Drug Week

Drug Development - Nitric oxide-donating aspirin is focus of review of pharmacological and clinical perspectives

Drug Development - Paclitaxel efficacy enhanced by novel compound 73R

Drug Development - Rifamycin-resistant Staphylococcus aureus susceptible to novel rifamycins

HIV/AIDS HAART - HAART discontinuation risk factors identified

Melanoma Therapy - Preclinical results support continued evaluation of CR011-vcMMAE for melanoma

Acid Reflux - Gastroesophageal acid reflux Rennie alginate treatment promising

Acute Hepatitis - In acute hepatitis, glycoprotein oligosaccharides are modified by reactive oxygen species

Acute Promyelocytic Leukemia - All-trans retinoic acid molecular effects in acute promyelocytic leukemia elucidated

Addiction Medicine - Dr. Raymond Johnson presents preliminary outcomes data on PROMETA addiction treatment

Adverse Drug Reaction - Epilepsy drugs carbamazepine, oxcarbazepine lower vitamin D and raise bone turnover

Adverse Drug Reaction - Gefitinib-induced interstitial lung disease is identified by serum markers

Aggressive Fibromatosis - Imatinib response in AF patients may be mediated by inhibition of PDGFRB kinase activity

Allergy & Immunology - Aspirin-triggered lipoxin anti-inflammatory activity is SOCS-2 dependent

Allergy & Immunology - Rheumatoid arthritis anti-TNF treatment efficacy linked to anti-CCP titer

Allergy Medicine - Method to determine phenylephrine, chlorpheniramine, and methscopolamine is developed

Alzheimer Disease - Alzheimer disease amyloid plaque suppressed by marrow-derived microglia

Alzheimer Disease - Humanetics, Mount Sinai School to launch trial of new Alzheimer compound

Anesthesia - Recent findings in anesthesia described

Aneurysms - Brain aneurysm healing sped by controlled release system for basic fibroblast growth factor

Angiology - Carotid arterial compliance may be impaired during menstrual cycle in young women

Angiology - Clopidogrel withdrawal is linked to proinflammatory and prothrombotic effects in diabetes

Angiology - Erectile dysfunction may represent generalized vascular dysfunction

Angiology - In coronary heart disease, inflammation enhances endothelial tissue plasminogen activator release

Angiology - Postnatal angiogenesis is guided by EphB4

Anthrax - Elusys Therapeutics completes human clinical study of the anthrax therapeutic Anthim

Anthrax Vaccine - N-fragment of edema factor is candidate antigen for anthrax vaccine

Antimicrobial Agents - Degenerate phosphorothioate oligonucleotides prevent prion conversion

Antisense Technology - Retinal ganglion cell transfection is achieved by retrograde transfer of antisense oligonucleotides

Anxiety - Pfizer's Lyrica approved for generalized anxiety disorder in Europe

Apoptosis - Apoptosis is regulated by peptides of fibronectin in human monocytes

Apoptosis - Osteosarcoma apoptosis induced by alpha-Tocopheryl succinate

Arterial Thrombosis - Targeting PAR1-PAR4 may offer opportunity to prevent arterial thrombosis

Arthritis - Findings describe new data in arthritis research

Arthritis - Image-guided therapy effective treatment for juvenile arthritis

Arthritis - Rheumatoid arthritis angiogenesis is driven by interleukin-18

Atherosclerosis - Atherosclerosis lesions may be prevented with aged garlic extract

Atherosclerosis - New research in the area of atherosclerosis detailed

Avian Influenza Vaccine - Adenovirus-based vaccine protects against lethal H5N1 avian influenza

Avian Influenza Vaccine - Antigen working with U.S. FDA to fast track flu vaccine

Avian Influenza Vaccine - Reverse-genetics is most rapid method to produce avian influenza vaccine

Awards - Johnson & Johnson PRD technology director Jeff Mathers receives 2006 Grid Visionary Award

Back Pain - Chronic back pain in postmenopausal osteoporotic women may not be relieved by calcitonin

Bladder Cancer - Bladder cancer treated by intravesical gemcitabine

Bone Cancer - Osteosarcoma inhibition by meloxicam involves COX-2-dependent and independent routes

