Addiction Medicine

Polymorphisms exist in the serotonin 1B receptor gene for heroin addiction

Published in Drug Week, March 31st, 2006

Polymorphisms exist in the serotonin 1B receptor (HTR1B) gene for heroin addiction.

According to recent research published in the journal Pharmacogenetics and Genomics, "5-hydroxytryptamine (serotonin)-1B receptors (HTR1B) may play an important role in psychiatric disorders and drug and alcohol dependence. In this study we report on genotype, molecular haplotype and statistically estimated haplotype analyses of previously identified polymorphisms in positions -261T >G, -161A >T, 129C >T, 861G >C and 1180A >G of the HTR1B gene in ethnically diverse populations (African-Americans, Caucasians, Hispanics and Asians) including 235 former heroin addicts...

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Source: Drug Week (2006-03-31)

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