View the NewsRx Library

Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Google 2009 PageRank: #2 Among Top Health News and Media Publications

Google 2009 PageRank: #2 Among Top Science Publications in Biology/Physiology

Google 2009 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals

Amazon's Alexa 2009 PageRank: #2 News and Media Site for the Pharmaceutical Industry

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Drug Week

Susan Hasty, Publisher
Table of Contents . . . March 24th, 2006
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Drug Week | Other Publications

Apoptosis - Antimonial compounds may work by disrupting thiol homeostasis

Cancer Therapy - Sutent approved for use in U.S. in kidney cancer, gastrointestinal stromal tumors

Drug Delivery - Rapamycin delivery via PEG-PCL micelles characterized

Fungal Infections - Caspofungin's mode of action and therapeutic applications evaluated

Pain Management - Significant pain relief in children demonstrated by Corgentech's ALGRX 3268 in trial

Addiction Medicine - 3,4-methylenedioxymethamphetamine acts most similarly to amphetamine

Addiction Medicine - Cannabis, hallucinogen, cocaine, and opiate disorder symptoms classified

Addiction Medicine - Cocaine reinforcement is attenuated by antisense-induced protein reduction

Addiction Medicine - Methamphetamine treatment center develops program to address cognitive damage of addiction

Addiction Medicine - Team discovers possible "universal strategy" to combat addiction

Adverse Drug Reaction - Oxaliplatin hypersensitivity reactions studied

Adverse Drug Reaction - Parenteral iron adverse reactions are focus of review

Adverse Drug Reaction - Public health advisory for Trasylol issued by U.S. FDA

Adverse Drug Reaction - Valproate lowers glucose and raises insulin, cortisol, leptin, and neuropeptide Y levels

Aggressive Behavior - Characterization of aggressive behavior influences the success of pharmacological treatment

Allergy & Immunology - Pen ch 13 may contribute to asthma

Alzheimer Disease - Anti-amyloid therapy may be an adjunct treatment for Alzheimer disease

Alzheimer Disease - Cerebrolysin was well tolerated and demonstrated improved cognition in Alzheimer patients

Alzheimer Disease - Metallothionein-3 and neuronal nitric oxide synthase found reduced in Alzheimer disease

Alzheimer Disease - Timing and duration of administration are important to optimize cholinergic Alzheimer disease treatment

Amebiasis Therapy - Antiprotozoal agent is effective for treating trichomoniasis, giardiasis, and amebiasis

Analgesia - Placebo analgesia may be configured through multiple brain pathways and mechanisms

Andropause - QuatRx Pharmaceuticals Company initiates phase II trial of fispemifene for andropause

Anemia - Health Canada authorizes ProMetic BioSciences to begin Ib/II trial of PBI-1402 for anemia

Anemia Therapy - Darbepoetin alfa saves costs and reduces number of office visits for treatment-related anemia

Anesthesia - Succinylcholine dose of 1 mg/kg total body weight is recommended for morbidly obese

Angina - Update on GENASIS trial announced by Corautus Genetics

Angiogenesis - Angiogenesis is inhibited by thrombospondin targeting of type I collagen

Angiology - Anti-SDF-1 treatment prevents retinal neovascularization in nonhuman primates, study shows

Angiology - Carotid artery intimal hyperplasia is improved by estrogen replacement in ovariectomized rats

Angiology - Chronic hypoxia modulates melatonin receptors in the rat carotid body

Angiology - Coronary artery stenting is feasible even with intraluminal thrombus

Angiology - Endothelium-independent vasorelaxation is induced by protamine sulfate via NO synthase pathway

Angiology - Findings in angiology provide new insights

Angiology - Pulmonary artery obstruction changes vessel growth in the non-obstructed lung

Angiology - Research in angiology provides new insights

Angiology - Tissue factor expression in cultured endothelial and smooth muscle cells is induced by nicotine

Angiology - Tumor angiogenesis flourishes in models with TIMP-3 gene deficiency

Antibacterial Agents - Antibiotic use during last days of life in cancer patients analyzed

Antidepressants - Amitriptyline, maprotiline, and fluoxetine do not affect retrieval of inhibitory avoidance learning

Anxiety - Internet-based program increased coping skills in traumatized patients

Apoptosis - Caffeine-induced calcium release in rat astrocytes increases ethanol mediated death

Apoptosis - Cyclin D1 overexpression induces apoptosis resistance linked to carcinoma BCL-2

Apoptosis - Imatinib reported to induce apoptosis

Apoptosis - Researchers describe findings in apoptosis studies

Apoptosis - Retinoblastoma plays a role in survival of Abl-dependent human tumor cells

Apoptosis - Studies advance knowledge in apoptosis research

Asthma - Dosing of first patient in trial of IV zileuton completed by Critical Therapeutics

Asthma - Researchers' work adds to asthma body of knowledge

Atherosclerosis - Monocyte adhesion is inhibited by 17-beta-estradiol via down-regulation of Rac1 GTPase

Atherosclerosis - Patients with high cholesterol levels benefit from simvastin treatment

Atherosclerosis - Two proteins participate in the repression of paraoxonase-1 gene expression

Autism - PediaMed completes clinical trial enrollment to study GI dysfunction in children with autism

Avian Influenza - Abt Associates helps Ghana prepare for avian influenza outbreak

Avian Influenza - Avian influenza vaccine well tolerated in patients

Avian Influenza - Bird flu virus advances in Nigeria

Avian Influenza - Indian marketing approval on generic Tamiflu obtained by Cipla

Avian Influenza - Positive pre-IND meeting with U.S. FDA for avian flu vaccine completed by Generex

Awards - James A. Spudich receives Outstanding Investigator in Single Molecule Biology award

Back Pain - Pain relief immediately after surgery for spinal malformations is good, but recurrence is common

Bacteria - Replidyne and Forest Laboratories announce FDA review of NDA for faropenem medoxomil

Bacteriology - Ants spread antimicrobial-resistant bacteria in Brazilian hospitals

Benign Prostatic Hyperplasia - BXL628 arrests prostate growth in patients with benign prostatic hyperplasia

Biliary Tract Carcinoma - Biliary tract carcinoma treated by chemoradiation

Biomedical Engineering - Angiogenesis flourishes when proteins are released from implanted hydrogel

Biomedical Engineering - Sigma-Aldrich, Genospectra sign agreements in RNAi, gene expression and cell-based assays

Bipolar Disorder - Functional polymorphisms are associated with bipolar disorder

Blood Pressure - Blood pressure response to 17beta-estradiol varies according to age

Blood Pressure - Pyridostigmine alone or with midodrine may improve standing blood pressure

Bone Marrow - Bone marrow failure compared in male vs. female rats

Bovine Spongiform Encephalopathy - Usefulness of MAb 2A11 in immunohistochemistry for the diagnosis of BSE confirmed

Brain Cancer - Glioma invasion is stimulated by angiopoietin 2 induction of matrix enzymes

Breast Cancer - Breast cancer drug, derived from botanical extract, could treat aggressive breast cancer

Breast Cancer - Breast cancer patients show preference for oral hormone therapy vs. monthly injections

Breast Cancer - Breast cancer treated by possible antimetastatic formylated hexapeptide ligand

Breast Cancer - Breast cancer treated with combination of oral vinorelbine and capecitabine

Breast Cancer - Breast carcinoma cells receive support from vascular endothelial growth factor-D

Breast Cancer - Hirsutenone inhibits COX-2 and MMP-9 upregulation in mammary epithelial cells

Breast Cancer - M. D. Anderson Cancer Center to investigate chemokine antagonist for breast cancer

Breast Cancer - MCF-7 breast cancer cell growth inhibited by Antrodia camphorata

Breast Cancer - Metastatic breast cancer treated by combination of pemetrexed and gemcitabine

Breast Cancer - New findings in breast cancer described

Breast Cancer - Recent findings in breast cancer provide new insights

Breast Cancer - Roche pursues European market approval of Herceptin for early-stage HER2-positive breast cancer

Breast Cancer Screening - Breast tumor size prediction methods were compared for accuracy

Breast Cancer Therapy - Breast cancer risk reduction awareness was evaluated among women from different ethnic groups

Breast Cancer Therapy - Researchers detail new studies and findings in the area of breast cancer therapy

Breast Cancer Therapy - Researchers provide details of new studies and findings in the area of breast cancer therapy

