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Adverse Drug Reaction
Valproate lowers glucose and raises insulin, cortisol, leptin, and neuropeptide Y levels
March 24th, 2006
Valproate lowers glucose and raises insulin, cortisol, leptin, and neuropeptide Y levels in epileptic children. According to a study from Turkey, "Weight gain is a common side effect of valproate treatment. The potential mechanisms of valproate-associated weight gain are not yet clear. Decreased blood glucose level, impairment of P-oxidation of fatty acids, and increased insulin levels are some of the possible mechanisms. The aim of the present study is to evaluate the role of insulin, leptin, and neuropeptide Y in valproate-related weight gain in epileptic children." K. Aydin and colleagues at Selcuk University explained, "In 20 epileptic children...
Source: Drug Week (2006-03-24)
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