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Ischemia

Postischemic vascular injury is limited by activation of A1 adenosine receptors

Published in Drug Week, June 16th, 2006

Vascular injury is intrinsically limited by endogenous, but not exogenous, activation of A1 adenosine receptors (AR), whereas exogenous A3 AR activation further limits dysfunction, improving postischemic vasoregulation.

According to recent research from Australia, "This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1 ), A2A , A2B and A3 AR antagonism (revealing 'intrinsic' responses), to modify post-ischemic coronary dysfunction in mouse heart."

Griffith University-Southport investigators A.J. Zatta and colleagues wrote,...

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