Breast Cancer Therapy - Timing of aromatase inhibitors added to breast cancer therapy affects cost-effectiveness

Bronchioloalveolar Cancer - Bronchioloalveolar carcinoma management discussed

Business & Finance - BioMS Medical records loss of $0.46 per share

Business & Finance - Biovest International reports quarterly loss of $0.04 per share

Business & Finance - Cadence Pharmaceuticals acquires second phase III product, $60.8M financing

Business & Finance - Coley Pharmaceutical Group reports Q4 revenue of $5.4 million

Business & Finance - Fourth-quarter 2005 results reported by Cepheid; total revenues increase 16%

Business & Finance - Schering increases net sales by 8%

Business & Finance - Wellcare Health Plans Inc. reports 50% growth in membership in Medicare plans during 2005

Business Update - Blood safety scientific advisory board established by Cerus

Business Update - Pharmaceutical company mulling divestiture of Consumer Health Unit, market report says

Business Update - Savient hires Citigroup to explore alternatives for subsidiary Rosemont Pharmaceuticals

Cancer Gene Therapy - Peroxiredoxin I expression affects lung tumor growth and radiosensitivity

Cancer Gene Therapy - RNA interference induces cell cycle arrest and apoptosis in breast carcinoma cells

Cancer Research - Morphotek announces U.S. FDA acceptance of MORAb-009 IND

Cancer Therapy - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase proposed as cancer therapy target

Cancer Therapy - Advanced pancreatic cancer celiac axis infusion and microembolization improves resection

Cancer Therapy - Advaxis' listeria cancer vaccine receives regulatory approval for phase I/II testing

Cancer Therapy - Aegera initiates third trial for AEG35156 for patients with acute myeloid leukemia

Cancer Therapy - Antifungal treatment for patients on chemotherapy deemed cost-effective

Cancer Therapy - Antimetastasis data to be presented by Chemokine at meeting

Cancer Therapy - Antisense therapy is well tolerated in patients with metastatic colorectal cancer

Cancer Therapy - Bioenvision's clofarabine receives positive opinion from European Medicines Agency

Cancer Therapy - Bone metastasis is prevented by a selective cyclooxygenase-2 inhibitor

Cancer Therapy - Brain cancer patients living longer after DCVax-Brain personalized vaccine therapy

Cancer Therapy - Cancer cell growth inhibited by digitoxin

Cancer Therapy - Cisplatin functions as ARF mimic

Cancer Therapy - High-dose cyclophosphamide may be unnecessary therapy for lymphoid malignancies

Cancer Therapy - Multikine treatment increases survival in head and neck cancer patients

Cancer Therapy - New findings in cancer therapy described

Cancer Therapy - Phenylcarbazoles display antitumor properties

Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy

Cancer Therapy - Researchers' data advance cancer therapy research

Cancer Therapy - Researchers' findings advance cancer therapy research

Cancer Therapy - Studies advance knowledge in cancer therapy research

Cancer Therapy - Studies describe new findings in cancer therapy research

Cancer Therapy - Thymosin beta 4 determines fibroblast transformation and invasiveness

Cancer Therapy - Tumor angiogenesis and growth proliferate in minimal disease models given TNP-470

Cancer Treatments - ProStrakan receives U.S. FDA approval of IND for patch to treat side effects of chemotherapy

Cancer Vaccine - Antitumor activity in human lymphocytes is triggered by vaccine

Cancer Vaccine - Contract arrangement announced for cGMP production of GRNVAC1 for clinical trials

Cancer Vaccine - Vaccine induces response against carcinoembryonic antigen in patients with metastases

Candida - U.S. FDA approves new treatment for fungal infections

Cardiac Cell Therapy - Enrollment in phase II trial of cardiac cell therapy ended by Genzyme

Cardiology - AngioJet therapy safe, effective as part of rescue percutaneous coronary interventions

Cardiology - Angiogenesis and cardiac function improve following bone marrow cell implantation

Cardiology - Findings advance knowledge in cardiology research

Cardiology - Findings in cardiology provide new insights

Cardiology - Janus Tacrolimus eluting carbostent study data show excellent safety, efficacy in patients

Cardiology - Maintenance of normal myocyte growth may require E2F-6

Cardiology - New clinical data shows antisense drug Isis 301012 significantly reduces triglycerides

Cardiology - Recent findings in cardiology described

Cardiology - Research report on heart disease in women released by WomenHeart, health research society

Cardiology - Researchers' work adds to cardiology body of knowledge

Cardiology - Sorin Group launch second generation drug eluting stent with new delivery system

Cardiomyocytes - Cardiac myocyte exposure to oxidative stress causes modifications to cytoprotective proteins

Cardiovascular Disease - Chronic antithrombotic therapy in post-myocardial infarction patients is reviewed

Cardiovascular Disease - Following intracerebral hemorrhage, antiplatelet use is not associated with increased recurrence risk

Cardiovascular Disease - Reports advance knowledge in cardiovascular disease research

Cardiovascular Disease - Surgical revascularization of LAD artery disease shows better midterm outcome compared to PCI

Cardiovascular Disease - Use of nonprescription medications for perceived cardiovascular health is common

Cardiovascular Research - After brief cardiac arrest, epinephrine increases mortality in an in vivo rat model

Cardiovascular Research - Research add new data to cardiovascular body of knowledge

Celiac Disease - ACS5 may be a suitable marker for the detection of celiac disease

Cell Biology - Adult angiogenesis is enhanced by accessory cells

Central Nervous System - Memory Pharmaceuticals announces positive preliminary phase I cognitive data for MEM 3454

Central Nervous System Lymphoma - Central nervous system lymphoma survival improved with combined-modality therapy

Cervical Cancer - Cervical cancer growth is inhibited by the angiogenesis modulator NOL7

Cervical Cancer - Cervical cancer therapy with cisplatin appears comparable to other agents in same setting

Cervical Cancer - Drug-delivery system for cervical cancer lesions licensed to CytoCore

Cervical Cancer Vaccine - Human papillomavirus-16 vaccine prevents cervical intraepithelial neoplasia

Chemotherapy - New findings in chemotherapy described

Chlamydia Vaccine - Chlamydia protection is better delivered by intranasal than transcutaneous vaccine

Chondrogenesis - SCRG1 is induced by glucocorticoid and stimulates chondrogenesis in vitro

Chronic Pain - Severe chronic pain agent Prialt to be acquired by Eisai, from Elan, for Europe

Cirrhosis - Recurrence of hepatocellular carcinoma after liver resection evaluated

Clinical Trials - Celsion signs Agreement with Fast Track Systems and CROCAS PBT

Clinical Trials - Clinical study of small molecule Telintra tablet for myelodysplastic syndrome initiated

Clinical Trials - Enrollment in phase 1 trials for anti-inflammatory therapeutic begun

Clinical Trials - Final trial results show intranasal morphine for post-surgical pain meets endpoints

Clinical Trials - Norwood Abbey commences phase II trial of Lupron Depot in autologous bone marrow transplants

Clinical Trials - Positive results reported from phase 3 trials of desonide topical steroid in aqueous gel

Clinical Trials - Summary results of phase 4 studies of niacin compound reported

Clinical Trials - Twice-yearly dosing of denosumab increased bone mineral density, phase 2 trial data show

Clinical Trials - U.S. FDA lifts hold on clinical trial of natalizumab dosing in multiple sclerosis

Collaborations - BioSyntech closes transaction with Kuhnil Pharma

Collaborations - BioSystems International signs agreement with AstraZeneca for biomarker discovery

Collaborations - Bioheart and Cleveland Clinic sign patent licensing agreement

Collaborations - Biosite and FivePrime finalize antibody collaboration

Collaborations - Bruker Daltonics signs alliance for identification of microorganisms

Collaborations - Licensing agreement for anti-inflammatory therapies inked by G2 Therapies and Novo Nordisk

Collaborations - Mammalian-cell-lines engineering collaboration formed by Cellectis, Celonic

Collaborations - Nanosyn to provide chemistry-based services to Amphora Discovery for multiple drug targets

Collaborations - New U.S. federal health initiative to improve cancer therapy

Collaborations - Novel pain therapeutics to be developed by Evotec and Apeiron Biologics

Collaborations - Olympus granted exclusive right by Cytori to negotiate commercialization collaboration

Collaborations - Research collaboration to develop micro-RNA related therapies for liver cancer announced

