Drug Week

Diabetes & Erectile Function - In men with type 1 diabetes, vardenafil significantly improves erectile function

Drug Development - Early study provides evidence that investigational drug phenoxodiol targets prostate cancer protein

HIV/AIDS Drug Development - Non-nucleoside inhibitors select nucleoside inhibitor resistance mutations in HIV-1 RT

Meningococcal Vaccine - Meningococcal group C vaccine elicits protective immunity within four days upon antigen challenge

Multiple Myeloma Therapy - Proteasome inhibitor drugs are under development

Accreditation - MinuteClinic receives JCAHO accreditation for retail healthcare sites

Addiction Medicine - Chicago deaths from fentanyl-laced heroin overdoses could be reduced by medical treatment

Adverse Drug Reaction - Cancer chemotherapy-induced diarrhea and constipation discussed

Allergic Rhinitis - Investigational drug ciclesonide found safe and effective for allergic rhinitis symptoms

Allergy & Immunology - Cytos Biotechnology's CYT003-QbG10 achieves efficacy in phase IIa pilot study

Alzheimer Disease - Alzheimer disease is not associated with vascular endothelial growth factor gene changes

Alzheimer Disease - Medivation reports phase 2 trial of Alzheimer drug meets all five efficacy endpoints

Alzheimer Disease - Pfizer, TransTech agree to develop, commercialize potential treatment for Alzheimer disease

Alzheimer Disease - Roskamp Institute announces launch of clinical study on Alzheimer treatment

Alzheimer Disease Vaccine - Papillomavirus-like particles act as platform for Abeta immunization

Anaphylactic Shock - Anaphylactic shock depends on PI3K and eNOS-derived NO

Anesthesia - Diastolic dysfunction in patients with impaired relaxation was not exacerbated by isoflurane

Anesthesia - Postop neurologic injury marker shows no effect from two anesthetic techniques for CPB surgery

Anesthesia - Video laryngoscope improves MCLS and POGO scores in patients with ankylosing spondylitis

Aneurysm Therapy - Neurosurgeon reports benefits of InnerCool system in inducing hypothermia during aneurysm surgery

Angiology - Acute stent thrombosis risk factors are determined

Angiology - Calcium channel blockade prevents inward remodeling in subendocardial resistance vessels

Angiology - Cardiac development is a function of platelet-derived growth factor B activity

Angiology - Carotid artery relaxation is impaired during hyperhomocysteinemia-evoked endothelial dysfunction

Angiology - Compensatory arterial flow supplies sinusoids after partial portal vein ligation

Angiology - Inhibition of thrombin generation is reversed by a recombinant factor

Angiology - K⁺-dependent Na⁺/Ca²⁺ exchangers are players in cytoplasmic free Ca²⁺ regulation

Angiology - Migration and actin remodeling of vascular smooth muscle cells toward SPC were analyzed

Angiology - Pathological angiogenesis is alternately regulated by Akt and rapamycin

Angiology - Peripheral vascular endothelial function is evaluated with a portable ultrasound device

Angiology - Pseudo-occlusion of the internal carotid artery is treated with stenting

Angiology - Pulmonary embolism emergency temporary pulmonary stent placement improves circulation

Angiology - Recurrent DVT and mortality risk is associated with residual thrombus

Angiology - Recurrent venous thromboembolism is associated with polymorphism homozygosity

Antibacterial Agents - Chlorhexidine-impregnated dressing reduces vascular and epidural catheter colonization

Antibacterial Agents - Moxifloxacin pharmacokinetics and peritoneal penetration are investigated

Antibacterial Agents - Oragenics' lead antibiotic kills bacteria by a novel mechanism

Anticancer Therapy - Glycolysis inhibition proposed as anticancer treatment

Antifungal Therapy - Published study finds Candida albicans rapid diagnostic text saves on antifungal therapy costs

Antifungal Therapy - U.S. FDA approves Schering-Plough's posaconazole for preventing invasive fungal infections

Antimicrobial Resistance - Antimicrobial agents have excellent activity against recently recovered MRSA isolates

Antioxidants -  Mangifera indica L. extract protects T cells from activation-induced cell death

Apoptosis - Apoptosis involved in Bax and caspase activation plus PKC delta signaling

Apoptosis - Apoptosis protein may function therapeutically in melanoma cells

Apoptosis - Arthritis pathology is mediated by tumor necrosis factor-like inducer of apoptosis

Apoptosis - Renal carcinoma and melanoma apoptosis overcome by DNA demethylation

Aspergillosis - European Commission grants OMP designation to Nektar's Amphotericin B Inhalation Powder

