
Lung Cancer Therapy - Combination ZD1839 and trastuzumab inhibit cell growth in non-small-cell lung cancer
Lyme Disease Vaccine - Study identified epitopes defining specificity of OspC murine antibody response to Lyme disease
Lymphoma - MabThera maintenance therapy shown to improves survival for patients with non-Hodgkin lymphoma
Macroadenomas - Strategies for management of invasive macroadenomas are needed
Malaria - Two new malaria treatments available in 2006
Malaria Therapy - Semi-mechanistic model of antimalarial effect of artemisinin is developed
Malaria Vaccine - Plasmodium vivax MSP1 Pv200L is potential malaria vaccine subunit
Malaria Vaccine - Epitopes delivered by polymeric linear peptides protect against malaria
Malaria Vaccine - Synthetic malaria vaccine is immunogenic in clinical trial
Malaria Vaccine - Vaccine based on P. vivax Duffy binding protein provides partial malaria protection
Market Analysis - Biotech venture capital company reviews 2005
Marketing - Biotech company engages Isserman Consulting for public awareness and investor relations
Marketing - Cost of care module launched to help pharmaceutical companies assess product value
Marketing - Exaeris commences formal operations
Marketing - RNA-focused companies sign marketing agreement for in vivo validation services
Marketing - Study shows mid-level brands can offer high-level revenue streams for pharma companies
Matrix Metalloproteinase - Platelet-activating factor requires calcium or kinase signals to boost matrix metalloproteinase production
Medical Devices - First sale of batch coating system for small devices and implantables announced
Medical Devices - Medical device company announces initial clinical trial use of next-generation drug-eluting stent
Medical Devices - U.S. 510k application filed for collagen based advanced wound care product
Medicare - Blue Cross Blue Shield of Michigan teams with retailer to educate consumers about Medicare programs
Medicare - MemberHealth partners with SHPS for expansion of retiree health plans
Medicare - National healthcare advocacy company offers tips on understanding Medicare Plan D
Medicare - Safeway pharmacies partner with healthcare insurers on Medicare Part D education program
Medicare - Study finds seniors in mid-Atlantic states have bewildering Medicare coverage choices
Medicare - U.S. HHS announces 21 million Medicare beneficiaries are covered for prescription drugs
Melanoma - Lupeol suppressed migration of malignant melanoma cells
Melanoma - O-6-benzylguanine and BCNU did not improve outcome of melanoma
Melanoma Therapy - Combination chemotherapy may be new option for metastatic skin cancer
Mental Health - Barriers remain to receiving post-disaster services for those in need of care
Mental Health - Nine percent of adolescents experienced a major depressive episode in the past year
Mental Health - Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells
Mental Health - U.S. FDA issues approvable letter for transdermal patch to treat ADHD in children 6-12
Mergers & Acquisitions - Acquisition of Zeneus Holdings complete
Mergers & Acquisitions - Allergan merger agreement approved by Inamed board
Mergers & Acquisitions - Assets of analgesics maker sold to Sun Pharmaceutical Industries, Inc.
Mergers & Acquisitions - Biopharma signs contract to purchase two companies specializing in medical aids and consumables
Mergers & Acquisitions - Biopharmaceutical company stockholders approve proposal of merger with EpiCept
Mergers & Acquisitions - Biotechnology company acquisition will enhance AstraZeneca's ability to generate cancer treatments
Mergers & Acquisitions - Consent order signed, anticipated closing date set for merger signed by Israeli pharmaceutical firm
Mergers & Acquisitions - Drug delivery company acquires French pharmaceutical firm
Mergers & Acquisitions - Drugmaker completes merger with Maxim Pharmaceuticals
Mergers & Acquisitions - Extensive gene therapy assets acquired
Mergers & Acquisitions - Flexpoint affiliate announces acquisition of home infusion pharmacy services company
Mergers & Acquisitions - Formal documentation entered for acquisition of HealthLinx
Mergers & Acquisitions - Genomics company completes acquisition of Ellipsis Biotherapeutics
Mergers & Acquisitions - Inamed announces mutual termination of merger agreement with dermatology-focused drug maker
Mergers & Acquisitions - Medical device maker proposes to acquire Guidant for $25 billion
Mergers & Acquisitions - Pharma company acquires fqubed, Inc.