Collaborations - Rexahn and University of Maryland Nanomedicine Center to develop cancer and CNS therapies

Colon Cancer - 9-aminocamptothecin-HPMA copolymer conjugates developed for colon cancer drug delivery

Colon Cancer - Clinical trial Buddy Program offered by Colon Cancer Alliance

Colorectal Adenocarcinomas - Colorectal carcinoma tumor-associated stroma has a metabolic survival role

Colorectal Cancer - Colorectal cancer metastasis is hampered by antibodies targeting VEGF

Colorectal Cancer - Colorectal cancer patients preferred oral to intravenous therapy

Complementary & Alternative Medicine - (-)-Epicatechin mediates beneficial effects of flavonol-rich cocoa on vascular function in humans

Complementary & Alternative Medicine - Citrus aurantium reviewed as alternate overweight and obesity treatment

Complementary & Alternative Medicine - 5-OH-isoflavone consumption is of no direct cytotoxic risk to the human vascular endothelium

Complementary & Alternative Medicine - Anthocyanidins decrease endothelin-1 production, increase endothelial NOS in endothelial cells

Complementary & Alternative Medicine - Chromium supplement enhances cellular insulin signaling in obese insulin-resistant rats

Complementary & Alternative Medicine - Degraded lambda-carrageenan could add antitumor activities of 5-Fu

Complementary & Alternative Medicine - New class of CDK2 inhibitors developed

Complementary & Alternative Medicine - Protective mechanisms of omega-3 long-chain polyunsaturated fatty acids are reviewed

Corticosteroids - Corticosteroids associated with poor outcomes, death in the trauma intensive care unit

Critical Care Medicine - Fibrin sealant dressing was the only alternative wound care that reduced hemorrhage time

Cryopreservation - BioLife study examines Calpains and their influence on overall cell survival

Cystic Fibrosis - Inhaled hypertonic saline is safe and effective additional therapy for cystic fibrosis patients

DNA Research - Cellular delivery of nucleic acid conjugates is mediated by cationic lipids

DNA Vaccine - Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine

Dengue Fever - Dengue antigen developed

Dental Care - Use of an atomizer improved pediatric dental patient receptivity to intranasal midazolam

Dental Research - Periodontal status of osteoporotic women may improve with risedronate therapy

Depression - A relationship exists between nicotinic acetylcholine receptors and depression

Depression - Depression may relapse in women who discontinue medication during pregnancy

Depression - Fluoxetine pharmacokinetics in elderly patients was evaluated

Depression - Men with symptoms of depression were more likely to be offered treatment

Depression - Research links coverage by top current affairs program to rise in adverse drug reports

Depression - The period for N-methyl-D-aspartate receptor-dependent synapse destabilization is defined by retinal arbors

Dermatitis - Ciclopirox shampoo is effective and safe for treating seborrheic dermatitis of the scalp

Dermatology - Pimecrolimus cream is safe and well tolerated in infants

Diabetes - Cortisol synthesis inhibitor taken into phase II clinical trial by DiObex

Diabetes & Depression - Chromium picolinate shows antidepressant and antidiabetic action in diabetic rat model

Diabetes Complications - ATP-WR related to neuropathy in diabetics without signs of coronary artery disease

Diabetes Complications - Diabetic retinopathy retreats with antioxidants and advanced glycation inhibitors

Diabetes Control - OSI Pharmaceuticals initiates phase IIa trial for glycogen phosphorylase inhibitor, PSN357

Diabetes Pathogenesis - ATGL contributes to net adipocyte lipolysis and is negatively linked to insulin levels

Diabetes Therapy - Antidiabetic and sulphonyureas drug interactions with K_ATP channels discussed

Diabetes Therapy - Data advance knowledge in diabetes therapy research

Diabetes Therapy - Nuclear receptor activation improves hyperglycemia and hyperlipidemia in diabetic mice

Diabetes Therapy - Reports add new data to diabetes therapy research

Diabetes Therapy - Research add new data to diabetes therapy body of knowledge

Diabetes Therapy - Resistin exposure regulates skeletal muscle cell insulin signaling, glucose uptake, and metabolism

Diabetes Therapy - Selenium TD with gliclazide TD combination enhanced gliclazide glucose lowering effects

Diabetes Treatment - Intravitreal triamcinolone acetonide improved hard exudates, fluorescein leakage, and visual acuity

Diabetic Angiopathy - Diabetic angiopathy may be controlled by the transcription factor ATF3

Diabetic Nephropathy - Diabetes is attenuated by 17-beta estradiol, a regulator of renal transporter expression

Diabetic Retinopathy - Diabetic retinopathy in rat models may not reflect angiogenic patterns in human eyes

Diabetic Retinopathy - Diabetic retinopathy may be encouraged by glucose-induced neutrophil interactions

Diagnostics - Adenocarcinoma angiogenesis is identified by a double immunolabeling technique

Diagnostics - Atorvastatin HPLC assay developed

Diagnostics - Findings describe new data in diagnostics research

Diagnostics - New findings in the area of diagnostics described

Diagnostics - Recent findings in diagnostics described

Diagnostics - Researchers provide details of new studies and findings in the area of diagnostics

Diagnostics - U.S. FDA 510(k) clearance for Nanopia wrCRP Assay received by Clinical Data

Diet & Nutrition - Does folic acid and vitamins B₆ and B₁₂ reduce the risk of major CV events?

Diet & Nutrition - Racial, ethnic minority women urged by researchers to increase folic acid intake

Diet & Nutrition - Rutin shows antihyperglycemic and antioxidant activity in streptozotocin-induced diabetic rats

Diet & Nutrition - Vegetable-derived isothiocyanates examined for anti-proliferative activity

Diet & Nutrition - Visceral fat mass with diet-induced obesity reduced by SRCD in rats

Diet & Nutrition - Vitamin C supplementation might reduce frequency of common cold

Disease Associations - Cardiovascular events are predicted in dialysis patients by fibrinogen, calcium x phosphate product

Disease Associations - Corticotropin-releasing hormone increases monocyte endothelin-1, decreases NO release

Drug Delivery - A biodegradable polymer functions as a carrier material

Drug Delivery - Biodegradable nerve guidance channels with protein-eluting microspheres developed

Drug Delivery - CoStar drug-eluting stent gets CE Mark

Drug Delivery - Intramuscular delivery methods for DNA vaccine in primate model were compared

Drug Delivery - Miniaturized ChronoDose Prototype unveiled by ChronoTherapeutics

Drug Delivery - Periodontal disease antibiotic delivery with biodegradable device promising

Drug Delivery - Polymer-coated targeted drug delivery systems stochastically modeled

Drug Development - Access Pharmaceuticals initiates a new AP5346 study in patients with head and neck cancer

Drug Development - Advanced Magnetics panel recommends continuation of ferumoxytol phase III trial

Drug Development - Allergy Therapeutics commences sublingual allergy vaccine trial

Drug Development - Angiogenesis protein is counteracted by new aminonucleosides

Drug Development - AnorMED responds to shareholder's SEC filing

Drug Development - Aridol recommended for sale in Australia

Drug Development - Arixtra shown to reduce risk of venous thromboembolism in acutely ill patients

Drug Development - AstraZeneca withdraws Exanta from the market, terminates development

Drug Development - Berlex seeks approval of Betaseron in patients with first episode suggestive of MS

Drug Development - BioMS Medical secures manufacturing agreements for multiple sclerosis drug

Drug Development - BioSante Pharmaceuticals submits Bio-E-Gel new drug application to U.S. FDA

Drug Development - BioVex begins dosing of patients in phase II trial of OncoVEXGMCSF

Drug Development - Biodegradable microspheres prolong antigen presentation by macrophages

Drug Development - Biomarker discovery program initiated to streamline drug development for tuberculosis

Drug Development - Biota commences phase I trial of common cold drug candidate

Drug Development - Biotech company selects Isis to manufacture, supply antisense drug for eye diseases

Drug Development - Biotech firms seek pre-qualification from World Health Organization

Drug Development - Biovest submits amendment request to U.S. FDA for BiovaxID personalized anticancer vaccine

Drug Development - Bristol-Myers Squibb seeks to expand access to HIV/AIDS medicine

Drug Development - CIP-Fenofibrate approval from Health Canada received by Cipher

