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Alzheimer Disease
Metallothionein-3 and neuronal nitric oxide synthase found reduced in Alzheimer disease
March 24th, 2006
According to recent research from the United States, metallothionein-3 (MT3) and neuronal nitric oxide synthase (nNOS) are reduced in a mouse model of Alzheimer disease. "Using antiserum against the recombinant isoform 3 of mouse brain MT3, the amount of MT3 protein was determined in whole brain homogenates from the Tg2576 transgenic mouse model of Alzheimer disease. Twenty-two month old transgenic positive mice showed a 27% decrease of MT3 normalized to the total protein in the extracts compared to same age, control transgenic negative mice," wrote B.L. Martin and colleagues, University of Minnesota. They explained, "Metallothioneins bind seven...
Source: Drug Week (2006-03-24)
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