Drug Week
Susan Hasty, Publisher
Table of Contents . . . March 31st, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Drug Week | Other Publications
Azithromycin - Azithromycin is a potential therapy for Plasmodium vivax malaria in India
Drug Development - European regulatory authorities approve Glaxo SmithKline's Rotarix rotavirus vaccine
Influenza - Influenza symptoms receive reduced duration and severity from oseltamivir
Mental Health - Cipralex superiority supported by new data
Addiction Medicine - New findings in addiction medicine described
Addiction Medicine - Polymorphisms exist in the serotonin 1B receptor gene for heroin addiction
Adenoviruses - An oncolytic adenovirus demonstrates greater efficacy without increased toxicity
Adverse Drug Reaction - Antipsychotic medication does not necessarily induce diabetes
Adverse Drug Reaction - Fulminant type 1 diabetes caused by DHS with HHV-6 infection is reviewed
Allergy & Immunology - Arachidonic acid analogs modulate Fc epsilon RI-mediated mast cell activation
Allergy & Immunology - Home improvement expert to help allergic asthma sufferers reduce allergens at home
Allergy & Immunology - Patients with seasonal allergic rhinitis can be treated with azelastine nasal spray
Allergy & Immunology - Survey links allergy symptoms to quality of life and occupational consequences
Alzheimer Disease - Medivation exceeds patient enrollment target in phase II Alzheimer disease trial
Amebiasis Vaccine - Amebiasis vaccine progress is reviewed
Ameloblastomas - Ameloblastoma apoptosis was induced by inhibition of Akt and MAPK pathways
Analgesia - Sodium channel subtypes are a possible target for orofacial pain drugs
Anaphylactic Shock - Patients with omeprazole-induced anaphylaxis benefit from newly designed desensitization protocol
Anesthesia - Clonidine is a good alternative to midazolam as a premedication for anesthesia in children
Anesthesia - For local anesthesia, needle-free injection system was more effective than eutectic mixture
Anesthesia - Regional anesthesia with ropivacaine alone does not affect cardiovascular system
Aneurysm - Aneurysm treatment furthered by a proposed outcome measurement tool
Aneurysm - CT angiography is useful for detecting and treating intracranial aneurysms
Angiology - Adult blood vessels are stabilized by vascular endothelial growth factor
Angiology - Angiogenesis increases following endovenous ablative therapy
Angiology - Angiotensin-(1-7) enhances antiaggregatory effects of nitroprusside
Angiology - Cardioprotective effect of metallothionein may be studied via induction by cadmium, isoproterenol
Angiology - Coronary vasodilation is induced by adrenomedullin, partially through nitric oxide production increase
Angiology - High-dose folic acid does not protect vascular endothelium from IR injury in humans
Angiology - Neovascular pathology is triggered by reactive oxygen species
Angiology - Vascular diseases may derive from bone morphogenetic protein-2
Antifungal Drugs - Anion channel inhibitors enhance the anticandida activity of antifungal drugs
Antisense Technology - Allele loss selects for amplification of proto-oncogene in neuroblastoma cells
Antisense Technology - Antisense technology can reduce tamoxifen-induced CYP3A2 expression and DNA adducts
Antituberculosis Therapy Adherence - Anti-TB chemoprophylaxis adherence improved by shorter regimens in children
Antiviral Drugs - Antiviral drugs against influenza virus vary in efficacy
Anxiety Disorder - MediciNova completes enrollment in a phase II/III generalized anxiety disorder trial with MN-305
Apoptosis - Data advance knowledge in apoptosis research
Apoptosis - Mitochondrial signaling pathway functions in coronavirus-induced oligodendrocyte apoptosis
Apoptosis - Research add new data to apoptosis body of knowledge
Apoptosis - T cell infiltration is associated with apoptosis and rejection of tumor cells
Apoptosis - Triphala proposed as novel anticancer drug
Arthritis Therapy - Arthritis Advantage clinically proven to relieve pain for rheumatoid arthritis and osteoarthritis
Arthroplasty - Patients with lower limb arthroplasty benefit from self-administered thromboprophylaxis
Asthma - Asthma Control Test and spirometry are equally effective in identifying asthma
Atopic Dermatitis - Genes involved with atopic dermatitis are differentially expressed
Attention Deficit Hyperactivity Disorder - Dopamine transporter gene polymorphisms are not associated with ADHD
Avian Influenza - Baxter receives contract from U.K. to produce stockpile of H5N1 flu vaccine
Avian Influenza - Concern grows over possible avian influenza spread in West Africa
Avian Influenza - DelSite and Invitrogen Corp. ink avian H5 influenza nasal vaccine agreement
Avian Influenza - Sanofi pasteur supplies avian flu pre-pandemic vaccine to Italian Ministry of Health
Avian Influenza - World Health Organization provides update on avian influenza and food safety status
Bacteriology - Neutrophil microbicidal activity must be evaluated in the presence of certain agents
Behavioral Medicine - Treatments based on human behavior could reduce drug prescribing
Bioethics - Stanford ethics program provides consultation on issues surrounding biomedical research
Biomedical Engineering - New vessel growth in skin substitutes is influenced by pore characteristics
Bioterrorism - Hollis-Eden Pharmaceuticals submits proposal on acute radiation syndrome therapy
Bioterrorism - VaxGen, BD to evaluate micro dermal injection technology for anthrax vaccine delivery
Bladder Cancer - Management of stage T1 bladder tumors discussed
Bladder Cancer - Receptor Tyr kinase expressed in bladder cancer is a signal for cell survival
Botulinum Toxin - Botulinum toxins' unlabeled uses are focus of review
Bowel Endoscopy - Polyethylene glycol-electrolyte solution cleansed the bowel better in preparation for endoscopy
Brain Cancer - Reduced glioma risk in women may not be related to hormonal or reproductive factors
Brain Cancer - Survival of rats with glioma extended with synchrotron stereotactic radiotherapy
Breast Cancer - Breast cancer angiogenesis may depend on estrogen receptor status
Breast Cancer - Breast cancer risk in estrogen-progestin therapy users is increased across ethnic groups
Breast Cancer - Breast cancer risk is associated with increased body mass index in non-hormone therapy users
Breast Cancer - Breast cancer treated with high-dose-rate brachytherapy and chemotherapy
Breast Cancer - Breast cancer volume falls after tumors receive lapatinib plus trastuzumab
Breast Cancer - Efficacy of breast cancer treatment by chemoradiotherapy evaluated
Breast Cancer - Glucosylceramide synthase suppression reverses breast cancer cell multidrug resistance
Breast Cancer - Green tea compound affects gene expression of transformed breast cancer cells
Breast Cancer - Recent studies add new data to breast cancer research
Breast Cancer - Reports describe recent advances in breast cancer research
Breast Cancer - Research add new data to breast cancer body of knowledge
Breast Cancer - Researchers publish new studies and findings in the area of breast cancer
Breast Cancer - Researchers' data advance breast cancer research
Breast Cancer - Technetium-99m-sestamibi monitors treatment in human breast cancer cells
Business & Finance - Anadys Pharmaceuticals reports revenues of $2M
Business & Finance - Anormed announces CEO exercises options to acquire 350,000 common shares
Business & Finance - Atrium continues its growth with 47% increase in revenues
Business & Finance - Basilea Pharmaceutica reports increase in combined cash, short-term investments
Business & Finance - BioSyntech reports loss of $0.04 per share
Business & Finance - Biotech company Tanox reports $5.6 million Q4 2005 revenues, $44.7 million for full year
Business & Finance - Cardiogenesis reports Q4 revenues of $4.1M, 2005 revenues of $16.3M
Business & Finance - Cardium moves to OTC bulletin board
Business & Finance - Cerus Corp. reports $5.6 million in Q4 revenues
Business & Finance - Corgentech announces 2005 net loss of $33.0 million
Business & Finance - Dyax Corp. reports Q4 net loss of $5.6 million
Business & Finance - First Horizon announces fourth quarter and year-end revenues up
Business & Finance - Inspire reports loss of $0.17 per share
Business & Finance - Sirna reports $5.8 million net loss in Q4 2005, $23.9 million net loss for year
Business & Finance - YM BioSciences reports total Q2 2006 revenues of $549,230, up from $521,524 a year ago
Business Update - Biosensors International hosts symposium on stents
Business Update - BrainStorm's stem cell hospital partnering discussed in report
Business Update - CV Technologies reports growth strategies
Business Update - Genmab reaches first milestone in HuMax-TAC agreement with Serono
Business Update - Interleukin Genetics enters into new purchase agreements
Business Update - Oncology drug developer changes name to Xanthus Pharmaceuticals, Inc.
