Drug Week
Susan Hasty, Publisher
Table of Contents . . . March 3rd, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Breast Cancer - Fluorouracil-epirubicin-navelbine deemed effective in advanced breast cancer
Cancer Therapy - Analysis of Genasense trial confirms major efficacy variables in patients with melanoma
Cardiovascular Disease - Single bolus dalteparin may be alternative to unfractionated heparin during PCI
Pharmacology - Mouse pneumonia model requires human epithelial penetration data for extrapolation to human dosing
Addiction Medicine - Opioid withdrawal symptoms not associated with buprenorphine dose, formulation or plasma levels
Addiction Medicine - Study supports a flexible approach to methadone dosing
Adverse Drug Reactions - Anticholinergic drugs linked to mental impairment in elderly people
Adverse Drug Reactions - Antidepressant use in pregnancy appears associated with neonatal withdrawal symptoms
Adverse Drug Reactions - Cisplatin may trigger retinal neovascularization
Adverse Drug Reactions - Osteonecrosis of the jaw in cancer occurred after treatment with bisphosphonates
Adverse Drug Reactions - Ototoxicity in children receiving platinum chemotherapy may impact academic and social development
Age-Related Macular Degeneration - European commission approves Macugen for treatment of all types of wet AMD
Allergy & Immunology - Mouse model identifies method to reduce migration of white blood cells in autoimmune disease
Allergy & Immunology - U.S. FDA approves Clarinex-D 12 Hour
Alopecia - Alopecia a frequent complication in women receiving tacrolimus after SPK transplantation
Alzheimer Disease - Apolipoprotein E4 is a potential therapeutic target for Alzheimer disease
Amyotrophic Lateral Sclerosis - Low vascular endothelial growth factor expression may encourage neurodegeneration in mice
Anesthesia - Fentanyl reduced emergent agitation for developmentally disabled dental patients
Anesthesia - TransDermal Delivery System beta suitable for local anesthesia in venipuncture
Anesthesia - Using intrathecal morphine with remifentanil enhances post-OPCAB analgesia
Angina - U.S. FDA approves Ranexa
Angiology - Adverse CV influence of low testosterone may be mediated via vascular structure, function
Angiology - Nebivolol is novel beta-blocker with endothelium-derived NO enhancement benefit
Angiology - Normal capillaries regress upon vascular endothelial growth factor inhibition
Angiology - Researchers provide details of new studies and findings in the area of angiology
Angiology - Skin cholesterol content identifies increased carotid intima-media thickness
Anthrax Vaccines - Adenovirus expressing B. anthracis antigen protects against anthrax
Anthrax Vaccines - Researchers report details of new studies and findings in the area of anthrax vaccines
Anti-Inflammatories - COX mechanisms play a role in maintaining pain hypersensitivity
Antibiotics - Continuing antibiotics is associated with failure of metronidazole for C. difficile-associated diarrhea
Antibiotics - In vitro, in vivo studies support development of pharmacodynamic parameters to determine drug dose
Antimicrobials - Second study to test persistency of chlorhexidine hand sanitizer commissioned in Europe
Anxiety - Depression severity unrelated to psychic and somatic anxiety components
Anxiety - Reduced perceived control were associated with anxiety sensitivity and agoraphobia
Apoptosis - Arsenic trioxide is a novel human neutrophil pro-apoptotic agent
Apoptosis - Flavonoids inhibited cell growth and induced apoptosis in osteosarcoma cells
Apoptosis - Inhibition of P13K/PKB signaling did not directly result in apoptosis in cancer
Apoptosis - Interferon gamma-inducible protein 10 inhibits tumor angiogenesis
Apoptosis - Mechanism by which diosgenin induces apoptosis in COX-2 deficient K562 described
Apoptosis - P73 regulation may have implications for neurological disease treatment
Apoptosis - Phorbol ester-induced apoptosis in prostate cancer cells involves protein kinase C delta
Apoptosis - Suppression of PKCalpha may contribute to hepatic apoptosis during sepsis
Apoptosis - VSOR Cl-channels are involved in H2 O2 -induced apoptosis in cultured mesangial cells
Apoptosis - p53 deficiency rescues apoptosis and differentiation of multiple cell types
Asthma - Exercise induced asthma impacts 1 in 6 Olympic athletes
Asthma Therapy - Treatment with budesonide does not affect pregnancy outcome
Atherosclerosis - Estradiol valerate plus levonorgestrel therapy reduces plasma trans-fatty acid
Atherosclerosis - Local vascular endothelial growth factor gene transfer may not prevent arterial restenosis
Attention Deficit Hyperactivity Disorder - Drugmaker provides update on regulatory status of Sparlon
Attention Deficit Hyperactivity Disorder - Novel assay detects therapeutic and illicit amphetamine enantiomers in hair and blood
Attention Deficit Hyperactivity Disorder - U.S. FDA accepts new drug application for NRP104 as treatment for ADHD
Avian Influenza - Applications of Hemopurifier expanded to include avian influenza
Avian Influenza - Safety issues may hamper production of bird flu vaccine
Awards - Kaiser Foundation, CNN International announce new award for HIV/AIDS journalism in Africa
Bacteriology - Aerosol treatment reduced bacteria concentrations
Bacteriology - Studies report 2 million Americans carry drug-resistant Staph bacterium
Barrett Adenocarcinomas - Hypermethylation and loss of GPx3 expression linked to Barrett adenocarcinomas
Biomedical Engineering - Injectable nanofibers allow controlled protein delivery to myocardium
Biomedical Engineering - Vancomycin-loaded CaPO4 cement may resolve osteomyelitis and prosthesis infection
Bioterrorism - Pharmaceutical firm responds to call for acute radiation syndrome therapy for U.S. forces
Bipolar Disorder - Course of bipolar disorder in children described for the first time
Bladder Cancer - Intravesical gemcitabine used to treat superficial transitional cell carcinoma
Bladder Cancer - New drug inhibited in vitro bladder cancer migration and invasion
Bone Development - The peripheral cannabinoid receptor CB2 regulates bone mass
Brain Cancer - Molecularly targeted therapy for pediatric brain tumors discussed
Breast Cancer - Breast cancer marker receives diagnostic and therapeutic patent approval
Breast Cancer - Coffee consumption may have protective effect on breast cancer risk in premenopausal women
Breast Cancer - Endometrial thickness in breast cancer patients is not associated with tamoxifen
Breast Cancer - Long-term treatment recommended in breast cancer patients with severe radiation-induced fibrosis
Breast Cancer - Macrophages can initiate breast tumor angiogenesis
Breast Cancer - Mitomycin c and capecitabine used to treat metastatic breast cancer patients
Breast Cancer - Ospemifene inhibited growth of dimethylbenzanthracene-induced mammary tumors
Breast Cancer - PIK3Ca mutations correlate with gene expression and drug sensitivity
Breast Cancer - Reports add new data to breast cancer research
Breast Cancer - Survey reveals deficiencies in management of cancer treatment-induced bone loss for women
Bronchopulmonary Dysplasia - U.S. FDA grants Surfaxin fast track designation for prevention and treatment of BPD
Business & Finance - Allergan extends expiration date of exchange offer
Business & Finance - Cancer drug developer posts net loss of $0.17 per share
Business & Finance - Cancer drug developer reports loss of $0.23 per share
Business & Finance - Company reports Q4 revenue of $132.7M, discusses remarketing of Tysabri
Business & Finance - Drug delivery-focused company receives notice of AMEX delisting
Business & Finance - Hematology-focused biotech firm adopts shareholder rights plan
Business & Finance - Pharmaceutical company regains Nasdaq compliance
Business & Finance - Pharmaceutical company reports Q4 05 revenues of $437,000, down from $2.6 million in Q4 04
Business & Finance - Pharmaceutical company shareholders approve spinout of targeted immunotherapy assets
Business & Finance - Polymun development and manufacturing agreement sold for $1 million
Business & Finance - Protein, antibody developer reports net loss of $73.2M for 2005
Business & Finance - Specialty oncology company completes merger, raises $5.9 million in private financing
Business Update - CRO retains The Equity Group to provide investor relations services
Cancer Gene Therapy - Spirulina platensis phycocyanin antitumoral activities are affected by CD59
Cancer Gene Therapy - AIM2 suppresses human breast cancer cell proliferation and mammary tumor growth
Cancer Gene Therapy - Adenovirus vector is more infective for esophageal and oral carcinoma cells
Cancer Gene Therapy - p27(KIP1) prolongs cell cycle and induces apoptosis in gastric cancer cells
Cancer Gene Therapy - p53 cDNA sequence mutations are introduced by a retroviral vector
Cancer Genetics - PKCalpha expression is regulated by Elk-1 and MZF-1 in hepatocellular carcinoma
Cancer Research - Genetics research may hold key to destroying cancer cells
Cancer Research - Structure of protein essential for promoting cancer development described
Cancer Risk Factors - Glucose transporter polymorphisms may increase susceptibility to clear-cell renal carcinoma
Cancer Screening - Pennsylvania governor proposes giving more women access to breast and cervical cancer screening
