Drug Week

Finance - Protein-based diagnostic products developer announces annual revenues of $2,818,000

Finance - Specialty pharmaceutical company reports 13% revenue increase in Q3 06 over a year ago

Finance - Stretta System developer reports a 37% increase in revenues in Q4 over Q3

Finance - Symlin maker reports loss of $0.61 per share

Finance - Therapeutic products company reports total operating expenses of $35 million

Finance - Tumor therapy developer completes $5M convertible offering

Finance - U.S. NASA awards $600,000 phase II grant to advance nanoscale drug delivery

Finance - Uremic pruritus drug maker closes second series C financing

Forensic Medicine - Hypoxia inducible factor levels display a time-related response to myocardial ischemia

Gastric Cancer - Biweekly irinotecan and cisplatin found effective in treating advanced gastric cancer

Gastroenterology - European filings of mesalazine compound for treating ulcerative colitis announced

Gastroenterology - GLP-2 stimulates glucagon secretion, raises lipid absorption, inhibits gastric acid secretion

Gene Delivery - Tumor specific gene delivery is achieved using a pH-responsive system

Gene Research - Antisense drug restores dystrophin in Duchenne muscular dystrophy in mouse model study

Gene Research - Studies advance knowledge in gene research

Gene Therapy - Reports advance knowledge in gene therapy research

Genetic Engineering - Intravenous MDMA self-administration in naive mice modeled reliably

Genetics & Genomics - Data presented at AGBT show potential to transform DNA sequencing and expression profiling

Genetics & Genomics - Gene expression patterns correlate with early progression to fibrosis in liver transplants

Genetics & Genomics - Genetic Association Information Network launched

Genetics & Genomics - Primary glioblastomas show similar genetic alterations in patients in Japan and Switzerland

Genetics & Genomics - Researchers assemble rhesus macaque genome

Genetics & Genomics - Resequencing, genotyping research initiated on five projects picked by U.S. NIH institute

Genetics & Genomics - Salt intake affects relation between hypertension and T-786C polymorphism

Genetics & Genomics - Studies add new findings to genetics & genomics body of knowledge

Glioblastomas - Glioblastoma subgroups possess distinct transcription profiles

Gliomas - AKT pathway contributes to the development and progression of gliomas

Gliomas - H-1 magnetic resonance spectroscopic imaging can assess glioma response to chemotherapy

Gliomas - Trichostatin A could be used to achieve tumor growth inhibition and cytotoxicity of gliomas

Gynecology - Researchers' work adds to gynecology body of knowledge

HIV/AIDS Demographics - HIV/AIDS epidemic continues to hit non-Hispanic blacks hardest in U.S.

HIV/AIDS Diagnostics - Diagnostic tests company upgrades dry filter spot HIV-1 collection solution to monitor viral load

HIV/AIDS Drug Abuse - Methadone maintenance in HIV-infected drug users associated with better HAART compliance

HIV/AIDS Drug Development - NNRTI DABO analogues are moderately active against HIV-1 and HIV-2

HIV/AIDS HAART - Prolonged HAART increases cardiovascular disease risk in HIV-infected children

HIV/AIDS Mental Health - Dehydroepiandrosterone appears to treat depression in HIV/AIDS

HIV/AIDS Pathogenesis - Ezrin immunoreactivity in HIV/AIDS correlates with additional HIV encephalopathy

HIV/AIDS Pathogenesis - Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection

HIV/AIDS Pathogenesis - NF-kappaB p50-histone deacetylase 1 complexes constitutively bind latent HIV LTR

HIV/AIDS Pathogenesis - PTX-B-oligomer suppresses IL-6-induced HIV-1 and chemokine expression via AP-1 inhibition

HIV/AIDS Research - CypA effects HIV-1 replicative ability such that both high and low CypA limits replication

HIV/AIDS Research - New research reaffirms ability of TNX-355 to block HIV-1

HIV/AIDS Research - Pharma company discontinues U.S. Fortovase sales and distribution