Brain Cancer - Glioma proposed as possible target for antitumor agent perillyl alcohol

Breast Cancer - Breast cancer angiogenesis is stimulated by stromal syndecan-1

Breast Cancer - Breast cancer cells find an adenovirus cytotoxic

Breast Cancer - Breast cancer metastasis is controlled by a combined approach to angiogenesis inhibition

Breast Cancer - Breast cancers use hypoxia inducible factor to boost angiogenesis and metastasis

Breast Cancer - Erythropoietin inhibits apoptosis in breast cancer cells without modulating chemosensitivity

Breast Cancer - Fulvestrant may be effective against breast cancers that progress after aromatase inhibitor therapy

Breast Cancer - HER2-overexpressing breast tumors suppressed by novel synthetic triterpenoid

Breast Cancer - Metastatic breast cancer survival improved with anticancer drugs

Breast Cancer - New findings in the area of breast cancer described

Breast Cancer - New findings in the area of breast cancer detailed

Breast Cancer - Pelvic MR imaging may enhance diagnostic analysis of endometrium in breast cancer patients

Breast Cancer - Recent studies add new data to breast cancer research

Breast Cancer - Reports describe recent advances in breast cancer research

Breast Cancer - Researchers detail new studies and findings in the area of breast cancer

Breast Cancer - Study provides data for price-setting policies related to Herceptin in breast cancer therapy

Breast Cancer Screening - Hormone replacement therapy does not appear to adversely affect accuracy of mammography

Breast Cancer Therapy - Hot flashes may be reduced with sertraline (Zoloft) therapy in breast cancer survivors

Breast Cancer Vaccine - Anti-idiotypic vaccine elicits immune responses in metastatic breast cancer patients

Burn Medicine - Acute burn and smoke lung injury Vitamin E nebulization therapy effective

Business & Finance - Alteon reports year end results

Business & Finance - Ceragenix reports 2005 year-end financial results and business progress

Business & Finance - DOR BioPharma reports 2005 financial results, sees reduction in net loss

Business & Finance - Evotec announces 2005 financial results, performance markers

Business & Finance - Forbes Medi-Tech announces CDN$21 million in revenue for 2005

Business & Finance - Grifols closes out 2005 with a 15% increase in sales

Business & Finance - Hemispherx Biopharma announces delay in filing its form 10-K for 2005

Business & Finance - MIV Therapeutics announces availability of updated investor fact sheet

Business & Finance - Ophthalmic company InSite Vision reports Q4 2005 net loss of $4.1 million

Business & Finance - PanGenetics BV closes series B financing and announces board appointments

Business & Finance - WallStreet Research initiates coverage of BrainStorm Cell Therapeutics' shares

Business Update - Actavis CEO visits Croatia to advance Pliva proposal

Business Update - Affymetrix launches new array product line

Business Update - Akzo Nobel Pharma provides update on clinical pipeline

Business Update - Callisto CEO details clinical progress of anti-cancer drug development and other programs

Business Update - Covalent Group, Inc. announces additional new business contracts

Business Update - DRAXIS radiopharmaceuticals division updates product research and development strategy

Business Update - Diatos announces expansion of Medarex cancer product licensing agreement

Business Update - Elixir Pharmaceuticals acquires late-stage product for the treatment of type II diabetes

Business Update - FDA advisory committee recommends against approval of SPARLON for ADHD in children, teens

Business Update - ImmunoGen announces extension of technology access agreement by Millennium

Business Update - Symyx launches excipient compatibility system for accelerating drug development process

Business Update - Tripos releases enhanced and updated version of molecular modeling software system

Cancer Gene Therapy - Adenoviral-mediated gene therapy targets ovarian cancer

Cancer Gene Therapy - Chemosensitivity of malignant melanomas is increased by beta gene transfer

Cancer Gene Therapy - Epigenetically silenced tumor suppressor overcomes resistance to apoptosis induction by interferons

Cancer Gene Therapy - HCC cell proliferation is inhibited via decreased telomerase activity

