HIV/AIDS Drug Development
HIV-1 CD4 attachment inhibitor inhibits viral entry by altering envelope conformation
Published in Drug Week, June 16th, 2006
According to a study from the United States, "BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble CD4 (sCD4) binding to the 11 distinct HIV envelope gp120 proteins surveyed."
"Binding of BMS-488043 and that of sCD4 to gp120 are mutually exclusive, since increased concentrations of one can completely block the binding of the other without affecting the maximal gp120 binding capacity.
"Similarly," H.T. Ho and...
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Source: Drug Week (2006-06-16)
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