Breast Cancer
E2F-HDAC complexes negatively regulate breast cancer tumor suppressor gene
Published in Drug Week, March 10th, 2006
"ARHI is a maternally imprinted tumor suppressor gene whose expression is markedly downregulated in breast cancer. Reactivation of ARHI expression in breast cancer cells is associated with increased histone H3 acetylation and decreased lysine 9 methylation of histone H3."
"An ARHI promoter segment that spanned bases -420 to +58 (designated the P2 region) exhibits significantly higher promoter activity in normal cells than in cancer cells. To better understand the molecular mechanisms contributing to...
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Source: Drug Week (2006-03-10)
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