Asthma - Adrenal suppression in children with asthma can be screened using DHEA-S

Asthma - Aerosol therapy by pressured MDI-spacer during sleep is not feasible

Asthma - Asthma patient inhalation technique in Europe needs improvement

Asthma - Budesonide/formoterol improves lung function in children with asthma

Asthma - Exhaled nitric oxide levels and treatment compliance associations are studied

Asthma - M.D. Anderson, Baylor launch asthma research center funded by U.S. NIH $5.6 million grant

Asthma - Positive patient-reported outcomes follow Bronchial Thermoplasty trial for asthma

Atherosclerosis - Coronary disease markers are unaffected by modest dosing of renin-angiotensin system inhibition

Atherosclerosis - Optimal BP goal in coronary artery disease patients may be substantially lower than 140/90 mmHg

Atrial Fibrillation - Cardiome announces positive Phase 2A results for oral RSD1235 in atrial fibrillation

Avian Influenza Vaccine - sanofi pasteur generates first clinical trial lot of cell-based H7N1 vaccine for bird flu

Awards - Alexian Neurosciences Institute director honored for medical innovation

Awards - Biothera honored as Tekne award finalist

Awards - Dr. Victoria Hale, founder and CEO of the Institute for OneWorld Health, named MacArthur Fellow

Awards - Frost & Sullivan cites MIV Therapeutics' stent coating as among most advanced in its class

Awards - Three U.S. scientists win Lasker Award for basic medical research

Bacteremia Outbreaks -  Burkholderia cepacia bacteremia outbreak caused by contaminated nebulized sulbutamol

Bacteriology - Resistant bacteria is an increasing source of muscle infection

Benign Prostatic Hyperplasia - Nymox announces positive results from benign prostatic hyperplasia trial

Biofilms - Biofilm formation on medical in-dwelling devices may be inhibited by bacterial polysaccharides

Biofilms - Penile prosthetic material associated with biofilm formation

Biofilms - Staphylococcal biofilm formation on indwelling catheters influenced by catheter lock solutions

Biomedical Engineering - Angiogenesis and tumor proliferation may be controlled by synthesized esters

Biomedical Engineering - Bone substitute generates angiogenic factor and new vessels after implantation

Biotechnology - Dynamics of tumor-induced angiogenesis are highlighted in new mathematical models

Bladder Cancer - Bladder cancer patients' response to gemcitabine determined by assessing gene expression

Bladder Cancer - Bladder cancer vessels mature upon the up-regulation of endothelial delta-like 4

Blood Disorders - New once-daily oral iron chelator treats iron overload

Blood Separation - Polyurethane foaming membranes recover CD34+ cells from peripheral blood

Bone Disease - Amgen presents data on denosumab and sclerostin

Brain Cancer - Paclitaxel sustained delivery micro- and nanofibers are tested

Brain Cancer - Prenatal vitamins may reduce risk of brain tumors in children

Breast Cancer - Breast cancer chemotherapy affected cognitive function of older patients

Breast Cancer - Breast cancer growth inhibited by aromatase inhibitors

Breast Cancer - Breast cancer growth stimulated by Essiac and Flor-Essence herbal tonics

Breast Cancer - Breast cancer malignancy promoted by hyaluronan synthase expression

Breast Cancer - Breast cancer patient responsiveness to chemotherapy might be predicted by GRP78

Breast Cancer - Breast cancer patients who carry fibroblast growth factor polymorphism resist adjuvant therapy

Breast Cancer - Breast cancer progression controlled by targeting p38 gamma-dependent invasion pathways

Breast Cancer - Breast cancer proliferation inhibited by Ganoderma lucidum

Breast Cancer - Breast cancer risk is increased in women with prenatal exposure to diethylstilbestrol

Breast Cancer - Breast stem cells protected from carcinogen-induced tumorigenic progression

Breast Cancer - German biotech AdnaGen reports on diagnostic blood test to detect breast cancer spread

Breast Cancer - New biomarker technique detects early metastasis of breast cancer

Breast Cancer - New-onset breast discomfort may be related to increased mammographic density

Breast Cancer Vaccine - Cyclooxygenase-2 inhibitor enhances efficacy of breast cancer vaccine

Business & Finance - Aastrom Biosciences provides clinical, financial update

Business & Finance - Cyanotech board approves 1-for-4 reverse stock split and other developments

Business & Finance - Elekta reports proceedings of Annual General Meeting 2006

Business & Finance - Inex Pharmaceuticals shareholders approve spin-out of Tekmira Pharmaceuticals Corporation

