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Diet & Nutrition

Bitter orange does not cause false-positive response to CEDIA Amphetamines Assay

Published in Drug Week, June 9th, 2006

Bitter orange was not found to cause a false-positive response to the CEDIA Amphetamines Assay.

According to recent research from the United States, "Bitter orange has recently been substituted as an ingredient in many 'ephedra-free', dietary supplements used for weight loss. The primary active ingredient in bitter orange is synephrine. Previous reports have documented false-positive results from ephedrine with urine amphetamine assays. Because of the similarity in chemical structure of ephedrine and synephrine, it is hypothesized that ingestion of a bitter orange supplement may have the potential to cause false-positive results with urine amphetamine assays."

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