Cancer Gene Therapy - MIP-3 alpha gene therapy following radiation therapy boosts anti-tumor immunity

Cancer Gene Therapy - Virus dissemination in local gene delivery is governed by rate, volume, and dose

Cancer Immunotherapy - Endothelial progenitor cells offer a way to target tumor angiogenesis

Cancer Research - M.D. Anderson researchers find immune response may protect against brain tumor development

Cancer Research - Researchers seek alternative for CML patients who are resistant to standard therapies

Cancer Therapy - Alpha-tocopherol succinate inhibits oncogenic Ras signaling

Cancer Therapy - Angiogenesis is altered by the upstream activity of indole derivative DIM

Cancer Therapy - Argentatin B derivatives developed as growth inhibitors of human cancer cells

Cancer Therapy - CFD Therapeutics formed to advance monoclonal antibodies for cancer

Cancer Therapy - Capecitabine-metabolizing enzymes quantified with novel real-time RT-PCR assay

Cancer Therapy - Congestive heart failure, renal failure and cancer treated by cardiac natriuretic peptides

Cancer Therapy - Coramsine antitumor efficacy is potentiated by CpG-containing oligodeoxynucleotides

Cancer Therapy - DNA methyltransferase inhibitors are angiostatic in tumors

Cancer Therapy - Estrogen exerts a spatial and temporal influence on reactive oxygen species generation

Cancer Therapy - Findings describe new data in cancer therapy research

Cancer Therapy - G-quartet oligonucleotides target transduction and transcription in head and neck cancer

Cancer Therapy - Integrin-targeted chemotherapy may be compromised by antiangiogenic therapy

Cancer Therapy - L-Alanosine (SDX-102) efficacy influenced by circadian dosing time

Cancer Therapy - New chemotherapy technique implants drug-soaked fibers in the body

Cancer Therapy - Oncolytic viral therapy improved by matrix-modifying tumor treatments

Cancer Therapy - Proliferating cells should be targeted in cancer therapy

Cancer Therapy - Protein Tyr phosphatase PRL-3 functions in malignant and endothelial cells

Cancer Therapy - Recent findings in cancer therapy described

Cancer Therapy - Researchers publish new studies and findings in the area of cancer therapy

Cancer Therapy - Tumor response to vascular disrupting agents predicted by interstitial fluid pressure levels

Cancer Therapy - Use of thymidylate synthase inhibitors in cancer therapy examined

Cancer Vaccine - Dendritic cells pulsed with tumor lysate enhance immunity in pancreatic cancer

Cancer Vaccine - Fusion protein has pro-apoptotic activity in carcinomas overexpressing HER2

Cancer Vaccine - LAGE-1 peptide is recognized by cytolytic T lymphocytes on HLA-A68 tumors

Cancer Vaccine - Multi-epitope peptide vaccines alter CD8+ T cell responses

Cancer Vaccines - Findings advance knowledge in cancer vaccines research

Cancer Vaccines - New findings in cancer vaccines described

Cancer Vaccines - New research in the area of cancer vaccines detailed

Cancer Vaccines - Reports describe recent advances in cancer vaccines research

Cancer Vaccines - Researchers' findings advance cancer vaccines research

Candidiasis - DNA probes for rapid identification of Candida species have been developed

Cardiac Hypertrophy - Cardiac hypertrophy and myelo-lymphoproliferative disorders are caused by gene haploinsufficiency

Cardiology - Apolipoprotein infusion affects atheroma regression and change in lumen size

Cardiology - Carotid artery plaques could use angiogenesis and apoptosis intermediate modulation

Cardiology - Cellular basis for manifestations of Andersen-Tawil syndrome are examined

Cardiology - Coronary restenosis is prevented by the tyrosine kinase inhibitor SU11218

Cardiology - Findings advance knowledge in cardiology research

Cardiology - In atrial fibrillation ablation, monitoring of luminal esophageal temperature may prevent injury

Cardiology - In high-transfusion-risk cardiac surgery, aprotinin and tranexamic acid are similarly effective

Cardiology - Rate control in atrial fibrillation provides important benefits to patients

