Drug Delivery
Discriminant analysis can identify potential transdermal enhancers
Published in Drug Week, February 10th, 2006
In a recent study from Wales, "structure-activity relationships were sought for 73 enhancers of hydrocortisone permeation from propylene glycol across hairless mouse skin."
"Enhancers had chain lengths (CC) from 0 to 16 carbon atoms, 1 to 8 H-bonding atoms (HB), molecular weight 60 to 450, log P (calculated) -1.7 to 9.7 and log S (calculated) -7.8 to 0.7," explained W.J. Pugh and coauthors at Cardiff University. "These predictive properties were chosen because of their ready availability."
"Enhancement ratio (ER) was defined as...
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Source: Drug Week (2006-02-10)
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