Business & Finance - Inovio forms Asian subsidiary and announces plans to raise about $15.25M

Business & Finance - Kos announces compliance with NASDAQ continued listing requirements

Business & Finance - Palatin Technologies reports fiscal year end 2006 results

Business & Finance - Patheon announces third quarter results; MOVA financials continue to deteriorate

Business & Finance - Pozen receives $40 million upfront payment from AstraZeneca; provides revised 2006 guidance

Business Update - ABMI provides update on progress in development of stroke treatment

Business Update - Actavis gets U.S. FDA warning letter following inspection

Business Update - Aeterna Zentaris launches Cetrotide (cetrorelix) in Japan for in vitro fertilization

Business Update - Akorn gets $3.5 million order for calcium, zinc products

Business Update - Alfacell selects TS Communications and Feinstein Kean Healthcare for communications

Business Update - Alliance Pharma acquires marketing rights to wound care treatment

Business Update - American Society of Hematology reports access to science enhanced by new agreement

Business Update - Anormed amends license agreement for cancer drug

Business Update - Avant reports that GlaxoSmithKline pays royalties on sales of Rotarix

Business Update - BayBio adds location management services for expanding life sciences industry

Business Update - Bedford Laboratories to begin shipping Lorazepam Injection USP

Business Update - Bentley Pharmaceuticals named a fast growing company

Business Update - Bioenvision to expand into Japan and Southeast Asia

Business Update - Bioxel achieves key milestone in manufacturing of docetaxel

Business Update - Bristol-Myers Squibb recognized for benefits and protections for gay employees

Business Update - Cargill expands GRAS status of Oliggo-Fiber inulin and oligofructose products

Business Update - Catalyst Rx recognized by HR Policy Association for transparency in pharmaceutical purchasing

Business Update - Cheetah Medical presents at Medtech Insight and Windhover Information's In3 Medical Device Summit

Business Update - Chromos and Y's Therapeutics sign cell line engineering contract

Business Update - Clinical Data and PharmaCare sign landmark pharmacogenomics testing agreement

Business Update - Corning launches high-throughput label-free drug screening system

Business Update - Eden Biodesign and Aquapharm BioDiscovery join forces to help combat MRSA

Business Update - Mayne Pharma receives approval for generic oncology drug epirubicin in the U.S.

Business Update - Molecular Devices introduces microplate handling system for readers

Business Update - Molecular Devices introduces next-generation system for kinetic cell-based assays

Business Update - Molecular Vision and partners secure UKP 440,000 award from the U.K. National Health Service

Business Update - NEXUS Biosystems, Inc. and Covaris, Inc. announce marketing and distribution agreement partnership

Business Update - Opexa begins Phase IIb multiple sclerosis study; reports positive Phase I/II data

Business Update - Pepscan secures second financing round to finance cancer vaccine development

Business Update - Polydex Pharmaceuticals reports second quarter financial results

Business Update - Poniard Pharmaceuticals expands picoplatin agreement

Business Update - Prism Pharmaceuticals raises $68 million to advance acute care portfolio

Business Update - U.S. CDC selects McKesson for national children's vaccine distribution program

Cancer Gene Therapy - Bladder cancer tumor rejection achieved following interleukin gene transfection

Cancer Gene Therapy - Endostatin gene therapy warranted for familial desmoid tumors

Cancer Gene Therapy - Epithelium-derived factor gene transfer suppresses tumor growth

Cancer Gene Therapy - Gastric cancer inhibited gene expression reduces peritoneal metastasis

Cancer Gene Therapy - Liver tumor growth inhibited by use of liposomal plasmid DNA

Cancer Incidence - Increased cancer incidence not associated with fluvastatin treatment

Cancer Research - Data presented show molecular biomarker test may predict efficacy of Advexin cancer therapy

Cancer Research - Researchers report Peregrine's phospholipid-targeted antibodies reduce tumor growth in animals

Cancer Research - Rigel initiates Phase I study evaluating R763 in solid tumors

Cancer Therapy - Bladder cancer cell telomerase disruption down-regulates growth factor receptor

Cancer Therapy - Cancer bows to the antiangiogenic effects of ginseng derivative

Cancer Therapy - Cancer is targeted by the collaborative effects of vinblastine and rapamycin

Cancer Therapy - Data: Introgen INGN 241 works synergistically with Avastin to cut blood supply to cancers

Cancer Therapy - DNA-binding anticancer drug egress route clarified

Cancer Therapy - Free book helps support, empower patients undergoing chemotherapy