Cancer Therapy - Alemtuzumab induces caspase-independent cell death in lymphocytic leukemia cells
Cancer Therapy - Alternative regimens boost the efficacy of hypericin-photodynamic therapy
Cancer Therapy - Cancer organization updates to several clinical practice guidelines
Cancer Therapy - Data advance knowledge in cancer therapy research
Cancer Therapy - Docking studies shed light on folate binding in cancer therapy
Cancer Therapy - Enrollment complete in pivotal phase III trial of FavId for follicular B-cell NHL
Cancer Therapy - Findings describe new data in cancer therapy research
Cancer Therapy - Gefitinib used to treat non-small cell lung cancer
Cancer Therapy - Gemcitabine and carboplatin used to treat non-small cell lung cancer
Cancer Therapy - High-dose therapy increased complete response rate in multiple myeloma patients
Cancer Therapy - Lenalidomide and thalidomide exhibit distinct pharmacological profiles
Cancer Therapy - Multicenter phase II study with MKC-1 begins
Cancer Therapy - New findings in the area of cancer therapy detailed
Cancer Therapy - No evidence of gemcitabine accumulation during weekly administration detected
Cancer Therapy - Phase I trial of dendritic cell vaccine in patients with colorectal cancer meets endpoint
Cancer Therapy - Recent studies add new data to cancer therapy research
Cancer Therapy - Reports advance knowledge in cancer therapy research
Cancer Therapy - Research add new data to cancer therapy body of knowledge
Cancer Therapy - Researchers' work adds to cancer therapy body of knowledge
Cancer Therapy - Systemic chemotherapy produces antitumor activity for metastatic hepatocellular carcinoma
Cancer Therapy - The small molecule inhibitor PS1145 targets activity in prostate cancer cells
Cancer Vaccines - Antitumor immunity was induced by epitopes linked to beta2 -microglobulin
Cancer Vaccines - Geron clarifies license rights for cancer vaccines
Cancer Vaccines - Imiquimod enhances dendritic cell survival and promotes T-cell priming
Cancer Vaccines - TRICOM vector-based cancer vaccines are focus of review
Cardiac Arrhythmia - Cardiac Cryoablation System not approvable, U.S. FDA determines
Cardiology - Beta-blockers remain a cornerstone of cardiovascular therapy
Cardiology - Reports add new data to cardiology research
Cardiology - Researchers report details of new studies and findings in the area of cardiology
Cardiology - Researchers studied natural history of valvular regurgitation in anorexigen-treated subjects
Cardiology - Sirolimus-eluting stent may reduce re-blockage in complex coronary lesions, study shows
Cardiology - Studies add new findings to cardiology body of knowledge
Cardiovascular Disease - Cardiovascular benefits of nebivolol persist long after therapy withdrawal in rat model
Cardiovascular Disease - Clopidogrel with early interventional strategy is associated with low CV event rates
Cardiovascular Disease - Nearly half of people who need cholesterol treatment don't get it
Cardiovascular Disease - Pharma company introduces heart disease campaign to help women with physician conversations
Cardiovascular Therapy - Phase III study examines ability of drug to slow atherosclerosis
Central Nervous System - Glutamate receptor agonist may be an effective tool for investigating stress-related CNS disorders
Cervical Cancer - Nude rat is orthotopic model for cervical cancer
Cervical Cancer - RT-CHT resulted in prolonged suppression of NK-cells and T-suppressor cells
Cervical Cancer - Researchers' data advance cervical cancer research
Cervical Cancer - Serum hemoglobin is prognostic indicator of neoadjuvant response to chemotherapy
Cervical Carcinoma - Cell death occurs independent of apoptosis signals in cervical squamous cell carcinoma
Chemotherapy - Findings describe new data in chemotherapy research
Chemotherapy - Paclitaxel pharmacokinetics and effect in patients with advanced cancer studied
Chronic Hepatitis C Virus - Interferon therapy is efficient in elderly patients with chronic hepatitis C
Clinical Trials - Blood cancer patients not directed by their specialists to clinical trials, survey shows
Clinical Trials - ComfortScan maker provides update
Clinical Trials - Enrollment opened in phase 2 trial of DNA vaccine against cytomegalovirus
Clinical Trials - Investigational New Drug Application filed to test safety of anticancer compound IT-101
Clinical Trials - Microbiologic surrogate end points in otitis media trials are evaluated
Clinical Trials - Patient treatment begun in phase 1 clinical trial of anticancer cell-cycle inhibitor
Clinical Trials - Phase 2 program of antisense drug in patients with familial high cholesterol initiated
Clinical Trials - Plans for phase 2 trial of anticancer agent in elderly poor-risk AML patients announced
Clinical Trials - Report announces the MICHELANGELO OASIS-5 trial evaluating fondaparinux
Clinical Trials - TopoTarget, partner, initiate phase II clinical trial of PXD101 for T-cell lymphomas
Clinical Trials - WAVE trial to determine if oral anticoagulation improves on antiplatelet therapy alone
Collaborations - Abbott Laboratories grants rights for new cancer and transplantation drug tests
Collaborations - Advanced gene expression service provider expands globally
Collaborations - Alliance signed for promotion and support of clinical trials
Collaborations - Biosciences company, Bristol-Myers Squibb extend the term of research agreement
Collaborations - Cellomics and Evotec to collaborate on cell-biology solutions for life-science markets
Collaborations - Collaboration formed to provide primate-human gene expression and SNP assays
Collaborations - Collaboration to develop ophthalmic therapeutics built from synergistic drug combinations
Collaborations - Commercialization deal signed for atherosclerosis treatment
Collaborations - Deal signed in Taiwan for development of Immunogene therapy for cancer indication
Collaborations - Licensing and commercialization agreements expanded into Europe for IGN311
Collaborations - Locus announces research agreement with Eli Lilly and Company for protein kinase target
Collaborations - Louisiana court partners with Southern University to evaluate substance abuse protocols
Collaborations - Partners form joint Center for Systems and Computational Biology
Collaborations - Partnership forged to develop new solutions for assessing drug toxicity
Collaborations - Partnership formed to develop RNAi therapeutics for childhood cancer
Collaborations - Research and development collaboration with Astellas Pharma extended
Colon Cancer - Disease-free survival after 3-year follow-up proposed as end point for colon cancer clinical trial
Colon Cancer - Expression of licensing factors, Cdt1 and Geminin in human colon cancer examined
Colon Cancer - New research in the area of colon cancer detailed
Colon Cancer - Oral endostatin therapy does not significantly affect colon tumors
Colon Cancer - SL4 cells used to study mechanism of hepatic metastasis of colon carcinoma cells
Colorectal Cancer - Fluorouracil-based chemotherapy does not improve survival among MSI-H patients
Colorectal Cancer - Nitric oxide does not change colorectal cancer risk
Complementary & Alternative Medicine - A green tea extract cocktail with amino acids impedes tumor angiogenesis
Complementary & Alternative Medicine - Alternative medicine use is not uncommon following genetic testing results for BRCA1/2
Complementary & Alternative Medicine - Curcumin blocks the angiogenic capacity of endothelial cells
Corneal Infections - Pseudomonas vaccine elicits passive protection against corneal infection
Coronary Stenting - Heparin coronary stent coating may not reduce thrombosis risk
Critical Care Medicine - S-enantiomer of albuterol does not affect airway secretions in long-term intubated patients
Cyclosporin - Cyclosporin monitoring improves therapy in early and late stages post-transplantation
Cystic Fibrosis - Cationic lipid mediated gene transfer is inhibitory in CF tracheal gland cells
Cystic Fibrosis - Denufosol proceeding to phase III trials in cystic fibrosis
Cytokines - Splenocyte cytokines are induced by heat shock proteins and concanavalin A
Cytomegalovirus - Valcyte did not protect against CMV infection in liver transplant recipients
DNA Research - New anthracycline is more cytotoxic than a structurally related predecessor
DNA Research - Transcriptional activation is stimulated by bidirectional RNA polymerase II elongation
Depression - Findings advance knowledge in depression research
Depression - Gene therapy used to prevent depression in mice
Depression - Individual illness characteristics are predictive of treatment expectations
Depression - Women with major depression at risk of relapse during pregnancy without medication
Dermatology - Report examines safety and efficacy of sunscreen products
Dermatology - Research may point to diagnostic tests for women predisposed to stretch marks
Dermatology - Survey shows majority of Americans did not know that OTC products can make scars worse
Developmental Biology - Crescent modulates Wnt signaling in early Xenopus embryogenesis
Diabetes Complications - Angiotensin-converting enzyme is linked to angiogenic factors in diabetic retinopathy
Diabetes Complications - Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats
