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Cancer Therapy

Supplemental BLA submitted for Avastin in relapsed metastatic colorectal cancer

Published in Drug Week, January 27th, 2006

Genentech, Inc., (DNA) has submitted a supplemental Biologics License Application (sBLA) with the U.S. Food and Drug Administration (FDA) for Avastin (bevacizumab) in combination with 5-fluorouracil (5-FU)-based chemotherapy for patients with relapsed, metastatic colorectal cancer.

Avastin is currently approved as a first-line treatment of metastatic colorectal cancer in combination with intravenous 5-FU-based chemotherapy.

The sBLA submission is based on results of a randomized, controlled, multicenter phase III trial (E3200) of 829 patients with advanced or metastatic colorectal cancer (CRC) whose disease progressed following previous treatment...

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