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Angiogenesis
Angiogenesis is inhibited by thrombospondin targeting of type I collagen
March 24th, 2006
According to recent research from the United States, type I collagen is a molecular target for inhibition of angiogenesis by endogenous thrombospondin-1 (TSP-1). "Three-dimensional explant cultures of muscle tissue were used to characterize secreted proteins regulated by endogenous levels of the angiogenesis modulator TSP-1," wrote L. Zhou and colleagues, U.S. National Cancer Institute. "Explants from TSP1 null mice exhibit enhanced neovascularization associated with increased endothelial outgrowth but decreased outgrowth of perivascular smooth muscle cells. The absence of endogenous TSP1 did not diminish activation of latent transforming growth...
Source: Drug Week (2006-03-24)
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