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Drug Week

Susan Hasty, Publisher
Table of Contents . . . March 24th, 2006
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Drug Week | Other Publications

Apoptosis - Antimonial compounds may work by disrupting thiol homeostasis

Cancer Therapy - Sutent approved for use in U.S. in kidney cancer, gastrointestinal stromal tumors

Drug Delivery - Rapamycin delivery via PEG-PCL micelles characterized

Fungal Infections - Caspofungin's mode of action and therapeutic applications evaluated

Pain Management - Significant pain relief in children demonstrated by Corgentech's ALGRX 3268 in trial

Addiction Medicine - 3,4-methylenedioxymethamphetamine acts most similarly to amphetamine

Addiction Medicine - Cannabis, hallucinogen, cocaine, and opiate disorder symptoms classified

Addiction Medicine - Cocaine reinforcement is attenuated by antisense-induced protein reduction

Addiction Medicine - Methamphetamine treatment center develops program to address cognitive damage of addiction

Addiction Medicine - Team discovers possible "universal strategy" to combat addiction

Adverse Drug Reaction - Oxaliplatin hypersensitivity reactions studied

Adverse Drug Reaction - Parenteral iron adverse reactions are focus of review

Adverse Drug Reaction - Public health advisory for Trasylol issued by U.S. FDA

Adverse Drug Reaction - Valproate lowers glucose and raises insulin, cortisol, leptin, and neuropeptide Y levels

Aggressive Behavior - Characterization of aggressive behavior influences the success of pharmacological treatment

Allergy & Immunology - Pen ch 13 may contribute to asthma

Alzheimer Disease - Anti-amyloid therapy may be an adjunct treatment for Alzheimer disease

Alzheimer Disease - Cerebrolysin was well tolerated and demonstrated improved cognition in Alzheimer patients

Alzheimer Disease - Metallothionein-3 and neuronal nitric oxide synthase found reduced in Alzheimer disease

Alzheimer Disease - Timing and duration of administration are important to optimize cholinergic Alzheimer disease treatment

Amebiasis Therapy - Antiprotozoal agent is effective for treating trichomoniasis, giardiasis, and amebiasis

Analgesia - Placebo analgesia may be configured through multiple brain pathways and mechanisms

Andropause - QuatRx Pharmaceuticals Company initiates phase II trial of fispemifene for andropause

Anemia - Health Canada authorizes ProMetic BioSciences to begin Ib/II trial of PBI-1402 for anemia

Anemia Therapy - Darbepoetin alfa saves costs and reduces number of office visits for treatment-related anemia

Anesthesia - Succinylcholine dose of 1 mg/kg total body weight is recommended for morbidly obese

Angina - Update on GENASIS trial announced by Corautus Genetics

Angiogenesis - Angiogenesis is inhibited by thrombospondin targeting of type I collagen

Angiology - Anti-SDF-1 treatment prevents retinal neovascularization in nonhuman primates, study shows

Angiology - Carotid artery intimal hyperplasia is improved by estrogen replacement in ovariectomized rats

Angiology - Chronic hypoxia modulates melatonin receptors in the rat carotid body

Angiology - Coronary artery stenting is feasible even with intraluminal thrombus

Angiology - Endothelium-independent vasorelaxation is induced by protamine sulfate via NO synthase pathway

Angiology - Findings in angiology provide new insights

Angiology - Pulmonary artery obstruction changes vessel growth in the non-obstructed lung

Angiology - Research in angiology provides new insights

Angiology - Tissue factor expression in cultured endothelial and smooth muscle cells is induced by nicotine

Angiology - Tumor angiogenesis flourishes in models with TIMP-3 gene deficiency

Antibacterial Agents - Antibiotic use during last days of life in cancer patients analyzed

Antidepressants - Amitriptyline, maprotiline, and fluoxetine do not affect retrieval of inhibitory avoidance learning

Anxiety - Internet-based program increased coping skills in traumatized patients

Apoptosis - Caffeine-induced calcium release in rat astrocytes increases ethanol mediated death

Apoptosis - Cyclin D1 overexpression induces apoptosis resistance linked to carcinoma BCL-2

Apoptosis - Imatinib reported to induce apoptosis

Apoptosis - Researchers describe findings in apoptosis studies

Apoptosis - Retinoblastoma plays a role in survival of Abl-dependent human tumor cells

Apoptosis - Studies advance knowledge in apoptosis research

Asthma - Dosing of first patient in trial of IV zileuton completed by Critical Therapeutics

Asthma - Researchers' work adds to asthma body of knowledge

Atherosclerosis - Monocyte adhesion is inhibited by 17-beta-estradiol via down-regulation of Rac1 GTPase

Atherosclerosis - Patients with high cholesterol levels benefit from simvastin treatment

Atherosclerosis - Two proteins participate in the repression of paraoxonase-1 gene expression

Autism - PediaMed completes clinical trial enrollment to study GI dysfunction in children with autism

Avian Influenza - Abt Associates helps Ghana prepare for avian influenza outbreak

Avian Influenza - Avian influenza vaccine well tolerated in patients

Avian Influenza - Bird flu virus advances in Nigeria

Avian Influenza - Indian marketing approval on generic Tamiflu obtained by Cipla

Avian Influenza - Positive pre-IND meeting with U.S. FDA for avian flu vaccine completed by Generex

Awards - James A. Spudich receives Outstanding Investigator in Single Molecule Biology award

Back Pain - Pain relief immediately after surgery for spinal malformations is good, but recurrence is common

Bacteria - Replidyne and Forest Laboratories announce FDA review of NDA for faropenem medoxomil

Bacteriology - Ants spread antimicrobial-resistant bacteria in Brazilian hospitals

Benign Prostatic Hyperplasia - BXL628 arrests prostate growth in patients with benign prostatic hyperplasia

Biliary Tract Carcinoma - Biliary tract carcinoma treated by chemoradiation

Biomedical Engineering - Angiogenesis flourishes when proteins are released from implanted hydrogel

Biomedical Engineering - Sigma-Aldrich, Genospectra sign agreements in RNAi, gene expression and cell-based assays

Bipolar Disorder - Functional polymorphisms are associated with bipolar disorder

Blood Pressure - Blood pressure response to 17beta-estradiol varies according to age

Blood Pressure - Pyridostigmine alone or with midodrine may improve standing blood pressure

Bone Marrow - Bone marrow failure compared in male vs. female rats

Bovine Spongiform Encephalopathy - Usefulness of MAb 2A11 in immunohistochemistry for the diagnosis of BSE confirmed

Brain Cancer - Glioma invasion is stimulated by angiopoietin 2 induction of matrix enzymes

Breast Cancer - Breast cancer drug, derived from botanical extract, could treat aggressive breast cancer

Breast Cancer - Breast cancer patients show preference for oral hormone therapy vs. monthly injections

Breast Cancer - Breast cancer treated by possible antimetastatic formylated hexapeptide ligand

Breast Cancer - Breast cancer treated with combination of oral vinorelbine and capecitabine

Breast Cancer - Breast carcinoma cells receive support from vascular endothelial growth factor-D

Breast Cancer - Hirsutenone inhibits COX-2 and MMP-9 upregulation in mammary epithelial cells

Breast Cancer - M. D. Anderson Cancer Center to investigate chemokine antagonist for breast cancer

Breast Cancer - MCF-7 breast cancer cell growth inhibited by Antrodia camphorata

Breast Cancer - Metastatic breast cancer treated by combination of pemetrexed and gemcitabine

Breast Cancer - New findings in breast cancer described

Breast Cancer - Recent findings in breast cancer provide new insights

Breast Cancer - Roche pursues European market approval of Herceptin for early-stage HER2-positive breast cancer

Breast Cancer Screening - Breast tumor size prediction methods were compared for accuracy

Breast Cancer Therapy - Breast cancer risk reduction awareness was evaluated among women from different ethnic groups

Breast Cancer Therapy - Researchers detail new studies and findings in the area of breast cancer therapy

Breast Cancer Therapy - Researchers provide details of new studies and findings in the area of breast cancer therapy

Breast Cancer Therapy - Timing of aromatase inhibitors added to breast cancer therapy affects cost-effectiveness

Bronchioloalveolar Cancer - Bronchioloalveolar carcinoma management discussed

Business & Finance - BioMS Medical records loss of $0.46 per share

Business & Finance - Biovest International reports quarterly loss of $0.04 per share

