Published in Drug Week, June 16th, 2006
Study 1: According to a study from the United States, engineering conditionally replication-competent adenoviral vectors carrying the Cyt deaminase (CD) gene increases the infectivity and therapeutic effect for breast cancer gene therapy.
"We constructed a conditionally replication-competent adenoviral vector Ad.Lp-CD-IRES-E1A(control) in which the expression of both the prodrug-activating CD gene and the viral replication E1A gene were driven by the L-plastin tumor-specific promoter," wrote Y. Liu and colleagues, Sidney Kimmel Cancer Center.
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