Drug Development
Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes
Published in Drug Week, June 9th, 2006
According to recent research published in the journal Prostaglandins Leukotrienes and Essential Fatty Acids, "Cyclooxygenase-2 (COX-2) plays an important role in tumorigenesis of several tissues, including skin. We report here that troglitazone, a thiazolidinedione class of antidiabetic drug, induced COX-2 expression at both the protein and mRNA levels and increased production of prostaglandin E2 (PGE2) in cultured keratinocytes."
"Troglitazone-induced COX-2 expression in keratinocytes was likely peroxisome proliferator-activated receptor gamma (PPAR...
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Source: Drug Week (2006-06-09)
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