Business & Finance - Cadence Pharmaceuticals acquires second phase III product, $60.8M financing

Business & Finance - Coley Pharmaceutical Group reports Q4 revenue of $5.4 million

Business & Finance - Fourth-quarter 2005 results reported by Cepheid; total revenues increase 16%

Business & Finance - Schering increases net sales by 8%

Business & Finance - Wellcare Health Plans Inc. reports 50% growth in membership in Medicare plans during 2005

Business Update - Blood safety scientific advisory board established by Cerus

Business Update - Pharmaceutical company mulling divestiture of Consumer Health Unit, market report says

Business Update - Savient hires Citigroup to explore alternatives for subsidiary Rosemont Pharmaceuticals

Cancer Gene Therapy - Peroxiredoxin I expression affects lung tumor growth and radiosensitivity

Cancer Gene Therapy - RNA interference induces cell cycle arrest and apoptosis in breast carcinoma cells

Cancer Research - Morphotek announces U.S. FDA acceptance of MORAb-009 IND

Cancer Therapy - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase proposed as cancer therapy target

Cancer Therapy - Advanced pancreatic cancer celiac axis infusion and microembolization improves resection

Cancer Therapy - Advaxis' listeria cancer vaccine receives regulatory approval for phase I/II testing

Cancer Therapy - Aegera initiates third trial for AEG35156 for patients with acute myeloid leukemia

Cancer Therapy - Antifungal treatment for patients on chemotherapy deemed cost-effective

Cancer Therapy - Antimetastasis data to be presented by Chemokine at meeting

Cancer Therapy - Antisense therapy is well tolerated in patients with metastatic colorectal cancer

Cancer Therapy - Bioenvision's clofarabine receives positive opinion from European Medicines Agency

Cancer Therapy - Bone metastasis is prevented by a selective cyclooxygenase-2 inhibitor

Cancer Therapy - Brain cancer patients living longer after DCVax-Brain personalized vaccine therapy

Cancer Therapy - Cancer cell growth inhibited by digitoxin

Cancer Therapy - Cisplatin functions as ARF mimic

Cancer Therapy - High-dose cyclophosphamide may be unnecessary therapy for lymphoid malignancies

Cancer Therapy - Multikine treatment increases survival in head and neck cancer patients

Cancer Therapy - New findings in cancer therapy described

Cancer Therapy - Phenylcarbazoles display antitumor properties

Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy

Cancer Therapy - Researchers' data advance cancer therapy research

Cancer Therapy - Researchers' findings advance cancer therapy research

Cancer Therapy - Studies advance knowledge in cancer therapy research

Cancer Therapy - Studies describe new findings in cancer therapy research

Cancer Therapy - Thymosin beta 4 determines fibroblast transformation and invasiveness

Cancer Therapy - Tumor angiogenesis and growth proliferate in minimal disease models given TNP-470

Cancer Treatments - ProStrakan receives U.S. FDA approval of IND for patch to treat side effects of chemotherapy

Cancer Vaccine - Antitumor activity in human lymphocytes is triggered by vaccine

Cancer Vaccine - Contract arrangement announced for cGMP production of GRNVAC1 for clinical trials

Cancer Vaccine - Vaccine induces response against carcinoembryonic antigen in patients with metastases

Candida - U.S. FDA approves new treatment for fungal infections

Cardiac Cell Therapy - Enrollment in phase II trial of cardiac cell therapy ended by Genzyme

Cardiology - AngioJet therapy safe, effective as part of rescue percutaneous coronary interventions

Cardiology - Angiogenesis and cardiac function improve following bone marrow cell implantation

Cardiology - Findings advance knowledge in cardiology research

Cardiology - Findings in cardiology provide new insights

Cardiology - Janus Tacrolimus eluting carbostent study data show excellent safety, efficacy in patients

Cardiology - Maintenance of normal myocyte growth may require E2F-6

Cardiology - New clinical data shows antisense drug Isis 301012 significantly reduces triglycerides

Cardiology - Recent findings in cardiology described

Cardiology - Research report on heart disease in women released by WomenHeart, health research society

Cardiology - Researchers' work adds to cardiology body of knowledge

Cardiology - Sorin Group launch second generation drug eluting stent with new delivery system

Cardiomyocytes - Cardiac myocyte exposure to oxidative stress causes modifications to cytoprotective proteins

Cardiovascular Disease - Chronic antithrombotic therapy in post-myocardial infarction patients is reviewed

Cardiovascular Disease - Following intracerebral hemorrhage, antiplatelet use is not associated with increased recurrence risk

Cardiovascular Disease - Reports advance knowledge in cardiovascular disease research

Cardiovascular Disease - Surgical revascularization of LAD artery disease shows better midterm outcome compared to PCI

Cardiovascular Disease - Use of nonprescription medications for perceived cardiovascular health is common

Cardiovascular Research - After brief cardiac arrest, epinephrine increases mortality in an in vivo rat model

Cardiovascular Research - Research add new data to cardiovascular body of knowledge

Celiac Disease - ACS5 may be a suitable marker for the detection of celiac disease

Cell Biology - Adult angiogenesis is enhanced by accessory cells

Central Nervous System - Memory Pharmaceuticals announces positive preliminary phase I cognitive data for MEM 3454

Central Nervous System Lymphoma - Central nervous system lymphoma survival improved with combined-modality therapy

Cervical Cancer - Cervical cancer growth is inhibited by the angiogenesis modulator NOL7

Cervical Cancer - Cervical cancer therapy with cisplatin appears comparable to other agents in same setting

Cervical Cancer - Drug-delivery system for cervical cancer lesions licensed to CytoCore

Cervical Cancer Vaccine - Human papillomavirus-16 vaccine prevents cervical intraepithelial neoplasia

Chemotherapy - New findings in chemotherapy described

Chlamydia Vaccine - Chlamydia protection is better delivered by intranasal than transcutaneous vaccine

Chondrogenesis - SCRG1 is induced by glucocorticoid and stimulates chondrogenesis in vitro

Chronic Pain - Severe chronic pain agent Prialt to be acquired by Eisai, from Elan, for Europe

Cirrhosis - Recurrence of hepatocellular carcinoma after liver resection evaluated

Clinical Trials - Celsion signs Agreement with Fast Track Systems and CROCAS PBT

Clinical Trials - Clinical study of small molecule Telintra tablet for myelodysplastic syndrome initiated

Clinical Trials - Enrollment in phase 1 trials for anti-inflammatory therapeutic begun

Clinical Trials - Final trial results show intranasal morphine for post-surgical pain meets endpoints

Clinical Trials - Norwood Abbey commences phase II trial of Lupron Depot in autologous bone marrow transplants

Clinical Trials - Positive results reported from phase 3 trials of desonide topical steroid in aqueous gel

Clinical Trials - Summary results of phase 4 studies of niacin compound reported

Clinical Trials - Twice-yearly dosing of denosumab increased bone mineral density, phase 2 trial data show

Clinical Trials - U.S. FDA lifts hold on clinical trial of natalizumab dosing in multiple sclerosis

Collaborations - BioSyntech closes transaction with Kuhnil Pharma

Collaborations - BioSystems International signs agreement with AstraZeneca for biomarker discovery

Collaborations - Bioheart and Cleveland Clinic sign patent licensing agreement

Collaborations - Biosite and FivePrime finalize antibody collaboration

Collaborations - Bruker Daltonics signs alliance for identification of microorganisms

Collaborations - Licensing agreement for anti-inflammatory therapies inked by G2 Therapies and Novo Nordisk

Collaborations - Mammalian-cell-lines engineering collaboration formed by Cellectis, Celonic

Collaborations - Nanosyn to provide chemistry-based services to Amphora Discovery for multiple drug targets

Collaborations - New U.S. federal health initiative to improve cancer therapy

Collaborations - Novel pain therapeutics to be developed by Evotec and Apeiron Biologics

Collaborations - Olympus granted exclusive right by Cytori to negotiate commercialization collaboration

Collaborations - Research collaboration to develop micro-RNA related therapies for liver cancer announced

Collaborations - Rexahn and University of Maryland Nanomedicine Center to develop cancer and CNS therapies