HIV/AIDS Research - Phase II trial shows MK-0518 plus OBT has greater antiretroviral activity than placebo plus OBT

HIV/AIDS Research - Study shows HIV patients respond well to Reyataz therapy

HIV/AIDS Therapy - IL-7 induces immunological improvement in SIV infection under antiviral therapy

HIV/AIDS Vaccine - Replication-defective viruses safe and efficient for vaccines and vaccine vectors

HIV/AIDS Vaccine - Vaccination with adenovirus vectors elicited broad immunity to SIV

HIV/AIDS Vaccines - Researchers publish new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Related Disorders - HIV-associated amyotrophic lateral sclerosis syndrome may improve following HAART

HIV/GB Virus C Coinfection - African GB virus C genotypes can inhibit HIV replication

Headache & Migraine - Recognizing hemicrania continua as a headache syndrome component is critical for prompt treatment

Healthcare Costs - Canadian pharmaceutical manufacturers begin to raise patented drug prices

Healthcare Costs - German government hopes reference pricing will save healthcare system billions of euros

Healthcare Coverage - Merck launches consumer health resource, "Guide to Affordable Medicine"

Healthcare Coverage - Study recommends more focus on generic drugs to reduce healthcare costs

Healthcare Coverage - Trustmark Universal Life launches new plans for voluntary life and long term care

Heart Disease - Physician knowledge of guidelines improves secondary prevention of heart disease

Heart Failure - Average mortality in acute decompensated HF in Argentina is unchanged in last decade

Heart Failure - Data advance knowledge in heart failure research

Heart Failure - Heart failure patients treated effectively with tolvaptan

Heart Valve Disease - Dobutamine and exercise have different effects on prosthetic mitral valve hemodynamics

Hematology - A vascular wall protein inhibits collagen-induced platelet aggregation

Hematology - Thrombin autoantibodies target both of its cryptic exosites

Hepatitis B Virus - Antioxidant supplementation may be warranted in acute or chronic hepatitis B

Hepatitis B Virus - Emtricitabine assisted in the treatment of chronic hepatitis B infection

Hepatitis B Virus - Epitope diversity is displayed by hepatitis B virus capsids

Hepatitis C Virus - Anti-HCV effect is mechanistically linked to control of viral replication

Hepatitis C Virus - Early preservation injury may predict poor outcome after liver transplantation

Hepatitis C Virus - HCV NS3 protein protects dendritic cells from recombinant virus expressing NS3

Hepatitis C Virus - HCV affects dendritic cell cytokine induction and T-cell stimulation

Hepatitis C Virus - Hepatitis C virus polyprotein translation is linked to polymerase function

Hepatitis C Virus - Interferon-alpha/beta upregulates IL-15 expression in vitro and in vivo

Hepatitis C Virus - Intrahepatic cytokine expression is downregulated during HCV/HIV co-infection

Hepatitis C Virus - New findings in the area of hepatitis C virus detailed

Hepatitis C Virus - Saliva nitric oxide levels are unchanged in HCV infected patients

Herpesvirus Vaccine - HF10 lacks neuro-invasiveness and protects against herpes simplex virus

Hip Replacement - Research in hip replacement provides new insights

Hormone Replacement Therapy - Disease prevention, control of menopausal symptoms are top reasons for hormone use in women

Hormone Replacement Therapy - Estrogen therapy was not shown to improve cardiopulmonary function in postmenopausal women

Human Papillomavirus Vaccine - HPV-16 peptide-specific immune responses reduce recurrence of cervical intraepithelial neoplasia

Huntington Disease - Antirejection drug treats Huntington disease

Huntington Disease - Drug may cut down involuntary movements in Huntington's disease patients by 25%

Hyperparathyroidism - Parathyroidectomy likely to promote healing, associated with long-term survival

Hypertension - Adiponectin is predictor of aortic pulse wave velocity but not augmentation index

Hypertension - Gender disparities may exist in hypertension therapy for acute coronary syndrome patients

Hypertension - Noninvasive Doppler index is useful to follow children with triscupid regurgitation