Cancer Therapy - Hana provides Talvesta (talotrexin) for Injection update

Cancer Therapy - Head, neck, and brain radiotherapy optimized localization methods are investigated

Cancer Therapy - Heat shock protein is a vehicle for taxotere control of endothelial cell migration

Cancer Therapy - Human cancer cell cisplatin resistance reversed by RNA interference

Cancer Therapy - Locally injectable gel depot system for anticancer drugs is developed

Cancer Therapy - Lung cancer cell invasion suppressed by a kinase

Cancer Therapy - Oral squamous cell carcinoma patient response to intra-arterial chemotherapy reduced by granisetron

Cancer Therapy - Peritoneal surface malignancy is treated with cytoreductive surgery and chemotherapy

Cancer Therapy - Targeted delivery of siRNAs mediated by aptamer-siRNA chimeras

Cancer Therapy - Tumor angiogenesis and proliferation is attenuated by tetrathiomolybdate analogue

Cancer Vaccine - Long-term tumor-specific immunity generated using calreticulin

Cardiology - Amlodipine manages nitric oxide synthase discharge from endothelial cell caveolin

Cardiology - Cardiac endothelial cells produce glia maturation factor-gamma during angiogenesis and inflammation

Cardiology - Myocardial infarction genetic risk assessed

Cardiology - Pediatric heart failure is beneficially treated using nesiritide

Cardiology - Redox regulation of endogenous substrate oxidation by cardiac mitochondria is described

Cardiology - Women with atrial fibrillation were more prone to anticoagulant-related bleeding than men

Cardiovascular Disease - Circadian rhythms are important in drug response in hypertension and coronary heart disease

Cardiovascular Disease - Evidence-based use of levosimendan is reviewed in different clinical settings

Cardiovascular Research - beta₃ -adrenoceptors in cardiovascular system are focus of review

Cardiovascular Research - Combined blockade of AT₁ receptor, HMG-CoA reductase shows additive effects on LV remodeling

Cardiovascular Research - New drug activation technique would prevent re-clogged arteries

Cardiovascular Research - The cardiovascular risks associated with traditional NSAIDs are small, but worth being aware of

Cardiovascular Research - Therapy with statin medications reduces death and cardiovascular events in heart attack survivors

Celiac Disease - Alba initiates phase II trial for Zonulin antagonist AT-1001 for autoimmune disorder

Cell Biology - Stromal cell-derived factor 1 does not use CXCR4 to bind to endothelial cells

Cerebral Palsy - Botox injection into the gastrocnemius muscle improves sit-to-stand transfer

Cervical Cancer - Cervical cancer oxygen tension inversely correlates with circulating endothelial progenitor cells

Cervical Cancer - Protein contributes to cervical tumorigenesis by regulating cyclin expression

Chronic Idiopathic Constipation - Sucampo's Amitiza effective in treating constipation in people age 65 and older

Chronic Myeloid Leukemia - Some adult chronic myeloid leukemia patients respond poorly to imatinib

Clinical Trials - Acorda announces positive Phase III Fampridine-SR study in people with multiple sclerosis

Clinical Trials - Acrux to start U.S. trial of its testosterone lotion for men

Clinical Trials - Cardioprotective effects of sevoflurane were not supported

Clinical Trials - Recurrence prevention in lone paroxysmal atrial fibrillation is better with amiodarone combinations

Collaborations - ACRS and WebbWrites announce strategic alliance

Collaborations - Affymetrix signs translational medicine agreement in China

Collaborations - Biogen Idec, Alnylam partner to develop therapy for progressive multifocal leukoencephalopathy

Collaborations - Clavis Pharma and Mount Sinai School of Medicine collaborate on cancer drug development

Collaborations - Schering AG and AstraZeneca collaborate to develop SERD drug for treating breast cancer

Collaborations - Schering, Organon end collaboration on male fertility control, agree to continue separately

Collaborations - Serono and Syntonix agree to pursue development of long-acting, inhaled infertility therapy

Collaborations - Somanta signs cancer drug development agreement with University of Bradford

Colon Cancer - Reasons why colon cancer management recommendations not followed were explained

Colorectal Cancer - Colorectal cancer liver metastasis rates may rise after primary tumor resection

Complementary & Alternative Medicine - Expressed sequence tag analysis of Madagascar periwinkle conducted

Creutzfeldt-Jakob Disease - CSF tests are valuable for the differential diagnosis of Creutzfeldt-Jakob disease