Drug Development - Combination of porphyrins and DNA-alkylation agents described

Drug Development - Compound with smaller diluent for treating von Willebrand disease now available

Drug Development - CytRx enrolls first patient in phase IIA trial of arimoclomol for ALS

Drug Development - Cytochroma granted U.S. FDA approval to commence phase II trial of psoriasis treatment

Drug Development - DTH-inducing proteins from cDNA library have been identified

Drug Development - Dendrons with spermine surface groups are building blocks for nonviral vectors

Drug Development - Equilibrative nucleoside transporter can be fine-tuned with alternatively spliced variant

Drug Development - Erbitux indication extended to include head and neck cancer

Drug Development - European regulatory authorities recommend authorization to market Preotact

Drug Development - Fluorescent phorboxazole A analog developed

Drug Development - HIV-1 fusion inhibitors moderately inhibit fusion of SARS-CoV with target cells

Drug Development - Hepatitis drug data presented at meeting

Drug Development - InNexus Biotechnology launches bioequivalent program

Drug Development - InSite Vision to present results from phase III trial of AzaSite for eye infections

Drug Development - Itopride does not meet primary endpoint in phase III trial

Drug Development - King Pharmaceuticals, Arrow International, affiliates collaborate on ramipril formulation

Drug Development - Lymphoproliferative disorders may occur in RA patients not treated with MTX

Drug Development - Nateglinide showed good therapeutic effect in patients with short diabetes duration

Drug Development - Neurochem submits new drug application to U.S. FDA for Fibrillex for Amyloid A (AA) amyloidosis

Drug Development - Oral iclaprim shown to achieve results comparable to intravenous administration

Drug Development - Pharmacogenomics added to development of new marine-derived anticancer agents

Drug Development - Phoqus Group and Diurnal Limited complete phase I Chronocort trial for adrenal insufficiency

Drug Development - Potent inhibitor of antiapoptotic protein Bcl-x(L) discovered

Drug Development - Recruitment interrupted for AEterna Zentaris phase III trial of Neovastat in lung cancer

Drug Development - Strategic alliance with Par signed for sale, distribution of Spectrum's generic products

Drug Development - Toxicology studies with MPI Research begun by Diffusion Pharmaceuticals, LLC

Drug Development - Two novel, small-molecule inhibitors of DNA methylation discovered

Drug Development - U.S. FDA accepts Schering-Plough's NDA to review antibacterial agent garenoxacin

Drug Development - U.S. FDA approves rimonabant for weight management, denies approval for smoking cessation

Drug Development - U.S. FDA grants NDA for 6-month priority review of treatment for invasive fungal infection

Drug Development - U.S. FDA grants orphan drug status to Coramsine for malignant melanoma

Drug Development - U.S. FDA releases comparison analysis of its drug review process

Drug Development - Vaccinia virus Ankara multiplies in rat IEC-6 cells

Drug Discovery - Compound library for German FMP provided by ChemDiv

Drug Discovery - Models for simulation of signaling network aid in silico evaluation of drug candidates

Drug Resistance - Community-acquired MRSA has a high potential to become endemic

Drug Resistance - Fusidic acid should be combined with other agents to prevent emergence of resistance

Drug Resistance - Methicillin-resistant S. aureus pyomyositis diagnosed in an intravenous drug user

Drug Resistance - Methicillin-resistant S. aureus treatment may become ineffective as cases increase

Drug Resistance - Reduced Neisseria gonorrhoeae ceftriaxone susceptibility is linked to multidrug-resistance

Drug Safety - Ezetimibe/simvastatin clinical trials suggest ezetimibe does not aggravate simvastatin muscle effects

Eating Disorders - Eating disorders are common in individuals with body dysmorphic disorder

Ebola Vaccine - Ebola vaccine with Vical technology produces immune responses in trial volunteers

Echocardiography - Recent findings in echocardiography provide new insights

Encephalitis - Heparan sulfate mimetic PI-88 demonstrated a beneficial effect on encephalitic flaviviruses

Endocrinology - Antimicrobial peptides with insulin activity were found in Rana saharica frog secretions

Endocrinology - Insulin dynamics of obese children predict BMI and z-score response to insulin suppression

Endocrinology - Melatonin attenuates diabetes-induced oxidative stress in rabbits

Endocrinology - Olanzapine therapy does not affect basal or insulin-stimulated glucose transport

Endocrinology - Pronounced vessel development in the perinatal period may foster pancreatic islet activity

Endometrial Cancer - Endometrial cancer therapy may be enhanced with adjuvant whole abdominal radiotherapy

Endometriosis - Endometriosis declines after short synthetic endostatin peptide treatment in murine models

Environmental Health - Hexabromocyclododecane exposure induces drug-metabolizing enzymes in rats

Escherichia Coli Vaccine - E. coli O157O-specific vaccine is safe and immunogenic in children

Esophageal Cancer - Two-year survival from esophageal cancer predicted with FDG-PET upstaging

Facilities - BioProgress plc announces cGMP upgrade, expansion

Facilities - Cambridge, Massachusetts new office site for Gene Network

Facilities - Hospira reports $60M investment in McPherson manufacturing facility

Facilities - Northwest Kinetics announces grand opening of new clinical facility

Facilities - Novo Nordisk opens hemostasis research facility in New Jersey

Feline Immunodeficiency Syndrome - Low-dose interferon-alpha treatment prolongs survival in FIV infection

Finance - Adolor closes sale of 5.75M shares of common stock in a public offering

Finance - Alba Therapeutics receives new federal, state grant awards for work on zonulin pathway

Finance - Albany Molecular Research reports 15% decrease in revenue

Finance - Alnylam Pharmaceuticals reports loss of $0.56 per share

Finance - Amarin posts quarterly loss of $0.10 per share

Finance - American Pharmaceutical Partners records 18% increase in sales

Finance - Antigenics reports loss of $0.39 per share

Finance - Arena Pharmaceuticals reports net loss of $0.55 per share

Finance - Aspreva Pharmaceuticals reports earnings of $0.68 per share

Finance - Baxter supports earthquake victims in India and Pakistan through donation of vaccines

Finance - Baxter's board authorizes $1.5B share repurchase program

Finance - BioDelivery Sciences receive $2M payment for development of Bema Fentanyl

Finance - BioSphere Medical signs deal for $13.4M private placement

Finance - BioSyntech announces extension of BDC loan

Finance - Biogen Idec reports income of $165M

Finance - Caliper Life Sciences reports becoming cash-flow positive

Finance - Callisto Pharmaceuticals CEO discusses uses of recent financing

Finance - Cambrex reports loss of $5.26 per share

Finance - Cel-Sci raises $1M in new equity

Finance - Cell Genesys reports net income of $19.1 million

Finance - Ciphergen reports Q4 revenue of $6.6

Finance - Clinical Data reports third-quarter revenues of $19.9 million

Finance - CryoCor reports 2005 revenues of $843,000, provides 2006 guidance

Finance - Cutera achieves record revenue and earnings growth, reports Q4 revenues of $24M

Finance - Exelixis announces Q4 losses of $24.5 million

Finance - Express Scripts reports record fourth-quarter net income of $111 million

Finance - Gen-Probe reports Q4 net income of $16.8 million

Finance - ISTA Pharmaceuticals posts $0.41 per share loss

Finance - Immtech reports loss of $0.35 per share

Finance - Incyte reports loss of $0.33 per share

Finance - Laserscope reports Q4 2005 record revenues up 19% over year ago to $35 million

Finance - Lexicon Genetics reports 23% annual revenue growth for 2005

Finance - Matrixx Initiatives announces net sales of $44 million for fourth quarter

Finance - Memory Pharmaceuticals reports net loss of $3.6 million for quarter

Finance - Mesothelioma Applied Research Foundation awards nearly $1 million for research aimed at a cure

Finance - Monogram announces revenue of $12.7 million for the fourth quarter

Finance - Onyx Pharmaceuticals reports net loss of $38.4 million for fourth quarter

Finance - PPD reports net revenue of $274.6 million for the fourth quarter 2005

Finance - PRA International announces increase in net income of 55%

Finance - Panacos reports net loss of $8.3 million or $0.17 per share

Finance - Pharmaceutical company reports Q4 2005 revenue up 42% to $213.9 million over year ago