Cardiology - Researchers describe findings in cardiology studies

Cardiology - Studies advance knowledge in cardiology research

Cardiomyocytes - Ischemic preconditioning, 17 beta-estradiol may share a final common effector

Cardiovascular Disease - Findings in cardiovascular disease provide new insights

Cardiovascular Disease - New findings in the area of cardiovascular disease detailed

Cardiovascular Disease - Nitric oxide in coronary artery disease and effects of antioxidants are focus of review

Cardiovascular Disease - Preclinical data show Samaritan's cardiovascular drug reduces cholesterol

Cardiovascular Disease - Therapeutic effects of xanthine oxidase inhibitors are considered in review

Cardiovascular Research - After cardiopulmonary bypass, aprotinin attenuates elevation of pulmonary vascular resistance

Cell Biology - BIG2 may have an important role in Tfn uptake and TfnR recycling

Cervical Cancer - Metastases in primary cervical cancer linked to carbonic anhydrases

Chagas Disease - Chagas disease amiodarone-posaconazole treatment synergistic in mice

Chagas Disease - Hypervariable region of Trypanosoma helps elude immune recognition

Chickenpox Vaccine - Varicella-zoster virus vaccine is safe and immunogenic in pediatric transplant recipients

Chronic Hepatitis - HBeAg-positive chronic hepatitis B is more responsive to entecavir than to lamivudine

Chronic Myelogenous Leukemia - SGX Pharmaceuticals and Novartis collaborate on BCR-ABL inhibitors for chronic myelogenous leukemia

Chronic Obstructive Pulmonary Disease - GSK announces positive results of Seretide survival study in COPD patients

Cirrhosis - Endotoxic liver damage in cirrhotic rats reduced by bosentan ET-1 blockade

Clinical Trials - Book reviews good clinical practice interpretation in drug trials

Clinical Trials - Clinical Data initiates patient enrollment for Vilazodone Phase 3 clinical trial

Clinical Trials - Cubist Pharmaceuticals submits response to FDA Approvable Letter on Cubicin

Clinical Trials - Flaws in Pfizer's antifungal trials of voriconazole are discussed in professional publication

Clinical Trials - Guidant to temporarily suspend XIENCE V supply, stops enrollment in SPIRIT III

Clinical Trials - Innocoll Technologies initiates Phase 2a clinical study of bupivacaine collagen sponge

Clinical Trials - Inspire to provide added information to U.S. FDA after meeting on dry eye program

Clinical Trials - Phase 2 data show antiviral drug maribavir significantly reduces CMV reactivation in transplants

Clinical Trials - SciClone presents phase 2 liver cancer data at international congress in Shanghai

Clinical Trials - YM BioSciences' partner Oncoscience AG cleared for phase 3 trial in Germany with nimotuzumab

Clinical Trials - Yale researchers find phenoxodiol restores sensitivity to chemotherapy in some cancer patients

Collaborations - Aethlon Medical, Commonwealth Biotechnologies sign research agreement

Collaborations - Akorn signs purchase and supply agreement with Natco Pharma for anti-emetic drug

Collaborations - Alnylam inks deals for access to RNAi technologies

Collaborations - Aperio secures exclusive reseller license for Zoomify software

Collaborations - Aspect Medical Systems collaborates with researchers to initiate depression study

Collaborations - BG Medicine to conduct preclinical study for muscle toxicity with Mitsubishi Pharma

Collaborations - Caprion Pharmaceuticals announces biomarker discovery collaboration with Vertex Pharmaceuticals

Collaborations - ChemDiv, Inc. and Carna Biosciences, Inc. form strategic alliance

Collaborations - Columbia U Medical Center uses Cyberkinetics' NeuroPort System to research brain activity

Collaborations - CytoPathfinder signs agreement for joint research of ophthalmic drug

Collaborations - INEX and Alnylam ink research collaboration for systemic delivery of RNAi therapeutics

Collaborations - Noxxon Pharma and Pfizer to collaborate on the discovery and development of Spiegelmer products

Collaborations - Nutralogix Laboratories inks product distribution agreement with Dynamic Health Products

Collaborations - Omnia Biologics and Intradigm sign deal for cGMP manufacturing services