Hypertension - Project launches campaign to arm patients, doctors with hypertension facts

Hypertension - Reductions in LV mass index achieved with telmisartan were superior to carvedilol

Hypertension - Researchers describe findings in hypertension studies

Hypertension - Telmisartan was more effective than ramipril in reducing blood pressure

Hypertension - Use of iloprost or nitroglycerin offers hypertension relief during valvular heart surgery

Hypothyroidism - Cognitive function in serum-defined hypothyroid patients unchanged by T4 substitution

Imaging - Coronary flow reserve offers independent prognostic information in coronary artery disease

Imaging - Noninvasive images depict vascular endothelial growth factor gene expression in murine models

Immunology - Subunits within the IL-17 receptor undergo conformational change upon ligand binding

Inflammatory Bowel Disease - Budesonide is effective for treatment of inflammatory bowel disease

Inflammatory Bowel Disease - CD146 reflects vascular disturbances in patients with inflammatory bowel disease

Inflammatory Diseases - Mouse model may aid in drug development for autoimmune and inflammatory disorders

Influenza - Australian firm to apply for license to market influenza vaccine in the U.S.

Influenza Vaccine - New influenza vaccine takes weeks - not months - to mass produce

Influenza Vaccine - New recommendations take aim to improve influenza vaccination rates among healthcare workers

Influenza Vaccine - Vaccination against influenza in rheumatoid arthritis was not affected by disease-modifying drugs

Information Technology - Deal signed for implementation of AurSCOPE Knowledge databases

Information Technology - Perceptive Informatics announces release of clinical trial interactive web response system

Information Technology - Provider of medical software content broadens relationship with PatientKeeper

Information Technology - SupplyScape and VeriSign announce interoperability of electronic drug pedigree systems

Information Technology - U.S. FDA and information compiler sign R&D agreement for toxicity databases from FDA files

Information Technology - deCode genetics becomes a customer for drug model explorer

Ischemia - HSP70 functions in Ca²⁺ homeostasis in ischemic ventricular myocytes

Ischemic Stroke - Study shows NXY-059 reduces stroke related disability

Keratoconjunctivitis - Treating childhood phlyctenular keratoconjunctivitis with topical cyclosporine A reported effective

Kidney Disease - Renal insufficiency remains independent predictor of increased mortality after percutaneous coronary intervention

Legal Issues - Fluvirin maker announces termination of SEC investigation

Legal Issues - Generics maker to continue to market its bioequivalent version of OxyContin

Leishmaniasis - New drug resistance gene of Leishmania donovani has been identified

Leukemia - Combined treatment with BB-1 and TRAIL proposed as new cancer therapy strategy

Leukemia - Decitabine induces apoptosis in acute myeloid leukemia

Leukemia - Researchers' work adds to leukemia body of knowledge

Leukemia - Studies add new findings to leukemia body of knowledge

Leukemia - Studies describe new findings in leukemia research

Lipid Research - Gap widens between optimal versus actual cholesterol levels

Liver Cancer - Molecular fingerprints convey the angiogenic makeup of hepatocellular carcinoma

Liver Diseases - Nonalcoholic fatty liver disease is treatable by gastroplasty

Liver Diseases - Nutrition alters hepatocellular damage in NASH and alcoholic liver disease

Lung Cancer - A GSTP1 polymorphism may be linked to survival in advanced non-small cell lung carcinoma

Lung Cancer - First patient enrolled in phase III clinical trial in metastatic non-small cell lung cancer

Lung Cancer - Gemcitabine and cisplatin found effective in treating elderly patients with lung cancer

Lung Cancer - Gemcitabine used as first and second-line chemotherapy of lung cancer

Lung Cancer - Hepatoma-derived growth factor encourages tumor growth and invasion

Lung Cancer - Magnetometer enabled in vivo sentinel lymph node mapping in lung cancer patients

Lung Cancer - Monitoring circulatory TBARs and SB could help prognosticate lung cancer

Lung Cancer - New research in the area of lung cancer detailed

Lung Cancer - U.S. FDA grants fast track status to drug for PS2 women with advanced non small lung cancer