Finance - Pharmacopeia announces revenues of $5.6 million for quarter

Finance - Pharmion Corporation announces sales of $221.2 million in 2005

Finance - PolyMedix raises $21 million in equity financing

Finance - Quigley increases revenues to $53.7 million; net income to $3.2 million for fiscal year 2005

Finance - Repligen reports total revenue for the quarter of $2,988,000 for fiscal year 2005

Finance - Serologicals reports Q4 2005 revenue up 26%, pro forma net income up 75.1%

Finance - Tapestry Pharmaceuticals reports Q4 2005 net loss from continuing operations of $3 million

Finance - Tercica reports Q4 2005 net loss of $14.4 million compared to $11.2 million in Q4 2004

Finance - U.S. CMS awards $993,000 to Ohio groups to study impact of e-prescribing of medications

Finance - US Oncology reports revenue of $665 million for Q4 2005, $2,518.6 million for full year

Finance - United Therapeutics reports that 2005 full-year revenues grew to $115.9 million

Finance - Watson Pharmaceuticals reports Q4 2005 net revenues down 1% to $418.8 compared to year ago

Fitness & Wellness - Aerobic exercise training raises skeletal muscle protein turnover in healthy adults at rest

Gastric Cancer - Gastric cancer may be suppressed by reversion-inducing-cysteine-rich protein with Kazal motifs

Gastric Cancer - Gastric cancer patients had favorable outcome after mosapride citrate therapy

Gastric Cancer - Outcomes with laparoscopic stage M1, unresected gastric adenocarcinoma reviewed

Gastroenterology - Myofibroblasts play a role in prostaglandin-induced intestinal activity

Gastrointestinal Stromal Tumors - Researchers describe findings in gastrointestinal stromal tumors studies

Generic Drug Trends - Report: Denmark has one of the largest rates of generic penetration in Europe

Generic Drugs - Par Pharmaceutical begins shipment of generic Flonase

Generic Drugs - Ranbaxy enjoined by Finnish court from marketing generic Lipitor

Generic Drugs - Tentative U.S. FDA approval of generic equivalent of acid pump inhibitor Aciphex announced

Generic Drugs - USAN and WHO approve generic name of sexual dysfunction drug bremelanotide

Genetics & Genomics - A novel mutation at the JK locus causes Jk(Null) phenotype

Genetics & Genomics - GenomeQuest adopted by Chiron, says Gene-IT

Genetics & Genomics - Post-transcriptional signals yield macrophage VEGF

Gorham-Stout Syndrome - Gorham-Stout syndrome is propelled by angiogenic and osteoclastogenic molecules

Graft-vs-Host Disease - Positive new survival findings from phase II, III orBec trials presented by DOR BioPharma

Gynecology - Research add new data to gynecology body of knowledge

HIV/AIDS Adverse Drug Reactions - Adverse events are most common reasons for generic HAART modification in Southern India

HIV/AIDS Diagnostics - Genotypic and phenotypic clinical cut-off levels determined for ritonavir-boosted saquinavir

HIV/AIDS Diagnostics - HPLC-MS/MS simultaneously quantifies seven protease inhibitors in plasma

HIV/AIDS Diagnostics - Simple and accurate diagnostic tools monitor HIV infection

HIV/AIDS Drug Development - Findings describe new data in HIV/AIDS drug development research

HIV/AIDS Drug Interaction - Lopinavir/ritonavir and valproic acid interaction may exacerbate bipolar disorder

HIV/AIDS Drug Resistance - Infant-only prophylaxis eliminates nevirapine resistance development in mothers and infants

HIV/AIDS HAART - Calculations of creatinine clearance and anion-gap related to tenofovir therapy are minor

HIV/AIDS HAART - New findings in the area of HIV/AIDS HAART described

HIV/AIDS HAART - New findings in the area of HIV/AIDS HAART detailed

HIV/AIDS HAART - Poor HAART adherence and an increased drug resistant HIV-1 strain in China related

HIV/AIDS Molecular Structure - Rous sarcoma virus virions contain fewer copies of Gag than HIV-1

HIV/AIDS Pathogenesis - HIV-1 Vpr induces ATR activation by targeting host cell DNA

HIV/AIDS Pathogenesis - Uracil DNA glycosylase is dispensable for HIV-1 replication

HIV/AIDS Pharmacokinetics - Interpatient variability in plasma efavirenz levels determined by gender and race

HIV/AIDS Prognosis - Despite moderate HIV viremia, clinical progression risk is low

HIV/AIDS Research - Monogram and Merck collaborate on phase III trials of HIV-1 integrase inhibitor

HIV/AIDS Research - Progenics Pharmaceuticals HIV drug, PRO 140, receives U.S. FDA fast-track designation

HIV/AIDS Research - Tanox research reaffirms tropism independence of TNX-355 for HIV

HIV/AIDS Testing - Chembio's rapid HIV test selected by Nigeria

HIV/AIDS Therapy - HIV/malaria therapies given concurrently during pregnancy may prove incompatible

HIV/AIDS Therapy - Medivir designates a clinical candidate drug for HIV/AIDS

HIV/AIDS Transmission - Nevirapine dose timing is important to insure adequate serum concentration in infants

HIV/AIDS Treatment - HIV management complex in elderly due to drug interactions from comorbid conditions

HIV/AIDS Treatment & Prevention - United Nations supports and strengthens the response to AIDS in China

HIV/AIDS Vaccine - International AIDS Vaccine Initiative brings new science and technology to the poor

HIV/AIDS Vaccines - Recent studies add new data to HIV/AIDS vaccines research

HIV/AIDS Vaccines - Researchers report details of new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Related CNS Lymphoma - Ganciclovir related to low or undetectable EBV DNA in CSF of AIDS-related CNS lymphoma

HIV/AIDS-Related Immune Reconstitution Syndrome - Immune reconstitution syndrome common in children receiving HAART during advanced AIDS

Head & Neck Cancer - Angiogenesis inhibitor helps radiotherapy treat oral squamous cell carcinoma

Head & Neck Cancer - Complementary and alternative medicine use in European head and neck cancer patients investigated

Head & Neck Cancer - Vaccinia virus expressing IL-2 elicits immunity in head and neck cancer model

Healthcare Costs - Diabetic nephropathy to ESRD prevention involving losartan-based treatment may reduce cost

Healthcare Costs - Economic impact of acute ischemic stroke highlighted in new study

Healthcare Coverage - MinuteClinic becomes participating provider with MedCost in North Carolina

Heart Disease - Statins, beta-blockers lessen heart attack risk, says Stanford-Kaiser study

Heart Failure - Decompensated heart failure with preserved ejection fraction shows poorer outcome with conduction defect

Helicobacter Pylori - H. pylori reduces secretory leukocyte protease inhibitor levels in gastroduodenal mucosa

Hematology - Platelets promote angiogenesis but thwart hemorrhage

Hematology - Researchers' work adds to hematology body of knowledge

Hepatitic C Virus - Severe HBV liver disease is treatable with interferon-alpha-ribavirin-interleukin-2

Hepatitis A Virus - CD4 count and gender predicts response to HAV vaccine in HIV-positive patients

Hepatitis B Virus - HBV DNA levels predict nonresponse in chronic HBe-antigen positive patients

Hepatitis B Virus - HBV isolates in Mexico display genotypic resistance to lamivudine

Hepatitis C Therapy - Phase II clinical study of Actilon for hepatitis C initiated by Coley

Hepatitis C Virus - Hydrazones and derived ring systems may display antitumor and anti-HCV activity

Hepatitis C Virus - Intracellular hepatitis C RNA in the virus core protein coding region is cleaved

Hepatitis C Virus - Macrocyclic inhibitors potently inhibit hepatitis C virus NS3 protease

Hepatitis C Virus - Translation efficiency correlates with therapy outcome in chronic HCV infection

Hepatitis C Virus - Volunteer blood donors with hepatitis C experience a worse quality of life

Hepatitis Coronavirus - Coronavirus is redirected to a nonnative receptor via a targeting adapter

Herpes Vaccine - Herpes simplex virus ocular infection is prevented by T cell chimeric epitopes

Hormones - 17beta-estradiol suppresses TLR3-induced cytokine and chemokine production

Hormones - Researchers detail new studies and findings in the area of hormones

Human Metapneumovirus - Chimeric recombinant human metapneumovirus immunogenic and protective

Huntington Disease - Systems cell biology profile of Huntington disease to be created by Cellumen, CHDI