Colon Cancer - 9-aminocamptothecin-HPMA copolymer conjugates developed for colon cancer drug delivery

Colon Cancer - Clinical trial Buddy Program offered by Colon Cancer Alliance

Colorectal Adenocarcinomas - Colorectal carcinoma tumor-associated stroma has a metabolic survival role

Colorectal Cancer - Colorectal cancer metastasis is hampered by antibodies targeting VEGF

Colorectal Cancer - Colorectal cancer patients preferred oral to intravenous therapy

Complementary & Alternative Medicine - (-)-Epicatechin mediates beneficial effects of flavonol-rich cocoa on vascular function in humans

Complementary & Alternative Medicine - Citrus aurantium reviewed as alternate overweight and obesity treatment

Complementary & Alternative Medicine - 5-OH-isoflavone consumption is of no direct cytotoxic risk to the human vascular endothelium

Complementary & Alternative Medicine - Anthocyanidins decrease endothelin-1 production, increase endothelial NOS in endothelial cells

Complementary & Alternative Medicine - Chromium supplement enhances cellular insulin signaling in obese insulin-resistant rats

Complementary & Alternative Medicine - Degraded lambda-carrageenan could add antitumor activities of 5-Fu

Complementary & Alternative Medicine - New class of CDK2 inhibitors developed

Complementary & Alternative Medicine - Protective mechanisms of omega-3 long-chain polyunsaturated fatty acids are reviewed

Corticosteroids - Corticosteroids associated with poor outcomes, death in the trauma intensive care unit

Critical Care Medicine - Fibrin sealant dressing was the only alternative wound care that reduced hemorrhage time

Cryopreservation - BioLife study examines Calpains and their influence on overall cell survival

Cystic Fibrosis - Inhaled hypertonic saline is safe and effective additional therapy for cystic fibrosis patients

DNA Research - Cellular delivery of nucleic acid conjugates is mediated by cationic lipids

DNA Vaccine - Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine

Dengue Fever - Dengue antigen developed

Dental Care - Use of an atomizer improved pediatric dental patient receptivity to intranasal midazolam

Dental Research - Periodontal status of osteoporotic women may improve with risedronate therapy

Depression - A relationship exists between nicotinic acetylcholine receptors and depression

Depression - Depression may relapse in women who discontinue medication during pregnancy

Depression - Fluoxetine pharmacokinetics in elderly patients was evaluated

Depression - Men with symptoms of depression were more likely to be offered treatment

Depression - Research links coverage by top current affairs program to rise in adverse drug reports

Depression - The period for N-methyl-D-aspartate receptor-dependent synapse destabilization is defined by retinal arbors

Dermatitis - Ciclopirox shampoo is effective and safe for treating seborrheic dermatitis of the scalp

Dermatology - Pimecrolimus cream is safe and well tolerated in infants

Diabetes - Cortisol synthesis inhibitor taken into phase II clinical trial by DiObex

Diabetes & Depression - Chromium picolinate shows antidepressant and antidiabetic action in diabetic rat model

Diabetes Complications - ATP-WR related to neuropathy in diabetics without signs of coronary artery disease

Diabetes Complications - Diabetic retinopathy retreats with antioxidants and advanced glycation inhibitors

Diabetes Control - OSI Pharmaceuticals initiates phase IIa trial for glycogen phosphorylase inhibitor, PSN357

Diabetes Pathogenesis - ATGL contributes to net adipocyte lipolysis and is negatively linked to insulin levels

Diabetes Therapy - Antidiabetic and sulphonyureas drug interactions with K_ATP channels discussed

Diabetes Therapy - Data advance knowledge in diabetes therapy research

Diabetes Therapy - Nuclear receptor activation improves hyperglycemia and hyperlipidemia in diabetic mice

Diabetes Therapy - Reports add new data to diabetes therapy research

Diabetes Therapy - Research add new data to diabetes therapy body of knowledge

Diabetes Therapy - Resistin exposure regulates skeletal muscle cell insulin signaling, glucose uptake, and metabolism

Diabetes Therapy - Selenium TD with gliclazide TD combination enhanced gliclazide glucose lowering effects

Diabetes Treatment - Intravitreal triamcinolone acetonide improved hard exudates, fluorescein leakage, and visual acuity

Diabetic Angiopathy - Diabetic angiopathy may be controlled by the transcription factor ATF3

Diabetic Nephropathy - Diabetes is attenuated by 17-beta estradiol, a regulator of renal transporter expression

Diabetic Retinopathy - Diabetic retinopathy in rat models may not reflect angiogenic patterns in human eyes

Diabetic Retinopathy - Diabetic retinopathy may be encouraged by glucose-induced neutrophil interactions

Diagnostics - Adenocarcinoma angiogenesis is identified by a double immunolabeling technique

Diagnostics - Atorvastatin HPLC assay developed

Diagnostics - Findings describe new data in diagnostics research

Diagnostics - New findings in the area of diagnostics described

Diagnostics - Recent findings in diagnostics described

Diagnostics - Researchers provide details of new studies and findings in the area of diagnostics

Diagnostics - U.S. FDA 510(k) clearance for Nanopia wrCRP Assay received by Clinical Data

Diet & Nutrition - Does folic acid and vitamins B₆ and B₁₂ reduce the risk of major CV events?

Diet & Nutrition - Racial, ethnic minority women urged by researchers to increase folic acid intake

Diet & Nutrition - Rutin shows antihyperglycemic and antioxidant activity in streptozotocin-induced diabetic rats

Diet & Nutrition - Vegetable-derived isothiocyanates examined for anti-proliferative activity

Diet & Nutrition - Visceral fat mass with diet-induced obesity reduced by SRCD in rats

Diet & Nutrition - Vitamin C supplementation might reduce frequency of common cold

Disease Associations - Cardiovascular events are predicted in dialysis patients by fibrinogen, calcium x phosphate product

Disease Associations - Corticotropin-releasing hormone increases monocyte endothelin-1, decreases NO release

Drug Delivery - A biodegradable polymer functions as a carrier material

Drug Delivery - Biodegradable nerve guidance channels with protein-eluting microspheres developed

Drug Delivery - CoStar drug-eluting stent gets CE Mark

Drug Delivery - Intramuscular delivery methods for DNA vaccine in primate model were compared

Drug Delivery - Miniaturized ChronoDose Prototype unveiled by ChronoTherapeutics

Drug Delivery - Periodontal disease antibiotic delivery with biodegradable device promising

Drug Delivery - Polymer-coated targeted drug delivery systems stochastically modeled

Drug Development - Access Pharmaceuticals initiates a new AP5346 study in patients with head and neck cancer

Drug Development - Advanced Magnetics panel recommends continuation of ferumoxytol phase III trial

Drug Development - Allergy Therapeutics commences sublingual allergy vaccine trial

Drug Development - Angiogenesis protein is counteracted by new aminonucleosides

Drug Development - AnorMED responds to shareholder's SEC filing

Drug Development - Aridol recommended for sale in Australia

Drug Development - Arixtra shown to reduce risk of venous thromboembolism in acutely ill patients

Drug Development - AstraZeneca withdraws Exanta from the market, terminates development

Drug Development - Berlex seeks approval of Betaseron in patients with first episode suggestive of MS

Drug Development - BioMS Medical secures manufacturing agreements for multiple sclerosis drug

Drug Development - BioSante Pharmaceuticals submits Bio-E-Gel new drug application to U.S. FDA

Drug Development - BioVex begins dosing of patients in phase II trial of OncoVEXGMCSF

Drug Development - Biodegradable microspheres prolong antigen presentation by macrophages

Drug Development - Biomarker discovery program initiated to streamline drug development for tuberculosis

Drug Development - Biota commences phase I trial of common cold drug candidate

Drug Development - Biotech company selects Isis to manufacture, supply antisense drug for eye diseases

Drug Development - Biotech firms seek pre-qualification from World Health Organization

Drug Development - Biovest submits amendment request to U.S. FDA for BiovaxID personalized anticancer vaccine

Drug Development - Bristol-Myers Squibb seeks to expand access to HIV/AIDS medicine

Drug Development - CIP-Fenofibrate approval from Health Canada received by Cipher

Drug Development - Combination of porphyrins and DNA-alkylation agents described

Drug Development - Compound with smaller diluent for treating von Willebrand disease now available