Business Update - Servier renews and expands license to Aureus Pharma's knowledge databases
Business Update - Wyeth Research expands pharmacogenomic testing services agreement with Expression Analysis
Cancer Gene Therapy - Adenovirus-alphavirus hybrid vector increases liver cancer treatment efficacy and safety
Cancer Gene Therapy - Cancer gene therapy receives a boost from transforming growth factor-beta receptor inhibition
Cancer Gene Therapy - Pancreatic cancer CaSm antisense gene therapy is affected by bystander effect
Cancer Prevention - Bladder cancer is prevented by soy-induced alterations of angiogenesis and apoptosis
Cancer Risk Factors - Diet adopted by ulcerative colitis patients may impact development of colon cancer
Cancer Therapy - Activating p38 protects dormant tumor cells from stress insults
Cancer Therapy - Angiogenesis blockade limits cancer in animal models
Cancer Therapy - Antisoma's AS1411 granted E.U. orphan drug status for renal and pancreatic cancers
Cancer Therapy - Atiprimod trial in cancer patients uncovers clear response against carcinoid tumors
Cancer Therapy - Chemotherapy resulted in negative short-term effects on some cognitive functions
Cancer Therapy - Colorectal cancer trials detailed in new on-line resource
Cancer Therapy - Data advance knowledge in cancer therapy research
Cancer Therapy - F-18-FDG PET used to manage gestational trophoblastic tumors
Cancer Therapy - Management of Hodgkin disease undergoes a paradigm shift due to new drug regimens
Cancer Therapy - Morphine, haloperidol and hyoscine N-butyl bromide combined in solutions
Cancer Therapy - Northwest Biotherapeutics announces CXCR4 offers significant reduction in metastases to the lung
Cancer Therapy - Recent studies add new data to cancer therapy research
Cancer Therapy - Research add new data to cancer therapy body of knowledge
Cancer Therapy - Researchers detail new studies and findings in the area of cancer therapy
Cancer Therapy - Researchers report details of new studies and findings in the area of cancer therapy
Cancer Therapy - Studies describe new findings in cancer therapy research
Cancer Therapy - Targeting cell-impermeable prodrug activation to tumor microenvironment reduced drug toxicity
Cancer Vaccine - Anaplastic lymphoma kinase is antigen for immune interventions
Cancer Vaccine - Antitumor responses can be targeted using attenuated Listeria
Cancer Vaccine - Cancer vaccine's effects depend on blocking CTLA-4 signaling
Cancer Vaccine - Glioma antigen is identified using cytotoxic T lymphocytes induced by HSV cancer vaccine
Cancer Vaccine - Tumor antigen that plays key role in immunomodulation is blocked by antibodies
Cancer Vaccine - Tumor cells transduced with MHC II transactivator and CD80 activate tumor-specific CD4+ T cells
Cancer Vaccine - Vaccine therapy is achieved by genetic modification of dendritic cells
Cancer Vaccines - Findings in cancer vaccines provide new insights
Cancer Vaccines - Researchers publish new studies and findings in the area of cancer vaccines
Carcinogenesis - Hyperinsulinism plus hyperglycemia induces hepatocellular carcinomas development
Cardiology - Cardiac dysfunction is associated with depression of proteasome activities
Cardiology - Epinephrine-induced arrhythmia susceptibility is greater in male than in female rat hearts
Cardiology - Erythropoietin prevents cardiac dysfunction in doxorubicin-induced cardiomyopathy
Cardiology - Findings advance knowledge in cardiology research
Cardiology - For atrial fibrillation patients undergoing cardioversion, rapid anticoagulation improves outcome
Cardiology - Healing stent 9-month MACE rate is similar to drug eluting stents
Cardiology - In refractory atrial fibrillation, oral sotalol results in high rate of sinus rhythm restoration
Cardiology - Myocardial infarction areas improve when implanted with skeletal muscle satellite cells
Cardiology - New HFSA guidelines recommend VADs for treating heart failure patients, Thoratec reports
Cardiology - Recent findings in cardiology described
Cardiology - Reports describe recent advances in cardiology research
Cardiology - Researchers' data advance cardiology research
Cardiology - Researchers' findings advance cardiology research
Cardiology - Researchers' work adds to cardiology body of knowledge
Cardiomyocytes - Complement C5a is essential in the pathogenesis of septic cardiac dysfunction
Cardiomyocytes - Ventricular myocyte contraction is altered by C-type natriuretic peptide, NO in eNOS-/- mice
Cardiovascular Disease - Cardiac rehabilitation is safe and helpful for elderly coronary patients
Cardiovascular Disease - Coronary heart disease and the clinical potential of pharmacogenetics are discussed
Cardiovascular Disease - In diabetic adults in the U.S., aspirin use is increasing
Cardiovascular Disease - In stable angina treatment, ivabradine is the first selective sinus node If channel inhibitor
Cardiovascular Disease - Pharmacogenetics of multigenic disease is focus of review
Cardiovascular Research - RAMP2 is key player in sensitivity of adrenomedullin-induced hypotensive responses via AM1 receptor
Cardiovascular Research - Vasoconstriction, lowered cardiac output are induced by epinephrine infused during hypothermia
Cerebrovascular Disease - Ischemic stroke recedes with adrenomedullin-induced angiogenesis
Cervical Cancer - Cervical cancer chemoradiation trials need more focus on optimal dosing strategies
Cervical Cancer - Cervical cancer patients treated with chemoradiation therapy may have improved survival rates
Chagas Disease - Night blindness now considered clinical symptom of Chagas disease
Chlorthalidone - Chlorthalidone is superior for heart failure prevention, independent of renal function
Chronic Conditions - Study shows Ohioans needlessly suffer because they are not properly caring for chronic conditions
Chronic Hepatitis - HLA class I allelic diversity has minor role in fibrosis in chronic hepatitis C
Chronic Hepatitis - Leukocyte stress-related molecules are upregulated in chronic viral hepatitis
Clinical Research - Investigator-initiated clinical research receives regulatory support from university program
Clinical Trials - Applied Genetic initiates phase I trial of drug for Alpha-1 antitrypsin deficiency
Clinical Trials - Corautus to complete enrollment of patients in phase IIb GENASIS trial in June
Clinical Trials - Enrollment of second nBCC trial completed by Peplin
Clinical Trials - First patient treated in phase 1/2 trial with alkylating drug in sarcoma, Ziopharm reports
Clinical Trials - Genitope Corporation initiates clinical trial to evaluate MyVax Personalized Immunotherapy
Clinical Trials - New selective estrogen receptor modulator for menopausal symptoms reported
Clinical Trials - Northfield Laboratories phase III trial plans to complete trial of PolyHeme
Clinical Trials - Patient treatment in phase III clinical trial begun by Delcath
Clinical Trials - Phase 1 clinical studies of treatment for peripheral artery disease successfully completed
Clinical Trials - Phase 1-2a clinical pharmacokinetics study of small molecule drug in MDS initiated
Clinical Trials - Positive results reported in long-term trial of treatment for noninfectious uveitis
Clinical Trials - Professor warns about unfair terms for patients in clinical trials
Clinical Trials - Second phase 1 study for selective muscarinic agonist for treating Alzheimer initiated
Clinical Trials - Sweden approves alpha interferon for first-line adjuvant treatment of malignant melanoma
Clinical Trials - Trial of tibolone for treating osteoporosis stopped due to elevated risk of stroke
Collaborations - 7TM Pharma receives milestone payment in deal with Procter & Gamble
Collaborations - AXM Pharma receives notice of trademark termination from Sunkist
Collaborations - Alnylam grants license to Integrated DNA Technologies for Kreutzer-Limmer patents
Collaborations - Artemis Pharmaceuticals signs target validation deal with Bristol-Myers Squibb
Collaborations - Avecia and TriLink partner to offer seamless scale-up in oligonucleotide manufacturing
Collaborations - CytoDyn gets green light for China joint venture
Collaborations - HemoSense signs agreement with Reliant to distribute INRatio for home INR testing