Diabetes Complications - SR58611A improves wound healing in diabetic animal models
Diabetes Complications - STZ-induced diabetes may offer protection against cyclosporine A-induced renal dysfunction
Diabetes Drugs - Approval and availability of Avandaryl (rosiglitazone maleate and glimepiride) announced
Diabetes Management - Case management decreases diabetic retinopathy risk in patients with type 2 diabetes
Diabetes Pathogenesis - Diabetic youth demonstrate insulin resistance but retain first-phase insulin response
Diabetes Research - Article indicates drug target RIP140 controls insulin sensitivity and glucose tolerance
Diabetes Research - Nitric oxide scavenger AMD6221 augments cardiac response to noradrenaline in rat model
Diabetes Risk Factors - Guidelines are needed for preventing diabetes from antipsychotic use
Diabetes Therapy - Shakuyakukanzoto effect in diabetics may rely on descending noradrenergic neuron activation
Diabetes Therapy - Heat tolerance improves in diabetics when taking rosiglitazone for glycemic control
Diabetes Therapy - KCP256 shows lower drug-induced hypoglycemia risk compared with sulfonylurea drugs
Diabetes Therapy - Long-term treatment with novel GSK-3 inhibitor improves glucose homeostasis in ob/ob mice
Diabetes Therapy - New data illuminates research in diabetes therapy
Diabetes Therapy - Researchers provide details of new studies and findings in the area of diabetes therapy
Diabetes Therapy - Rosiglitazone improves exercise capacity in individuals with type 2 diabetes
Diabetes Therapy - Studies add new findings to diabetes therapy body of knowledge
Diabetes Therapy - Studies advance knowledge in diabetes therapy research
Diabetic Retinopathy - Intravitreal hepatocyte growth factor reflects fibrotic processes in diabetic eyes
Diagnostics - A new radioreceptor assay detects signs of angiogenic inhibition in preclinical models
Diagnostics - Label change granted for Thyrogen
Diagnostics - Pulmonary tuberculosis diagnosed in child presenting with acute hemoptysis
Diagnostics - Quantum dots detect early cervical cancer
Diagnostics - Researchers report details of new studies and findings in the area of diagnostics
Dialysis - Hematopoietic response to recombinant erythropoietin is modulated in dialysis
Dialysis - Levocarnitine therapy is justified in selected dialysis patients
Diet & Nutrition - Beef tallow increases linoleic acid potency in reduction of mammary tumor metastasis
Diet & Nutrition - Nutrition-/diet-induced changes in gene expression in white adipose tissue are reviewed
Diet & Nutrition - Retailer launches Women's Ultra Mega Bone Density supplement
Disease Associations - Eotaxin and eotaxin mRNA levels in visceral adipose tissue were raised in obese
Disease Associations - Fruit fly research reveals potential connection between dementia and cancer
Disease Associations - Functional polymorphism identified in polycystic ovary syndrome
Disease Associations - High blood pressure, kidney disease increase heart disease risk in older Americans
Doxorubicin - Doxoform suspected as a prodrug for doxazolidine
Drug Delivery - Age and tumor type influence transdermal fentanyl absorption in cancer pain patients
Drug Delivery - Biodegradable periodontal intrapocket device effective for antibiotic delivery
Drug Delivery - European Commission approves IONSYS
Drug Delivery - Findings describe new data in drug delivery research
Drug Delivery - In vitro tests support feasibility of transdermal iontophoretic triptorelin delivery
Drug Delivery - Novel HPLC assay developed for measuring atorvastatin in plasma
Drug Delivery - Novel dehydration-rehydration liposome vesicles show promise in antibiotic delivery
Drug Delivery - Same-day initiation of contraceptive patch does not improve continuation rates
Drug Delivery - Scientists characterize hot-melt extruded poly(ethylene oxide) films
Drug Delivery - Subcutaneous microsphere injection effective for sustained clonazepam release
Drug Delivery - Terpene enhancers improve transdermal selegiline delivery in vitro
Drug Development - APEX-AMI pexelizumab trial to complete enrollment in March
Drug Development - Access to investigational chickenpox product expanded to meet U.S. supply
Drug Development - Apoptosis induced by plant alkaloid sampangine in human HL-60 leukemia cells
Drug Development - Arixtra administered the morning after orthopedic surgery prevented VTE
Drug Development - Biologics license application for cervical cancer vaccine is on track
Drug Development - CD46-transgenic mice were used to study replication-incompetent adenoviral vectors
Drug Development - Data on Phenserine and Posiphen for Alzheimer disease to be presented in Geneva
Drug Development - Dendritic cell immaturity during infancy impairs vaccine-specific T-cell memory
Drug Development - Diphtheria toxin-mediated antigen delivery into dendritic cells stimulates CD8+ T cells
Drug Development - Dosing cycle completed on first patient in phase I trial of blood cancer drug
Drug Development - Dr. Gerald Yakatan joins allergy company's board of directors
Drug Development - Drugmaker provides CIP-Tramadol Extended Release update
Drug Development - European Design Examination Certificate granted for wound care management product
Drug Development - Good bioavailability reported from phase I trial of iclaprim
Drug Development - Hepatitis C candidate moves into preclinical development
Drug Development - Human T cell leukemia virus type 1 protease is target for anticancer drug design
Drug Development - IND application filed for anticancer drug with nanotechnology delivery platform
Drug Development - Icon retained for phase II/III trial for MBP8298 to treat multiple sclerosis
Drug Development - Lundbeck, collaborator to discover allosteric modulators of G-protein coupled receptors
Drug Development - Maryland Industrial Partnerships program approves 14 university-based research projects
Drug Development - Method is developed for generation of monoclonal antibody against SNEV protein
Drug Development - NDA submitted to U.S. FDA for involuntary emotional expression disorder therapy
Drug Development - New subsidiary to accelerate RNAi therapeutics programs
Drug Development - Novel boronated derivatives of 5,10,15,20-tetraphenylporphyrin developed
Drug Development - Pharma company in phase II trials of therapeutic for wet AMD
Drug Development - Pharma company initiates clinical trials of antisense drug in cancer patients
Drug Development - Pharma company receives milestone payment from Merck for ubiquitin ligases research
Drug Development - Pharmaceutical firm focused on diseases of aging and diabetes provides clinical pipeline update
Drug Development - Pharmacological improvements may help KRN633 beat diseases related to pathological angiogenesis
Drug Development - Phase I trial initiated with c-Met inhibitor in patients with multiple metastatic tumors
Drug Development - Phase I trial of Type 2 diabetes drug initiated
Drug Development - Phase I trial underway of skin patch for prevention of chemo induced emesis
Drug Development - Phase II trial of Hematide initiated in patients with anemia associated with cancer
Drug Development - Phase II trial of MF101 launched for treatment of menopausal symptoms
Drug Development - Positive results reported in phase III study of Entereg in postoperative ileus
Drug Development - Predictive modeling software company introduces new product for pharma companies
Drug Development - Prescription product with nutritional components for osteoarthritis introduced nationally
Drug Development - Study investigated effect of bacterial CpG DNA on immune system organs
Drug Development - Switching cytokine treatment induces monocyte differentiation into dendritic cells
Drug Development - Synthetic heparin could replace animal-derived anticoagulant
Drug Development - The new agent DN-9693 alters VEGF induction of connective tissue growth factor
Drug Development - U.S. FDA grants final approval for testosterone gel 1% product
Drug Development - U.S. FDA grants orphan medicinal product designation for rare disease protein therapeutic
Drug Development - U.S. FDA requests additional data for Delta opioid agonist; application on hold
Drug Interactions - Isoniazid-rifampin caused most adverse events in an outpatient study
Drug Resistance - Drug resistance may travel same path as quorum sensing
Drug Resistance - New findings in the area of drug resistance described
Drug Resistance - Routine screening for antiplatelet drug resistance should not yet be standard practice
Drug Safety - Chain-owned pharmacies less likely to provide prescription label translations
Drug Safety - Report on drug withdrawal in U.S. notes effect on selective COX-2 inhibitor market
Endocrinology - Amygdala plays a role in regulating emotionality through glucocorticoids
Endocrinology - Effects of increased plasma ghrelin levels on metabolism and endocrine system are studied
Endocrinology - Estradiol stimulates vaginal Candida albicans through a ligand-binding mechanism
Endocrinology - Insulin upregulates angiogenic protein in regenerating livers after partial hepatectomy
Enzymology - Chymase-positive cells increase the angiogenic burden of gastric cancer
Epidemiology - Prevalence of Staphylococcus aureus nasal colonization is high in U.S.