Collaborations - Ono and Medarex enter second collaboration to develop fully human antibody therapeutic

Collaborations - Santen, Oakwood Laboratories sign deal for development of diabetic macular edema technology

Collaborations - Surgical Specialties signs deal for Dermalogen injectable dermal filler products

Collaborations - Two Arizona cardiology consultant practices form joint sleep disorders venture REM Medical

Colon Cancer - Colon cancer prevention via antioxidant apple flavonoids possible

Colon Cancer - Colorectal cancer and angiogenesis give way to aged garlic extract

Colon Cancer - Liver metastasis has a selective response to antiangiogenic therapy

Colorectal Cancer - Celecoxib may help prevent colorectal cancer in high-risk patients

Colorectal Cancer - Changing trends in the management of colorectal cancers reviewed

Colorectal Cancer - Colon cancer DNA microarray study reveals novel markers of chemotherapy response

Colorectal Cancer - Colorectal cancer should be treated according to age and comorbidities

Colorectal Cancer - Colorectal cancer tissues analyzed for distinct gene expression patterns

Colorectal Cancer - Colorectal cell-induced apoptosis involves c-Abl-independent p73 stabilization

Colorectal Cancer - Panitumumab showing great promise against colorectal cancer

Colorectal Liver Metastases - Surgery for four or more colorectal liver metastases justified

Complementary & Alternative Medicine - Aged garlic extract may inhibit aggregation in human platelets by suppressing calcium mobilization

Complementary & Alternative Medicine - Aged garlic extract retards progression of coronary artery calcification

Complementary & Alternative Medicine - Cardiovascular health benefit of garlic compounds may be due to suppression of LDL oxidation

Complementary & Alternative Medicine - Cardiovascular homeostasis in mice and rats maintained by aged garlic extract

Complementary & Alternative Medicine - Garlic and cardiovascular disease are considered in a critical review

Complementary & Alternative Medicine - Homocysteine-induced endothelial dysfunction is improved by aged garlic extract

Complementary & Alternative Medicine - Risedronate and calcitriol improve cancellous bone strength in rats with osteopenia

Condylomata Acuminata - Pegylated IFN alfa-2b safe and effective for HIV-related condylomata acuminata

Contraception - Effective use of combined oral contraceptive pills is focus of review

Contraception - Use of hormonal injectables and contraceptive implants is focus of review

Contraceptive Vaccine - Anti-fertility vaccines for foxes are developed with bacterial artificial chromosomes

Contraceptive Vaccine - DNA vaccine expressing brLDH-C4' possesses anti-fertility effects

Contracts - MP-Technopharma to start contract manufacturing of Chugai Pharma's four prescription products

Coronavirus - Coronavirus clearance is delayed via inhibition of interferon signaling in oligodendroglia

Critical Care Medicine - Volume expansion outcome may be altered by adrenergic drugs

DNA Research - Cancer cell DNA methyltransferase inhibitors display functional diversity

DNA Research - Fibrinogen peptide resolution is increased by G-quartet DNA stationary phase destabilization

DNA Vaccine - DNA vaccination elicits anti-HBV immune responses in rhesus macaques

Dendritic Cell Vaccine - Adenovirus vectors enhance presentation of vectored antigen

Depression - Lundbeck initiates phase I trial of Lu AA34893 for depression

Dermatology - Cholinergic drugs may be a promising approach for cutaneous blistering disorders

Developmental Biology - Renal tubular epithelial cell connective tissue growth factor is induced by dexamethasone

Diabetes Complications - Albuminuria lowering in hypertension and diabetes patients appears to be beneficial

Diabetes Complications - Amadori products may play a role in the development of diabetic heart disease

Diabetes Complications - Angiotensin-converting enzyme-inhibitors may raise long-term end-stage renal failure risk

Diabetes Complications - Diabetic retinopathy can be detected by serum anti-aldolase autoantibody

Diabetes Complications - Diabetic retinopathy changes glial cell swelling characteristics

Diabetes Complications - InsR signaling in diabetes-impaired wounds is sensitive to inflammatory conditions

