Allergy & Immunology
CC chemokine receptor antagonists selectively inhibit eosinophil influx into lungs
Published in Drug Week, August 25th, 2006
According to a study from the United States, "CC chemokine receptor (CCR) 3 is a chemokine receptor implicated in recruiting cells, particularly eosinophils (E Phi), to the lung in episodes of allergic asthma. To investigate the efficacy of selective, small-molecule antagonists of CCR3, we developed a murine model of E Phi recruitment to the lung."
"Murine eotaxin was delivered intranasally to mice that had previously received i.p. injections of ovalbumin (OVA), and the effects were monitored by bronchoalveolar lavage. A selective eosinophilic...
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Source: Drug Week (2006-08-25)
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