Collaborations - HollisterStier Contract Manufacturing signs agreement with Roxro Pharma
Collaborations - Memory Pharmaceuticals amends agreement with Roche, expanding nicotinic alpha-7 agonists resources
Collaborations - Novavax announces strategic alliance with PacificGMP on pandemic influenza vaccine
Collaborations - OrthoLogic announces alliance with Quintiles to develop Chrysalin
Collaborations - Qiagen signs comarketing agreement for protein crystallography
Collaborations - Rexahn and University of Maryland Nanomedicine Center partner to develop cancer and CNS therapies
Colon Cancer - Colon cancer cells use hypoxia-inducible factor-1 alpha for growth despite non-hypoxic environments
Colon Cancer - Colorectal cancer treated with oxaliplatin and capecitabine
Colon Cancer - Studies advance knowledge in colon cancer research
Colorectal Cancer - 5-fluorouracil inhibited cytochrome P4502C9 activity in cancer patients
Colorectal Cancer - Colorectal cancer shows VEGF and p53 are correlated
Colorectal Cancer - The risk for hereditary nonpolyposis colorectal cancer is modified by IGF-1 variants
Colorectal Cancer - Treatment strategies of peritoneal carcinomatosis of colorectal origin discussed
Complementary & Alternative Medicine - Catechin compounds recovered from Korean tea by solvent extraction
Complementary & Alternative Medicine - Diabetic cardiomyopathy prevention by zinc supplement is mediated by cardiac MT levels
Complementary & Alternative Medicine - Ecdysterone exerts an insulin independent glucose-lowering effect in hepatocytes
Complementary & Alternative Medicine - Putative mechanism for anticancer properties of plant polyphenols proposed
Contracts - PDI announces termination of AstraZeneca fee-for-service contract sales programs
Coronary Artery Disease - Point Biomedical Corporation's Cardiosphere NDA accepted for review by U.S. FDA
Coronary Stenting - Medication-releasing stents may be alternative to coronary artery bypass
Crohn Disease - NPS Pharmaceuticals to advance clinical development of teduglutide for Crohn disease
Cytomegalovirus - Peromyscus cytomegalovirus expressing hantavirus glycoprotein was examined
DNA Research - DNA vaccination at multiple sites enhances immune responses in mice
DNA Research - Tetrahydrobiopterin supplementation improves vascular dysfunction in insulin-resistance
Dalbavancin - Dalbavancin demonstrated greater potency than vancomycin against resistant Gram-positive isolates
Dengue Fever Vaccine - Dengue infection's effects in dendritic cells were examined
Dermatology - Delayed pressure urticaria is safely and effectively treated by clobetasol propionate foam
Dermatology - Fraxel laser treatment focus of American Academy of Dermatology's annual meeting
Dermatology - Optoderma Cellular Memorizer psoriasis treatment products registered by the U.S. FDA as OTC
Dermatology - Patients with atopic eczema do not benefit from wet wrap bandages
Developmental Biology - Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes
Developmental Biology - Type I postplasmic/PEM mRNAs function in ascidian embryonic development
Developmental Biology - Zebrafish Foxd3 is required for neural crest development
Diabetes Complications - Diabetes-related limb ischemia resolves in models treated with benfotiamine
Diabetes Complications - Pioglitazone reduces proinflammatory markers in diabetic nephropathy patients
Diabetes Complications - Researchers' data advance diabetes complications research
Diabetes Control - Apidra now available in the U.S. for hyperglycemia
Diabetes Drug Therapy - Glimepiride and rosiglitazone improve metabolic control in conjunction with metformin
Diabetes Pathogenesis - Recent findings illuminate research in diabetes pathogenesis
Diabetes Therapy - 1-hydroxy-4,5,6-substituted 2(1H)-pyrimidinones complexes improve glucose tolerance
Diabetes Therapy - Antidiabetic and hypolipidemic effects of Collybia confluens mycelia observed in diabetic rat
Diabetes Therapy - Antidiabetic effects observed for alkaline-reduced water in OLETF rats
Diabetes Therapy - Diabetes and intestinal disease therapy may make use of proglucagon-derived peptides
Diabetes Therapy - Insulin secretion from human artificial chromosome vector has been achieved
Diabetes Therapy - Metformin therapy improved AMPK and aPKC activity in muscles of diabetics
Diabetes Therapy - NN344 may be a longer lasting and more predictable insulin supplement
Diabetes Therapy - Once-daily gliclazide-modified release improved blood glucose control in type 2 diabetics
Diabetes Therapy - Premixed insulin analogues for the treatment of diabetes mellitus are reviewed
Diabetes Therapy - Research add new data to diabetes therapy body of knowledge
Diabetes Therapy - Researchers' data advance diabetes therapy research
Diabetes Therapy - Sulfonylureas, biguanides and insulin overdoses lead to heath risk and occasionally death
Diagnostics - COBAS AMPLICOR PCR less sensitive than culture for tuberculosis diagnosis
Diagnostics - Findings describe new data in diagnostics research
Diagnostics - New findings in diagnostics described
Dialysis - Patients on home dialysis experience QOL benefits and reduced need for meds
Diet & Nutrition - ADRP is upregulated in fatty liver in human and liver steatosis in mice fed high fat diet
Diet & Nutrition - Dietary cholesterol affects monocyte chemoattractant protein-1 gene expression
Diet & Nutrition - Homocysteine-lowering by B vitamins was maximal in those with B12 deficiency
Diet & Nutrition - Intakes of vitamins A, C, E, folate and multivitamins did not reduce lung cancer
Diet & Nutrition - Nutraceuticals affect the structure of intestinal mucosa, according to animal study
Diet & Nutrition - Pomegranate seed oil may enhance beta-cell function in vivo
Diet & Nutrition - Researchers' work adds to diet & nutrition body of knowledge
Drug Delivery - Growth of drugs targeted for childhood diseases is driving advances in pediatric drug delivery
Drug Delivery - Lysalbinic acid can be applied as absorption enhancer for peptide-drug buccal delivery
Drug Delivery - Sublingual absorption of propanolol and verapamil are similar
Drug Delivery - Tumor cell adhesion and packing density contributed to drug resistance
Drug Development - M. tuberculosis in adjuvant modulates the Th immune response balance
Drug Development - 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan identified as novel anticancer agent
Drug Development - AZD-103 shown to neutralize disease effects of amyloid beta in preclinical model
Drug Development - ActiveSight launches four new crystal targets for structure-based drug design
Drug Development - Alcon receives positive opinion for DuoTrav eye drops solution in Europe
Drug Development - Alcon withdraws application to extend marketing authorization for Opatanol nasal spray
Drug Development - Alfacell achieves full patient enrollment for Onconase phase IIIb study for malignant mesothelioma
Drug Development - Almirall to publish clinical trial data
Drug Development - Amphotericin B antifungal activity potentiated by Cinnamomum cassia essential oil
Drug Development - Anacor presents nine posters for antifungal drugs
Drug Development - ArQule initiates toxicology studies of RQ 171
Drug Development - AstraZeneca withdraws application for ximelagatran in Europe
Drug Development - Avant announces TP10 does not meet primary endpoint in phase IIb study in female cardiac patients
Drug Development - Bentley Pharmaceuticals gets 12 product dosage approvals in Spain
Drug Development - BioPartners gets CHMP positive opinion for Valtropin
Drug Development - Boehringer Ingelheim receives positive opinion from E.U. panel for Sifrol/Mirapexin
Drug Development - Caraco Pharmaceutical announces U.S. FDA approval to market Fluvoxamine
Drug Development - CardioVascular BioTherapeutics' Kenneth Thomas discusses clinical progress
Drug Development - Cervical cancer apoptosis was induced by 3 beta-hydroxy-12-oleanen-27-oic acid
Drug Development - Clofarabine receives positive opinion from the European Medicines Agency
Drug Development - Cytotoxicity of isoxazolidinyl polycyclic aromatic hydrocarbons examined
Drug Development - Gamma-retroviral and lentiviral SIN vectors are equally potent