Drug Development - CytRx enrolls first patient in phase IIA trial of arimoclomol for ALS

Drug Development - Cytochroma granted U.S. FDA approval to commence phase II trial of psoriasis treatment

Drug Development - DTH-inducing proteins from cDNA library have been identified

Drug Development - Dendrons with spermine surface groups are building blocks for nonviral vectors

Drug Development - Equilibrative nucleoside transporter can be fine-tuned with alternatively spliced variant

Drug Development - Erbitux indication extended to include head and neck cancer

Drug Development - European regulatory authorities recommend authorization to market Preotact

Drug Development - Fluorescent phorboxazole A analog developed

Drug Development - HIV-1 fusion inhibitors moderately inhibit fusion of SARS-CoV with target cells

Drug Development - Hepatitis drug data presented at meeting

Drug Development - InNexus Biotechnology launches bioequivalent program

Drug Development - InSite Vision to present results from phase III trial of AzaSite for eye infections

Drug Development - Itopride does not meet primary endpoint in phase III trial

Drug Development - King Pharmaceuticals, Arrow International, affiliates collaborate on ramipril formulation

Drug Development - Lymphoproliferative disorders may occur in RA patients not treated with MTX

Drug Development - Nateglinide showed good therapeutic effect in patients with short diabetes duration

Drug Development - Neurochem submits new drug application to U.S. FDA for Fibrillex for Amyloid A (AA) amyloidosis

Drug Development - Oral iclaprim shown to achieve results comparable to intravenous administration

Drug Development - Pharmacogenomics added to development of new marine-derived anticancer agents

Drug Development - Phoqus Group and Diurnal Limited complete phase I Chronocort trial for adrenal insufficiency

Drug Development - Potent inhibitor of antiapoptotic protein Bcl-x(L) discovered

Drug Development - Recruitment interrupted for AEterna Zentaris phase III trial of Neovastat in lung cancer

Drug Development - Strategic alliance with Par signed for sale, distribution of Spectrum's generic products

Drug Development - Toxicology studies with MPI Research begun by Diffusion Pharmaceuticals, LLC

Drug Development - Two novel, small-molecule inhibitors of DNA methylation discovered

Drug Development - U.S. FDA accepts Schering-Plough's NDA to review antibacterial agent garenoxacin

Drug Development - U.S. FDA approves rimonabant for weight management, denies approval for smoking cessation

Drug Development - U.S. FDA grants NDA for 6-month priority review of treatment for invasive fungal infection

Drug Development - U.S. FDA grants orphan drug status to Coramsine for malignant melanoma

Drug Development - U.S. FDA releases comparison analysis of its drug review process

Drug Development - Vaccinia virus Ankara multiplies in rat IEC-6 cells

Drug Discovery - Compound library for German FMP provided by ChemDiv

Drug Discovery - Models for simulation of signaling network aid in silico evaluation of drug candidates

Drug Resistance - Community-acquired MRSA has a high potential to become endemic

Drug Resistance - Fusidic acid should be combined with other agents to prevent emergence of resistance

Drug Resistance - Methicillin-resistant S. aureus pyomyositis diagnosed in an intravenous drug user

Drug Resistance - Methicillin-resistant S. aureus treatment may become ineffective as cases increase

Drug Resistance - Reduced Neisseria gonorrhoeae ceftriaxone susceptibility is linked to multidrug-resistance

Drug Safety - Ezetimibe/simvastatin clinical trials suggest ezetimibe does not aggravate simvastatin muscle effects

Eating Disorders - Eating disorders are common in individuals with body dysmorphic disorder

Ebola Vaccine - Ebola vaccine with Vical technology produces immune responses in trial volunteers

Echocardiography - Recent findings in echocardiography provide new insights

Encephalitis - Heparan sulfate mimetic PI-88 demonstrated a beneficial effect on encephalitic flaviviruses

Endocrinology - Antimicrobial peptides with insulin activity were found in Rana saharica frog secretions

Endocrinology - Insulin dynamics of obese children predict BMI and z-score response to insulin suppression

Endocrinology - Melatonin attenuates diabetes-induced oxidative stress in rabbits

Endocrinology - Olanzapine therapy does not affect basal or insulin-stimulated glucose transport

Endocrinology - Pronounced vessel development in the perinatal period may foster pancreatic islet activity

Endometrial Cancer - Endometrial cancer therapy may be enhanced with adjuvant whole abdominal radiotherapy

Endometriosis - Endometriosis declines after short synthetic endostatin peptide treatment in murine models

Environmental Health - Hexabromocyclododecane exposure induces drug-metabolizing enzymes in rats

Escherichia Coli Vaccine - E. coli O157O-specific vaccine is safe and immunogenic in children

Esophageal Cancer - Two-year survival from esophageal cancer predicted with FDG-PET upstaging

Facilities - BioProgress plc announces cGMP upgrade, expansion

Facilities - Cambridge, Massachusetts new office site for Gene Network

Facilities - Hospira reports $60M investment in McPherson manufacturing facility

Facilities - Northwest Kinetics announces grand opening of new clinical facility

Facilities - Novo Nordisk opens hemostasis research facility in New Jersey

Feline Immunodeficiency Syndrome - Low-dose interferon-alpha treatment prolongs survival in FIV infection

Finance - Adolor closes sale of 5.75M shares of common stock in a public offering

Finance - Alba Therapeutics receives new federal, state grant awards for work on zonulin pathway

Finance - Albany Molecular Research reports 15% decrease in revenue

Finance - Alnylam Pharmaceuticals reports loss of $0.56 per share

Finance - Amarin posts quarterly loss of $0.10 per share

Finance - American Pharmaceutical Partners records 18% increase in sales

Finance - Antigenics reports loss of $0.39 per share

Finance - Arena Pharmaceuticals reports net loss of $0.55 per share

Finance - Aspreva Pharmaceuticals reports earnings of $0.68 per share

Finance - Baxter supports earthquake victims in India and Pakistan through donation of vaccines

Finance - Baxter's board authorizes $1.5B share repurchase program

Finance - BioDelivery Sciences receive $2M payment for development of Bema Fentanyl

Finance - BioSphere Medical signs deal for $13.4M private placement

Finance - BioSyntech announces extension of BDC loan

Finance - Biogen Idec reports income of $165M

Finance - Caliper Life Sciences reports becoming cash-flow positive

Finance - Callisto Pharmaceuticals CEO discusses uses of recent financing

Finance - Cambrex reports loss of $5.26 per share

Finance - Cel-Sci raises $1M in new equity

Finance - Cell Genesys reports net income of $19.1 million

Finance - Ciphergen reports Q4 revenue of $6.6

Finance - Clinical Data reports third-quarter revenues of $19.9 million

Finance - CryoCor reports 2005 revenues of $843,000, provides 2006 guidance

Finance - Cutera achieves record revenue and earnings growth, reports Q4 revenues of $24M

Finance - Exelixis announces Q4 losses of $24.5 million

Finance - Express Scripts reports record fourth-quarter net income of $111 million

Finance - Gen-Probe reports Q4 net income of $16.8 million

Finance - ISTA Pharmaceuticals posts $0.41 per share loss

Finance - Immtech reports loss of $0.35 per share

Finance - Incyte reports loss of $0.33 per share

Finance - Laserscope reports Q4 2005 record revenues up 19% over year ago to $35 million

Finance - Lexicon Genetics reports 23% annual revenue growth for 2005

Finance - Matrixx Initiatives announces net sales of $44 million for fourth quarter

Finance - Memory Pharmaceuticals reports net loss of $3.6 million for quarter

Finance - Mesothelioma Applied Research Foundation awards nearly $1 million for research aimed at a cure

Finance - Monogram announces revenue of $12.7 million for the fourth quarter

Finance - Onyx Pharmaceuticals reports net loss of $38.4 million for fourth quarter

Finance - PPD reports net revenue of $274.6 million for the fourth quarter 2005

Finance - PRA International announces increase in net income of 55%

Finance - Panacos reports net loss of $8.3 million or $0.17 per share

Finance - Pharmaceutical company reports Q4 2005 revenue up 42% to $213.9 million over year ago

Finance - Pharmacopeia announces revenues of $5.6 million for quarter

Finance - Pharmion Corporation announces sales of $221.2 million in 2005

Finance - PolyMedix raises $21 million in equity financing

Finance - Quigley increases revenues to $53.7 million; net income to $3.2 million for fiscal year 2005

