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Angiology
Tissue factor expression in cultured endothelial and smooth muscle cells is induced by nicotine
March 24th, 2006
Nicotine induces tissue factor expression in cultured endothelial and smooth muscle cells. Investigators working in Italy report, "Cigarette smoking is associated with an increased risk to develop myocardial infarction and ischemic stroke. However, the mechanisms responsible for these effects are still poorly understood." According to P. Cirillo and colleagues at the University of Naples, Federico II, the aim of their study was "to investigate whether nicotine, the major component of cigarette smoking, and its main metabolite, cotinine, might induce a pro-thrombotic state via stimulation of tissue factor (TF) expression in two cell populations widely...
Source: Drug Week (2006-03-24)
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