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SARS

Recent findings in SARS described

Published in Drug Week, April 28th, 2006

SARS research advances have been reported from The Netherlands, People's Republic of China and Canada.

Study 1: According to recent research from the Netherlands, the transmembrane domain of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) spike protein (S) functions during entry.

"The S of the SARS-CoV is responsible for receptor binding and membrane fusion. It contains a highly conserved transmembrane domain that consists of three parts: an N-terminal tryptophan-rich domain, a central domain, and a cysteine-rich C-terminal domain.

"The cytoplasmic tail of S has previously been shown to be required for assembly....

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