Finance - Repligen reports total revenue for the quarter of $2,988,000 for fiscal year 2005

Finance - Serologicals reports Q4 2005 revenue up 26%, pro forma net income up 75.1%

Finance - Tapestry Pharmaceuticals reports Q4 2005 net loss from continuing operations of $3 million

Finance - Tercica reports Q4 2005 net loss of $14.4 million compared to $11.2 million in Q4 2004

Finance - U.S. CMS awards $993,000 to Ohio groups to study impact of e-prescribing of medications

Finance - US Oncology reports revenue of $665 million for Q4 2005, $2,518.6 million for full year

Finance - United Therapeutics reports that 2005 full-year revenues grew to $115.9 million

Finance - Watson Pharmaceuticals reports Q4 2005 net revenues down 1% to $418.8 compared to year ago

Fitness & Wellness - Aerobic exercise training raises skeletal muscle protein turnover in healthy adults at rest

Gastric Cancer - Gastric cancer may be suppressed by reversion-inducing-cysteine-rich protein with Kazal motifs

Gastric Cancer - Gastric cancer patients had favorable outcome after mosapride citrate therapy

Gastric Cancer - Outcomes with laparoscopic stage M1, unresected gastric adenocarcinoma reviewed

Gastroenterology - Myofibroblasts play a role in prostaglandin-induced intestinal activity

Gastrointestinal Stromal Tumors - Researchers describe findings in gastrointestinal stromal tumors studies

Generic Drug Trends - Report: Denmark has one of the largest rates of generic penetration in Europe

Generic Drugs - Par Pharmaceutical begins shipment of generic Flonase

Generic Drugs - Ranbaxy enjoined by Finnish court from marketing generic Lipitor

Generic Drugs - Tentative U.S. FDA approval of generic equivalent of acid pump inhibitor Aciphex announced

Generic Drugs - USAN and WHO approve generic name of sexual dysfunction drug bremelanotide

Genetics & Genomics - A novel mutation at the JK locus causes Jk(Null) phenotype

Genetics & Genomics - GenomeQuest adopted by Chiron, says Gene-IT

Genetics & Genomics - Post-transcriptional signals yield macrophage VEGF

Gorham-Stout Syndrome - Gorham-Stout syndrome is propelled by angiogenic and osteoclastogenic molecules

Graft-vs-Host Disease - Positive new survival findings from phase II, III orBec trials presented by DOR BioPharma

Gynecology - Research add new data to gynecology body of knowledge

HIV/AIDS Adverse Drug Reactions - Adverse events are most common reasons for generic HAART modification in Southern India

HIV/AIDS Diagnostics - Genotypic and phenotypic clinical cut-off levels determined for ritonavir-boosted saquinavir

HIV/AIDS Diagnostics - HPLC-MS/MS simultaneously quantifies seven protease inhibitors in plasma

HIV/AIDS Diagnostics - Simple and accurate diagnostic tools monitor HIV infection

HIV/AIDS Drug Development - Findings describe new data in HIV/AIDS drug development research

HIV/AIDS Drug Interaction - Lopinavir/ritonavir and valproic acid interaction may exacerbate bipolar disorder

HIV/AIDS Drug Resistance - Infant-only prophylaxis eliminates nevirapine resistance development in mothers and infants

HIV/AIDS HAART - Calculations of creatinine clearance and anion-gap related to tenofovir therapy are minor

HIV/AIDS HAART - New findings in the area of HIV/AIDS HAART described

HIV/AIDS HAART - New findings in the area of HIV/AIDS HAART detailed

HIV/AIDS HAART - Poor HAART adherence and an increased drug resistant HIV-1 strain in China related

HIV/AIDS Molecular Structure - Rous sarcoma virus virions contain fewer copies of Gag than HIV-1

HIV/AIDS Pathogenesis - HIV-1 Vpr induces ATR activation by targeting host cell DNA

HIV/AIDS Pathogenesis - Uracil DNA glycosylase is dispensable for HIV-1 replication

HIV/AIDS Pharmacokinetics - Interpatient variability in plasma efavirenz levels determined by gender and race

HIV/AIDS Prognosis - Despite moderate HIV viremia, clinical progression risk is low

HIV/AIDS Research - Monogram and Merck collaborate on phase III trials of HIV-1 integrase inhibitor

HIV/AIDS Research - Progenics Pharmaceuticals HIV drug, PRO 140, receives U.S. FDA fast-track designation

HIV/AIDS Research - Tanox research reaffirms tropism independence of TNX-355 for HIV

HIV/AIDS Testing - Chembio's rapid HIV test selected by Nigeria

HIV/AIDS Therapy - HIV/malaria therapies given concurrently during pregnancy may prove incompatible

HIV/AIDS Therapy - Medivir designates a clinical candidate drug for HIV/AIDS

HIV/AIDS Transmission - Nevirapine dose timing is important to insure adequate serum concentration in infants

HIV/AIDS Treatment - HIV management complex in elderly due to drug interactions from comorbid conditions

HIV/AIDS Treatment & Prevention - United Nations supports and strengthens the response to AIDS in China

HIV/AIDS Vaccine - International AIDS Vaccine Initiative brings new science and technology to the poor

HIV/AIDS Vaccines - Recent studies add new data to HIV/AIDS vaccines research

HIV/AIDS Vaccines - Researchers report details of new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Related CNS Lymphoma - Ganciclovir related to low or undetectable EBV DNA in CSF of AIDS-related CNS lymphoma

HIV/AIDS-Related Immune Reconstitution Syndrome - Immune reconstitution syndrome common in children receiving HAART during advanced AIDS

Head & Neck Cancer - Angiogenesis inhibitor helps radiotherapy treat oral squamous cell carcinoma

Head & Neck Cancer - Complementary and alternative medicine use in European head and neck cancer patients investigated

Head & Neck Cancer - Vaccinia virus expressing IL-2 elicits immunity in head and neck cancer model

Healthcare Costs - Diabetic nephropathy to ESRD prevention involving losartan-based treatment may reduce cost

Healthcare Costs - Economic impact of acute ischemic stroke highlighted in new study

Healthcare Coverage - MinuteClinic becomes participating provider with MedCost in North Carolina

Heart Disease - Statins, beta-blockers lessen heart attack risk, says Stanford-Kaiser study

Heart Failure - Decompensated heart failure with preserved ejection fraction shows poorer outcome with conduction defect

Helicobacter Pylori - H. pylori reduces secretory leukocyte protease inhibitor levels in gastroduodenal mucosa

Hematology - Platelets promote angiogenesis but thwart hemorrhage

Hematology - Researchers' work adds to hematology body of knowledge

Hepatitic C Virus - Severe HBV liver disease is treatable with interferon-alpha-ribavirin-interleukin-2

Hepatitis A Virus - CD4 count and gender predicts response to HAV vaccine in HIV-positive patients

Hepatitis B Virus - HBV DNA levels predict nonresponse in chronic HBe-antigen positive patients

Hepatitis B Virus - HBV isolates in Mexico display genotypic resistance to lamivudine

Hepatitis C Therapy - Phase II clinical study of Actilon for hepatitis C initiated by Coley

Hepatitis C Virus - Hydrazones and derived ring systems may display antitumor and anti-HCV activity

Hepatitis C Virus - Intracellular hepatitis C RNA in the virus core protein coding region is cleaved

Hepatitis C Virus - Macrocyclic inhibitors potently inhibit hepatitis C virus NS3 protease

Hepatitis C Virus - Translation efficiency correlates with therapy outcome in chronic HCV infection

Hepatitis C Virus - Volunteer blood donors with hepatitis C experience a worse quality of life

Hepatitis Coronavirus - Coronavirus is redirected to a nonnative receptor via a targeting adapter

Herpes Vaccine - Herpes simplex virus ocular infection is prevented by T cell chimeric epitopes

Hormones - 17beta-estradiol suppresses TLR3-induced cytokine and chemokine production

Hormones - Researchers detail new studies and findings in the area of hormones

Human Metapneumovirus - Chimeric recombinant human metapneumovirus immunogenic and protective

Huntington Disease - Systems cell biology profile of Huntington disease to be created by Cellumen, CHDI

