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Alzheimer Disease
Timing and duration of administration are important to optimize cholinergic Alzheimer disease treatment
March 24th, 2006
Timing and duration of administration are important to optimize cholinergic Alzheimer disease (AD) treatment. According to recent research published in the journal Dementia and Geriatric Cognitive Disorders, "Therapies for AD at present augment the deteriorating cholinergic system, are reasonably well tolerated, and are convenient, given once or twice a day. They may, however, support or oppose endogenous circadian cholinergic rhythms." B. Davis and colleagues, Synaptec, wrote, "Drugs with a duration of action longer than a day are at odds with the physiology of the cholinergic system, which is active during the day and quiescent at night....
Source: Drug Week (2006-03-24)
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