Epidemiology - Tuberculosis dynamics linked to economic growth
Escherichia Coli Vaccines - Escherichia coli vaccine strain is safe and immunogenic in healthy adults
Escherichia Coli - Escherichia coli O157 survival varies according to type of metal surface
Esophageal Adenocarcinoma - Neoadjuvant and adjuvant chemotherapy for esophageal adenocarcinoma discussed
Esophageal Cancer - Use of neoadjuvant chemoradiation in squamous cell carcinoma of the esophagus examined
Facilities - Aptamer-based therapeutic developer moves to new headquarters
Facilities - Critical Care Systems opens branch pharmacy featuring on-site ambulatory infusion suite
Facilities - Healthcare management systems company to open fifth medical facility in California
Facilities - Pharma company divests AWD.pharma manufacturing plant in Dresden, Germany
Fetal Medicine - Pro-inflammatory cytokines inhibit placental 11beta-hydroxysteroid dehydrogenase type 2 activity
Finance - Biopharmaceutical company reports 2005 U.S. and Canada net sales of anti-HIV drug up 32%
Finance - Canadian biopharmaceutical firm reports 9% increase in revenue
Finance - Cancer drug developer reports loss of $0.99 per share, provides clinical pipeline update
Finance - Cancer immunotherapies developer receives delist determination from NASDAQ panel
Finance - Cancer vaccine developer completes $3M institutional financing
Finance - Cancer-focused biotech firm announces put option
Finance - Cardiovascular products company reports record Q4 revenue, 2005 revenues up 17% to $202 million
Finance - Chemically derived drug distributor posts decline in revenue
Finance - Company focused on age-related macular degeneration receives investment
Finance - Drug developer focused on respiratory diseases reports 75% increase in sales
Finance - Drugstore chain reports 0.9% same store sales increase for January 2006
Finance - Gastroesophageal reflux disease drug developer completes Series E financing
Finance - Gastrointestinal drug maker reports 10% increase in sales
Finance - Healthcare products company reports Q4 05 net revenue up 2% to $4.7 billion
Finance - Healthcare, drug company reports GAAP net Q4 05 sales of $2.3 billion, up 6% from year ago
Finance - Healthcare, life sciences company reports Q3 2006 revenue increase of 5% to $287.5 million
Finance - Israel-based generic drug company sets pricing of $1.25 billion of convertible debentures
Finance - Lilly reports $3.879 billion in sales
Finance - MedImmune reports revenues of $1.2 billion
Finance - Myeloma foundation awards over $8 million in 2005 to Multiple Myeloma Research Consortium
Finance - Mylan Laboratories reports earnings per share of $0.25 for third quarter
Finance - Natural and organic products company reports record Q2 2005 sales up 10% from year ago
Finance - Neurobiological Technologies receives $1.4 million quarterly royalty payment related to Memantine
Finance - Neuroscience drug maker receives $4.2M from exercise of warrants
Finance - Neuroscience drug maker reports loss of $0.10 per share
Finance - Nutritional products company reports net sales of $455 million for first quarter
Finance - Ophthalmology company reports 10.7% increase in sales
Finance - OrthoLogic reports net loss of 7.5 million or $0.20 per share for the fourth quarter
Finance - Pharma company announces Tarceva net sales of $25 million for fourth quarter
Finance - Pharma company announces intention to raise $40 million in new capital
Finance - Pharma company begins trading under symbol NHPI, announces $4.35 million private placement
Finance - Pharma company sales increase 16% in 2005
Finance - Pharma firm focused on Asian markets receives American Stock Exchange notification
Finance - Pharma giant reports 1.1% decline in sales
Finance - Pharmaceutical company reports revenues up 13% for fiscal Q3 2006 over year ago
Finance - Pharmaceutical division to be separated from parent company
Finance - Pharmaceutical firm files amended report to the U.S. S.E.C.