Drug Development - Graffinity and Mutabilis announce second research collaboration
Drug Development - IDM Pharma plans to submit NDA for Junovan to treat osteosarcoma
Drug Development - Immunoadjuvant activity is linked to chaperoning function of stress protein
Drug Development - Miliusanes proposed as potential anticancer agents
Drug Development - Multidrug-resistant HIV-1 protease is drug target
Drug Development - N-(7-indazolyl)benzenesulfonamide derivatives identified as potent cell cycle inhibitors
Drug Development - New lead compound, MOR103, to be taken into clinical development by MorphoSys
Drug Development - Novel potential anticancer naphthyl phosphoramidites of BvdU studied
Drug Development - Phenazine-1-carboxamides evaluated
Drug Development - Polyethylene imine grafted to poly(ethylene glycol)-like core shows promise for gene delivery
Drug Development - Post-injury angiogenesis weakens with VEGF-A activation
Drug Development - Potential cancer chemopreventive activity of isoquinolines analyzed
Drug Development - Promising anticancer agents discovered
Drug Development - Protein kinase C and tyrosine kinase provide examples of drug design crystallography
Drug Development - Quindoline derivatives identified as promising agents for cancer treatment
Drug Development - Receptor concept in pharmacology is the focus of review
Drug Development - Researcher looks for more targeted way to deliver cancer drugs
Drug Development - Signal transduction inhibitors of pre-mRNA help treat diseases caused by missplicing
Drug Development - Synthesis and antitumor activity of platinum acetonimine complexes described
Drug Development - Tumor antigen-specific CD8+ memory T cells are induced by lentivectors
Drug Development - U.S. FDA grants tentative approval for generic equivalent of Glaxo's Zofran Injection
Drug Efficacy - Ezetimibe lipid-lowering benefit has been demonstrated, but questions remain
Drug Resistance - Acquired rifamycin resistance risk increases with twice-weekly HIV-related TB treatment
Drug Resistance - AsnB involved in natural resistance of Mycobacterium smegmatis resistance
Drug Resistance - Drug-resistant tuberculosis epidemic fueled by inappropriate treatment in the former Soviet Union
Drug Resistance - HBV core-related antigen measurement helps identify low risk of lamivudine resistance
Drug Resistance - MTB gyrase mutations identified as quinolone-resistant and -hypersusceptible
Drug Resistance - New findings in the area of drug resistance described
Drug Resistance - Symbollon announces intention to develop family of antimicrobials without drug resistance
Drug Resistance - rpoB mutations confer rifampicin resistance in Mycobacterium avium
Drug Safety - Drug safety study financing is proposed by augmenting FDA user fees
Drug Safety - Inhaled insulin absorbed best as dry powder either with or without alkylglycosides
Drug Safety - MedivoxRx spokesman testifies before Maryland committees on audible prescription devices
Drug Safety - U.S. FDA, manufacturers of Accutane and its generics to implement risk management program
Embryogenesis - Lung morphogenesis relies on VEGF-mediated cellular crosstalk
Endocrinology - Primary hyperparathyroidism diagnosed by intraoperative quick parathormone
Endocrinology - Research in endocrinology provides new insights
Endocrinology - Researchers provide details of new studies and findings in the area of endocrinology
Enzymology - Cancers originate from phosphatidylinositol 3-kinase mutations
Enzymology - Evolutionary paths intelligently designed
Epidemiology - Beijing MTB genotype associated with region but not with multidrug resistance
Epidemiology - MTB multidrug resistance prevalence lower after implementing DOTS strategy in South India
Epidemiology - Multidrug-resistant tuberculosis prevalent in previously treated pulmonary TB cases in Lebanon
Epidermolysis Bullosa - Domain mutations decrease collagen thermal stability in epidermolysis bullosa
Epilepsy - D-Pharm's DP-VPA shown to be well-tolerated for resistant epilepsy, reduces seizure frequency
Epithelial Cells - Annexin redistribution promotes epithelial cell calcium crystal agglomeration
Esophageal Cancer - Multimodality therapy for esophageal cancer holds promise, but optimal schedule is undefined
Esophageal Cancer - Recent findings illuminate research in esophageal cancer
Esophageal Cancer - Treatment and outcome for mid- and lower-thoracic esophageal cancer discussed
Facilities - Advanced Cell Technology opens new headquarters in California
Facilities - Eisai announces plans for parenteral oncology treatment plant in Research Triangle Park, N.C.
Facilities - InNexus Biotechnology moves corporate headquarters
Facilities - Tepnel buys land in Scotland to build pharmaceutical, protein, genomic analysis facility
Fibromyalgia - Duloxetine was safe and effective in the treatment of fibromyalgia
Finance - Acadia Pharmaceuticals reports loss of $10.2M
Finance - Advanced Life Sciences enters into stock purchase agreements for $36M
Finance - Amgen donates $1.1M to The Wellness Community
Finance - Antares to raise approximately $11M in a private placement
Finance - Arius records loss of $0.28 per share
Finance - Arizona's Stardust Foundation awards $7.5 million in research grants to area organizations
Finance - AtheroGenics reports loss of $0.49 per share
Finance - Avalon Pharmaceuticals raises $7.25M in private placement of common stock
Finance - Axcan Pharma announces record first quarter revenue of $70.6 million
Finance - Barrier Therapeutics posts loss of $0.43 per share
Finance - Baylor Research Institute receives $2.9 million to study lupus
Finance - BioMarin reports loss of $0.20 per share
Finance - Capsulution Nanosciences raises additional EUR 1.3M
Finance - Cerus Corp. announces proposed public offering of common stock
Finance - China Health Holding announces stock dividends
Finance - Cleveland Clinic spin-off Symphony Medical raises $6M to develop treatments for AF
Finance - Cyanotech reports Q3 2006 financial results; sales down 27% from Q3 2005
Finance - Discovery Labs reports Q4 net loss of net loss of $29.4 million
Finance - Enzon reports second quarter $285M loss and 2006 revenue estimates
Finance - GPC Biotech raises EUR 36.2 million in private placement with SAP cofounder
Finance - Genaera Corporation announces 2005 net loss of $26M
Finance - Haemacure posts net loss of $0.02 per share
Finance - Hospira board authorizes $400M share repurchase program
Finance - Minrad International generates $2,466,000 of revenue for the quarter and $8,345,000 for 2005
Finance - MorphoSys AG announces revenues for the year 2005 of EUR 33.5 million
Finance - Nabi Biopharmaceuticals announces decrease in annual revenues
Finance - Nanogen reports revenues for the quarter of $3.1 million
Finance - NationsHealth announces revenue increases 13% to $25.2 million for quarter
Finance - NeoPharm announces fourth quarter net loss of $9.7 million
Finance - NeoRx reports net loss of $4 million for the fourth quarter of 2005
Finance - NicOx reports revenues increased 442% to EUR 6.5 million in 2005
Finance - Novavax announces revenues for fourth quarter were $2.2 million
Finance - Nuvelo reports net loss of $20.9 million or $0.49 per share for 2005 fourth quarter
Finance - PDL BioPharma announces net loss of $23.1 million for fourth quarter 2005
Finance - Paladin reports revenue for the fourth quarter of 2005 increased 28% to $10.4 million
Finance - Par Pharmaceutical reports total revenues of $433.2 million for the year ended 2005
Finance - Proposed public offering of its common stock announced by Corautus Genetics
Finance - QLT announces a loss of 4.04 per share in the fourth quarter 2005
Finance - Regeneron reports net loss of $29.7 million for fourth quarter 2005
Finance - Rockwell Medical Technologies reports sales increased 35% in the fourth quarter
Finance - Salix Pharmaceuticals reports Q4 2005 product revenue increase of 52% to $154.7 million
Finance - Seven states share $19.2 million from SAMHSA for hurricane aftermath crisis counseling aid
Finance - StemPath announces CDN$1 million private financing with New Generation Biotechnology
Finance - SuperGen reports 2005 net loss of $14.5 million, down from $46.9 million for 2004