Lymphocytes - RNA electroporation allows high-efficiency transfection of primary human and mouse T lymphocytes

Lymphoma - Phosphatidylinositol-3 kinase/Akt inhibition promoted apoptosis in Hodgkin lymphoma

Malaria Vaccines - Reports add new data to malaria vaccines research

Malaria Vaccines - Researchers describe findings in malaria vaccines studies

Malaria Vaccines - Studies advance knowledge in malaria vaccines research

Market Analysis - Administrative staffing levels reveal right-sizing trends at pharma, biotech firms

Market Analysis - Aging population drives healthy prescription dermatological drug growth

Market Analysis - Apoptosis becomes a new focus for pharmaceutical companies

Market Analysis - Blockbuster drugs' companies spend on ads while mid-level brands focus elsewhere

Market Analysis - Insurers will support electronic patient data capture advocated by Medicare, report says

Marketing - Direct-to-consumer advertising can be powerful and effective

Marketing - Therapeutics company retains Trilogy Capital Partners as investor relations firm

Marketing Agreements - Letter of intent executed for marketing of SOLTAMOX

Medical Devices - Affirm skin rejuvenation device launched

Medical Devices - Chinese FDA approval granted for ambulatory infusion pump for pain management

Medical Devices - Dexamethasone-eluting nitinol stent may inhibit pseudo-intimal hyperplasia in TIPS

Medical Devices - MIV Therapeutics to collaborate on future drug eluting stent technologies with Sahajanand

Medical Devices - Multichannel microfluidic chips show promise for high-throughput chiral drug screening

Medical Devices - New Adapta-Cap Bottle Adapter released

Medical Devices - New service enables anticoagulant patients to self-test levels at home

Medical Devices - Paclitaxel-eluting Taxus coronary stent reduces restenosis risk during renal insufficiency

Medical Devices - Spot-check device introduced

Medical Devices - Titan offerings expanded to provide faster treatments and enhanced visibility

Medical Devices - U.S. FDA approves new SurTrak Line of brachytherapy preloaded needle kits

Medicare - Pennsylvania governor announces Pace plus Medicare program to expand prescription drug coverage

Medicare - U.S. CMS asserts new Medicare drug coverage will have lower premiums and costs to taxpayers

Medulloblastomas - Antiproliferative and radiosensitizing effects of CAPE for medulloblastoma shown

Melanoma - Adjuvant treatment of malignant melanoma reviewed

Melanoma - Paclitaxel and carboplatin were combined to treat metastatic melanoma

Melanoma Therapy - Melanoma trial receives NCI Institutional Review board approval

Melanoma Vaccine - Allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 has been developed

Melanoma Vaccines - Studies add new findings to melanoma vaccines body of knowledge

Menopause - Analysis indicates younger women may receive heart protection from estrogen therapy

Mergers & Acquisitions - 3M to acquire oral pharmaceuticals developer

Mergers & Acquisitions - Acquisition of Targeted Molecules Corp. completed

Mergers & Acquisitions - Biopharma company announces sale of its European subsidiary, sublicenses rights to Perfan I.V.

Mergers & Acquisitions - Boston Scientific files premerger notification for acquisition of Guidant

Mergers & Acquisitions - Chiron receives European Commission approval for proposed merger with Novartis

Mergers & Acquisitions - Shareholders approve merger between acquisition company and etrials Worldwide, Inc.