Hyperprolactinemia - Prolactin suppresses GnRH but not TSH secretion in hyperprolactinemia

Hypertension - Hypertension is transient after surgical closure of an abdominal wall defect

Hypertension - In isolated systolic hypertension, indapamide shows distinctive pulse pressure reduction effect

Hypertension - In moderate hypertension, telmisartan is more effective than ramipril to reduce blood pressure

Hypertension - Major cardiovascular event risk is directly related to degree of blood pressure lowering

Hysteroscopy - Endometrial thinning prior to hysteroscopy may be achieved with oral contraceptives

Imaging - Coronary artery disease identification may be more effective with addition of BMIPP to T1-201 imaging

Imaging - North American Scientific receives Chinese approval of image-guided radiation therapy equipment

Imaging - The contrast agent HE-24.8 detects tumor vessels in magnetic resonance angiography

Immunizations - Call for pertussis vaccination for healthcare workers endorsed by NFID

Immunology - IL-IM subunits within the IL-17R complex undergo conformational change upon ligand binding

Immunotherapy - Dendritic cells are regulated by physiologically relevant thermal stress

Immunotherapy - Heat shock proteins HSP70 and GP96 are focus of review

Immunotherapy - Transfection with cytokine may have limited long-term effectiveness

Immunotherapy - U.S. CDC committee recommends inclusion of Rotateq in Vaccines for Children Program

Infectious Diseases - Despite flu concerns, HIV, hepatitis most important viral infections to drug developers

Infectious Diseases - Pneumococci with mef and erm macrolide resistance determinants is reported in an American city

Inflammatory Bowel Disease - Exclusive worldwide rights to Simulect for inflammatory bowel disease licensed to Cerimon

Influenza - Haemophilus influenzae antimicrobial susceptibility is reported in Brazil

Influenza - Novartis and Alnylam announce collaboration to develop RNAi Therapeutics for pandemic flu

Influenza Vaccine - Proteosome-influenza vaccine induces influenza antibodies in humans

Information Technology - Enhanced software for drug-target discovery, safety assessment launched by Gene Logic

Information Technology - Frost & Sullivan study finds shift to electronic technologies in drug discovery industry

Information Technology - Health insurer signs letter of intent to provide electronic prescribing software to physicians

Information Technology - License with Johnson & Johnson expanded to include GeneGo's MetaBase access

Information Technology - MediQuest Therapeutics chooses TranSenda to deploy clinical trial portal

Information Technology - Online personal health record service to provide secure medication histories and updates

Information Technology - Pharmedium launched enhanced bar coding for syringe admixture services

Information Technology - U. S. FDA, Leadscope, Inc. sign cooperative R&D agreement for toxicity databases

Information Technology - U.K. regulatory agency implements pharmacovigilance signal detection and signal management product

Ischemia - In ischemia, enhanced NO may balance ATP supply/demand and protect cells from reperfusion injury

Keratoacanthoma - Case of giant keratoacanthoma of the eyelid reported

Kidney Transplantation - HHV8 prevalence is low in renal donors and recipients in Greece

Legal Issues - California group launched to support medical marijuana

Legal Issues - Takeda wins patent infringement case against ANDAs for generic pioglitazone HCl

Legal Issues - Third Wave, Chiron and Bayer dismiss without prejudice hepatitis C virus patent lawsuit

Lethal Radiation - Novelos Therapeutics submits proposal to treat subjects exposed to lethal radiation

Leukemia - Apoptosis of leukemia cells induced by mycotoxin citrinin

Leukemia - Chronic lymphocytic leukemia linked to CpG island methylation

Leukemia - Human T-cell leukemia virus oncoprotein inhibits Fas-mediated apoptosis

Leukemia - Scoring system to distinguish elderly leukemia patients with different prognosis proposed

Leukemia Therapy - Clinical benefit analysis of Genasense plus chemotherapy reported

Limb Allograft - Limb allograft survival prolonged by donor leukocytes and delayed immunosuppressive therapy

Lipid Research - Myeloperoxidase-mediated oxidation of HDL yields markers for atherosclerosis

Liver Cancer - Liver cancer metastasis receives a boost from macrophage inflammatory protein-2

Liver Cancer - Paclitaxel-loaded nanoparticles target drug delivery in liver cancer

Lung Cancer - Adjuvant chemotherapy for non-small cell lung cancer discussed

Lung Cancer - First-line treatment regimens for elderly patients with lung cancer compared

Lung Cancer - Introgen reports positive results from phase II trial of INGN 225 for advanced lung cancer

Lung Cancer - Lung cancer patient response to chemoradiotherapy predicted by FDG-PET

Lung Cancer - Lung cancer suppressed by SC-560

Lung Cancer - New data illuminates research in lung cancer

Lung Cancer - Non small cell lung cancer survival improved in a selected population

Lung Cancer - Start of trial to evaluate drug eluting bead in lung cancer announced

Lymphangioleiomyomatosis - Clinical and molecular insights into lymphangioleiomyomatosis reviewed

Macroadenomas - Macroadenomas treated by octreotide long-acting repeatable

Market Analysis - New rheumatoid arthritis drugs may push biologics above traditional therapies, report says

Marketing - Health Canada grants regulatory clearance for marketing of skin tightening system

Marketing - Qiagen and ActiveSight sign comarketing agreement targeting protein crystallography

Medical Devices - Alfa Laval Biokinetics delivers CytoGenix DNA production module

Medical Devices - Boston Scientific announces French reimbursement for Taxus Liberte stent

Medical Devices - MD Turbo device may help asthma sufferers

Medical Devices - New investigational procedure for asthma studied at Brigham and Women's Hospital

Medicare Drug Benefit - Researchers find deeper-than-expected discounts in Medicare drug benefit

Medulloblastomas - Adolescents with medulloblastoma followed a distinctive clinical course

Medulloblastomas - Medulloblastoma can be treated by fenretinide

Melanoma - Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Melanoma Therapy - SPA from U.S. FDA for Delcath system with melphalan received by Delcath

Meningitis Vaccines - Researchers' findings advance meningitis vaccines research

Menopause - Menopausal symptoms appear to be relieved by new oral estradiol therapy

Menopause - Soybean phytoestrogens may have very limited benefit on bone health

Mental Health - Clinical depression may be associated with higher risk of out-of-hospital cardiac arrest

Mental Health - Depression treatment in coronary artery disease trial is announced

Mergers & Acquisitions - Allergan extends expiration date of Inamed exchange offer

Mergers & Acquisitions - Andara Life Science to be acquired by Cyberkinetics Neurotechnology

Mergers & Acquisitions - Aptuit ramps up investment in India with acquisition of IT company

Mergers & Acquisitions - BCY LifeSciences and Pipex Therapeutics discuss merger

Mergers & Acquisitions - GlaxoSmithKline purchases Pliva research and development arm

Mergers & Acquisitions - Nastech acquires RNAi therapeutics program from Galenea

Mergers & Acquisitions - OncoVista acquires controlling interest in AdnaGen AG

Mergers & Acquisitions - PLIVA's Research Institute acquired by GlaxoSmithKline

Mergers & Acquisitions - ReGen to acquire Sciencom Limited

Mergers & Acquisitions - Targeted Molecules to be acquired by Chromos; financing commitments secured

Mergers & Acquisitions - Walgreens Home Care to acquire Oklahoma City-based Canadian Valley Medical Solutions

Mesothelioma - Mesothelioma patients treated early with chemotherapy had survival advantage

Metabolic Diseases - Pharmacopeia and Biovitrum discover compounds targeting novel kinase involved in metabolic diseases

Metabolic Syndrome - Propanoic acid derivatives are a potential treatment for metabolic syndrome

Multiple Myeloma - Multiple myeloma treated with bendamustine and prednisone

Multiple Myeloma - Orphan status for GPC's anticancer monoclonal antibody recommended by EMEA committee

Multiple Sclerosis - Clinical studies of Tysabri (natalizumab) for MS treatment allowed to resume by U.S. FDA

Myelodysplastic Syndromes - National Comprehensive Cancer Network announces updates to myelodysplastic syndromes guidelines

Myocardial Infarction - In patients with myocardial infarction, N-acetylcysteine diminished oxidative stress, improved LV function

Myocardial Infarction - Mitral regurgitation after myocardial infarction is reviewed

Nanotechnology - Functionalized nanoparticles may be a useful drug carrier for tumor targeting

