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Drug Development

Human primary renal cells used as model for toxicity assessment of chemotherapeutic drugs

Published in Drug Week, September 8th, 2006

The human primary renal proximal tubule cells (hRPTEC) system could be used as an in vitro model for assessing potential nephrotoxicity of chemo-therapeutic drugs.

"Chemo-therapeutic drugs act on cancerous and normal cells non-selectively and often cause organ impairments during treatment. Improving safety or reducing toxicity becomes an important challenge for developing better anticancer drugs," scientists in the United States reported.

"In the present study, effects of selected anticancer drugs (camptothecin, doxorubicin, colchicine, paclitaxel, cisplatin, and carboplatin) on cell viability and proliferation was investigated. The...

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