Lung Cancer

siRNA targeting of survivin might increase sensitivity to anticancer drugs

Published in Drug Week, March 31st, 2006

Small interfering (si)RNA targeting of survivin might increase sensitivity to anticancer drugs.

According to recent research from Japan, "Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is specifically overexpressed in cancer tissues. p53 is one of the tumor suppressor genes; its induction in response to DNA damage causes apoptosis and correlates with drug sensitivity. To investigate the possible regulation of survivin by p53, we examined the level of survivin expression in lung cancer cell lines in response to adriamycin."

"Levels of survivin mRNA and protein in cell lines with wild-type p53 decreased dramatically after...

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Source: Drug Week (2006-03-31)

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