Diabetes Complications - New findings in the area of diabetes complications described

Diabetes Control - DexCom receives FDA approval for STS Continuous Glucose Monitoring System

Diabetes Control - New long-acting insulin analog Levemir now available in United States

Diabetes Diagnosis - Dobutamine stress echocardiography can assess diabetes-related cardiovascular morbidity

Diabetes Epidemiology - AMPK genes PRK4A2, PRKAB1, and PRK4B1 plus BMI appear to be linked to type 2 diabetes

Diabetes Pathogenesis - AdipoR1 and AdipoR2 do not appear to have a key role in insulin sensitivity modulation

Diabetes Pathogenesis - Findings advance knowledge in diabetes pathogenesis research

Diabetes Pathogenesis - MCHr1 deficiency raises insulin sensitivity in obese leptin-deficient, but not body weight

Diabetes Prevention - Hormone therapy may have antidiabetic effect but may also increase risk of heart disease

Diabetes Risk Factors - Increased diabetes risk is seen in women with gestational diabetes using injectable progestin

Diabetes Therapy - Addition of rapid-acting insulin to basal insulin therapy in diabetes may offer better control

Diabetes Therapy - Antecedent hypoglycemia does not alter epinephrine-induced lipolysis in type 1 diabetes

Diabetes Therapy - Asparagus adscendens stimulates insulin secretion, insulin action and inhibits starch digestion

Diabetes Therapy - Benfluorex in combination with sulfonylurea was beneficial for type 2 diabetics

Diabetes Therapy - Caffeic acid phenethyl ester improves IGFs secretion and gene expression changes in diabetic rats

Diabetes Therapy - Chromium has no effect in obese type 2 diabetics with poorly controlled insulin

Diabetes Therapy - Findings advance knowledge in diabetes therapy research

Diabetes Therapy - Glucose-dependent insulinotropic peptides are long-acting stable analogues for diabetes therapy

Diabetes Therapy - Incretin mimetics and dipeptidyl peptidase-IV inhibitors offer new type 2 diabetes therapies

Diabetes Therapy - PPARdelta regulates glucose metabolism and insulin sensitivity

Diabetes Therapy - Recent findings in diabetes therapy provide new insights

Diabetes Therapy - Research add new data to diabetes therapy body of knowledge

Diabetes Therapy - Researchers' data advance diabetes therapy research

Diabetes Therapy - Researchers' findings advance diabetes therapy research

Diabetes Therapy - Researchers' work adds to diabetes therapy body of knowledge

Diabetes Therapy - Takeda submits new drug application for extended-release type 2 diabetes medication, ACTOplus met

Diabetic Neuropathy - Nerve growth factor delays nociceptive deficits in diabetic neuropathy model

Diagnostics - Colorectal carcinoma microarray transcriptome maps can improve diagnosis and treatment

Diagnostics - Foundation for Innovative New Diagnostics reaches second milestone in rapid TB test development

Diagnostics - Low serotonin levels in plasma accurately measured by novel HPLC assay

Diagnostics - Modified ELISA detects and quantifies heparanase

Diagnostics - New findings in the area of diagnostics detailed

Diagnostics - St. Jude develops follow-up test to identify children with acute lymphoblastic leukemia

Diet & Nutrition - Casitas b-lineage lymphoma-deficient mice protected against obesity and diabetes

Diet & Nutrition - Cranberry juice consumption did not alter antioxidant or lipid status in healthy subjects

Diet & Nutrition - Intestine and kidney contribute to glucose fluxes when nutritional conditions are changing

Diet & Nutrition - Long-term lifestyle changes can lower rates of high blood pressure and risk of heart disease

Diet & Nutrition - Mannatech will begin selling glyconutritional products in Germany

Diet & Nutrition - Seablue dermal vitamin therapy offers magnesium supplement product

Diet & Nutrition - Studies advance knowledge in diet & nutrition research

Diet & Nutrition - alpha-Tocopherol stereoisomer bioavailability depends on intake of alpha-tocopheryl acetates

Drug Abuse - $3.3M available for prevention of methamphetamine abuse in U.S.