Finance - Protein therapeutics developer prices initial public offering
Finance - Public offering of common stock priced by RNAi therapeutics company
Finance - Q4 2005 sales of Copaxone up 24% to $323 million, annual sales up 26%, company reports
Finance - Risperdal Consta maker reports second consecutive profitable quarter
Finance - SBIR grant to be used for study of drug for stroke patients
Finance - Specialty pharma company signs definitive agreement for $65 million private financing
Finance - TEDCO awards grant for a smallpox DNA vaccine delivery project
Fitness & Wellness - High-dose growth hormone increases glucose production and uptake
Food Allergies - FAAN announces availability of free school food allergy programs
Gastric Cancer - ELF/TGF-beta signaling inactivated in human gastrointestinal cancer
Gastric Cancer - Recent studies add new data to gastric cancer research
Gastroenterology - Conserved gene regions leave gastric cancers invulnerable to gefitinib
Gastroenterology - Endoscopic therapy optimal for bleeding peptic ulcer with adherent clot
Gastroenterology - Gut protein protects against infection, intestinal breakdown
Gastroenterology - U.S. FDA grants approval for oral treatment for chronic idiopathic constipation in adults
Gastroesophageal Reflux Disease - Medicare increases reimbursement rate for Plicator procedure
Gastrointestinal Cancer - Study finds no association between hormone replacement therapy and GI cancer
Gene Research - CST6 modulates genes linked to breast cancer progression
Gene Therapy - STAT3 activation is differentially regulated in squamous cell carcinomas
Generic Drugs - Drug maker announces Aventis' preliminary injunction motion denied in Allegra litigation
Generic Drugs - Pharma company announces final U.S. FDA approval for alprazolam extended-release tablets
Generic Drugs - U.S. FDA approves ANDA for generic desmopressin acetate tablets
Genetics & Genomics - Genetic variation detection tool used on mutations associated with therapy in lung cancer
Genetics & Genomics - Link between common deletion polymorphisms can be evaluated in whole-genome association studies
Genetics & Genomics - Metformin and oleic acid reduce resistin gene expression in isolated adipocytes
Genetics & Genomics - Review examines sarcomeric proteins and familial hypertrophic cardiomyopathy
Genetics & Genomics - SNAI1, functioning as E-cadherin repressor, is implicated in gastric cancer
Germ-Cell Tumors - Follow-up advised for 2 years after first-line treatment of germ-cell tumors
Glioma - Dihydroartemisinin enhanced radiosensitivity of human glioma cells
Glioma - Temozolomide might benefit glioma patients with deletions of chromosomes 9p/10q
Gynecological Tumors - Hysterectomy may be best treatment option for placental site trophoblastic tumor
Gynecology - Calcyclin-binding protein may help regulate apoptosis during early pregnancy
Gynecology - Estradiol uses paracrine mechanisms to regulate VEGF receptor in the uterus
Gynecology - Researchers' findings advance gynecology research
HIV-2 Pathogenesis - HIV-2-specific T-cell response does not correlated with CD4 cell counts
HIV/AIDS Behavioral Medicine - Alcohol consumption linked to high-risk sexual behavior in Gauteng province
HIV/AIDS Behavioral Medicine - Methadone maintenance therapy reduces heroin use and HIV risk behavior
HIV/AIDS Behavioral Medicine - Prevention counseling reduces HIV transmission among uninfected partners
HIV/AIDS Drug Delivery - HIV Tat fusion proteins reduce brain injury following ischemic stroke
HIV/AIDS Drug Development - LC method provides accurate and precise analysis of ritonavir in soft capsules
HIV/AIDS Drug Interaction - Tenofovir drug interactions increase risk for acute renal failure
HIV/AIDS Drug Resistance - Impact of transmitted HIV-1 drug resistance on CD4 cell decline is time dependent
HIV/AIDS Genetics - HIV-1 RNA binding protein interacts with Dicer and functions in RNA silencing
HIV/AIDS Genetics & Genomics - Genetic variants in associated host genes may play important role in HIV-1 susceptibility
HIV/AIDS HAART - HIV-1 K103N mutation after HAART withdrawal has little impact on viral fitness
HIV/AIDS HAART - Psychological distress and pain not associated with episodes of detectable viremia
HIV/AIDS HAART - Ritonavir and nelfinavir inhibit a DIDS-sensitive anion current in B-cells
HIV/AIDS HAART - Ritonavir impairs lipoprotein lipase-mediated lipolysis
HIV/AIDS HAART - Three of 8 mutations in ATV/RTV genotypic resistance score predict reduced response
HIV/AIDS Healthcare Costs - Feasible to effectively treat same number of patients at same or lower cost per patient
HIV/AIDS Hypoalphalipoproteinemia - Hypoalphalipoproteinemia in HIV/AIDS likely to be secondary to HIV infection itself
HIV/AIDS Mutations - HIV-1 subdomain insertions alter polymerase fidelity and mutation frequencies
HIV/AIDS Opportunistic Infection - Oral manifestations occur commonly among HIV-infected children in Romania
HIV/AIDS Palliative Care - HIV/AIDS patients report significant physical and psychological symptoms despite treatment
HIV/AIDS Pathogenesis - CD4 cells induce plasmacytoid dendritic cell activation and maturation in HIV/AIDS
HIV/AIDS Pathogenesis - HIV infection associated with increased NTPDase activity that correlates with CD39+ cells
HIV/AIDS Pathogenesis - HIV-1 Tat is directly involved in AIDS-associated intestinal dysfunction
HIV/AIDS Pathogenesis - LIF induced in initial stages of viral dissemination during primary HIV-1 infection
HIV/AIDS Pathogenesis - Neutralizing antibody responses drive HIV-1 Env evolution during recent infection
HIV/AIDS Pathogenesis - R362A mutation at the C-terminus of capsid inhibits HIV-1 RNA packaging
HIV/AIDS Pathogenesis - TNF-alpha contributes to induction of an effective immune response against HIV-1
HIV/AIDS Pharmaceutical Research - Extended-release clarithromycin well tolerated and bioequivalent to IR formulation
HIV/AIDS Prevention - Anti-HIV drug has potential to prevent transmission in women
HIV/AIDS Prevention - Journal takes in-depth look at HIV/AIDS over the past 25 years
HIV/AIDS Prevention - Lewis X component in human milk inhibits HIV-1 transfer to CD4+ T lymphocytes
HIV/AIDS Sociology Research - Thailand community reactions are positive toward persons with HIV/AIDS and their parents
HIV/AIDS Therapy - Dextrin sulphate 4% appears to be well tolerated in low-risk HIV-negative women
HIV/AIDS Therapy - Sequencing antiretroviral drugs extends the suppression of HIV replication
HIV/AIDS Tobacco Use - Tobacco smoking increases mortality and decreases quality of life in HIV/AIDS
HIV/AIDS Transmission - HIV interacts with target cells in the genital mucosa in multiple ways
HIV/AIDS Vaccines - Researchers provide details of new studies and findings in the area of HIV/AIDS vaccines
HIV/AIDS Vaccines - Study compared protocols to optimize production of HIV-1 lentiviral particles
HIV/AIDS-Related Infection - HIV/AIDS impacts skin diseases through multifaceted mechanisms
HIV/AIDS-Tuberculosis Coinfection - No particular MTB or M. avium clones prevail in HIV-infected persons in Japan
HIV/AIDS-Tuberculosis Coinfection - Tuberculosis modestly increases T-cell proliferation in the absence of HIV
Head & Neck Cancer - I-HDR brachytherapy and cervical dissection used to treat head and neck cancer
Health Promotion - New consumer education campaign focuses on immune system threats
Healthcare Costs - Administration says Medicare drug coverage will drop overall costs substantially
Healthcare Costs - Generic drug makers speak out against President Bush's budget
Healthcare Coverage - State of South Carolina selects ActiveHealth Management to provide decision support services
Heart Failure - Forty U.S. centers enrolling heart failure patients in new pacing device safety study
Heart Failure - Research reports a validated clinical, biochemical score for diagnosis of acute heart failure
Heart Failure - Review examines drugs for left ventricular remodeling in heart failure
Heart Failure - Urodilatin may be new therapeutic agent in treatment of decompensated chronic heart failure
Heart Failure - Use of spironolactone in severe CHF patients does not preclude need for beta blockers
Hematology - Antiphospholipid antibodies can affect point-of-care INR test results
Hematology - Dipyridamole decreases protease-activated receptor and annexin-v binding on platelets
Hematology - Prolyl hydroxylase domain protein 2 is essential for hypoxia-inducible factor regulation
Hematology - Researchers' data advance hematology research
Hepatitis B Immunization - Lipid microparticles aid in mucosal immunization against hepatitis B