Finance - Teva reports record sales, net income up 9% and 10% for Q4 and full year 2005
Finance - Teva underwriters exercise option for convertible debentures of financial subsidiaries
Finance - Threshold reports 2005 net loss of $44.4 million, compared to $23.6 million in 2005
Finance - Vaso Active Pharmaceuticals, Inc. stock now quoted on OTC Bulletin Board
Finance - Vion Pharmaceuticals reports full year 2005 net loss of $18 million
Finance - WebMD reports revenue for Q4 2005 of $49.1 million, up from $39.1 million a year ago
Finance - West Pharmaceutical reports Q4 and full year 2005 record sales for both periods
Fitness & Wellness - Quality of life improved in cancer patients participating in physical exercise
Follicular Neoplasm - Follicular neoplasm treated by minimally invasive video-assisted thyroidectomy
Gastroenterology - U.S. FDA approves immediate-release proton pump inhibitor capsule for heartburn, GERD
Gene Therapy - Research add new data to gene therapy body of knowledge
Generic Drugs - U.S. FDA approves first generic version of Flonase
Generic Drugs - Wockhardt receives U.S. FDA approval for generic version of anti-ulcer drug Zantac
Genetics & Genomics - Glucocorticoid receptor deacylation enables NF-kappa B suppression
Genetics & Genomics - Histidine button engineered into cardiac troponin I protects ischemic and failing hearts
Genetics & Genomics - Studies describe new findings in genetics & genomics research
Geriatrics - For dementia, efficacy and safety of atypical antipsychotics are uncertain
Glioma Cells - Intracellular signaling pathways were involved in inhibition of glioma cells by melatonin
Gynecology - Findings in gynecology provide new insights
Gynecology - Recent findings in gynecology provide new insights
HIV/AIDS & Cervical Cancer - HIV/AIDS is an adverse prognostic factor for cervical cancer therapy outcome
HIV/AIDS Diet & Nutrition - Glutathione synthesis stimulated by whey protein in children with rapid HIV progression
HIV/AIDS Drug Monitoring - Plasma nevirapine quantitation sensitivity increased by HPLC method
HIV/AIDS Drug Resistance - Primary HAART resistance in drug-naive HIV/AIDS patients increasing in Spain
HIV/AIDS Exposure - HIV postexposure prophylaxis suboptimal adherence related to ethnicity and oral sex
HIV/AIDS Facilities - Baylor-Bristol-Myers Squibb children's HIV/AIDS medical center opens in Swaziland, Africa
HIV/AIDS HAART - Viremia decline enhanced by 4-drug HAART regimen at the cost of toxicity
HIV/AIDS Pathogenesis - Data advance knowledge in HIV/AIDS pathogenesis research
HIV/AIDS Pathogenesis - HIV latency promoted by NF-kappa B p50 through HDAC recruitment and transcription repression
HIV/AIDS Therapeutic Monitoring - Six protease inhibitors and NNRTI simultaneously monitored by simple chromatography
HIV/AIDS Therapy - Generic and brand name nevirapine, zidovudine, and lamivudine are bioequivalent
HIV/AIDS Therapy - HAART-resistant HIV strains susceptible to bleomycin
HIV/AIDS Therapy - Infants with HIV-1 benefit from early combined antiretroviral therapy
HIV/AIDS Therapy - Study shows AIDS drugs cost-effective, care underfunded
HIV/AIDS Transmission - HIV/AIDS mother-to-child transmission was focus of review
HIV/AIDS Treatments - HAART access attainable under universal income grant for all South Africans
HIV/AIDS Vaccine - Dendritic cells from HIV-infected patients partially reconstitute CD4 T-cell responses
HIV/AIDS Vaccine - HIV-1 subtype B third variable region peptide motifs have been analyzed
HIV/AIDS Vaccine - Standardized antiretroviral regime is needed for HIV vaccine trial subjects who seroconvert
HIV/AIDS Vaccines - Findings describe new data in HIV/AIDS vaccines research
HIV/AIDS Vaccines - New findings in the area of HIV/AIDS vaccines described
HIV/AIDS-Associated Coinfection - Infectious syphilis re-emerging among gay men with high rates of coinfection
HIV/AIDS-Related Cytomegalovirus Retinitis - CMV retinitis control related to cytotoxic and lymphoproliferative response to CMV acquisition
Head & Neck Cancer - Outcome of primary head-and-neck squamous cell carcinoma reviewed
Head & Neck Cancer - PET-CT could help select head and neck cancer patients who will benefit from surgery
Head & Neck Cancer - Radiotherapy-induced mucositis in head and neck cancer patients treated by tetracaine gel
Head & Neck Cancer - Squamous cell cancer of the esophagus overproduces epidermal growth factor receptor
Healthcare Access - Late referral of chronic kidney disease deprives patients of reno- and cardioprotective care
Heart Failure - Findings in heart failure provide new insights
Heart Failure - In chronic congestive heart failure patients, adjuvant oral doxazosin gave no hemodynamic benefit
Helicobacter Pylori - New levofloxacin cures MET- and CLA-susceptible H. pylori strains
Hematology - Antiphospholipid-mediated thrombosis is the focus of review
Hematology - Myelodysplastic syndrome is not delineated by angiogenesis
Hematology - Occlusive arterial thrombosis can be reduced with melagatran + aspirin or clopidogrel
Hemorrhagic Shock - Fluid resuscitation with hemoglobin vesicles modeled in acute hemorrhagic shock
Hepatitis B Therapy - Long-term lamivudine therapy is effective for chronic pediatric hepatitis B
Hepatitis B Virus - HBV replication is inhibited in vivo by short hairpin RNAs
Hepatitis B Virus - Hepatitis B antigen loss during interferon treatment is associated with viral genotype
Hepatitis B Virus - Lamivudine protects against HBV in hematopoietic stem cell transplant recipients
Hepatitis B Virus - Preemptive lamivudine reduces HBV reactivation in transarterial chemo-lipiodolization
Hepatitis C & HIV-1 - Hepatitis C coinfection influences liver enzyme elevation in HIV-1
Hepatitis C Therapy - Chronic hepatitis C treatment may be aided by thalidomide
Hepatitis C Therapy - Trial data indicates Peregrine's antiviral agent Tarvacin safe, well-tolerated in HCV patients
Hepatitis C Virus - Combination therapy is influenced by fatty liver in chronic hepatitis C
Hepatitis C Virus - Early interferon HCV monotherapy leads to high virological response rates
Hepatitis C Virus - HCV refractory T cell response is activated by ablation of hydrophobic domains
Hepatitis C Virus - Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase
Hepatitis C Virus - Iron overload does not affect HCV genotype and response to interferon and ribavirin therapy
Hepatitis C Virus - PPAR antagonism inhibits hepatitis C virus replication
Hepatitis C Virus - Prolonged PEG interferon alpha-2b plus ribavirin is effective for chronic HCV
Hepatitis C Virus - Toll-like receptor 3 participates in hepatitis C-associated glomerulonephritis
Hepatocellular Cancer - Cytotoxic T lymphocytes recognize alpha-fetoprotein-derived peptides in HCC
Hepatocellular Cancer - HCC liver and periphery natural killer cells display differing cytotoxicities
Hepatocellular Cancer - Hepatocellular cancer survival linked to racial differences
Hepatocellular Cancer - Liver cancer reflects stage-driven reactions to fibroblast growth factor
Hepatocellular Cancer - Number of tumor markers present indicated prognosis of hepatocellular cancer
Hepatocellular Cancer - Researchers' data advance hepatocellular cancer research
Hereditary Angioedema - Pharming confirms positive rhC1INH outlook for hereditary angioedema
Herpes Vaccine - HSV protection and humoral immunity are enhanced by DNA priming-protein
Hodgkin Lymphoma - Pure infradiaphragmatic Hodgkin lymphoma described
Human Papillomavirus Vaccines - New findings in the area of human papillomavirus vaccines described
Hyperalgesia - Inflammatory pain is induced and maintained by activation of CB1 and CB2 receptors
Hypertension - Hypertension, antihypertensive therapy, and erectile dysfunction are focus of review
Hypertension - In hypertensive patients, atenolol impacts central systolic BP less than eprosartan
Imaging - Additional myocardial redistribution is demonstrated by 24-hour late thallium-201 imaging
Imaging - MRI-guided ultrasound targets antibody delivery through the blood-brain barrier
Imaging - Reports advance knowledge in imaging research
Immunology - Gold's power against autoimmune diseases defined