Mergers & Acquisitions - Surgical technology-focused firm files Hart-Scott-Rodino notification for acquisition

Molecular Diagnostics - Data highlighting the role of molecular diagnostics presented at major HIV/AIDS meeting

Multiple Sclerosis - Enrollment complete in phase II multiple sclerosis trial of MN-166

Multiple Sclerosis Therapy - Honeybee venom extract is safe for patients with multiple sclerosis

Muscular Dystrophy - Banyan Biomarkers to develop test to evaluate effectiveness of Myodur for DMD

Myocardial Infarction - Combination prevention therapy offers additional protection after MI

Nanotechnology - Nanotechnology company, Medical University of SC contract to codevelop new protein array

Nanotechnology - Nanoweapons may be used to eliminate hospital-related infections

Nanotechnology - Testing method developed to assess safety, health risks of nanomaterials

Nasopharyngeal Cancer - Expression of VEGF might prognosticate primary nasopharyngeal cancer

Natural Products - Two fractions from neem tree leaf fractions may form the basis of new antimalarial drugs

Nerve Injury - Peripheral nerve injury may be treated with exogenous tissue plasminogen activator

Neurogenesis - Transforming growth factor beta increases neurogenesis in adult dentate gyrus

Neurology - Angiotensin II AT(1) receptor blockade spurs microvessel growth in the cerebral cortex

Neurology - Hippocampal neurons participate in the depolarization-induced increase in choline acetyltransferase activity

Neurology - Myelinolysis reduced when hyponatremia is rapidly corrected with myoinositol

Neuroscience - Disulfide bond alterations in the angiogenesis inhibitor endostatin affect fibrillogenesis

Neuroscience - Recent findings in neuroscience provide new insights

Neuroscience - Researchers publish new studies and findings in the area of neuroscience

Neurotransmitters - Dopamine plays a role in naive CD⁸⁺ T cell migration and homing via D3

Non-Small Cell Lung Cancer - Oxigene commences phase II trial for the treatment of stage IIIa/IIIb non small cell lung cancer

Nosocomial Infections - Iseganan does not prevent ventilator-associated pneumonia during prolonged ventilation

Nosocomial Infections - Scientists re-engineer antibiotic to counter drug resistance

Obesity - Genetically modified mice become efficient at burning fat

Obesity - New study finds chromium picolinate helps muscles use blood sugar

Obesity Pathogenesis - Exendin-4, a GLP-1 receptor agonist, reverses hepatic steatosis in ob/ob mice

Obesity Pathogenesis - Researchers' findings advance obesity pathogenesis research

Obesity Therapy - Chlorogenic acid modifies insulin receptor exon 11^+/- and improves some cellular mechanisms

Obesity Therapy - Enhanced external counterpulsation benefits are similar among all BMI groups

Obesity Therapy - GES induced tachygastria is mediated by an adrenergic pathway and inhibits antral motility

Obesity Therapy - Pyrrolo(Iso)quinoline derivatives reduce food intake in rats

Obstetrics - Birth defects prevention organization commits additional $2.4 million to research

Obstetrics - Placental angiogenesis is dysfunctional in intrauterine growth-restricted pregnancies

Oncology - Bortezomib uses alternate signals to control multiple myeloma angiogenesis

Oncology - LY294002-induced PI3K inhibition radiosensitizes cervical tumor cells in vitro

Oncology - Researchers detail new studies and findings in the area of oncology

Oncology - Therapeutic targeting of RhoB may control tumor hypoxia and proliferation

Ophthalmology - Neuropilin-1 may produce choroidal neovascularization in age-related macular degeneration

Ophthalmology - Subretinal implants coated with amorphous aluminum oxide damage retinal tissue

Orthopedics - Growth factors augment the repair of meniscal defects in laboratory studies

Orthopedics - Ibandronate treatment may improve durability of cementless metal orthopedic implants

Osteoarthritis - Pharma company initiates dosing in phase II clinical trial of bicifadine for osteoarthritis

Osteoporosis - Data advance knowledge in osteoporosis research

Osteoporosis - Nutritional supplements company offers suggestions for precluding osteoporosis

Osteoporosis - Reports advance knowledge in osteoporosis research

Osteosarcomas - Use of cisplatin in metastatic osteosarcoma justified despite toxicity

Ovarian Cancer - Cisplatin plus aspirin derivative reduces ovarian cancer cell chemoresistance

Ovarian Cancer - Long-acting octreotide used to treat bowel obstruction in ovarian cancer

Ovarian Cancer - Taxol and discodermolide join to decrease angiogenesis and tumor growth in ovarian cancer models