Hepatitis B Virus - HBV surface antigen is well-tolerated in healthy young adults
Hepatitis B Virus - Natural and lamivudine-induced HBV surface gene mutants characterized
Hepatitis B Virus - Outcome of interferon treatment of chronic hepatitis B determined histologically
Hepatitis B Virus - U.S. FDA approves hepatitis B-specific immune globulin for acute exposure
Hepatitis C Research - Most common HCV type grown in lab for first time
Hepatitis C Therapy - Scientists call for hepatitis treatment of young injection drug users
Hepatitis C Therapy - U.S. FDA grants Civacir fast track designation for hepatitis C
Hepatitis C Therapy - U.S. FDA grants fast track designation to investigational oral HCV protease inhibitor
Hepatitis C Virus - CD81 activates naive B lymphocytes
Hepatitis C Virus - HCV-like particles generated in different cells bind differently to target hepatoma cells
Hepatitis C Virus - Hepatitis B virus Ig-lamivudine combination protects liver allografts
Hepatitis C Virus - Hepatitis C virus protein 5A regions are not required for genome replication
Hepatitis C Virus - Histological HCV-related abnormalities are coincident with elevated aminotransferase levels
Hepatitis C Virus - Nongenetic determinants operate in spontaneous clearance of HCV in hemophiliacs
Hepatitis Vaccines - HBV CpG-optimized protein and DNA vaccines perform poorly in chimpanzees
Hepatitis Vaccines - Immunoreactive hepatitis B and C epitopes are useful in vaccine development
Hepatocellular Cancer - Inducible nitric oxide synthase and MMP-9 promote liver cancer angiogenesis and progression
Herpes Simplex Virus - Marine alga extract suppresses herpes simplex virus in in vivo models
Hodgkin Disease - Chemotherapy alone used to treat Hodgkin disease in Indian children
Human Papillomavirus - Cervical mucosal antibodies protect against human papillomavirus 16
Hypertension - Beta-blockers worsen pulmonary dynamics in portopulmonary hypertension patients
Hypertension - Hypertension-associated nucleotide polymorphism did not diminish treatment efficacy with irbesartan
Hypertension - Hyperuricemia associated with need for antihypertensive therapy
Hypertension - Review examines role of the new beta-blockers in treating cardiovascular disease
Hypertension - Selective ANGII receptor antagonism raises insulin sensitivity and glucose transport rat model
Imaging - Imaging reveals effects of bronchodilator and airway clearance treatment in cystic fibrosis
Imaging - Myocardial perfusion imaging with ATP is as effective as dipyridamole for diagnosis of CAD
Inflammatory Bowel Disease - Prescription painkillers effective in patients with dormant IBD
Inflammatory Bowel Disease - Review examines complications of biological therapy for inflammatory bowel diseases
Influenza - Copper industry group says copper could help contain flu
Influenza - Media coverage on flu effective in influencing parents to vaccinate their children
Influenza - Thiovir proven active against various influenza A viruses
Influenza Vaccines - Antibody response to influenza vaccine is low in nursing home residents
Influenza Vaccines - Influenza vaccine effectiveness estimated during an outbreak
Influenza Vaccines - Influenza vaccine with broad spectrum of efficacy urgently needed
Influenza Vaccines - Misconceptions about influenza vaccination exist among healthcare workers
Influenza Vaccines - Modified surfactant stimulates IgA in response to influenza antigen
Information Technology - FFF Enterprises uses ERP product-tracking software in electronic drug pedigree system
Information Technology - IT company releases upgrades of chemistry lab software tools
Information Technology - Partners In Care participates in federally funded test of electronic prescribing program
Information Technology - Software simplifies connectivity between logic analyzers and oscilloscopes
Insomnia - Self-help behavioral intervention reported effective in alleviating insomnia symptomatology
Ischemia - A protein kinase modulates GluR6 Ser phosphorylation during cerebral ischemia
Japanese Encephalitis - European Commission grants Japanese encephalitis vaccine orphan drug status
Kidney Cancer - Agency approves new treatment for gastrointestinal and kidney cancer
Legal Issues - Drugmaker announces dismissal of amended class action complaint relating to Mucotrol
Leukemia - Combination of HDAC inhibitors and TRAIL used to treat leukemia
Leukemia - Extracellular KIT receptor mutants in leukemia respond to imatinib mesylate
Leukemia - HRQOL concerns over use of dexamethasone in pediatric leukemia addressed
Leukemia - License agreement signed to develop Fodosine for use in oncology
Leukemia - NS-187 proposed as novel agent for imatinib-resistant leukemia
Leukemia - New findings in leukemia described
Leukemia - Research add new data to leukemia body of knowledge
Licensing Agreements - License agreement set with Baylor, M.D. Anderson to develop antimicrobial coated implants
Licensing Agreements - Potential migraine compound licensed to BTG
Liver Cancer - New findings in the area of liver cancer detailed
Liver Diseases - Angiogenic regulators drive sinusoidal changes after partial liver removal
Liver Metastasis - Low-dose leucovorin and 5-fluorouracil used to treat liver metastasis
Lung Cancer - Altered EGFR signaling implicated in genetic susceptibility to lung cancer
Lung Cancer - Maintenance/consolidation chemotherapy improved survival in lung cancer patients
Lung Cancer - Recent findings in lung cancer described
Lung Cancer - Recent findings in lung cancer provide new insights
Lung Cancer - Researchers publish new studies and findings in the area of lung cancer
Lung Cancer - Tumor cell-stromal fibroblast interaction revealed in model of human small-cell lung cancer
Lymphangiogenesis - Embryonic stem cells have the capacity to become lymphatic endothelial cells
Lymphoma - Local tumor invasiveness was most important predictor of survival in lymphoma
Macular Degeneration - Macugen receives European regulatory marketing approval as AMD treatment
Macular Degeneration - Phase I study of VEGF Trap shows rapid, substantial and prolonged reductions in retinal thickness
Macular Degeneration - Retinal thickness mapping monitors choroidal neovascularization in treated eyes
Malaria - Malaria-related lactic acidosis safely treated with dichloroacetate
Malaria - Microscopy can improve antimalarial drug targeting in low-transmission areas
Market Analysis - Generics erosion will lead to slow market growth for chronic heart failure treatment
Market Analysis - Market report says personalized medicine and molecular diagnostics to show robust growth
Market Analysis - Report finds every 1% increase in generic dispensing cuts pharmaceutical expenditures by 0.6%
Market Analysis - U.S. has the largest over-the-counter drug market in the world, according to new report
Marketing - Ascend Therapeutics selects sales and marketing services provider to promote EstroGel
Marketing - Market report says 2006 launch of cancer vaccine to prevent human papillomavirus expected
Marketing - Promotion "arms race" looks set to continue for the foreseeable future
Measles Vaccines - Combination of measles virus peptides elicit antigen-specific immune response
Medical Devices - Immunoprofiling platform with global population coverage launched
Medical Devices - MEMS SmartCaps useful for measuring cystic fibrosis treatment adherence
Medical Devices - Stable polymer nanotubes may have a biotech future
Medicare - Pennsylvania governor seeks to expand comprehensive drug package for seniors
Medicare - U.S. HHS secretary issues progress report on Medicare Prescription Drug Benefit
Melanoma - Immunotherapy company may add additional trial to explore IVIg efficacy for melanoma
Meningitis Vaccines - Meningococcal vaccine doses can be reduced with pertussis-containing vaccine
Menopause - New look at HRT highlights the value of starting soon after menopause
Mental Health - Depression is not linked to pro-inflammatory cytokine production in CAD patients
Mental Health - Guidelines are released on pharmacogenetic testing for CYP450 2D6 and CYP4502C19
Mental Health - Lyrica receives positive opinion from CHMP for treatment of generalized anxiety disorder in adults
Mental Health - New York medical center geriatric psychiatry program head says depression in elderly widespread
Mental Health - Research firm finds launch of triple reuptake inhibitors will drive the market for depression
Mergers & Acquisitions - Agreement signed to acquire European drug discovery service company
Mergers & Acquisitions - Angiogenesis-focused biopharmaceutical firm merges with eClic, Inc.
