Cardiology

Coronary artery endothelial cell behavior inhibited by thymosin beta10

Published in Drug Week, May 26th, 2006

A study from the United States has reported on the inhibition of human coronary artery endothelial cell (HCAEC) migration and capillary-like tube formation by thymosin beta10.

"Thymosin beta10 is a cytoplasm G-actin sequestering protein whose functions are largely unknown. To determine the direct effects of exogenous thymosin beta10 on angiogenic potentials as endothelial cell migration and capillary-like tube formation, HCAECs were incubated with increasing doses of thymosin beta10 (25-100 ng/ml)," wrote H. Mu and colleagues, Baylor College of Medicine.

"By using a modified Boyden chamber assay, thymosin beta10 inhibited cell migration in a dose-...

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Source: Drug Week (2006-05-26)

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