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Atherosclerosis

Monocyte adhesion is inhibited by 17-beta-estradiol via down-regulation of Rac1 GTPase

According to a report from Germany, "Estrogens confer atheroprotective effects that remain poorly understood. We hypothesized that estrogens directly target monocytes, and investigated the pathways via which estrogens might impact on monocyte adhesion."

"In an in vitro model of the vasculature (parallel plate laminar flow chamber, 2 dynes/cm²) 17 beta-estradiol (24 h, 0.1-1 mcM) potently inhibits monocyte adhesion," wrote E.B. Friedrich and colleagues at te University Hospital of the Saarland. "In parallel, 17 beta-estradiol downregulates Rac1 GTPase activity in...

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