Immunology - Infection alarm yields clues to immune system behavior
Immunotherapy - Function of immunoglobulin A in immunity is focus of review
Influenza Outbreaks - Nosocomial influenza outbreak limited in high-risk patients with zanamivir prophylaxis
Influenza Vaccine - Chiron inks pandemic influenza vaccine contract with the U.K. government
Influenza Vaccine - Influenza protective and nonprotective T cell epitopes have been identified
Information Technology - Agilent Technologies launches intelligent services to aid efficiency in lab operations
Information Technology - Vitamin and nutraceutical information company launches new online resource
Information Technology - WKHealth releases easier-to-use version of NLM nomenclature for clinical drugs
Intestinal Non-Hodgkin's Lymphoma & Celiac Disease - Intestinal diffuse large B-cell lymphoma was related to celiac disease
Ischemia - After hypoxia-ischemia, carnitine inhibits increases in cerebral carnitine esters and glutamate
Ischemia - Ischemia-reperfusion injury is prevented by trimetazidine
Legal Issues - Angiotech to appeal U.K. judgment regarding U.K. patent
Leukemia - Genasense new drug application accepted for review by U.S. FDA
Leukemia - Itraconazole and caspofungin used as antifungal prophylaxis in leukemic patients
Leukemia - Leukemia is sustained by angiogenesis activators
Leukemia - Research in leukemia provides new insights
Leukemia - Researchers detail new studies and findings in the area of leukemia
Leukemia - Researchers' findings advance leukemia research
Leukemia - Studies describe new findings in leukemia research
Leukemia Vaccine - Antileukemia response is elicited by beta-defensin 2-transduced leukemic cells
Lipid Research - Lipoprotein(a) level is increased by fenofibrate therapy
Liposomal Delivery - Reactive oxygen species contribute to the liposomal induced death of macrophage-like cells
Liver Cancer - New data illuminates research in liver cancer
Liver Fibrosis - Celecoxib potentiates experimental liver fibrosis
Liver Injuries - Eosinophil chemoattractant is highly expressed in drug-induced liver injury
Liver Tumors - Blood transfusion-free hepatectomy made viable with parenteral tranexamic acid
Lung Cancer - Findings advance knowledge in lung cancer research
Lung Cancer - German cancer center administers gated radiation treatments for lung cancer patients
Lung Cancer - Lung cancer cell growth was inhibited by quercetin glucuronides
Lung Cancer - Primary tumor volume and total tumor volume used as prognostic factor in lung cancer
Lung Cancer - Recent studies add new data to lung cancer research
Lung Cancer - Research add new data to lung cancer body of knowledge
Lung Cancer - Researchers' findings advance lung cancer research
Lung Cancer - Studies add new findings to lung cancer body of knowledge
Lung Cancer - Studies advance knowledge in lung cancer research
Lung Cancer - Timing of non-small cell lung cancer treated with surgery and chemotherapy reviewed
Lung Cancer - siRNA targeting of survivin might increase sensitivity to anticancer drugs
Lymphangiogenesis - Lens lymphatic vessel angiogenesis is accelerated by dendritic cells
Lymphoma - Patients with nasal natural killer (NK)/T-cell lymphoma carry poor prognosis
Malaria Therapy - Trial of intermittent malaria treatment in children reduces cases by 86%
Malaria Vaccine - Cellular immunity against malaria is linked to P7 and P8 orientation in MHC-peptide-TCR complex
Malaria Vaccine - Malaria vaccine development is aided by adjuvants that induce CD4 memory
Market Analysis - Biotech instrumentation field set to grow, play key role in genomics, proteomics
Market Analysis - Biotech's mid caps post solid gain in February
Market Analysis - Broad partnerships enable maximization of opportunities for proteomics sector
Market Analysis - Business development, licensing team functions offer remedy for generic competition
Market Analysis - Driven by sanofi-aventis, Pfizer blockbusters, metabolic syndrome market to nearly double
Market Analysis - HCV incidence may be rising due to blood transfusion, Chinese physicians speculate
Marketing - Campbell Alliance moderates session on sales force effectiveness at conference
Marketing - Dendrite announces European deployment of multi-country marketing initiatives
Medicare - Market Strategies research shows seniors not yet enrolled in Medicare Part D have lowest awareness
Medicare - More than 25 million Medicare beneficiaries now have prescription drug coverage
Medicare - Verispan reports seniors filling 11% more prescriptions with Medicare reform
Melanoma - Gammacan files two provisional patent applications for the treatment of malignant melanoma
Melanoma - Melanoma could be treated by oridonin
Melanoma Vaccine - In melanoma, antibody SM5-1 recognizes expression of fibronectin variant
Melanoma Vaccines - Researchers report details of new studies and findings in the area of melanoma vaccines
Memory - Procholinergic and memory-enhancing properties are demonstrated by atomoxetine
Meningitis Vaccine - H. influenzae type b polysaccharide production is improved
Mental Health - Combination lithium and divalproex sodium restabilizes pediatric patients with bipolar disorder
Mental Health - Depressive medications produce true response when compared with placebo
Mental Health - Patients with schizophrenia had better outcomes with clotiapine than with chlorpromazine
Mental Health - Schizophrenia patients using olanzapine had lower discontinuation rates than with risperidone
Mental Health - Venlafaxine XR and SSRIs are similar in cost to treat depression
Mergers & Acquisitions - Astellas Pharma acquires Dynogen research operation
Mergers & Acquisitions - BioVisioN acquired by Digilab
Mergers & Acquisitions - MicroVention to be acquired by Terumo Corporation
Mergers & Acquisitions - OrthoLogic announces acquisition of assets from AzERx
Mergers & Acquisitions - Pfizer completes acquisition of Exubera worldwide rights from sanofi-aventis
Mergers & Acquisitions - Procyon's shareholders approve merger via acquisition with Cellpep S.A
Mergers & Acquisitions - Proposed purchase of BETASERON assets by Schering confirmed by Chiron
Mergers & Acquisitions - Terumo acquires MicroVention to enter market of catheter-based cerebral aneurysm treatment
Migraine Therapy - Migraine clinical trial strategies are designed to address complex issues in clinical practice
Molecular Biology - Vascular elastin calcification is subject to osteogenic and degenerative control
Morbid Obesity - Morbid obesity does not adversely affect laparoscopic Nissen fundoplication outcome
Munchausen Syndrome - Anesthetic abuse keratopathy is a manifestation of ocular Munchausen syndrome
Myocardial Infarction - For elderly patients with acute ST-elevation myocardial infarction, primary PCI is preferred
Myocardial Infarction - Reperfusion therapy with fibrinolytic agents remains first therapy choice where PCI is unavailable
Myocardial Infarction - Treatment of non-ST-elevation acute coronary syndrome in the elderly is discussed
Nasopharyngeal Carcinoma - Locally advanced nasopharyngeal carcinoma treated by radiation dose escalation
Nausea Therapy - Marijuana may suppress anticipatory nausea
Neisseria Gonorrhea - Neisseria gonorrhoeae treatment was accelerated by faropenem
Nerve Injury - Transporter downregulation after nerve injury is regulated by glucocorticoid receptors
Neurology - Cerebral angiogenesis and circulation derive from separate factors during chronic cerebral hypoxia
Neuroscience - A negative cell cycle regulator functions in motor skill learning
Neuroscience - Neuronal nitric oxide synthase activity was detected by fluorescent cell-based assay
Neuroscience - Propofol block suppresses thalamocortical neuron excitability and rhythmic burst firing
Neuroscience - Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation
Neuroscience - RNA-binding protein Musashi-1 regulates neural development
Neuroscience - The angiogenesis factor VEGF supports neurogenesis through neurite outgrowth
Non-Hodgkin Lymphoma - Non-Hodgkin lymphoma treated by oral fludarabine phosphate
Obesity & Asthma - Obesity may influence response to asthma medications
Obesity Diagnostics - Adiposity rebound estimates made by visual approach reflect physiological basis of rebound
