Allergy & Immunology
Asthma protection is associated with IL-17F sequence variant (His161Arg)
Published in Drug Week, June 9th, 2006
"IL-17F is a recently discovered cytokine that plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. Upregulated IL17F gene expression has been observed at sites of allergen challenge in the airways of patients with asthma, suggesting that IL-17F is involved in the pathophysiology of asthma.
"To investigate the role of IL-17F in asthma pathogenesis, we conducted genetic analyzes of association of asthma with the common variants of IL17F,...
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Source: Drug Week (2006-06-09)
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