Mergers & Acquisitions - Pharmaceutical company to acquire Miikana Therapeutics
Mergers & Acquisitions - South African sales and marketing company acquired
Mesothelioma - Met receptor is inhibited in mesothelioma
Multiple Myeloma - Orally active proteasome inhibitor induced apoptosis in multiple myeloma cells
Multiple Myeloma - VAD treatment affected levels of circulating serum proinflammatory mediators
Muscular Dystrophy - Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, study finds
Mycobacterium Tuberculosis - Dexamethasone suppresses cytokines/chemokines induced after MTB microglia infection
Myelodysplastic Syndrome - Federal agency approves new treatment for subtype of myelodysplastic syndrome
Myelodysplastic Syndrome - U.S. FDA grants Revlimid NDA approval
Myeloid Leukemia - More than 90% of patients taking Gleevec for myeloid leukemia are alive after 4 1/2 years
Myocardial Infarction - Amino acid supplement following heart attack yields no benefit, may be harmful
Nanotechnology - Dendrimers with high drug payload can improve drug efficacy
Neuropathic Pain - Endothelin A receptor is a potential therapeutic target for neuropathic pain
Neuroscience - Glutamatergic receptor upregulation may mediate persistent drug intake, craving in cocaine addiction
Neuroscience - Hyperphosphorylation of intermediate filament proteins may be involved in neuropathology
Neuroscience - Lipopolysaccharide post-conditioning reduces brain and spinal cord inflammation
Neuroscience - Neuronal differentiation is unaffected by the reduction of neuropathy target esterase
Neuroscience - Recent studies add new data to neuroscience research
Neuroscience - Researchers describe findings in neuroscience studies
Neuroscience - Restraint stress alters opiate withdrawal
Neuroscience - Serotonin transporter gene polymorphisms influence cognitive abilities
Neuroscience - Studies show brain endocannabinoid protects neurons against inflammation after injury
Non-Hodgkin Lymphoma - Positive interim results reported from phase I trial for CB3304 (noscapine) in non-Hodgkin lymphoma
Noncutaneous T-Cell Lymphoma - Encouraging responses reported with HuMax-CD4 in noncutaneous T-cell lymphoma
Nosocomial Infections - MSRA patterns in intensive care units changing nationally in U.S.
Obesity Therapy - Findings describe new data in Obesity Therapy research
Obesity Therapy - Orexin antagonist reduced food intake in dietary-induced obesity and resistant rats
Obesity Therapy - Polymorphisms in SLC6A2 and GRIN1 affect weight loss response of GW320659 in obese subjects
Obesity Therapy - Valsartan and atenolol effectively lowered blood pressure in obese hypertensives
Obstetrics - Angiogenic elements within the placenta are challenged during fetal growth restriction
Occupational Exposure - Test method developed to assess spill and leakage from drug preparation systems
Oncology - Findings in oncology provide new insights
Oncology - Galectin-3 phosphorylation leads to epithelial cell malignant transformation
Oncology - Recent findings in oncology provide new insights
Oncology - Recent studies add new data to oncology research
Oncology - Reports add new data to oncology research
Oncology - Research in oncology provides new insights
Oncology - Researchers detail new studies and findings in the area of oncology
Oncology - Thymic tumors in murine models maintain a large neovascular component
Oncology - Vascular endothelial growth factor bolsters prostate cancer-related osteoblast activity
Ophthalmology - Findings describe new data in ophthalmology research
Ophthalmology - Reports describe recent advances in ophthalmology research
Orthopedics - Orthopedics company reports over 3,000 two-incision hip replacement procedures performed
Osteoporosis - Insulin-like growth factor-I pathways may reveal novel therapeutic targets for osteoporosis
Osteoporosis - Risedronate was found safe and effective in osteoporotic women with renal impairment
Osteoporosis - Risedronate-induced changes in bone mineral density do not reduce incidence of fractures
Osteoporosis - U.S. FDA approves osteoporosis indication for once-a-week hormone therapy patch
Osteoporosis - Younger women are more compliant with osteoporosis medications
