HIV/AIDS Pharmacogenetics
Pharmacogenetic characteristics determined among antiretroviral drugs in HIV/AIDS
Published in Drug Week, September 29th, 2006
"The aim of the study was to investigate relationships among indinavir, lamivudine-triphosphate, and zidovudine-triphosphate pharmacokinetics and pharmacodynamics with polymorphisms in CYP3A5, MDR1, MRP2, MRP4, BCRP, and UGT1A1 genes," wrote investigators in the United States.
P.L. Anderson and colleagues at the University of Colorado conducted a retrospective "pilot investigation among 33 subjects who participated in a randomized pharmacological study of indinavir, lamivudine, and zidovudine. Subjects were defined as genetic variant carriers or...
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Source: Drug Week (2006-09-29)
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