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Apoptosis
Cyclin D1 overexpression induces apoptosis resistance linked to carcinoma BCL-2
March 24th, 2006
According to recent research from Venezuela, cyclin D1 overexpression induces epidermal growth factor-independent resistance to apoptosis linked to BCL-2 in human A431 carcinoma. "Overexpression of EGF receptors and constitutive cyclin D1 expression are frequently associated with human squamous carcinomas. We have now investigated whether these parameters influence susceptibility to okadaic acid induced cell death in EGF-receptor overexpressing mutant p53 A431 human carcinoma," wrote M. Rieber and colleagues, CMBC. They explained, "Exposure of these cells to 20 nM okadaic acid induced apoptosis-associated caspase 3 activation, DNA fragmentation,...
Source: Drug Week (2006-03-24)
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