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Angiology
Tumor angiogenesis flourishes in models with TIMP-3 gene deficiency
March 24th, 2006
Angiogenesis flourishes in models with tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) gene deficiency. "Tumor cells, stromal cell compartment and the extracellular matrix (ECM) together generate a multifaceted tumor microenvironment. Matrix metalloproteinases and their TIMPs provide a means for tumor-stromal interaction during tumorigenesis," scientists in Canada report. "Among TIMPs, TIMP-3 is uniquely localized to the ECM and is frequently silenced in human cancers. Here, we asked whether the absence of TIMP-3 in the tumor cell or the host affects the process of tumorigenesis. Timp-3(-/-) ES-cell clones were generated and used to develop...
Source: Drug Week (2006-03-24)
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