Critical Care Medicine - Postintubation tracheobronchial rupture nonoperative management is investigated

Crohn Disease - Avidia initiates trial of inhibitor of interleukin-6 for Crohn disease

Crohn Disease - Endoanal ultrasound is accurate for staging perianal fistulas and abscesses

DNA Research - Study shows role for ataxia-telangiectasia mutated in protecting embryo from embryopathies

DNA Vaccine - Trichostatin-A enhances adaptive immune responses to DNA vaccination

Demyelinating Disease - ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli

Dental Research - Computer-guided implant dentistry is reviewed

Dental Research - Dental implant immediate provisional restoration after tooth extraction is tested

Dental Research - Dental implants with a natural taper design are assessed in clinical practice

Dental Research - Orthodontic-associated apical root resorption is not correlated with invagination

Depression - Depression, especially combined with substance abuse, deemed significant risk factor for suicide

Depression - Electroconvulsive seizure boosts angiogenesis in the rodent hippocampus

Depression Therapy - Antidepressants should be reconsidered in adults with depressive mixed state

Depression Therapy - More frequent followup is needed for depressed patients after initiating therapy

Depression Therapy - Use of antidepressants effectively treats and protects depressed patients from suicide

Dermatology - NUCRYST Pharmaceuticals announces preliminary results of Phase II dermatology study

Dermatology - Organotypic skin models expose the value of short interference RNA gene silencing

Dermatology - Unilateral nevoid telangiectasia response to pulsed dye laser is evaluated

Diabetes Complications - Diabetic retinopathy responds to hyperbaric oxygen therapy in animal models

Diabetes Complications - Type 1 diabetes patients do not develop vascular diseases because of low birth weight

Diabetes Control - Glycemic control is better during modified intensified insulin therapy

Diabetes Prevention - GlaxoSmithKline's Avandia reduced risk of progression from pre-diabetes to type 2 diabetes

Diabetes Research - Diabetes trial quality leaves room for improvements

Diabetes Therapy - Antidiabetic and hypoglycemic effects are seen for fermented seeds of Parkia biglobosa

Diabetes Therapy - HbA_1c of a type 2 diabetes patient can indicate the best therapeutic approach

Diabetes Therapy - In diabetic rats, antioxidant N-acetylcysteine attenuates myocardial dysfunction

Diabetes Therapy - Pioglitazone mitigates renal glomerular vascular changes in diet-induced type 2 diabetes

Diabetes Therapy - Rosiglitazone is effective and well tolerated in therapeutic regimens in type 2 diabetes

Diabetic Neuropathy - PDE5 inhibitors may be used in the treatment of diabetic peripheral neuropathy

Diabetic Neuropathy - Sangamo presents positive results on DNA-binding protein therapy in diabetic neuropathy

Diabetic Retinopathy - Diabetic retinopathy shows a strong correlation with faulty glycemic control

Diagnostics - Coronary artery stenosis severity inversely correlates with dobutamine-induced hyperemia

Diagnostics - Ekips announces interim report on world's largest breath analysis project for laser-based diagnostics

Diet & Nutrition - Citrulline modulates muscle protein metabolism in old malnourished rats

Diet & Nutrition - Dannon and employers unite to help professional women with workplace snacking environments

Diet & Nutrition - Inflammation patterns warm up with Western diets, cool down with prudent ones

Drug Delivery - Dry powder inhalation formulation effects of fine excipient particles are reviewed

Drug Delivery - Heparin immobilized microspheres stimulate angiogenesis

Drug Delivery - Intracellular drug delivery achieved with pH-responsive alkylamide copolymers

Drug Delivery - Nifedipine microparticles effect of drug loading on release kinetics is assessed

Drug Delivery - NSAID transdermal delivery and skin permeation effects of DOPC are studied

Drug Delivery - Osmotic chitosan capsules with in situ formation of delivery orifice are developed

Drug Delivery - Physicians prescribing new medication often do not communicate important details to patients

Drug Delivery - Polymeric micelles for hydrophobic drug delivery are developed

Drug Delivery - Topical drug bioavailability can be tested in pig ear skin ex vivo model

Drug Delivery - Topical iontophoresis improves cutaneous aciclovir delivery

Drug Development - 2-[C-11]thymidine positron emission tomography used to help study and develop new TS inhibitors

Drug Development - A 50% reduction in breast tumor volume size seen with Eirx lead molecule

Drug Development - Acceleron Pharma presents positive ACE-011 preclinical data

Drug Development - Adventrx presents positive data on CoFactor combination in colorectal tumor model