Natural Products - Antidiabetic activity observed in alcohol extract of Pterocarpus marsupium

Natural Products - Essiac tea possesses antioxidant and DNA-protective activity

Nephrology - Tailoring fluid replacement and anticoagulation therapy increases metabolic control

Neuroendocrine Tumors - Tumor uptake in neuroendocrine tumors enhanced with I-131-labeled metaiodobenzylguanidine

Neurology - 4-hydroxynonenal may result in increased levels of intracellular zinc

Neurology - Crosstalk occurs between GTPases in mediating the effects of BDNF on retinal growth cone motility

Neuroscience - Anti-conflict effects of benzodiazepines and therapeutic doses evaluated

Neuroscience - Calpain-regulated p35/ccdk5-mediated inactivation plays a role in dopaminergic loss

Neuroscience - Corticotropin-releasing factor and urocortin have different influences on postsynaptic density

Neuroscience - Erythropoietin enhances neuroprotection against ischemia and reperfusion injury

Neuroscience - Methamphetamine and dopamine differentially affect transporter-mediated efflux

Neuroscience - Neurogenesis and post-stroke recovery relies on erythropoietin receptor

Neuroscience - Reports add new data to neuroscience research

Neuroscience - Reports advance knowledge in neuroscience research

Neuroscience - Researchers detail new studies and findings in the area of neuroscience

Newcastle Disease - Recombinant Newcastle disease virus vector protects against respiratory syncytial virus

Non-Hodgkin Lymphoma - Certain autoimmune disorders and risk of NHL have associations

Nosocomial Infections - Pfizer receives U.S. FDA approval for Eraxis to treat candidemia

Obesity Epidemiology - Anthropometric body fat composition reference values determined for Spanish youth

Obesity Management - Americans, Michiganders weigh in on child obesity

Obesity Research - Obesity-targeting drug moving forward; Glenmark expects to file for phase I by May 2006

Obesity Therapy - Bariatric surgery with gastric banding model developed in rats

Obesity Therapy - Laparoscopic gastric banding does not affect esophageal motility in the short-term

Obesity Therapy - Pioglitazone increases nonesterified fatty acid clearance in upper body obesity

Obesity Therapy - Weight loss produced by orlistat reduced the incidence of diabetes

Obstetrics - American Fertility Association releases U.S. HHS-funded brochures on embryo donation

Obstetrics - Decidual angiogenesis is driven by cytokine-stimulated fibroblasts

Obstetrics - Postpartum hemorrhage treatment with misoprostol may be viable therapy in remote areas

Obstetrics - Preeclampsia is detected by low levels of angiogenesis factor in urine

Oncology - Complications in cancer patients with central venous catheters were not prevented with dalteparin

Oncology - Findings in oncology provide new insights

Oncology - Heparanase involvement in melanoma metastasis is shown by a brain slice model

Oncology - Melanoma progression may correlate with tumor lymphangiogenesis

Oncology - Recent findings in oncology described

Oncology - Researchers publish new studies and findings in the area of oncology

Ophthalmology - Antiangiogenesis molecules reveal diffusion after transscleral delivery

Ophthalmology - Choroidal angiogenesis may increase in response to connective tissue growth factor

Ophthalmology - Choroidal neovascularization is amplified by a complement factor H variant and smoking

Ophthalmology - Corticosteroids advised in cases of vestibulocochlear symptoms, retinal perivasculitis

Ophthalmology - Endostatin downregulates angiogenesis signals in retinopathy models

Ophthalmology - Novartis licenses to co-promote intravitreal drug implant for eye condition

Ophthalmology - Survey shows consumers prefer eye care provider with medical degree for eye surgeries

Oral Health - Pharmacologist receives 510(k) clearance to market Sucralfate HCl Topical Paste for oral lesions

Oral Mucositis - Phase II results on velafermin for the prevention of oral mucositis announced by CuraGen

Orthopedics - Recombinant human BMP-7 prevents non-union in both young and old rats

Orthopedics - Study confirms not all chondroitin sulfates are the same

Osteoporosis - Bisphosphonate antifracture therapy efficacy may be predicted by elevated bone turnover

Osteoporosis - Combination osteoporosis therapy addresses bone loss and new bone formation

Osteoporosis - Denosumab therapy shown to increase bone mineral density in women with osteoporosis

Osteoporosis - Hip fracture incidence appears to be reduced by antiresorptive bisphosphonates

Ovarian Cancer - Bcl-X-L is functionally non-equivalent for ovarian cancer cell regulation

Ovarian Cancer - Impact of age on outcome in advanced ovarian cancer evaluated

Ovarian Cancer - Ovarian cancer inhibited by 9-methoxy-2-methylellipticinium acetate

Ovarian Cancer - Ovarian cancer invasion and migration are stimulated by matrix enzyme and VEGF

Ovarian Cancer - Ovarian cancer patients did not benefit beyond six cycles of platinum-taxane therapy

Ovarian Cancer - Ovarian cancer prognosis predicted by glutathione S-transferase polymorphisms

Ovarian Cancer - Ovarian cancer therapy with pegylated liposomal doxorubicin has good tolerability

Ovarian Cancer - Ovarian cancer treated by abraxane

Ovarian Cancer - Ovarian cancer treated by weekly dosing of irinotecan

Overactive Bladder - Antares Pharma announces positive Anturol phase II trial results for overactive bladder

Pain Management - Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia

Pain Management - Glucosamine and chondroitin relieve osteoarthritis pain, U.S. NIH-sponsored trial shows

Pain Management - Once daily Ultram ER tablets now available in the United States

Pain Management - Pain immediately after hysterectomy was not relieved by gabapentin

Pancreatitis - Curcumin reversed lipid peroxidation of tropical pancreatitis without reducing pain

Parkinson Disease - Preliminary results shows creatine, inocycline warrant further study in Parkinson disease

Patents - Alexion issued key patent for eculizumab in Japan

Patents - Arachnova portfolio strengthened with new patents for MCI-225

Patents - Barr summary judgment affirmed by federal court in DDAVP patent challenge

Patents - European appeals board affirms p53 therapy patent following opposition by Schering-Plough

Patents - New patent issued to Entremed covering analogs of its lead compound, 2-methoxyestradiol

Pediatric Dermatitis - Vusion ointment for diaper dermatitis complicated by candidiasis approved by U.S. FDA

Pediatric Vaccine - Hepatitis A vaccination was successfully targeted to high-risk children

Pediatrics HIV/AIDS Risk Factors - Infants perinatally infected with HIV at risk from BCG vaccination

Peripheral Artery Disease - Peripheral arterial disease medical treatment is focus of review

Personnel - ARYx Therapeutics appoints Herm Rosenman to board of directors

Personnel - Abe Jacob named national director of development for TGen Foundation

Personnel - AcuNetx taps David Hanke to become senior VP of sales

Personnel - Akorn names David White vice president, new product development

Personnel - Anadys Pharmaceuticals names Michael Adam, PhD, as SVP of development operations

Personnel - Antares Pharma names Robert F. Apple senior VP and chief financial officer

Personnel - Athenagen adds A. Barr Dolan to its board of directors

Personnel - Avalon Pharmaceuticals appoints William H. Washecka to its board of directors

Personnel - Benitec appoints two new directors

Personnel - Bret Berner, PhD, promoted to chief scientific officer by Depomed

Personnel - CEO John L. Armstrong, Jr., elected to Genaera's board of directors

Personnel - Conforma Therapeutics names John E. Crawford to chief financial officer

Personnel - CytoDyn board restructured for anticipated growth; Allen D. Allen re-elected chair

Personnel - David Cade, MD, named medical director for U.S. operations by cancer-focused Sirtex

Personnel - David Carlucci named chairman, CEO, and president of IMS Health; David Thomas to retire

Personnel - Douglas Hamilton to step down as COO/CFO of Javelin Pharmaceuticals

Personnel - Dr. Donald Leung named to Ceragenix scientific advisory board

Personnel - Gerald Fink, PhD, joins Glycofi scientific advisory board

Personnel - Innovative Biosensors adds Phil Samper to board of directors

Personnel - Joseph M. Spagnardi promoted to VP, general counsel, secretary of pharmaceutical company

Personnel - Neuro-Hitech Pharmaceuticals appoints Mark Auerbach as chairman of the board of directors

