Published in Drug Week, April 28th, 2006
"The use of thiazolidinedione (TZD) derivatives is associated with fluid retention, especially when combined with insulin. Because TZDs improve the metabolic effect of insulin, they may also reverse the blunted vascular response to insulin. We hypothesize that improvement of the action of insulin on vascular tone or permeability is the key mechanism of TZD-related fluid retention," researchers in Netherlands report.
A.J.M. Rennings and colleagues at Radboud University conducted "a randomized, double-blind, placebo-controlled, cross-over study in 18...
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