Hyperprolactinemia - Prolactin suppresses GnRH but not TSH secretion in hyperprolactinemia

Hypertension - Hypertension is transient after surgical closure of an abdominal wall defect

Hypertension - In isolated systolic hypertension, indapamide shows distinctive pulse pressure reduction effect

Hypertension - In moderate hypertension, telmisartan is more effective than ramipril to reduce blood pressure

Hypertension - Major cardiovascular event risk is directly related to degree of blood pressure lowering

Hysteroscopy - Endometrial thinning prior to hysteroscopy may be achieved with oral contraceptives

Imaging - Coronary artery disease identification may be more effective with addition of BMIPP to T1-201 imaging

Imaging - North American Scientific receives Chinese approval of image-guided radiation therapy equipment

Imaging - The contrast agent HE-24.8 detects tumor vessels in magnetic resonance angiography

Immunizations - Call for pertussis vaccination for healthcare workers endorsed by NFID

Immunology - IL-IM subunits within the IL-17R complex undergo conformational change upon ligand binding

Immunotherapy - Dendritic cells are regulated by physiologically relevant thermal stress

Immunotherapy - Heat shock proteins HSP70 and GP96 are focus of review

Immunotherapy - Transfection with cytokine may have limited long-term effectiveness

Immunotherapy - U.S. CDC committee recommends inclusion of Rotateq in Vaccines for Children Program

Infectious Diseases - Despite flu concerns, HIV, hepatitis most important viral infections to drug developers

Infectious Diseases - Pneumococci with mef and erm macrolide resistance determinants is reported in an American city

Inflammatory Bowel Disease - Exclusive worldwide rights to Simulect for inflammatory bowel disease licensed to Cerimon

Influenza - Haemophilus influenzae antimicrobial susceptibility is reported in Brazil

Influenza - Novartis and Alnylam announce collaboration to develop RNAi Therapeutics for pandemic flu

Influenza Vaccine - Proteosome-influenza vaccine induces influenza antibodies in humans

Information Technology - Enhanced software for drug-target discovery, safety assessment launched by Gene Logic

Information Technology - Frost & Sullivan study finds shift to electronic technologies in drug discovery industry

Information Technology - Health insurer signs letter of intent to provide electronic prescribing software to physicians

Information Technology - License with Johnson & Johnson expanded to include GeneGo's MetaBase access

Information Technology - MediQuest Therapeutics chooses TranSenda to deploy clinical trial portal

Information Technology - Online personal health record service to provide secure medication histories and updates

Information Technology - Pharmedium launched enhanced bar coding for syringe admixture services

Information Technology - U. S. FDA, Leadscope, Inc. sign cooperative R&D agreement for toxicity databases

Information Technology - U.K. regulatory agency implements pharmacovigilance signal detection and signal management product

Ischemia - In ischemia, enhanced NO may balance ATP supply/demand and protect cells from reperfusion injury

Keratoacanthoma - Case of giant keratoacanthoma of the eyelid reported

Kidney Transplantation - HHV8 prevalence is low in renal donors and recipients in Greece

Legal Issues - California group launched to support medical marijuana

Legal Issues - Takeda wins patent infringement case against ANDAs for generic pioglitazone HCl

Legal Issues - Third Wave, Chiron and Bayer dismiss without prejudice hepatitis C virus patent lawsuit

Lethal Radiation - Novelos Therapeutics submits proposal to treat subjects exposed to lethal radiation

Leukemia - Apoptosis of leukemia cells induced by mycotoxin citrinin

Leukemia - Chronic lymphocytic leukemia linked to CpG island methylation

Leukemia - Human T-cell leukemia virus oncoprotein inhibits Fas-mediated apoptosis

Leukemia - Scoring system to distinguish elderly leukemia patients with different prognosis proposed

Leukemia Therapy - Clinical benefit analysis of Genasense plus chemotherapy reported

Limb Allograft - Limb allograft survival prolonged by donor leukocytes and delayed immunosuppressive therapy

Lipid Research - Myeloperoxidase-mediated oxidation of HDL yields markers for atherosclerosis

Liver Cancer - Liver cancer metastasis receives a boost from macrophage inflammatory protein-2

Liver Cancer - Paclitaxel-loaded nanoparticles target drug delivery in liver cancer

Lung Cancer - Adjuvant chemotherapy for non-small cell lung cancer discussed

Lung Cancer - First-line treatment regimens for elderly patients with lung cancer compared

Lung Cancer - Introgen reports positive results from phase II trial of INGN 225 for advanced lung cancer

Lung Cancer - Lung cancer patient response to chemoradiotherapy predicted by FDG-PET

Lung Cancer - Lung cancer suppressed by SC-560

Lung Cancer - New data illuminates research in lung cancer

Lung Cancer - Non small cell lung cancer survival improved in a selected population

Lung Cancer - Start of trial to evaluate drug eluting bead in lung cancer announced

Lymphangioleiomyomatosis - Clinical and molecular insights into lymphangioleiomyomatosis reviewed

Macroadenomas - Macroadenomas treated by octreotide long-acting repeatable

Market Analysis - New rheumatoid arthritis drugs may push biologics above traditional therapies, report says

Marketing - Health Canada grants regulatory clearance for marketing of skin tightening system

Marketing - Qiagen and ActiveSight sign comarketing agreement targeting protein crystallography

Medical Devices - Alfa Laval Biokinetics delivers CytoGenix DNA production module

Medical Devices - Boston Scientific announces French reimbursement for Taxus Liberte stent

Medical Devices - MD Turbo device may help asthma sufferers

Medical Devices - New investigational procedure for asthma studied at Brigham and Women's Hospital

Medicare Drug Benefit - Researchers find deeper-than-expected discounts in Medicare drug benefit

Medulloblastomas - Adolescents with medulloblastoma followed a distinctive clinical course

Medulloblastomas - Medulloblastoma can be treated by fenretinide

Melanoma - Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Melanoma Therapy - SPA from U.S. FDA for Delcath system with melphalan received by Delcath

Meningitis Vaccines - Researchers' findings advance meningitis vaccines research

Menopause - Menopausal symptoms appear to be relieved by new oral estradiol therapy

Menopause - Soybean phytoestrogens may have very limited benefit on bone health

Mental Health - Clinical depression may be associated with higher risk of out-of-hospital cardiac arrest

Mental Health - Depression treatment in coronary artery disease trial is announced

Mergers & Acquisitions - Allergan extends expiration date of Inamed exchange offer

Mergers & Acquisitions - Andara Life Science to be acquired by Cyberkinetics Neurotechnology

Mergers & Acquisitions - Aptuit ramps up investment in India with acquisition of IT company

Mergers & Acquisitions - BCY LifeSciences and Pipex Therapeutics discuss merger

Mergers & Acquisitions - GlaxoSmithKline purchases Pliva research and development arm

Mergers & Acquisitions - Nastech acquires RNAi therapeutics program from Galenea

Mergers & Acquisitions - OncoVista acquires controlling interest in AdnaGen AG

Mergers & Acquisitions - PLIVA's Research Institute acquired by GlaxoSmithKline

Mergers & Acquisitions - ReGen to acquire Sciencom Limited

Mergers & Acquisitions - Targeted Molecules to be acquired by Chromos; financing commitments secured

Mergers & Acquisitions - Walgreens Home Care to acquire Oklahoma City-based Canadian Valley Medical Solutions

Mesothelioma - Mesothelioma patients treated early with chemotherapy had survival advantage

Metabolic Diseases - Pharmacopeia and Biovitrum discover compounds targeting novel kinase involved in metabolic diseases

Metabolic Syndrome - Propanoic acid derivatives are a potential treatment for metabolic syndrome

Multiple Myeloma - Multiple myeloma treated with bendamustine and prednisone

Multiple Myeloma - Orphan status for GPC's anticancer monoclonal antibody recommended by EMEA committee

Multiple Sclerosis - Clinical studies of Tysabri (natalizumab) for MS treatment allowed to resume by U.S. FDA

Myelodysplastic Syndromes - National Comprehensive Cancer Network announces updates to myelodysplastic syndromes guidelines

Myocardial Infarction - In patients with myocardial infarction, N-acetylcysteine diminished oxidative stress, improved LV function

Myocardial Infarction - Mitral regurgitation after myocardial infarction is reviewed

