Published in Drug Week, August 25th, 2006
Study 1: IV injection for tumors resulted in a higher fraction of adoptively transferred cells with an activated phenotype.
According to a study from Denmark, "Accumulation of T cells at the tumor is essential in cancer immunotherapy based on adoptive transfer of tumor-specific T cells. To gain further insight into the accumulation process and to evaluate the effect of using different routes of cell transfer, we investigated the accumulation of ovalbumin-specific CD8(+) T cells (OT-I) injected either intravenously (IV) or intraperitoneally (IP) into mice...
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