Pain Management - Amiodarone improves beta-blocker therapy for preventing painful ICD shocks

Pain Management - Patient-controlled iontophoretic fentanyl system effective for postoperative pain control

Pain Medicine - Pharma company provides clinical test results on NRP290 and receives $50 million payment from Shire

Pancreas - Pancreatic leak incidence reduced by neoadjuvant chemoradiotherapy

Pancreatic Cancer - Depression does not affect survival among patients with pancreatic cancer

Pancreatic Cancer - New findings in the area of pancreatic cancer described

Parkinson Disease - Recent findings in Parkinson disease described

Patents - Drugmaker gets notice of allowance for U.S. patent protecting its muscle mass technology

Patents - EPO issues patent covering use of GR-II antagonists to treat psychotic major depression

Patents - Key patent issued for Eculizumab in Japan

Patents - Nutrition technology company announces receipt of patent for Accelerade sports drink

Patents - Second U.S. patent issued for cancer treatment using organic arsenic plus other agents

Pediatric Anesthesia - Povidone-iodine improves laryngeal mask airway safety in pediatric lacrimal duct surgery

Pediatric Cancer Therapy - Methodology presented for quantification of Act-D and VCR in pediatric cancers

Pediatric Cardiology - Somatostatin is safe, effective adjunct treatment for postoperative chylothorax in children

Pediatric HIV/AIDS - HIV-infected children have lower bone mass for their age and gender

Pediatric Obesity - Endocrine support organization joins Congress to combat childhood obesity

Peritumoral Brain Edema - Second pivotal phase III trial for Xerecept, a therapy for peritumoral brain edema, begins

Personnel - Biopharma company elects Kirk K. Calhoun to board of directors

Personnel - Biopharma names Regina E. Herzlinger to the company's board of directors

Personnel - Biotechnology software company announces formation of new scientific advisory board

Personnel - Cancer research authority Moshe Talpaz named chairman of scientific advisory board

Personnel - Cancer-focused company promotes Richard Crowley to senior VP

Personnel - Company focused on biologically active molecules appoints senior management team

Personnel - Deborah Tanner will be promoted to SVP, central laboratory services

Personnel - Dermatology company names Freddie Park vice president, intellectual property

Personnel - Dr. Larry Gold joins Protandim maker's scientific advisory board

Personnel - Dr. Mohammad Azab joins board of biotech company

Personnel - Drug delivery-focused company appoints Condella and Cunningham to senior management team

Personnel - GlaxoSmithKline's Dr. Tachi Yamada to retire; Dr. Moncef Slaoui appointed successor

Personnel - Ilan Cohn named vice chairman of the board at Israeli pharmaceutical firm

Personnel - Joseph Mastronardy, PhD, named president of Belcher Pharmaceuticals

Personnel - Michael Gallatin, Roy Whitfield appointed to board of company that created BioMAP

Personnel - NationsHealth names Robert E. Tremain as chief operating officer

Personnel - Pharma company commences operations in Europe, hires Mark Sanders as regional director

Personnel - Pharmaceutical analysis company appoints healthcare analyst

Personnel - RNAi development company appoints two new directors

Personnel - RNAi therapeutics company appoints Gregory Weaver, CPA, MBA, as chief financial officer

Personnel - Robert A Ollar to act as chairman of Designer Diagnostics' scientific advisory board

Personnel - Stem cell company names Chris McGuinn as vice president and chief operating officer

Personnel - Therapeutics company CEO, President and Director Ajit Gill announces retirement

Pertussis Vaccines - Researchers provide details of new studies and findings in the area of pertussis vaccines

Pharmaceutical Trends - Dedicated pricing departments exist in 56% of drug companies

Pharmacology - Center of excellence in targeted therapeutics will train selected pharmacologists

Pharmacology - Efficacy of depsipeptide in childhood cancer models studied

Physiology - Recent findings illuminate research in physiology

Physiology - Transport of polyamines in Drosophila S2 cells depends on proton gradient

Pituitary Gland - High-dose SST is safe for excluding secondary adrenal insufficiency