Nanotechnology - Functionalized nanoparticles may be a useful drug carrier for tumor targeting

Natural Products - Antidiabetic activity observed in alcohol extract of Pterocarpus marsupium

Natural Products - Essiac tea possesses antioxidant and DNA-protective activity

Nephrology - Tailoring fluid replacement and anticoagulation therapy increases metabolic control

Neuroendocrine Tumors - Tumor uptake in neuroendocrine tumors enhanced with I-131-labeled metaiodobenzylguanidine

Neurology - 4-hydroxynonenal may result in increased levels of intracellular zinc

Neurology - Crosstalk occurs between GTPases in mediating the effects of BDNF on retinal growth cone motility

Neuroscience - Anti-conflict effects of benzodiazepines and therapeutic doses evaluated

Neuroscience - Calpain-regulated p35/ccdk5-mediated inactivation plays a role in dopaminergic loss

Neuroscience - Corticotropin-releasing factor and urocortin have different influences on postsynaptic density

Neuroscience - Erythropoietin enhances neuroprotection against ischemia and reperfusion injury

Neuroscience - Methamphetamine and dopamine differentially affect transporter-mediated efflux

Neuroscience - Neurogenesis and post-stroke recovery relies on erythropoietin receptor

Neuroscience - Reports add new data to neuroscience research

Neuroscience - Reports advance knowledge in neuroscience research

Neuroscience - Researchers detail new studies and findings in the area of neuroscience

Newcastle Disease - Recombinant Newcastle disease virus vector protects against respiratory syncytial virus

Non-Hodgkin Lymphoma - Certain autoimmune disorders and risk of NHL have associations

Nosocomial Infections - Pfizer receives U.S. FDA approval for Eraxis to treat candidemia

Obesity Epidemiology - Anthropometric body fat composition reference values determined for Spanish youth

Obesity Management - Americans, Michiganders weigh in on child obesity

Obesity Research - Obesity-targeting drug moving forward; Glenmark expects to file for phase I by May 2006

Obesity Therapy - Bariatric surgery with gastric banding model developed in rats

Obesity Therapy - Laparoscopic gastric banding does not affect esophageal motility in the short-term

Obesity Therapy - Pioglitazone increases nonesterified fatty acid clearance in upper body obesity

Obesity Therapy - Weight loss produced by orlistat reduced the incidence of diabetes

Obstetrics - American Fertility Association releases U.S. HHS-funded brochures on embryo donation

Obstetrics - Decidual angiogenesis is driven by cytokine-stimulated fibroblasts

Obstetrics - Postpartum hemorrhage treatment with misoprostol may be viable therapy in remote areas

Obstetrics - Preeclampsia is detected by low levels of angiogenesis factor in urine

Oncology - Complications in cancer patients with central venous catheters were not prevented with dalteparin

Oncology - Findings in oncology provide new insights

Oncology - Heparanase involvement in melanoma metastasis is shown by a brain slice model

Oncology - Melanoma progression may correlate with tumor lymphangiogenesis

Oncology - Recent findings in oncology described

Oncology - Researchers publish new studies and findings in the area of oncology

Ophthalmology - Antiangiogenesis molecules reveal diffusion after transscleral delivery

Ophthalmology - Choroidal angiogenesis may increase in response to connective tissue growth factor

Ophthalmology - Choroidal neovascularization is amplified by a complement factor H variant and smoking

Ophthalmology - Corticosteroids advised in cases of vestibulocochlear symptoms, retinal perivasculitis

Ophthalmology - Endostatin downregulates angiogenesis signals in retinopathy models

Ophthalmology - Novartis licenses to co-promote intravitreal drug implant for eye condition

Ophthalmology - Survey shows consumers prefer eye care provider with medical degree for eye surgeries

Oral Health - Pharmacologist receives 510(k) clearance to market Sucralfate HCl Topical Paste for oral lesions

Oral Mucositis - Phase II results on velafermin for the prevention of oral mucositis announced by CuraGen

Orthopedics - Recombinant human BMP-7 prevents non-union in both young and old rats

Orthopedics - Study confirms not all chondroitin sulfates are the same

Osteoporosis - Bisphosphonate antifracture therapy efficacy may be predicted by elevated bone turnover

Osteoporosis - Combination osteoporosis therapy addresses bone loss and new bone formation

Osteoporosis - Denosumab therapy shown to increase bone mineral density in women with osteoporosis

Osteoporosis - Hip fracture incidence appears to be reduced by antiresorptive bisphosphonates

Ovarian Cancer - Bcl-X-L is functionally non-equivalent for ovarian cancer cell regulation

Ovarian Cancer - Impact of age on outcome in advanced ovarian cancer evaluated

Ovarian Cancer - Ovarian cancer inhibited by 9-methoxy-2-methylellipticinium acetate

Ovarian Cancer - Ovarian cancer invasion and migration are stimulated by matrix enzyme and VEGF

Ovarian Cancer - Ovarian cancer patients did not benefit beyond six cycles of platinum-taxane therapy

Ovarian Cancer - Ovarian cancer prognosis predicted by glutathione S-transferase polymorphisms

Ovarian Cancer - Ovarian cancer therapy with pegylated liposomal doxorubicin has good tolerability

Ovarian Cancer - Ovarian cancer treated by abraxane

Ovarian Cancer - Ovarian cancer treated by weekly dosing of irinotecan

Overactive Bladder - Antares Pharma announces positive Anturol phase II trial results for overactive bladder

Pain Management - Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia

Pain Management - Glucosamine and chondroitin relieve osteoarthritis pain, U.S. NIH-sponsored trial shows

Pain Management - Once daily Ultram ER tablets now available in the United States

Pain Management - Pain immediately after hysterectomy was not relieved by gabapentin

Pancreatitis - Curcumin reversed lipid peroxidation of tropical pancreatitis without reducing pain

Parkinson Disease - Preliminary results shows creatine, inocycline warrant further study in Parkinson disease

Patents - Alexion issued key patent for eculizumab in Japan

Patents - Arachnova portfolio strengthened with new patents for MCI-225

Patents - Barr summary judgment affirmed by federal court in DDAVP patent challenge

Patents - European appeals board affirms p53 therapy patent following opposition by Schering-Plough

Patents - New patent issued to Entremed covering analogs of its lead compound, 2-methoxyestradiol

Pediatric Dermatitis - Vusion ointment for diaper dermatitis complicated by candidiasis approved by U.S. FDA

Pediatric Vaccine - Hepatitis A vaccination was successfully targeted to high-risk children

Pediatrics HIV/AIDS Risk Factors - Infants perinatally infected with HIV at risk from BCG vaccination

Peripheral Artery Disease - Peripheral arterial disease medical treatment is focus of review

Personnel - ARYx Therapeutics appoints Herm Rosenman to board of directors

Personnel - Abe Jacob named national director of development for TGen Foundation

Personnel - AcuNetx taps David Hanke to become senior VP of sales

Personnel - Akorn names David White vice president, new product development

Personnel - Anadys Pharmaceuticals names Michael Adam, PhD, as SVP of development operations

Personnel - Antares Pharma names Robert F. Apple senior VP and chief financial officer

Personnel - Athenagen adds A. Barr Dolan to its board of directors

Personnel - Avalon Pharmaceuticals appoints William H. Washecka to its board of directors

Personnel - Benitec appoints two new directors

Personnel - Bret Berner, PhD, promoted to chief scientific officer by Depomed

Personnel - CEO John L. Armstrong, Jr., elected to Genaera's board of directors

Personnel - Conforma Therapeutics names John E. Crawford to chief financial officer

Personnel - CytoDyn board restructured for anticipated growth; Allen D. Allen re-elected chair

Personnel - David Cade, MD, named medical director for U.S. operations by cancer-focused Sirtex

Personnel - David Carlucci named chairman, CEO, and president of IMS Health; David Thomas to retire

Personnel - Douglas Hamilton to step down as COO/CFO of Javelin Pharmaceuticals

Personnel - Dr. Donald Leung named to Ceragenix scientific advisory board

Personnel - Gerald Fink, PhD, joins Glycofi scientific advisory board

Personnel - Innovative Biosensors adds Phil Samper to board of directors

Personnel - Joseph M. Spagnardi promoted to VP, general counsel, secretary of pharmaceutical company

