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Angiology
Endothelium-independent vasorelaxation is induced by protamine sulfate via NO synthase pathway
March 24th, 2006
Protamine sulfate causes endothelium-independent vasorelaxation via inducible nitric oxide synthase pathway. According to a study from Japan, "The precise mechanism of systemic hypotension frequently observed with the use of protamine is unclear. Although it has been reported that protamine stimulates the release of nitric oxide (NO) from endothelium NO synthase (eNOS), the association with inducible NOS (iNOS) remains unknown, despite the induction of iNOS by lipopolysaccharides (LPS) and/or inflammatory cytokines during cardiopulmonary bypass (CPB)." "The purpose of this study," wrote K. Takakura and colleagues at Asahi University in Mizuho," was...
Source: Drug Week (2006-03-24)
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