Pneumococcal Disease - Antibodies to CbpA and Ply may protect children against pneumococcal colonization

Pneumonia Vaccine - IgA modulates inflammatory responses in pneumonia in vitro model

Product Licensing - Alzheimer compounds licensed to Senexis

Product Licensing - Biotech company and Transgenomic enter exclusive European license and supply agreement

Product Licensing - Distribution and license agreement signed for Aloxi

Product Licensing - Medical device company obtains exclusive license for intraoperative nerve imaging

Product Licensing - Pharma company acquires expanded worldwide rights to Ramoplanin

Product Licensing - Pharma company sublicenses rights to Factive tablets in Mexico to Pfizer

Product Licensing - Stem cell company licenses intellectual property to Institute for Cellular Medicine

Product Licensing - Therapeutics company terminates exclusive license agreement with XenoTech

Product Licensing - U.S. FDA licenses vaccine to protect infants against rotavirus infection

Professional Education - Education organization and Learnwright partner to deliver education to pharma professionals

Prostate Cancer - A death receptor-mediated pathway helps doxazosin boost apoptosis in prostate cells

Prostate Cancer - Association between aspirin use and lowered risk of prostate cancer unsupported

Prostate Cancer - Effects of long-term finasteride treatment on prostate cancer evaluated

Prostate Cancer - Induction of apoptosis by 2-ME and paclitaxel in prostate cancer discussed

Prostate Cancer - Inosine 5'-monophosphate dehydrogenase inhibitors used to manage prostate cancer

Prostate Cancer - Macrophage signaling may affect hormone resistance in prostate tumors

Prostate Cancer - NaBu proposed as chemopreventive agent for prostate cancer

Prostate Cancer - Oligonucleotide microarrays allow assessment of prostate cancer treatment

Prostate Cancer - Prostate cancer patients may fail to achieve castration levels during leuprolide acetate treatment

Prostate Cancer - Researchers describe findings in prostate cancer studies

Proteomics - Article discusses structures of components comprising tripartite multidrug efflux pumps

Proteomics - Endostatin inhibits angiogenesis in a species-specific fashion

Proteomics - Ets1-related protein initiates vasculogenesis in zebrafish

Proteomics - Hypoxia inducible factor is a platelet derived growth factor regulator in cancer cells

Proteomics - Protein-protein interaction network analyses performed

Proteomics - Vascular smooth muscle cells use an array of signals to modify angiopoietin-2 expression

Quality Assurance - Electronic patient reported outcome solutions company achieves ISO 9001:2000 recertification

Quality Assurance - HealthGrades study shows hospitals rated in top 5% have mortality rates 27% lower

Quality Assurance - U.S. National Association of Boards of Pharmacy accredits two wholesale distributors

Respiratory Medicine - Health disparities in asthma highlighted in journal

Rotavirus Vaccine - Review examines risks and benefits of rotavirus vaccines in Latin America

Sepsis - Researchers challenge accepted theory of the cause of sepsis

Sepsis - Useful treatments identified for severe sepsis and septic shock

Sexual & Reproductive Health - Fertility-sparing surgery could be option for women with gynecological malignancies

Sexual & Reproductive Health - Researchers seek dual-purpose vaginal contraceptive for HIV/AIDS prevention

Sexual & Reproductive Health - USAN, WHO approve name bremelanotide for first in new class sexual dysfunction treatment

Sickle Cell Anemia - Sickle cell anemia treated by coregulating globin transgene expression and RNA interference

Sleep Disorders - No evidence that melatonin is effective in treating jet lag

Smallpox Vaccine - Deletion of gene A41L enhances vaccinia virus vaccine efficacy

Soft Tissue Sarcomas - ET-743 proposed as novel agent with activity in soft tissue sarcomas

Staphylococcus Vaccine - Protein A triggers supraclonal B-cell responses upon Staphylococcus infection