Drug Development - Calpain proposed as novel target for cancer therapy

Drug Development - Caprion completes Phase I clinical studies for its Shigatoxin-producing E. coli therapy

Drug Development - CepTor executes Letter of Intent with Ferring for late-stage product targeted for Phase 2B trials

Drug Development - Critical Therapeutics announces results of CTI-01 Phase II trial

Drug Development - Mississippi State University research may lead to treatments for bacterial infections

Drug Development - Pharmacopeia's delivery of advanced compounds to Organon triggers milestone payment

Drug Development - Positive efficacy results reported for RNAi therapeutic in mouse models of pancreatic cancer

Drug Development - Prometic expands sites for PBI-1402 trials for anemia

Drug Development - Researchers develop a new approach to web-based drug withdrawal warnings

Drug Development - Sansalvamide A derivatives evaluated for cytotoxicity in colon cancer cells

Drug Development - Two novel undecapeptides should be studied for anticancer potential

Drug Importation - Poll shows 80% of U.S. adults favor allowing importation of prescription drugs

Drug Research - Fluoxetine desensitizes hyperglycemia induced by serotonin in rats with fructose-enriched diet

Drug Research - Organon invests in automation platforms in drug discovery laboratories

Drug Research - Vasopressin and related V_1a and V₂ receptor agonists may treat hypertension or diabetes

Drug Resistance - KT-5720 could reverse multidrug resistance in hematological malignancies

Drug Safety - Secretary of U.S. Health and Human Services issues a statement on the Institute of Medicine report

Embryogenesis - Prostaglandin regulates vascular development during embryogenesis in mink models

Embryonic Stem Cell Research - Embryonic stem cells injected into amniotic cavity enhance reclosure of open neural tube defect

Endocrinology - Biological properties of a chimeric gonadotropin clarified

Endocrinology - Control of estradiol secretion in reproductive aging determined

Endocrinology - Estradiol blocks neutrophil adhesion to endothelial cells

Endocrinology - Recombinant human thrombin rapidly binds to inhibitors

Enzymology - Human aminopeptidase A enzymatic properties elucidated

Enzymology - Human hyaluronidase is localized in articular chondrocytes and cultured cell lines

Enzymology - Protein kinase signaling pathways trigger heparanase secretion

Epilepsy Research - U.S. Food and Drug Administration approves a new epilepsy indication for Lamictal

Esophageal Cancer - Esophageal cancer clinical outcomes predicted by individual single nucleotide polymorphisms

Esophageal Cancer - Esophageal carcinoma long-term survival predicted by downstaging of T or N

Facilities - AstraZeneca opens two major scientific laboratories

Facilities - Ortho-Clinical Diagnostics breaks ground for manufacturing facility in Wales

Facilities - SmartCare opens retail family medical centers in three North Carolina Kerr Drug stores

Finance - Addex raises CHF 40 million in series C private financing

Finance - Amicus Therapeutics raises $60 million in series D financing

Finance - Approval of Fosrenol in Germany triggers US$3 million payment to Anormed

Finance - Array BioPharma receives phase II milestone payment from AstraZeneca

Finance - Autism Speaks awards grant to Seaside to evaluate mGluR5 antagonists in animal autism model

Finance - Cellectricon receives Swedish governmental R&D grant

Finance - Dutton Associates announces Speculative Buy rating for Amarillo Biosciences

Finance - Integrated BioPharma reports 2006 revenues of $57.8 million, a 77% increase

Finance - Jade Pharmaceutical reports six-month revenues top $3 million

Finance - Migenix reports Q1 2007 loss of $2.5 million compared to $2.8 million loss in Q1 2006

Finance - Panbio announces audited net profit of $351,000 for fiscal year

Finance - SurModics board authorizes repurchase of $35 million of outstanding common stock

Finance - Three Stanford University scientists each win U.S. NIH $2.5 million prizes

Gastric Cancer - Gastric cancer progression and tumorigenicity involve metallopanstimulin-1 expression

Gastric Cancer - Gastric carcinoma potentially treated by 5-aza-CdR combined with SN38 and GEM

Gastric Cancer - Gastric intestinal metaplasia's link to COX-2 inhibitors requires further investigation

Gastroenterology -  Helicobacter pylori was treated effectively by esomeprazole-amoxicillin + gatifloxacin

Gastroenterology - Esophageal anastomotic strictures are repaired with balloon dilation

Gastroenterology - Pancreatic ductal stones are safely managed with extracorporeal shockwave lithotripsy

Gastroenterology - Progenics, Wyeth start Phase III clinical program of intravenous methylnaltrexone for post-op ileus

Gaucher Disease - Positive results in studies on mechanism of Amicus' treatment for Gaucher disease published

Gene Research - Drexel University uses Open Biosystems' retroviral library

Gene Research - Gene transfer to bladder smooth muscle achieved after bladder outlet obstruction

Gene Research - Steroidogenesis mediated by Cox protein in Leydig cells

Generic Drugs - Ranbaxy receives approval to commercialize furosemide tablets in U.S.