Mergers & Acquisitions - Company focused on glaucoma acquires Pro Top and Mediking
Mergers & Acquisitions - Drug discovery company signs definitive agreement to acquire Montigen Pharmaceuticals
Mergers & Acquisitions - Innovate will acquire 50% interest in pancreatic chemoresistance inhibitor
Mergers & Acquisitions - Oncology services company to acquire ivpcare
Mergers & Acquisitions - Private equity firm acquires majority interest in Bioniche Pharma Group Limited
Mergers & Acquisitions - Purchase of continuing medical education company completed
Mergers & Acquisitions - Research firm acquires Millennium Research Group
Metabolic Disease - 3-Hydroxyglutaric acid may produce the vasculopathy of glutaric aciduria type I
Metabolic Syndrome - Tesaglitazar improves metabolic anomalies related to insulin resistance in nondiabetics
Migraine Headaches - U.S. FDA approves new formulation of Imitrex injection
Monoclonal Antibodies - VEGF inhibitors in cancer therapy are focus of review
Muscular Dystrophy - Biopharma company initiates phase II study of PTC124 in Duchenne muscular dystrophy
Myocardial Infarction - Granulocyte colony-stimulating factor augments cellular cardiomyoplasty in the injured heart
Nanotechnology - Framework for risk analysis of nanoparticles is developed
Natural Products - Curcumin and quercetin improve early outcomes in cadaveric kidney transplant recipients
Natural Products - Hyperforin has a direct effect on mammary tumor angiogenesis
Neisseria Vaccine - Neisseria lactamica outer membrane vesicles are potential mucosal adjuvants
Neoplastic Diseases - Intestinal transplantation used to treat intra-abdominal neoplastic disease
Neuroblastoma - New strategies needed for neuroblastoma patients with MYCN-amplified tumors
Neurodegenerative Diseases - Rosiglitazone may help prevent progressive neurodegenerative disease
Neurology - Calcium-modulated voltage channels could be the mediators of alcohol tolerance
Neurology - Monocytes foster vascular repair following brain injury
Neuroprotection - Neurotrophic agent protects against mitochondrial dysfunction in cortical neurons
Neuroscience - Angiotensin II type 1 receptor blockade supports cerebral cortex angiogenesis
Neuroscience - Caspase-1 activates caspase-6 in human apoptotic neurons
Neuroscience - Research in neuroscience provides new insights
Neuroscience - Research paper validates radioiodinated clioquinol as a biomarker for beta-amyloid
Nocardia Keratitis - Topical moxifloxacin and imipenem successful in complicated case of Nocardia asteroides keratitis
Non-Hodgkin Lymphoma - FDG-PET used in staging and follow-up of children with non-Hodgkin lymphoma
Obesity Epidemiology - Tallness is significantly associated with increased obesity risk in 6-year-old children
Obesity Research - Review discusses IGF-I, growth hormone and insulin in white adipose tissue
Obesity Therapy - Rosiglitazone restores AMPK signaling in muscle of insulin-resistant obese rats
Obesity Therapy - Sibutramine may help achieve short-term weight loss in morbidly obesity adolescents
Obstetrics - Maternal serum-soluble vascular endothelial growth factor receptor-1 signals preeclampsia
Obstetrics - New findings in the area of obstetrics detailed
Oncology - Celecoxib challenges angiogenesis and bone metastasis in tumor models
Oncology - Glycochenodeoxycholate uses oxidative dysfunction to support biliary carcinogenesis
Oncology - Heat shock protein-90 inhibitors can control multiple myeloma
Oncology - Photodynamic therapy shuts down tumor angiogenesis and metastasis in cancer models
Oncology - Research in oncology provides new insights
Oncology - Researchers report details of new studies and findings in the area of oncology
Oncology - Study emphasizes women should see gynecological oncologists for ovarian cancer treatment
Ophthalmology - Homocysteine may present a risk for age-related macular degeneration
Ophthalmology - U.S. FDA approves expanded use of Xibrom to treat post-cataract surgery pain
Ophthalmology - University eye institute, neurology program join to offer ophthalmology diagnostic program
Osteoarthritis - Osteoarthritis sufferers may benefit from bone resorption effect of oral salmon calcitonin
Osteoporosis - CHMP recommends first quarterly IV for postmenopausal osteoporosis for approval
Osteoporosis - Pharma companies collaborate to develop and commercialize nasal spray for osteoporosis
Osteoporosis - Premenopausal women with diabetes have more fractures, less bone density, study shows
Osteoporosis - Studies add new findings to osteoporosis body of knowledge
Osteosarcomas - Effect of ifosfamide in patients with osteosarcoma of extremity evaluated
Ovarian Cancer - Oxaliplatin-resistant ovarian carcinoma cells possess unique gene expression
Ovarian Cancer - Research add new data to ovarian cancer body of knowledge
Pain Management - Cannabis-based Sativex effective for rheumatoid arthritis pain relief
Pain Management - Dominion Diagnostics and "The Legal Side of Pain" announce a joint venture
Pain Management - Postop pain higher, more analgesics needed in laparoscopy patients versus laparotomy patients
Pain Management - U.S. FDA accepts IND for OxyQD
Pain Management - U.S. FDA grants orphan drug status to high-concentration pain management therapy for PHN
Pancreatic Insufficiency - First of two phase III studies initiated for EUR-1008M in patients with EPI
Patents - Company receives second U.S. patent protecting polymer composition of delivery vehicle
Patents - Patent allowed for heat shock protein-derived peptides
Patents - Patent covers unique method of isolating adult stem cells
Patents - Patent issued for transmissible spongiform encephalopathies rapid test
Patents - Pharma announces Federal Circuit Court of Appeals remands OxyContin patent case
Patents - Provectus receives fourth pharmaceutical patent for anticancer agents
Patents - Transdermal science company serves patent infringement notice for insulin delivery system
Pediatric Obesity - Women's volunteer group launches 2006 childhood obesity initiative "Kids in the Kitchen"
Pediatrics - Children's asthma care improves on state health insurance program
Pediatrics - New moms identify infant gas as stressor for babies and moms
Peripheral Arterial Disease - U.S. FDA fast track status granted for rifalazil in peripheral arterial disease
Personnel - ATP-focused biopharma announces board change
Personnel - Argeris 'Jerry' Karabelas named non-executive chair of drug delivery company board
Personnel - Biopharma company elects Jean-Pierre Millon as chairman of the board
Personnel - Biopharmaceutical company names Thomas E. Rathjen vice president of investor relations
Personnel - Biotech company names Neil Roth acting president
Personnel - Biotechnology Council of New Jersey's board of trustees elects Dr. Leslie J. Browne
Personnel - Chemistry service firm adds two key human resources professionals
Personnel - Clinical research organization adds three experts to global product development services group
Personnel - Contract research organization names Sara Vidmar executive director for medical devices
Personnel - David B. Nash, MD, and Bruce Morra, PhD, named to InforMedix, Inc. board
Personnel - Drug delivery pharmaceutical company announces workforce reduction
Personnel - Drug delivery systems company appoints Mento A. Soponis chairman and CEO
Personnel - Drug development software company adds staff in product training and strategic consulting services
Personnel - Duncan Higgons joins biopharma as executive vice president, business operations
Personnel - Former U.S. Surgeon General Joycelyn Elders joins pharmaceutical company
Personnel - Infectious disease-focused pharmaceutical firm appoints chairman of the board
Personnel - Nanomaterials developer hires Dr. Jayant Tatake as VP research and development
Personnel - Nasal drug delivery developer forms scientific advisory board
Personnel - New thoracic cancer advisory board formed
Personnel - Ophthalmology firm promotes F. Michael Ball to president
Personnel - Peter Fellner named non-executive director at vaccines company
Personnel - Pharma company names Mark A. Varney as COO and chief scientific officer
Personnel - Pharma consulting company names Glenn A. Stiegman, III as vice president
Personnel - Pharma product development company appoints Rick A. Bright as VP vaccine research
Personnel - RNAi therapeutics-focused company appoints Akshay Vaishnaw as VP
Personnel - Respiratory disease-focused drug maker appoints William J. Newell as president
Personnel - Rich Daly returns to pharma company as vice president of marketing and commercial strategy
Personnel - Robert F. Apple named senior VP and chief financial officer at drug delivery firm
Personnel - Sirtris names Garen Bohlin chief operating officer
Pertussis Outbreaks - Early pertussis diagnosis may limit transmission and protect susceptible infants
Pertussis Vaccines - Researchers report details of new studies and findings in the area of pertussis vaccines
Pharmaceutical Research - Cyclosporin A destroys established angiogenesis in laboratory models
Pharmaceutical Research - Drug delivery company, Donaldson launch jointly developed nanofiber cell culture product