Personnel - Neuro-Hitech Pharmaceuticals appoints Mark Auerbach as chairman of the board of directors

Personnel - Perrigo company names Ran Gottfried as new board member

Personnel - Peter Licari, Pieter Timmermans named to biopharmaceutical company management team

Personnel - Point Therapeutics adds Charles Dinarello and Antonio Grillo-Lopez as advisors

Personnel - Progen Industries names Justus Homburg as chief executive officer

Personnel - RegeneRx adds L. Thompson Bowles, MD, PhD to board of directors

Pharmaceutical Research - Calcium lactate pentahydrate and its anhydrate follow a three-dimensional diffusion model

Pharmaceutical Research - Cutting Edge Information report examines the way pharma companies fight against generics

Pharmaceutical Research - Melanoma angiogenesis models display a significant response to PEGylated interferon

Pharmaceutical Research - Moxifloxacin kills S. pneumoniae faster than other antibiotics

Pharmaceutical Research - Recombinant antithrombin inhibits thrombin formation and interleukin release in endotoxemia

Philanthropy - Eli Lilly announces philanthropy in 2005 exceeded $500 million

Philanthropy - Pfizer announces new class of global health fellows

Physiology - Paracellular transport in Calu-3 cell layers is enhanced by Carbopol

Pneumonia - Community-acquired pneumonia effectively treated with azithromycin therapy

Preeclampsia - Hypertensive encephalopathy may arise from circulating growth factor in preeclamptic women

Pregnancy Termination - Preabortion psychological distress is reduced after abortion procedure

Product Licensing - Cambrex licenses cell line to Chugai Pharmaceutical Co.

Product Licensing - Erectile dysfunction treatment licensed to Plethora Solutions for North America

Product Licensing - License agreement announced to develop intranasal epinastine for rhinitis in U.S., Canada

Product Licensing - MNLpharma announces license agreement with Avexa to develop compounds to treat HIV/AIDS

Product Licensing - UCB licenses U.S. patents for antihistamine levocetirizine from Sepracor

Professional Education - AAMC task force to examine health industry influence on medical education

Prostate Cancer - Apoptosis in hormone-resistant prostate cancer was induced by Alisol B acetate

Prostate Cancer - Authorization to produce prostate cancer tracer received by Eckert & Ziegler

Prostate Cancer - Dosimetry and acute toxicity in prostate cancer patients treated with hypofractionation studied

Prostate Cancer - Prostate cancer prevented by oral administration of green tea catechins

Prostate Cancer - Studies add new findings to prostate cancer body of knowledge

Prostate Cancer - Unfolded protein response enhanced anticancer activity of selenium in prostate cancer

Proteomics - Avid Biotics obtains license to University of California's protein scaffold technology

Proteomics - Cambrex introduces Versalinx reagents for improved protein samples in drug discovery

Proteomics - LTBP-1 blockade in embryo fibroblasts decreases TGF-beta activity

Proteomics - Leucine regulates translation initiation of protein synthesis in muscle after exercise

Proteomics - Molecular elements help suramin inhibit fibroblast growth factor

Proteomics - Nucleoside transport in rabbit tracheal epithelial cells is described

Proteomics - Proteins governing angiogenesis and bone growth interact during osteoclastogenesis

Proteomics - Recent findings in proteomics provide new insights

Proteomics - Septin protein is linked to angiogenesis through hypoxia-inducible factor-1

Psoriasis - CRx-140 as an oral product candidate for psoriasis discontinued by CombinatoRx

RNA Research - siRNA silences Fas expression and inhibits Fas-mediated apoptosis

Radiation Therapy - Two dosimeters should be used for each site of interest in total body irradiation

Rectal Cancer - Rectal cancer treated by capecitabine in combination with preoperative radiation

Renal Therapy - Fibrin microbeads provide a 3D platform for kidney gene and cell therapy

Restructuring - Information on company's restructuring plans provided by CryoCor

Rheumatoid Arthritis - Rigel completes R788 plus methotrexate interaction study for rheumatoid arthritis

Rotavirus - Children's Hospital of Philadelphia includes rotavirus vaccine in infant immunization schedule

Rotavirus Vaccine - Rotavirus vaccine clinical trials in Europe are focus of review

SARS - Transmembrane domain of SARS coronavirus spike protein functions during entry

Sexual & Reproductive Health - Hypothyroidism treated with thyroxine is not associated with adverse perinatal outcome

Smallpox Vaccine - Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling

Smallpox Vaccines - Findings describe new data in smallpox vaccines research

Smallpox Vaccines - New findings in smallpox vaccines described

Sociology Research - Physician perceptions of patients' social characteristics are predictive of healthcare recommendations

Spermatogenesis - Transcription factors may mediate testicular response to reduced androgen

Spinal Cord Injury - Chronic spinal cord injury induced changes in the responses of thalamic neurons

Squamous Cell Carcinoma - Rac1 maintains malignant phenotype of mouse skin tumor cells

Squamous Cell Carcinoma - Squamous cell carcinoma antigen 1 functions as a biomarker in tongue cancer

Statins - New research in the area of statins detailed

Statins - Recent findings in statins provide new insights

Statins - Recurrent myocardial infarction, mortality are similar for immediate or delayed statin therapy post-MI

Stem Cell Engraftment - Cardiac function improved via engraftment of enriched embryonic stem cells and other medication

Stem Cell Research - Aldagen, Texas Heart Institute begin study of stem cell therapy for heart failure patients

Stem Cell Research - Oncolytics: Cancer cells purged from post-chemo stem-cell transplants by Reolysin

Stroke - Almost 70% of ischemic stroke patients had blood flow restored in Merci Retriever multicenter trial

Stroke - CardioVascular BioTherapeutics discusses advances in drug development program

Stroke - FG-4539 is neuroprotective and significantly reduces brain tissue damage, says FibroGen

Stroke - Few stroke patients get to hospital in time for treatment

Stroke - Reports add new data to stroke research

Stroke - Stroke spastic drop foot improves with low-dose Botox and short electrostimulation

Substance Abuse Treatment - Women's substance abuse treatment programs may have inherent design flaws

Surgical Technology - Drug-eluting stents for ostial de novo left anterior descending lesions show decreased restenosis

Surgical Technology - Rapamycin-eluting stents for coronary bifurcation lesions underexpand without restenosis impact

Systemic Lupus Erythematosus - A generalized vesiculobullous eruption can be the sole presenting manifestation of SLE

Systemic Lupus Erythematosus - In SLE, anti-CD40L autoantibody is associated with thrombocytopenia, not thromboembolism

Thyroid Disorders - Restoration of thyroid function improves quality of life and psychological symptoms

Toxicology - Angiogenesis is modified by polychlorobiphenyl interactions with estrogen receptors

Transfusion Medicine - In pediatric cardiac surgery, hydroxyethyl starch is a safe alternative for volume replacement

Transgenics - A virus-neutralizing antibody is not cytotoxic in vitro

Transplant Medicine - PEGylation, immunosuppressive agent cocktail makes for successful islet transplantation

Transplantation Biology - Hepatitis C virus antigen detected in cholestatic hepatitis after liver transplantation

Tuberculosis Therapy - Rifampin/pyrazinamide causes severe liver injury in tuberculosis patients

Tuberculosis Vaccine - Tuberculosis vaccine efficacy is affected by BCG strain and delivery route

Type 2 Diabetes - Arteries showed decreased myogenic tone after high glucose exposure

Type 2 Diabetes - Receiving higher sulfonylurea drug exposure increases mortality rate for diabetics

Vaccines Adjuvant - Findings advance knowledge in vaccines adjuvant research

Vancomycin-Resistant Enterococci - Epidemic-virulent clonal complex-17 strains of E. faecium increasing in German hospitals

Vector Development - Histidinylated cationic transfection lipids may function as transfection vectors

Virology - Adenovirus virus-associated RNA is processed to functional interfering RNAs

Virology - New research in the area of virology detailed

Virology - The angiogenesis of ocular herpes simplex virus infection involves interleukin-6

Wegener Granulomatosis - Wegener granulomatosis often diagnosed if destruction of the maxillary sinus' medial wall is found

Wound Care - Nitric oxide reduces the microbial burden in healing wounds

Zollinger-Ellison Syndrome - Zollinger-Ellison syndrome patients studied

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