Genetics & Genomics -  Drosophila model of Barth syndrome is generated by tafazzin mutations

Genetics & Genomics -  Plasmodium falciparum malarial topoisomerase inhibited by antisense nanoparticles

Genetics & Genomics - c-Fos critically mediates repression of a bile acid transporter

Genetics & Genomics - Coronary artery disease severity in Turkish patients is predicted by interaction of 3 polymorphisms

Genetics & Genomics - HIV minus strand strong stop DNA transfer stimulated by primer binding site

Genetics & Genomics - Primary human astrocyte gene expression altered by common insecticides

Geriatrics - Brain tumor and subdural hematoma management in the elderly is reviewed

Geriatrics - Increasing hypoxia in the aging kidney expands pathological factors

Geriatrics - Kyphoplasty as vertebral augmentation for compression fractures is reviewed

Glioblastoma - Glioblastoma epidermal growth factor receptor kinase inhibitors promoted

Graft-versus-Host Disease - Graft-versus-host disease is a major determinant of long-term quality of life of survivors

HIV/AIDS & Tuberculosis & Malaria - Global fund to fight AIDS, tuberculosis and malaria must translate knowledge into action

HIV/AIDS Dementia - Cognitive impairment in HIV/AIDS persists despite adequate use of HAART

HIV/AIDS Dementia - Immune reconstitution inflammatory syndrome suspect in HIV/AIDS patients with CNS symptoms

HIV/AIDS Drug Development - D-amino acid decapeptide HIV-1 entry inhibitor is biostable

HIV/AIDS Drug Monitoring - Rapid drug monitoring assay accurately and precisely measures antiretroviral drugs

HIV/AIDS Epidemiology - HIV-1 inter-subtype recombinants can be transmitted vertically to infants

HIV/AIDS HAART - Incomplete HIV suppression and increased inflammation may prevent CD4+ cell gut restoration

HIV/AIDS HAART - Rapid HAART scale-up at primary care sites in Zambia is feasible

HIV/AIDS HAART - Simplified maintenance therapy with atazanavir-ritonavir maintains virologic suppression

HIV/AIDS HAART - Time to virologic failure similar in HIV/AIDS patients taking 3- versus 4-drug regimens

HIV/AIDS HAART - Treatment recommendations are determined for adult HIV infection

HIV/AIDS Lipodystrophy - Lipodystrophic syndromes are congenital or acquired diseases of adipose tissue

HIV/AIDS Opportunistic Infection - Risk factors for opportunistic infections in HIV-infected children on HAART identified

HIV/AIDS Pathogenesis - Assay based on viruses expressing fluorescent proteins examines gene contribution to HIV fitness

HIV/AIDS Pathogenesis - HIV-1 gp120 upregulates the mu opioid receptor in TPA-differentiated cells

HIV/AIDS Therapy - Chugai launches HIV protease inhibitor Invirase Tablet 500mg

HIV/AIDS Therapy - Comorbid conditions complicate the management of advanced HIV disease

HIV/AIDS Therapy - Tenofovir disoproxil fumarate is linked to hypophosphatemia in patients receiving HAART

Head & Neck Cancer - Head and neck cancer progression follows the administration of colony-stimulating factors

Heart Failure - Acute decompensated heart failure patient outcomes associated with vasoactive therapy are described

Heart Failure - Benefits of Vasomedical's EECP therapy in heart failure presented

Hematology - Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation

Hepatitis B Therapy - Idenix announces telbivudine for chronic hepatitis B patients approved in Switzerland

Hepatitis B Virus - Chronic hepatitis B core promoter mutations associated with viral breakthrough

Hepatitis B Virus - Hepatitis B virus resistance mutations detected using DNA probe arrays

Hepatitis C Therapy - Peregrine's antiphospholipid platform broadened by newly validated anticancer target

Hepatitis C Virus - Anti-hepatitis C virus activity of hemin potentiated by artemisinin

Hepatitis C Virus - Chronic hepatitis C silent cirrhosis diagnostic tests compared