Personnel - Perrigo company names Ran Gottfried as new board member

Personnel - Peter Licari, Pieter Timmermans named to biopharmaceutical company management team

Personnel - Point Therapeutics adds Charles Dinarello and Antonio Grillo-Lopez as advisors

Personnel - Progen Industries names Justus Homburg as chief executive officer

Personnel - RegeneRx adds L. Thompson Bowles, MD, PhD to board of directors

Pharmaceutical Research - Calcium lactate pentahydrate and its anhydrate follow a three-dimensional diffusion model

Pharmaceutical Research - Cutting Edge Information report examines the way pharma companies fight against generics

Pharmaceutical Research - Melanoma angiogenesis models display a significant response to PEGylated interferon

Pharmaceutical Research - Moxifloxacin kills S. pneumoniae faster than other antibiotics

Pharmaceutical Research - Recombinant antithrombin inhibits thrombin formation and interleukin release in endotoxemia

Philanthropy - Eli Lilly announces philanthropy in 2005 exceeded $500 million

Philanthropy - Pfizer announces new class of global health fellows

Physiology - Paracellular transport in Calu-3 cell layers is enhanced by Carbopol

Pneumonia - Community-acquired pneumonia effectively treated with azithromycin therapy

Preeclampsia - Hypertensive encephalopathy may arise from circulating growth factor in preeclamptic women

Pregnancy Termination - Preabortion psychological distress is reduced after abortion procedure

Product Licensing - Cambrex licenses cell line to Chugai Pharmaceutical Co.

Product Licensing - Erectile dysfunction treatment licensed to Plethora Solutions for North America

Product Licensing - License agreement announced to develop intranasal epinastine for rhinitis in U.S., Canada

Product Licensing - MNLpharma announces license agreement with Avexa to develop compounds to treat HIV/AIDS

Product Licensing - UCB licenses U.S. patents for antihistamine levocetirizine from Sepracor

Professional Education - AAMC task force to examine health industry influence on medical education

Prostate Cancer - Apoptosis in hormone-resistant prostate cancer was induced by Alisol B acetate

Prostate Cancer - Authorization to produce prostate cancer tracer received by Eckert & Ziegler

Prostate Cancer - Dosimetry and acute toxicity in prostate cancer patients treated with hypofractionation studied

Prostate Cancer - Prostate cancer prevented by oral administration of green tea catechins

Prostate Cancer - Studies add new findings to prostate cancer body of knowledge

Prostate Cancer - Unfolded protein response enhanced anticancer activity of selenium in prostate cancer

Proteomics - Avid Biotics obtains license to University of California's protein scaffold technology

Proteomics - Cambrex introduces Versalinx reagents for improved protein samples in drug discovery

Proteomics - LTBP-1 blockade in embryo fibroblasts decreases TGF-beta activity

Proteomics - Leucine regulates translation initiation of protein synthesis in muscle after exercise

Proteomics - Molecular elements help suramin inhibit fibroblast growth factor

Proteomics - Nucleoside transport in rabbit tracheal epithelial cells is described

Proteomics - Proteins governing angiogenesis and bone growth interact during osteoclastogenesis

Proteomics - Recent findings in proteomics provide new insights

Proteomics - Septin protein is linked to angiogenesis through hypoxia-inducible factor-1

Psoriasis - CRx-140 as an oral product candidate for psoriasis discontinued by CombinatoRx

RNA Research - siRNA silences Fas expression and inhibits Fas-mediated apoptosis

Radiation Therapy - Two dosimeters should be used for each site of interest in total body irradiation

Rectal Cancer - Rectal cancer treated by capecitabine in combination with preoperative radiation

Renal Therapy - Fibrin microbeads provide a 3D platform for kidney gene and cell therapy

Restructuring - Information on company's restructuring plans provided by CryoCor

Rheumatoid Arthritis - Rigel completes R788 plus methotrexate interaction study for rheumatoid arthritis

Rotavirus - Children's Hospital of Philadelphia includes rotavirus vaccine in infant immunization schedule

Rotavirus Vaccine - Rotavirus vaccine clinical trials in Europe are focus of review

SARS - Transmembrane domain of SARS coronavirus spike protein functions during entry

Sexual & Reproductive Health - Hypothyroidism treated with thyroxine is not associated with adverse perinatal outcome

Smallpox Vaccine - Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling

Smallpox Vaccines - Findings describe new data in smallpox vaccines research

Smallpox Vaccines - New findings in smallpox vaccines described

Sociology Research - Physician perceptions of patients' social characteristics are predictive of healthcare recommendations

Spermatogenesis - Transcription factors may mediate testicular response to reduced androgen

Spinal Cord Injury - Chronic spinal cord injury induced changes in the responses of thalamic neurons

Squamous Cell Carcinoma - Rac1 maintains malignant phenotype of mouse skin tumor cells

Squamous Cell Carcinoma - Squamous cell carcinoma antigen 1 functions as a biomarker in tongue cancer

Statins - New research in the area of statins detailed

Statins - Recent findings in statins provide new insights

Statins - Recurrent myocardial infarction, mortality are similar for immediate or delayed statin therapy post-MI

Stem Cell Engraftment - Cardiac function improved via engraftment of enriched embryonic stem cells and other medication

Stem Cell Research - Aldagen, Texas Heart Institute begin study of stem cell therapy for heart failure patients

Stem Cell Research - Oncolytics: Cancer cells purged from post-chemo stem-cell transplants by Reolysin

Stroke - Almost 70% of ischemic stroke patients had blood flow restored in Merci Retriever multicenter trial

Stroke - CardioVascular BioTherapeutics discusses advances in drug development program

Stroke - FG-4539 is neuroprotective and significantly reduces brain tissue damage, says FibroGen

Stroke - Few stroke patients get to hospital in time for treatment

Stroke - Reports add new data to stroke research

Stroke - Stroke spastic drop foot improves with low-dose Botox and short electrostimulation

Substance Abuse Treatment - Women's substance abuse treatment programs may have inherent design flaws

Surgical Technology - Drug-eluting stents for ostial de novo left anterior descending lesions show decreased restenosis

Surgical Technology - Rapamycin-eluting stents for coronary bifurcation lesions underexpand without restenosis impact

Systemic Lupus Erythematosus - A generalized vesiculobullous eruption can be the sole presenting manifestation of SLE

Systemic Lupus Erythematosus - In SLE, anti-CD40L autoantibody is associated with thrombocytopenia, not thromboembolism

Thyroid Disorders - Restoration of thyroid function improves quality of life and psychological symptoms

Toxicology - Angiogenesis is modified by polychlorobiphenyl interactions with estrogen receptors

Transfusion Medicine - In pediatric cardiac surgery, hydroxyethyl starch is a safe alternative for volume replacement

Transgenics - A virus-neutralizing antibody is not cytotoxic in vitro

Transplant Medicine - PEGylation, immunosuppressive agent cocktail makes for successful islet transplantation

Transplantation Biology - Hepatitis C virus antigen detected in cholestatic hepatitis after liver transplantation

Tuberculosis Therapy - Rifampin/pyrazinamide causes severe liver injury in tuberculosis patients

Tuberculosis Vaccine - Tuberculosis vaccine efficacy is affected by BCG strain and delivery route

Type 2 Diabetes - Arteries showed decreased myogenic tone after high glucose exposure

Type 2 Diabetes - Receiving higher sulfonylurea drug exposure increases mortality rate for diabetics

Vaccines Adjuvant - Findings advance knowledge in vaccines adjuvant research

Vancomycin-Resistant Enterococci - Epidemic-virulent clonal complex-17 strains of E. faecium increasing in German hospitals

Vector Development - Histidinylated cationic transfection lipids may function as transfection vectors

Virology - Adenovirus virus-associated RNA is processed to functional interfering RNAs

Virology - New research in the area of virology detailed

Virology - The angiogenesis of ocular herpes simplex virus infection involves interleukin-6

Wegener Granulomatosis - Wegener granulomatosis often diagnosed if destruction of the maxillary sinus' medial wall is found

Wound Care - Nitric oxide reduces the microbial burden in healing wounds

Zollinger-Ellison Syndrome - Zollinger-Ellison syndrome patients studied

Return to Top of Page


Home \| Free Newsletters \| Products \| Article Library \| About Us \| Contact \| Privacy Policy \| Search \| Visit VerticalNews.com Copyright © 2009 NewsRx