Drug Approvals - FDA approves extended dosing of Aranesp to treat chemotherapy-induced anemia

Drug Delivery - Findings advance knowledge in drug delivery research

Drug Delivery - Kurve Technology announces agreement with development stage company DARA BioSciences

Drug Delivery - Liposome delivery of model tumor antigen depends on type-1 interferons

Drug Delivery - Postdural puncture headache risk low with small gauge epidural needles and catheters

Drug Delivery - Studies add new findings to drug delivery body of knowledge

Drug Development - Aastrom Biosciences receives orphan drug designation for bone marrow cells

Drug Development - Accentia's partner receives U.S. FDA approval for new pain medication dosage

Drug Development - Adams initiates phase II program for Erdosteine

Drug Development - Adherex receives regulatory clearance for phase II weekly dosing schedule

Drug Development - Algeta publishes results of new thorium-227 mAb conjugate

Drug Development - Allergan receives positive opinion for Ganfort in European Union

Drug Development - Alnylam scientists publish results of primate herapeutic gene silencing with systemic RNAi

Drug Development - Amgen, Abgenix complete BLA for U.S. FDA approval of panitumumab

Drug Development - AmpliMed begins enrollment of phase I trial of Amplimexon for multiple myeloma

Drug Development - Anthracycline prodrugs used in cancer chemotherapy reviewed

Drug Development - Antigenics reports phase III results for Oncophage in kidney cancer

Drug Development - Antitumor activity of novel 1,4-naphthoquinone derivatives (IV) evaluated

Drug Development - Arena Pharmaceuticals provides updates on obesity, insomnia drugs

Drug Development - Aspreva completes patient enrollment in phase III trial of CellCept in active pemphigus vulgaris

Drug Development - AstraZeneca reports preliminary results from TORCH trial for COPD

Drug Development - Axcan submits U.S. FDA amendment to its new drug application for Helizide

Drug Development - Berna Biotech reports first product approval for Quinvaxem vaccine

Drug Development - Biogen Idec, Elan initiate Tysabri monotherapy safety extension study in multiple sclerosis

Drug Development - Bionutrics initiates U.S. development for a generic oral controlled-release drug

Drug Development - Cancer drug assessment improved by MRI T₁ parametric mapping method

Drug Development - Cancer drug resistance overcome by novel daunorubicin analogue

Drug Development - Committee for Medicinal Products for Human Use adopts multiple opinions

Drug Development - CuraGen and TopoTarget announce initiation of first NCI-sponsored clinical trial with PXD101

Drug Development - Depomed, Madaus S.r.l. announces approval application accepted for ProQuin XR in Sweden

Drug Development - FemmePharma Global Healthcare, Inc. opens IND application for treatment of breast pain

Drug Development - Galapagos NV service division enters a three-year collaboration with Roche

Drug Development - Millenia's infectious disease program to develop malaria and HIV/AIDS drug discovery targets

Drug Development - Molecular library profiling technique may improve drug discovery

Drug Development - Novel anti-inflammatory steroidal antedrugs synthesized

Drug Development - Tumor angiogenesis collapses in the presence of fibulins 3 and 5

Drug Importation - Permanent court order against Canada Care Drugs halts illegal importation of prescription drugs

Drug Resistance -  Candida glabrata with amphotericin B and caspofungin resistance isolated

Drug Resistance -  Streptococcus pyogenes fluoroquinolone resistance involves spontaneous mutation and horizontal gene transfer

Drug Resistance - Aspirin and clopidogrel resistance is an emerging clinical entity

Drug Resistance - Multidrug-resistant tuberculous meningitis difficult to diagnose in children

Drug Resistance - Primagen virus discovery group chosen for E.U.-funded program on antibiotic resistance

Drug Resistance - Researchers' findings advance drug resistance research

Drug Safety - Clinical relevance of statin-clopidogrel interaction needs further clarification

Ebola Virus - Ebola virus amplification is inhibited by VP35 knockdown

Eczema - European Medicines Agency recommends cautious use of Protopic/Protopy and Elidel

Endocrinology - Low-potency PARP inhibitors raise insulin synthesis by increasing MafA gene transcription

