Hyperalgesia

Inflammatory pain is induced and maintained by activation of CB1 and CB2 receptors

Published in Drug Week, March 31st, 2006

Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat.

"The aim of the present study was to investigate the effects of cannabinoid agonists on established inflammatory hyperalgesia. We have compared the effects of pre-administration versus post-administration of a potent non-selective cannabinoid agonist HU210 and a selective CB, receptor agonist JWH-133 on hindpaw weight bearing and paw edema in the carrageenan model of inflammatory hyperalgesia," researchers in England report.

S.J.R. Elmes and colleagues from the University of Nottingham explained, "For comparative purposes we also determined...

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Source: Drug Week (2006-03-31)

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