Otorhinolaryngology - Academy advises on one of U.S.'s most diagnosed diseases, sinusitis
Ovarian Cancer - Combined treatment methods prolong survival in women with advanced ovarian cancer
Ovarian Cancer - Hyaluronan-linked beads help MRI follow angiogenic developments in ovarian cancer
Ovarian Cancer - Phosphatidylinositol 3-kinase inhibitor blocks ovarian tumor angiogenesis and vascular permeability
Pain Management - Pain treatment analyzed among patients with incurable malignant tumors
Pain Management - Pharma company files complete response to U.S. FDA on application for oxymorphone ER
Pain Management - Pregabalin or morphine and gabapentin offer treatment options for neuropathic pain
Pancreatic Ductal Adenocarcinoma - Protein overexpression influences pancreatic ductal adenocarcinoma cell growth
Parkinson Disease - Changes induced by levodopa and subthalamic nucleus stimulation on Parkinsonian speech
Parkinson Disease - Embryonic expression of alcohol and aldehyde dehydrogenases contributes to Parkinson disease
Patents - Agreement reached with Ranbaxy regarding settlement of Provigil patent litigation
Patents - USPTO issues reexamination update for patent covering its guaifenesin delivery system
Patient Compliance - Patients are compliant with statin therapy for 3 years regardless of gender or age
Pediatrics - Vancomycin clearance differs by size of newborns relative to their gestational age
Personnel - Alexander named general counsel at institute
Personnel - Barry Flannelly named global VP sales and marketing at oncology firm
Personnel - Biopharmaceutical company names General James T. Hill director of InB: Biotechnologies
Personnel - Canadian pharmaceutical firm announces new appointments to executive management team
Personnel - Cancer drug maker announces senior management transition plan
Personnel - Dr. Ralph Horwitz, Tom de Swaan join pharma's board as nonexecutive members
Personnel - Drug developer adds cancer specialist Ewa K. Carrier, MD, to scientific advisory board
Personnel - Drug development company announces resignations
Personnel - George A. Scangos named chairman of the board of company developing small molecule therapeutics
Personnel - Human therapeutics company appoints Louis G. Lange to its board of directors
Personnel - Imaging technology developer appoints Darryl L. Canfield to post of chief financial officer
Personnel - Jose L. Rodriguez named vice president of business development of specialty pharma
Personnel - Michele Gargano joins immune-health company as VP for clinical development
Personnel - Richard W. Dugan named to board of oncology-focused drug development company
Personnel - Sir Richard Sykes to join Abraxis BioScience Board of Directors following merger
Personnel - Stem cell-focused company announces management succession process
Personnel - Steve Groover appointed COO of company providing pharmacy benefit programs software
Personnel - Synthetic peptide drug maker announces executive appointments
Personnel - Timothy J. McIntyre named CEO of drug delivery-focused pharmaceutical company
Personnel - U.S. FDA appoints new acting director for National Center for Toxicological Research
Pharmaceutical Research - Discovery of new class of agents to target Staphylococcus aureus announced at meeting
Pharmaceutical Research - Environmental control system launched for live cell imaging, time lapse biology studies
Pharmaceutical Research - Imatinib synergizes with donor cell infusions for rapid molecular CML remission after ASCT
Pharmacogenetics - Genetics may influence efficacy and safety of commonly prescribed drugs
Pharmacogenetics - Researchers call for individualized approach to medicine and drug testing
Physiology - Lithospermi radix inhibitory activities revealed in peritoneal macrophages
Physiology - Charge screening alters Mg2+-inhibited cation channels
Physiology - Interleukin receptor antagonist purified
Physiology - Microbial products regulate caveolin-1 protein expression in murine macrophages
Polyomavirus JC - Polyomavirus JC-specific cytotoxic T cells are present in the CNS of PML patients
Product Licensing - Biopharmaceutical company licenses anti-sickling agent from Virginia Commonwealth
Product Licensing - Commercial license inked for the production of paclitaxel, taxane products from plant cell culture