Endocrinology - VEGF-A is differentially expressed during hypothalamic-pituitary axis development

Endometrial Cancer - Endometrial cancer outcome after chemotherapy and hormonal therapy is questionable

Endothelial Cells - Sphingosine 1-phosphate receptors mediate expression of endothelial cell adhesion molecules

Environmental Toxins - Lead-exposed children may get limited benefit from iron or zinc supplements

Environmental Toxins - Manganese sulfate, a MMT combustion product, toxicity can occur at low exposure levels

Enzymology - Vaccinia virus glycosylase forms heterodimeric processivity factor for viral DNA polymerase

Epidemiology -  Clostridium difficile strain isolates from symptomatic patients in Warsaw hospital characterized

Epidemiology -  Stenotrophomonas maltophilia bacteremia incidence determined in burn patients

Epilepsy Therapy - Brain tumor-related epilepsy resistance not due to blood-brain barrier BCRP

Esophageal Cancer - Esophageal carcinoma poor prognosis linked to activated NF-kappa B

Fibrinogen - Fibrinogen binding of synthetic B knobs changes the character of fibrin

Finance - Alexza Pharmaceuticals exercises over-allotment option

Finance - Amex agrees not to delist Calypte's common stock

Finance - Amylin Pharmaceuticals announces public offering of common stock

Finance - BioMarin prices concurrent public offerings

Finance - BioScrip reports loss of $0.70 per share for year

Finance - Biovail provides earnings, revenue guidance for 2006

Finance - Bovie Medical reports revenues of $0.03 per share for 2005

Finance - Carrington reports $5.3 million net loss for 2005

Finance - Cytori Therapeutics announces 2005 financials, big jump in research and development expense

Finance - Debiopharm S.A. invests in nanocarrier mezzanine funding round

Finance - Etrials Worldwide reports 2005 revenue of $13.6 million, 39% backlog increase

Finance - Hercules provides $15 million financing to AVEO Pharmaceuticals

Finance - MFIC Corporation announces year-end revenues of $11,645,000

Finance - Medarex announces public offering of common stock

Finance - MediGene reduces operating loss by 22%

Finance - Metabasis Therapeutics announces pricing of common stock in registered direct offering

Finance - North American Scientific secures $4 million line of credit agreement with partners for growth

Finance - Pure Bioscience raises $6.5 million in equity financing

Finance - SFBC International granted waivers for credit facility

Finance - Santaris Pharma raises EUR 40 million of new equity

Finance - Savient Pharmaceuticals reports total revenues of $87.8 million for the full year 2005

Finance - Schiff Nutrition reports Q3 2006 net sales of $49.6 million, up from $45.2 million in 2005

Finance - Toronto Stock Exchange confirms Stressgen's substitutional listing, new symbol

Finance - Valentis completes private placement of 2.1 million shares of common stock

Finance - Walgreen Co. reports record Q2 2006 net earnings of 51 cents per share

Finance - Ziopharm reports net loss of $9.5 million for 2005, compared to $5.7 million loss in 2004

Gastric Cancer - Gastric cancer treatment standards in the 21st century reviewed

Gastritis - Vaccine prevents Helicobacter pylori-induced alterations of gastric flora

Gastroenteritis - Optimer Pharmaceuticals initiates phase III trials of OPT-99 for gastroenteritis

Gastroenterology -  Helicobacter pylori infection prevents nocturnal gastric acid breakthrough

Gene Research - Genetic polymorphisms do not influence enzyme activity in cancer cell lines

Gene Silencing - Gene silencing of HIV chemokine receptors is achieved using ribozymes and antisense RNA

Gene Transfection - siRNA or siLNA transfection fails to induce anti-viral responses in HeLa and MCF cells

Gene Transfer - Human periodontal ligament fibroblasts are immortalized by SV40T-antigen and hTERT gene transfer

Genetics & Genomics - Allelic differential expression analyzed in human white blood cells

Genetics & Genomics - Cardiovascular disease studied in Hutchinson-Gilford progeria syndrome transgenic mouse model

Genetics & Genomics - Cytochrome P450 2C8 polymorphism common in Portuguese