Obesity Epidemiology - New findings in obesity epidemiology described
Obesity Therapy - Octreotide LAR resulted in weight loss in obese adults with insulin hypersecretion
Obesity Therapy - Positive 2-year trial results of rimonabant treatment in overweight patients published
Obesity Therapy - Reports advance knowledge in obesity therapy research
Obesity Therapy - Sibutramine therapy should be continued for 3 months before predicting results
Obstetrics - Estrogen-free birth control pill may be choice for child-bearing-age women
Obstetrics - Placenta accreta reveals altered angiogenesis protein expression
Obstetrics - Research add new data to obstetrics body of knowledge
Ocular Hypertension - Latanoprost and timolol combined are effective treatment for ocular hypertension
Oncology - Breast cancer cell apoptosis is suppressed by focal adhesion kinase and lymphangiogenic receptor
Oncology - Breast cancer metastasis may be propelled by post-lactational angiogenesis
Oncology - Cancer angiogenesis changes upon von Hippel-Lindau inactivation
Oncology - Cancer therapy distribution is changed by angiogenesis inhibitors
Oncology - Lung cancer cells lose Betaig-h3 protein expression
Oncology - New research in the area of oncology detailed
Oncology - Research in oncology provides new insights
Oncology - Researchers' data advance oncology research
Oncology - Varian's radiation oncology researchers discuss image, radiotherapy at partnership summit
Ophthalmology - Choroidal neovascularization may be stimulated by proinflammatory cytokines
Ophthalmology - Genaera announces interim Phase II data for wet macular degeneration drug
Ophthalmology - Genentech granted Priority Review for Lucentis use in wet macular degeneration
Ophthalmology - Researchers provide details of new studies and findings in the area of ophthalmology
Ophthalmology - Retinal angiogenesis remains sound with tailless activation
Ophthalmology - Retrobulbar hemodynamics is affected by treatment with dorzolamide/timolol
Ophthalmology - Systemic safety profile of Macugen in macular degeneration maintained through trials
Oral Cancer - Prognostic factors for recurrent oral and oropharyngeal cancer identified
Oral Cavity Cancer - Young patients with oral cavity cancers should be managed with more aggressive treatment
Oral Health - Dental association explains new technologies for less-painful root canal
Oral Squamous Cell Carcinoma - Oral squamous cell carcinoma apoptosis was induced by safingol
Oropharyngeal Cancer - Oropharyngeal carcinoma treated by intensity-modulated radiation therapy
Orthopedics - Research published in orthopedic surgeons' journal reviews treatment of trauma during pregnancy
Osteoarthritis - Efficacy of glucosamine and chondroitin sulfate may depend on level of osteoarthritis pain
Osteoarthritis - Nuvo's phase II trial confirms Pennsaid safety profile for treatment of osteoarthritis
Osteoporosis - Positive CHMP opinion moves Preotact closer to European approval as osteoporosis therapy
Osteoporosis - Providence Health System shows investigational osteoporosis therapy increases bone mineral density
Osteoporosis - U.S. FDA completes preapproval inspection of Nastech Pharmaceutical's Washington facility
Otorhinolaryngology - Merck KGaA receives EMEA positive opinion for use of Erbitux in head and neck cancer
Otorhinolaryngology - Regular palatal implants for snoring are more effective than rigid implants
Ovarian Cancer - MRP2 expression did not correlate with chemotherapy response in ovarian cancer
Ovarian Cancer - Multi-modality treatment recommended in small cell carcinoma of the ovary, hypercalcemic type
Ovarian Cancer - Ovarian cancer treated by prolonged topotecan infusion with cisplatin
Ovarian Cancer - Proteomics profile changes in cisplatin-treated ovarian cancer cells analyzed
Paget Disease - Novartis receives approvable letter from U.S. FDA for zoledronic acid 5 mg for Paget disease
Pain Management - U.S. FDA grants approval for cyclobenzaprine HCl tablets for pain relief
Pancreatic Cancer - Aortic stop-flow technique should not be used in palliation of pancreatic cancer
Pancreatic Cancer - Studies add new findings to pancreatic cancer body of knowledge
Pancreatitis - Polyamine catabolism is involved in the pathogenesis of acute pancreatitis
Paratyphoid Fever - Paratyphoid fever advances in Asia
Parkinson Disease - Caffeine may alter L-dopa responses in Parkinson Disease
Parkinson Disease - U.S. FDA approves less restrictive labeling for tolcapone in adjunctive Parkinson therapy
Patents - Aphios awarded Japanese patent for phospholipid nanosomes
Patents - Arisaph Pharmaceuticals grants license under dipeptidyl peptidase patents
Patents - Cel-Sci gets U.S. patent for use of L.E.A.P.S. vaccine technology
Patents - Millenia Hope acquires pending patent describing compounds that inhibit HIV-1 RNase_H
Patents - Takeda wins patent infringement litigation against ANDA filers for generic ACTOS
Patents - U.S. patent granted for metered dose transdermal spray applicator, Vivus announced
Pediatrics - Nasopharyngeal angiofibromas in juveniles exhibit angiogenesis and proliferation markers
Personnel - Advancis Pharmaceutical strengthens sales capability with addition of key employees
Personnel - Argenta Discovery strengthens senior management team
Personnel - Benitec appoints new company secretary
Personnel - Biota appoints Grant Latta as new director
Personnel - David Chess, MD, Sandeep Wadhwa, MD, join Institute on Aging board at U. of Pennsylvania
Personnel - Dynavax makes changes to board; Arnold L. Oronsky, PhD, elected chair
Personnel - Epix promotes Brenda Sousa and Dr. Phillip Graham
Personnel - Genzyme elects Richard F. Syron to its board of directors
Personnel - GlaxoSmithKline announces research and development appointments
Personnel - MedImmune promotes Michael Smullen to senior vice president, sales
Personnel - Medco announces organizational realignment; executive promotions
Personnel - Merrimack Pharmaceuticals announces addition of Barrett Rollins to its scientific advisory board
Personnel - Northfield Laboratories names Alan L. Heller to its board of directors
Personnel - Ocera Therapeutics, Inc. appoints Joe Davie, MD, PhD, to its board of directors
Personnel - Paul Bleicher, MD, PhD, named to Teranode Corporation board of directors
Personnel - RadPharm raises $8 million in equity financing
Personnel - Sirna Therapeutics names R. Scott Greer as board chairman and Lutz Lingnau as board member
Pharmaceutical Research - Cutting Edge Information study finds pharma companies spend 13% less on European advertising
Pharmaceutical Research - Samaritan receives CAS number for chemical substance caprospinol in its Alzheimer drug
Pharmaceutical Research - Two ramipril formulations were compared for bioavailability
Pharmaceutical Research - Ziopharm presents preclinical kidney toxicity data on metabolite of cancer drug ifosfamide
Philanthropy - Pfizer announces new class of Global Health Fellows to address health issues around the world
Physiology - Studies describe new findings in physiology research
Plague Vaccine - Plague is protected against by Yersinia pestis antigens expressed in plants
Polycystic Kidney Disease - Autosomal-dominant polycystic kidney disease in mice was developed by inserting Pkd1
Priapism - Superselective transcatheter embolization called useful treatment of high-flow priapism
Product Licensing - BioSante signs license for its CaP technology for use in aesthetic medicine
Product Licensing - Celtic Pharmaceutical licenses targeted drug delivery technology from Idea
Product Licensing - ImQuest licenses series of anti-HIV therapeutic compounds from Samjin
Product Licensing - ViroPharma licenses rights to develop therapy for Clostridium Difficile-associated disease
Professional Education - McGraw-Hill's AccessMedicine launches online neurology resource
Professional Education - Onmark launches preparation techniques for oncology hazardous drugs educational program
Progenitor Cells - Progenitor cell transplantation induces remyelination
Prostate Cancer - European Medicines Authority confirms survival data acceptable for satraplatin submission
