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Low temperature sensitive liposome-doxorubicin may improve drug delivery to solid tumors

Published in Drug Week, September 8th, 2006

Low temperature sensitive liposome (LTSL)-doxorubicin offers a novel approach to improving drug delivery to solid tumors.

In a recent report, researchers in the United States conducted a study "to determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a LTSL when given concurrently with local hyperthermia to canine solid tumors. Privately owned dogs with solid tumors (carcinomas or sarcomas) were treated. The tumors did not involve bone and were located at sites amenable to local hyperthermia."

M.L. Hauck and colleagues, North Carolina State University, wrote,...

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