Simian Immunodeficiency Syndrome Pathogenesis
Th-1-type CD8+ responses to SIV are consistent feature of natural SIV infection
Published in Drug Week, May 26th, 2006
According to recent research published in the Journal of Virology, "Sooty mangabeys are a natural host of simian immunodeficiency virus (SIV) that remain asymptomatic and do not exhibit increased immune activation or increased T-lymphocyte turnover despite sustained high levels of SIV viremia.
"In this study we asked whether an altered immune response to SIV contributes to the lack of immunopathology in sooty mangabeys as opposed to species with pathogenic lentivirus infection. SIV-specific cellular immune responses were investigated in a cohort of 25 sooty...
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Source: Drug Week (2006-05-26)
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