Statins - New findings in the area of statins detailed

Statins - Prevastatin treatment does not affect brain cholesterol metabolism

Statins - Recent findings in statins described

Statins - Safety profiles are comparable for Atorvastatin 80 mg versus 10 mg

Stem Cell Research - Cord blood-derived MSCs can be chemically transformed into cardiomyocytes

Stem Cell Research - Fibroblast growth factor receptor 1 not essential for lens fiber differentiation

Stem Cell Research - Key factor discovered for survival of human embryonic stem cells

Stem Cell Research - LIGHT induces ESC differentiation associated with activation of ERK5

Stem Cell Research - Multipotent stem/progenitor cells present in neonatal and adult salivary glands

Stem Cell Research - Primary bone-derived cells induce osteogenic differentiation

Stem Cell Transplantation - Donor KIR genotype has major influence on CMV reactivation rate after T-cell replete SCT

Stem Cell Transplantation - HLA-DPB1 matching status in HSCT associated with increased risk of disease relapse

Stem Cell Transplantation - IFNG 3/3 gene polymorphism associated with increased risk for EBV reactivation after AHSCT

Stem Cell Transplantation - Researchers publish new studies and findings in the area of stem cell transplantation

Stem Cell Transplantation - SCT with reduced-intensity conditioning favorable for hemophagocytic lymphohistiocytosis

Stem Cell Transplantation - p18(INK4C) deletion results in improved long-term HSC engraftment

Stents - New data illuminates research in stents

Suicide Risk Factors - Newer antidepressant drugs do not increase suicide risk

Surgical Technology - Clinical outcomes of CYPHER stents were better than TAXUS stents in bifurcation lesions

Surgical Technology - Hypersensitivity cases are associated with drug-eluting coronary stents

Surgical Technology - Midterm outcome of bilateral internal thoracic artery grafting is better than stenting

Surgical Technology - Paclitaxel-eluting stent compared with sirolimus-eluting stent in small coronary vessels

Systemic Lupus Erythematosus - Antimalarial drugs most effective in lupus patients at risk of high TNF-alpha levels

Systemic Lupus Erythematosus - Toll-like receptor 9 signaling protects against murine lupus

Systemic Sclerosis - Neuronal nitric oxide synthase varies in systemic sclerosis skin

Thrombosis - Eosinophil peroxidase product induces endothelial cell tissue factor activity

Thyroid Cancer - Optimal radiotherapy utilization for cancer treatment discussed

Transplant Medicine - Contamination of amphotericin B nebulizers common in unhygienic lung transplantees

Transplant Medicine - Cyclosporine suppresses hepatitis C virus after liver transplantation

Transplant Medicine - Heart transplant followed by SCT feasible in select cardiac AL amyloidosis patients

Tuberculosis - Active TB is associated with a defect in blood DC numbers and IFN-alpha production

Tuberculosis Neuropathogenesis - Microglia play an important role in the neuropathogenesis of tuberculosis

Tuberculosis Screening - Tuberculin skin testing increased among infliximab users following risk intervention

Tuberculosis Therapy Monitoring - Simple noninvasive methods effectively monitor ingestion of antituberculosis drugs

Type 1 Diabetes - Angiotensin II does not affect endothelial tone in type 1 diabetes

Type 1 Diabetes Control - Premixed insulin in pen delivery device now available for control of high blood sugar

Type 2 Diabetes - Increased decrement in insulin secretion improves glucagon responses to hypoglycemia

Vaccine Adjuvants - CpG oligodeoxynucleotides function as effective adjuvant in aged mice

Vaccine Delivery - Lipid emulsions increase transgene expression in hepatocytes after adenoviral transfer

Vaccine Development - Method to generate antibody against human protein SNEV has been developed

Vaccine Development - Phase I shows escalating doses of S. epidermidis and S. aureus vaccines are well-tolerated

Vector Development - Adeno-associated virus transduction regulates AADC expression

Virology - Antiviral siRNAs completely cured persistent virus infections

Wound Care - Pharma company announces European approval for Acticoat Moisture Control

Wound Care - The redox environment affects wound healing

Wound Care - Working model of antiseptic wand developed