Product Licensing - Company licenses monoclonal antibody technology from University of Cambridge
Product Licensing - Company receives license agreement term sheet for medical device ReVas program
Product Licensing - Global licensing deal signed for pain drug candidate
Product Licensing - Iodosorb gel, Iodoflex pad licensing agreement set to expire
Product Licensing - MedImmune licenses rights to XmAb proprietary engineered Fc domains
Product Licensing - Merck has access to HuCAL Gold antibody library for additional 5 years
Product Licensing - Pharma company acquires royalty and milestone rights for methylnaltrexone
Product Licensing - Pharma company signs license agreement for European rights to Rapinyl
Product Licensing - Vaccines company licenses Potelligent technology
Prostate Cancer - Advanced prostate cancer managed with first- and second-line chemotherapy
Prostate Cancer - Efficacy of androgen deprivation and radiotherapy for locally advanced prostate cancer assessed
Prostate Cancer - Increased Hsp27 facilitates androgen-independent progression in prostate cancer
Prostate Cancer - Misoprostol rectal suppositories did not prevent acute radiation proctitis
Prostate Cancer - PSP-94 and PCK3145 examined as therapeutic modalities for prostate cancer
Prostate Cancer - Parameters for treatment decisions for salvage radiation therapy discussed
Prostate Cancer - Pathogenesis and treatment of prostate cancer bone metastases discussed
Prostate Cancer - Recent studies add new data to Prostate Cancer research
Prostate Cancer - Relationship of vitamin E and prostate cancer benefits not resolved, men's newsletter says
Prostate Cancer - Rewards justify costs of phase III prostate cancer prevention trials
Prostate Cancer - Role of 5ARIs for prostate cancer chemoprevention needs further elucidation
Prostate Cancer - Study shows PSP94 diagnostic marker better at detecting aggressive prostate cancer
Prostate Cancer Therapy - Balsalazide prevented acute radiation-induced proctosigmoiditis in prostate cancer patients
Proteomics - Interactions between insulin-like growth factor and neurotensin may regulate fibroblasts
Proteomics - Recombinant endostatin generates a U-shaped dose-response curve
Proteomics - Researchers' data advance proteomics research
Proteomics - Study reveals that ALS and Parkinson disease distinguishing protein biomarkers differ
Proteomics - Technology company signs access and product development agreement with Bristol-Myers Squibb
Proteomics - Tumor endothelial marker 7 is a prerequisite for endothelial cell capillary morphogenesis
Pseudomonas aeruginosa - Syndecan 1 shedding contributes to Pseudomonas aeruginosa sepsis
Pseudotumors - Radiologic features of inflammatory pseudotumors described
Psoriasis - Methotrexate may treat psoriasis by limiting vessel growth
Psoriasis - Pharma company initiates phase IIa trial for a topical psoriasis treatment
Public Health - AmeriCares airlifts vaccine to Pakistan earthquake survivors
Quality Assurance - Elderly with alcoholism receive equal heart attack care
RNA Research - Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in MTB
Rectal Cancer - Clinical evaluation of therapy response could not be used to make treatment decisions
Rectal Cancer - Patient outcome after surgical excision of T4 rectal cancer analyzed
Renal Disease - Interwoven signals spawn renal fibrosis in experimental hypercholesterolemia
Respiratory Syncytial Virus - MedImmune licenses antiviral company's small molecule compounds for RSV
Respiratory Syncytial Virus - Pharma company completes enrollment in Phase III study comparing RSV prevention medicines
Rheumatoid Arthritis - Positive preliminary results reported from phase Ib trial of CH-1504
Rheumatoid Arthritis - Study supports use of combination therapy in early-stage disease
SARS Vaccines - Recent findings illuminate research in SARS Vaccines
Seizure Disorders - Nasal midazolam treatment after drug-induced seizure led to seizure cessation in rats
Sexual & Reproductive Health - A negative fetal fibronectin can avoid potentially harmful interventions
Sexual & Reproductive Health - Birth control pill could cause long-term problems with testosterone
