Drug Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Apoptosis
Antimonial compounds may work by disrupting thiol homeostasis
March 24th, 2006
Antimonial compounds may work by disrupting thiol homeostasis. According to recent research published in the journal Biochemical Pharmacology, "Trivalent antimonial compounds (Sb-III), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukemia (APL). Here, we examine the effects of Sb-III and pentavalent antimonial drugs (Sb-v) on glutathione homeostasis, oxidative stress and apoptosis in the human leukemia monocyte cell line, THP-1. Although growth of THP-1 macrophages is unaffected by Sb', macrophages are extremely sensitive to Sb-III." S. Wyllie and colleagues from the...
Source: Drug Week (2006-03-24)
|