Prostate Cancer - Findings presented from studies of Quadramet in prostate cancer with metastatic bone disease
Prostate Cancer - GPC Biotech presented new satraplatin clinical data
Prostate Cancer - Heightened prostate cancer angiogenesis indicates thrombin regulation
Prostate Cancer - Pharmion Corporation announces Satraplatin clinical data examining drug absorption rates
Prostate Cancer - Prostate cancer displays complex basic fibroblast growth factor expression
Prostate Cancer - Recent studies add new data to prostate cancer research
Prostate Cancer Therapy - Algeta's phase II clinical study highlights Alpharadin's potential
Prostate Cancer Vaccine - Prostate cancer vaccine encoding prostatic acid phosphatase was safe and immunogenic in rats
Proteomics - Age-related macular degeneration and amyloid diseases share similar protein misfolding
Proteomics - Angiogenesis protein response to p53 is implicated in microvascular pathology
Proteomics - Cancer VEGF is directly activated by heparinase
Proteomics - HDL/apoA-I binding protein is expressed on human macrophages and promotes cholesterol efflux
Proteomics - Hemorrhagic fever virus glycoprotein precursor cleaves to generate new glycoprotein
Proteomics - New findings in the area of proteomics described
Proteomics - New research in the area of proteomics detailed
Proteomics - Nod1 receptor stimulates chemokine production and neutrophil recruitment
Public Health - Risk of death is lower at a trauma center than at a non-trauma center
Pulmonary Medicine - Pulmonary vascular remodeling declines in dominant negative transforming growth factor models
Pulmonary Tuberculosis & Diabetes - Pulmonary tuberculosis treatment outcome not altered by diabetes
RNA Research - MicroRNA levels are rapidly altered by histone deacetylase inhibition
Radiotherapy - Melatonin prevented UV therapy-induced apoptosis in U937 cell line
Rectal Cancer - Mobetron extends survival rates and reduces tumor recurrence in rectal cancer
Rectal Cancer - Rectal cancer treated by preoperative chemoradiation
Rectal Cancer - Researchers detail new studies and findings in the area of rectal cancer
Renal Failure - Azathioprine-induced nephritis caused renal failure in a Wegener's granulomatosis patient
Rhabdoid Tumors - Cyclin D1, a downstream effector of INI1/hSNF5, is targeted in rhabdoid tumors
Rheumatoid Arthritis - Methotrexate treatment for rheumatoid arthritis effective the second time
Rheumatoid Arthritis - U.S. FDA approves the first targeted B-cell therapy for moderate to severe rheumatoid arthritis
Rosacea - MAA for Oracea with the U.K. MHRA filed by CollaGenex
Rotavirus Vaccine - Ricin toxin B subunit-rotavirus NSP4 fusion protein stimulates Th1 response
Rotavirus Vaccines - Researchers publish new studies and findings in the area of rotavirus vaccines
Salivary Gland Cancer - Treatment outcome of lymphoepithelioma-like carcinoma of salivary glands studied
Sarcomas - Retroperitoneal sarcomas treated by surgery and intraoperative brachytherapy
Schistosomiasis Vaccine - Schistosoma japonicum paramyosin fragments were effective in mice
Schistosomiasis Vaccine - Genes expressed in lung schistosomulum of Schistosoma mansoni are identified
Selegiline - U.S. FDA approves selegiline transdermal patch for treatment of major depressive disorder
Sickle Cell Disease - BSIs in adults with SCD may be related to venous catheter use; close monitoring needed
Sleep Apnea - Obstructive sleep apnea oral appliances are the focus of review
Sleep Apnea - Prevalence of sleep apnea following head and neck cancer treatment calculated
Smallpox Vaccine - Diluted Lister strain vaccinia virus vaccine is effective against smallpox
Smallpox Vaccine - Monkeypox virus infection is more effectively treated with antivirals than with smallpox vaccine
Smallpox Vaccine - Orthopoxvirus infection was partially protected against by enveloped virus protein
Solid Cancers - Patients with solid cancers could be treated by 7-hydroxystaurosporine and topotecan
Spinal Muscular Atrophy - PsychoGenics and SMA Foundation extend research agreement for spinal muscular atrophy
Squamous Cell Carcinoma - Patterns of tumor spread and consequences of incurable esophageal cancer studied
Statins - Pharmacogenomics of cholesterol-lowering therapy is focus of review
Statins - Studies advance knowledge in statins research
Stem Cell Research - Chemicon, Stem Cell Sciences launch ESGRO Complete product line
Stem Cell Research - Chronic myeloid leukemia remission involves functional hematopoietic progenitor cells
Stem Cell Research - Georgia Biomedical Partnership responds to Georgia Senate Bills 596 and 537
Stem Cell Research - Ischemia may resolve after alpha 4 integrin disruption
Stroke - Community-based exercise can improve upper-extremity function in persons with chronic stroke
Stroke - In stroke patients treated with IV tissue plasminogen activator, microbubbles accelerate clot lysis
Stroke - Neuromuscular stimulation and movement therapy restored hand function in chronic stroke patients
Stroke - Silent brain infarction is associated with metabolic syndrome as risk factor in healthy people
Surgical Technology - Study shows xenon gas safe in surgery and could help stop nerve-damaging illnesses
Systemic Sclerosis - Systemic sclerosis subtypes bear differential angiogenesis modulators
Testicular Seminoma - Stage IIA/B testicular seminoma could not be effectively treated with carboplatin
Thyroid Cancer - Autocrine production of interleukin is required by thyroid cancer cells
Thyroid Cancer - Thyroid cancer is stimulated by the proangiogenic marker AcSDKP
Thyroid Cancer - Thyroid cancer treated with second iodine-131 therapy
Thyroid Cancer - Thyroid carcinoma managed with radiolabeled somatostatin analogs
Tinnitus - Melatonin associated with alleviating tinnitus symptoms, better sleep
Tobacco Use - Pulmonary hypertension may correlate with vascular remodeling in cigarette smokers
Tracheobronchial Foreign Body Aspiration - Exploratory rigid bronchoscopy to rule out foreign body aspiration carries low morbidity
Transplant Medicine - Attitudes toward xenotransplantation evaluated among health professionals
Transplant Medicine - Researchers' findings advance transplant medicine research
Transplant Medicine - Studies add new findings to transplant medicine body of knowledge
Tuberculosis Drug Adherence - Tuberculosis treatment adherence improved by frequent return strategy
Tuberculosis Mortality - TB-related mortality associated with HIV infection and multidrug resistance
Tuberculosis Therapy - TB-related morbidity and mortality reduced by early diagnosis and effective treatment
Tuberculosis Vaccine - Immunity against tuberculosis is induced by extraordinarily few organisms of live BCG vaccine
Tumor Suppression - Octreotide suppresses tumors via altered kinase signaling and Zac1 expression
Type 2 Diabetes - Metformin is not linked to higher lactic acidosis risk in type 2 diabetics
Type 2 Diabetes - Phase I/II study of PC-DAC:Exendin-4 for type 2 diabetes to be initiated by ConjuChem
Type 2 Diabetes - Supplemental NDA submitted seeking to use exenatide injection with TZDs in type 2 diabetes
Urothelial Tract Tumors - High-dose intensity M-VAC reduced risk of progression of urothelial tract tumors
Vaccines Delivery - New findings in the area of vaccines delivery described
Vector Development - HSV replication is secured by temporarily evading apoptotic cellular responses
Virology - Antiviral protection by neonate CD8+ memory cells rivals adult memory cells
Virology - Pestivirus replication inhibitor targets viral RNA-dependent RNA polymerase
Virology - Researchers publish new studies and findings in the area of virology
Virology - Small interfering RNA inhibits Anatid Herpes Virus-1 replication
Virology - Wild-type hepatitis A virus has been stably grown in cell culture
Women's Health - Study shows no increased coronary heart risk with estrogen-alone therapy
Wound Care - Advanced Medical Solutions pursuing Chinese market for wound closure products
Wound Care - Skin ulcers benefit from combining hyperbaric oxygen with basic fibroblast growth factor
Wound Healing - Wound healing is regulated by plasmin-controlled vascular endothelial growth factor
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