Sexual & Reproductive Health - Lacker's mathematical model characterizes ovarian response to superstimulation
Sexual & Reproductive Health - Single-day treatment found to shorten duration of recurrent genital herpes outbreaks
Smallpox Vaccines - Researchers describe findings in Smallpox Vaccines studies
Smoking Cessation - Treatment options for smoking cessation therapy in aviators discussed
Squamous Cell Carcinoma - Case of primary squamous cell carcinoma of the stomach reported
Statins - Pravastatin maintains survival benefit in transplant patients
Statins - Statins have neutral effect on risk of cancer
Stem Cell Research - Gap between law and ethics impede ethical stem cell research in United States
Stem Cell Research - Mesenchymal stem cells sway endothelial repair
Stem Cell Research - Method is developed to isolate gene-corrected stem cells without drug selection
Stem Cell Transplantation - Adenovirus infection is a frequent complication after SCT from alternate donors
Stem Cell Transplantation - Busulfan-thiotepa followed by SCT toxic/ineffective in relapsed irradiated medulloblastoma
Stem Cell Transplantation - Cyclosporine decreases vascular progenitor cells after cardiac transplantation
Stem Cell Transplantation - Impact of donor factors identified for HSC graft failure from unrelated donors
Stents - EVENT registry is designed to assess outcomes in the drug-eluting stent era
Stents - Full metal jacket drug-eluting stents was effective for diffuse lesions
Stroke - Recombinant factor VIIa is potentially useful for intracerebral hemorrhage
Stroke - Researchers' findings advance stroke research
Systemic Lupus Erythematosus - Anti-SAP antibody titers decreased after treatment and correlated with clinical improvement
Testicular Cancer - Primary surveillance resulted in fewer testicular cancer therapeutic interventions
Tobacco Use - Scientists developing behavior- and physiology-based cancer prevention program
Toxicology - Heterodimerization of Pichia pastoris anticoagulant is functionally required
Transplant Medicine - Dipyridamole/NO combination identifies pulmonary hypertension reversibility
Transplant Medicine - Donor T cell chimerism supports a diagnosis of aGVHD
Transplant Medicine - Ganciclovir and acyclovir reduce risk of post-transplant lymphoproliferative disorder
Transplant Medicine - NDA submitted to U.S. FDA for immunosuppressant to prevent organ rejection after transplant
Transplant Medicine - Pharmacokinetics of cyclosporine is not affected by gender of renal transplant patients
Transplant Medicine - Preemptive use of CytoGam decreases cytomegalovirus infection in transplant patients
Transplant Medicine - Rejection may occur during bacterial pneumonia treatment after liver transplants
Transplant Medicine - Visceral leishmaniasis in transplant recipients is fatal without antileishmanial treatment
Transplantation Biology - Pre-emptive therapy is effective after liver transplantation
Tumors - Cytotoxic T cell functions are directly targeted during tumor evasion of immune surveillance
Ulcerative Colitis - Monoclonal antibody offers new treatment option
Ulcerative Colitis - New drug application filed with U.S. FDA on mesalamine treatment for ulcerative colitis
Urinary Tract Infections - MPC strategies incorporated into current fluoroquinolone dosing reduced resistant organisms in UTI
Urology - Darifenacin provides comparable efficacy to oxybutynin in overactive bladder treatment
Vaccine Delivery - Amine groups in the structure of polymeric transfectant affect DNA delivery
Vaccine Delivery - Thiol-modified gelatin nanoparticles for intracellular DNA delivery have been developed
Vaccines Development - Studies add new findings to Vaccines Development body of knowledge
Vaginal Intraepithelial Neoplasia - Trichloroacetic acid proves effective for low-grade vaginal intraepithelial neoplasia
Varicella-Zoster Virus - Small plaque varicella-zoster virus mutants are defective in viral gene expression
Vector Development - Researchers' findings advance Vector Development research
Virology - Recent findings in virology provide new insights
Wound Care - The muscle flap microenvironment is a haven for angiogenic components
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