Pharmaceutical Research - Market research firm introduces electronic format of Pharmcor report
Pharmaceutical Research - Market research firm study shows companies spent more than $1 trillion on acquisitions in 2005
Pharmaceutical Research - Phosphosulfomannan angiogenesis inhibitor analogues act variably
Pharmacoeconomics - Study shows taking medications as directed reduces overall healthcare costs
Pituitary Adenomas - Effect of cAMP-PKA pathway in nonfunctioning pituitary adenomas explored
Polycystic Kidney Disease - Scientists find cellular pathway that could lead to drug treatment for polycystic kidney disease
Polycystic Ovary Syndrome - Pioglitazone decreases hyperinsulinemia in obese patients with polycystic ovary syndrome
Pompe Disease - Biotech company receives positive opinion for Myozyme from European regulatory committee
Premenstrual Dysphoric Disorder - U.S. FDA clarifies status of YAZ PMDD application
Prodrugs - Tumor necrosis factor prodrug restores membrane TNF-like activity
Product Distribution - Patient compliance company named distributor of the SIMpill medication adherence system
Product Licensing - Beverly Hills California physician licenses Prometa physiological protocols
Product Licensing - Hepatitis C virus license agreement signed with Chiron
Product Licensing - Molecular tests company licenses newly discovered coronavirus CoV-NL63 to bioMerieux
Product Licensing - Pharma company licenses mitochondrial disease technology from Georgetown University
Product Licensing - Reproductive health organization licenses Biosyn-patented microbicides for the prevention of HIV
Product Licensing - Worldwide rights obtained for cetrorelix in benign prostate hyperplasia
Prognostics - Presence of ITC in lymph nodes not a prognostic marker for stage I/II colorectal cancer
Prostate Cancer - Combined androgen blockade with bicalutamide deemed cost-effective in prostate cancer
Prostate Cancer - Data show bicalutamide 150mg plus radiotherapy extends survival in locally advanced prostate cancer
Prostate Cancer - Diindolylmethane downregulates pro-survival pathway in prostate cancer
Prostate Cancer - Examination of antiestrogens as treatment for advanced prostate cancer advocated
Prostate Cancer - Feasibility of continuous infusion of epirubicin in prostate cancer assessed
Prostate Cancer - Ixabepilone was active in patients with hormone-refractory prostate cancer
Prostate Cancer - Leuprolide acetate is available as subcutaneous extended-release injection
Prostate Cancer - Studies describe new findings in prostate cancer research
Prostate Cancer - Therapeutic effect in prostate cancer assessed by magnetic resonance imaging
Prostate Cancer Vaccines - Provenge slows prostate cancer progression
Protein Production - Multi-product immunoassays are suitable to monitor host cell protein impurities
Proteomics - Human chemokine CCL23 may boost angiogenesis by promoting matrix metalloproteinase-2
Proteomics - Notch ligand Delta-like 4 hinders VEGF-related endothelial cell function
Proteomics - Recent findings in proteomics described
Proteomics - Researchers report details of new studies and findings in the area of proteomics
Pseudomonas Vaccines - Oral Pseudomonas vaccine is safe and immunogenic in healthy adults
Pulmonary Hypertension - Drugmaker in-licenses pulmonary hypertension compound for development
Renal Disease - First patient enrolled in FREEDOM daily home hemodialysis study
Reproductive Biology - Recombinant human lutropin alfa is not useful in late stimulation assisted reproduction cycles
Respiratory Medicine - Clinical practice guidelines on postinfectious cough are released
Respiratory Medicine - Group rankings shows no city is safe from asthma
Rheumatoid Arthritis - Cholesterol lowering drugs shown to have beneficial effect on rheumatoid arthritis cells in vitro
Rheumatoid Arthritis - Pristane induces MHC class II-restricted, arthritogenic T cells
Ricin Vaccines - Positive phase I results of RiVax vaccine announced
Rotavirus - Newly-licensed rotavirus vaccine traveled long road in development
Rubella - Many foreign-born women in Miami are not vaccinated for rubella
Schizophrenia - Nicotine downregulates dopamine D2 receptor availability in antipsychotic drug treatment
Schizophrenia - Schizophrenic patient's attitude toward drug therapy helps predict intervention compliance
Seizure Disorders - Oxycodone should be used with caution in patients with reduced threshold to seizures
Septicemia Vaccine - Immunization with detoxified endotoxin vaccine protects against sepsis
Sexual & Reproductive Health - Cervical cancer vaccine being altered to treat genital warts
Sleep Apnea - Acetazolamide improves central sleep apnea in heart failure
Sleep Apnea - Obstructive sleep apnea syndrome involves abnormal upper airway sensory input
Sleep Disorders - Regulatory update provided on status of NUVIGIL
Smoking Cessation - D-deprenyl, an L-deprenyl isomer, may have abuse potential
Sociology Research - Bounded awareness, cognitive blinders can prevent risk recognition in decision making
Spinal Muscular Atrophy - Licensing agreement aims to boost spinal muscular atrophy drug discovery efforts
Staffing - Kenexa selects vendor for employment process outsourcing services
Statins - Findings in statins provide new insights
Statins - New findings in the area of statins described
Statins - Questions regarding benefits of statin therapy are focus of review
Stem Cell Research - Researchers detail new studies and findings in the area of stem cell
Stem Cell Transplantation - HHV-6 infection associated with SCT from an allelic-mismatch donor and steroid therapy
Stem Cell Transplantation - Preemptive once-daily ganciclovir safe/effective for CMV viremia after ASCT
Stroke - Low-dose Botox with short electrostimulation improves poststroke spastic drop foot
Stroke - Recent findings illuminate research in stroke
Surgical Technology - Subcutaneous gentamycin implant does not prevent infections after loop-ileostomy closure
Synovial Sarcomas - Role of adjuvant therapies to treat grossly-resected synovial sarcoma discussed
T Cells - CD8+ and CD4+ T-cell tolerances can be broken
Tendinopathy - NSAIDS may do more harm than good in non-inflammatory tendon conditions
Testicular Cancer - Guidelines on testicular cancer updated
Thrombocytopenia - Recombinant factor VIIa can control bleeding caused by thrombocytopenia
Thrombosis - Higher levels of whole blood aggregation with anti-alpha(IIb)beta(3) suggest subacute thrombosis
Thyroid Cancer - U.S. FDA grants fast track designation for Zactima for the treatment of thyroid cancer
Tick-Borne Disease - Research add new data to tick-borne disease body of knowledge
Tobacco Use - Healthcare supplier receives U.S. FDA approval to market nicotine lozenges
Tobacco Use - Low level laser therapy for smoking cessation clinic opens in New York City
Tonsillitis - Parents happier with alternative to liquid medications for tonsillectomy
Transplant Medicine - Findings describe new data in transplant medicine research
Transplant Medicine - Research in transplant medicine provides new insights
Transplant Medicine - Rituximab therapy is effective for cryoglobulinemia in renal transplants
Transplant Medicine - Studies describe new findings in transplant medicine research
Treponema Pallidum - Different classes of superoxide reductases have different structures
Tuberculosis Vaccines - Advances in tuberculosis vaccine development summarized
Tuberculosis Vaccines - BCG causes quantitative changes in T-cell subpopulations in infants
Tuberculosis Vaccines - New data illuminates research in tuberculosis vaccines
Tuberculosis Vaccines - Reports add new data to tuberculosis vaccines research
Tuberculosis Vaccines - Review focuses on preclinical testing of new vaccines for tuberculosis
Type 2 Diabetes - PC-DAC:Exendin-4 to advance into human clinical testing for type 2 diabetes
Type 2 Diabetes - Rosiglitazone plus sulfonylurea drugs improved insulin resistance and beta-cell function
Type 2 Diabetes - Timing of Humalog Mix25 injections did not impact after meal glucose fluctuations in elderly
Ulcerative Colitis - European Medicines Agency CHMP recommends approval of Remicade for ulcerative colitis
Uterine Cancer - Platinum-based chemotherapy is efficacious in uterine papillary serous carcinoma
Uterine Cancer - Radiation therapy after uterine cancer surgery may have limited impact on survival
Vaccine Delivery - Dendritic cells were targeted using pH-responsive microparticle vaccine carriers
Vaccine Development - Multivalent liposome-based vaccines protect against Neisseria meningitidis
Vaccine Development - Protection induced by BCG vaccine can be augmented using plasmid DNA
Veno-Occlusive Disease - Defibrotide shows success treating severe veno-occlusive disease
Virology - Study compared drug therapy regimens in antiretroviral therapy-naive adults
West Nile Virus - Study subjects had 23 single nucleotide polymorphisms not found in controls
Wound Healing - Cytokine integration enhances the angiogenic potential of collagen matrices during wound repair
Zygomycosis - Zygomycosis is an emerging fungal infection
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