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Drug Delivery
Rapamycin delivery via PEG-PCL micelles characterized
March 24th, 2006
Rapamycin release after encapsulation in PEG-PCL micelles has been characterized in vitro. In a recent study from the United States, "an injectable formulation of rapamycin was prepared using amphiphilic block copolymer micelles of poly(ethylene glycol)-b-poly(epsilon-caprolactone) (PEG-PCL)." "Drug-loaded PEG-PCL micelles were prepared by a cosolvent extraction technique," explained M.L. Forrest and coauthors at the University of Wisconsin School of Pharmacy. "Resulting PEG-PCL micelles were less than 100 nm in diameter and contained rapamycin at 7 to 10% weight and >1 mg/mL." "PEG-PCL micelles released rapamycin over...
Source: Drug Week (2006-03-24)
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