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Diabetes Pathogenesis

Dipeptidyl peptidase IV inhibition does not eliminate satiety actions of peptide YY

Published in Drug Week, September 8th, 2006

Short-term dipeptidyl peptidase IV inhibition does not eliminate the satiety actions of exogenously administered peptide YY.

"Dipeptidyl peptidase IV (DP IV) inhibitors are currently being developed to prolong the biological activity of insulinotropic peptides as a novel approach in the treatment of diabetes. We hypothesised that DP IV inhibition could attenuate the satiety actions of peptide YY (PYY) by altering the conversion of PYY(1-36) to PYY(3-36)," scientists writing in the journal Diabetologia report.

S. Unniappan and colleagues at the University of British Columbia explained, "The effects of PYY delivered by osmotic mini-pumps were...

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