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Apoptosis
Imatinib reported to induce apoptosis
March 24th, 2006
Imatinib has been reported to induced apoptosis. According to recent research published in the journal Cell, "The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis due to interleukin-3 (IL-3) deprivation and iron transport. Here we report cloning of the 24p3 cell-surface receptor (24p3R)." L.R. Devireddy and colleagues from the University of Massachusetts wrote, "Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand: Iron-loaded 24p3 increases intracellular iron concentration without promoting apoptosis;...
Source: Drug Week (2006-03-24)
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