Hepatitis C Virus - Hepatitis C interferon-ribavirin therapy associated with hemoglobin decline in diabetes

Hepatocellular Cancer - Hepatocellular cancer apoptosis induced by cyclooxygenase-2 inhibitor and interferon-beta

Hepatocellular Cancer - Hepatocellular cancer patients might experience complications after acetic acid injection therapy

Hepatocellular Cancer - Hepatocellular carcinoma involves downregulation of a kinase inhibitor protein

Hepatoma - Hepatoma apoptosis induced by DHMEQ, a novel NF-kappa B inhibitor

Hypertension - BioMarin completes enrollment of phase II study of 6R-BH4

Hyponatremia Etiology - Etiology, assessment, and outcome of severe hyponatremia are outlined

Hyponatremia Therapy - Vasopressin antagonists are focus of review

Imaging - Contrast-enhanced dobutamine stress echo in coronary artery disease is prognostic of cardiac events

Imaging - Diffusion tensor imaging is used to detect degraded articular cartilage

Imaging - Dobutamine stress echo is of similar prognostic value for patients using two types of beta-blockers

Imaging - High-resolution X-ray refraction imaging of ventilating lung is performed

Imaging - Nuclear medicine imaging of bone infections is reviewed

Imaging - Pulmonary hemodynamics are not altered by PB127 infusion

Imaging - Thoracic imaging should consider intrapulmonary thoracostomy tube placement

Immunotherapy - Epithelial antigen expression triggers mediated intestinal inflammation

Immunotherapy - SciClone reports synthetic dipeptide for boosting immune system shows oral bioavailability

Infectious Diseases - Surveillance needed for pan-resistant Pseudomonas aeruginosa and Acinetobacter species

Influenza - American Heart Association asks heart doctors to administer flu shots

Influenza - Novavax initiates preclinical testing of intranasal influenza vaccine

Influenza Vaccine - Human parainfluenza virus interferon signaling is abrogated by mutations

Information Technology - NeoFax Web-based software reduces neonatal medication errors, streamlines critical care

Information Technology - Pharsight collaborates with LabLogic to link WinNonlin, Debra Products

Insulin Resistance - Insulin sensitivity improves after PPAR-alpha agonist in mouse model despite resistin levels

Intraocular Pressure - pSivida begins phase II clinical study of Mifepristone ophthalmic product

Ischemia - Myocardial ischemia-induced cytoplasmic and mitochondrial Ca²⁺ overload is reduced by SEA0400

Ischemia - Myocardial ischemia/reperfusion protection conferred by erythropoietin system

Kidney Cancer - Laparoscopic nephrectomy as treatment for renal cell carcinoma is studied

Kidney Disease - Primary hyperoxaluria type 2 may be diagnosed using blood mononuclear cells

Kidney Transplantation - Surgical marsupialization is the preferred primary treatment for lymphocele

Legal Issues - Jury finds in favor of Wyeth in hormone therapy case

Leukapheresis - Low doses of GM-CSF and G-CSF after cyclophosphamide enhance progenitor cell harvest

Leukemia - Leukemia patients were recommended daily dose of 5 mg/m²day of semisynthetic homoharringtonine

Licensing Agreements - Auriga Laboratories acquires Aquoral product line

Licensing Agreements - Cell Therapeutics announces licensing agreement with Novartis for Xyotax in treating NSCLC

Liver Cancer - BioAlliance reports final results of its doxorubicin Transdrug phase I/II trial for liver cancer

Lung Cancer - Gene mutation in lung cancer patients outpaces copy number for predicting gefitinib sensitivity

Lung Cancer - Lung adenocarcinoma central fibrosis associates with angiogenesis and lymphangiogenesis

Lung Cancer - Lung cancer treated by gemcitabine, ifosfamide, and cisplatin combination

Lung Cancer - Lung cancer treated by sequential paclitaxel, gemcitabine and carboplatin regimen

Lung Cancer - Non-small cell lung cancer gene expression clarified by oligonucleotide array

Lung Cancer - OSI Pharmaceuticals launches study of Tarceva as adjuvant treatment for non-small cell lung cancer

Lymphoma - Lymphoma patient survival was better with high-dose methylprednisolone versus whole-brain radiotherapy

Lymphoma - Pharmion initiates Phase II clinical trial in B-cell lymphoma

Malaria - Pfizer commits $15 million through President Clinton's initiative to address malaria

Malaria Treatment - Malaria effectively treated by fosmidomycin plus clindamycin in children over 3 years of age

Market Analysis - Medical modelling discussed in new Research and Markets report

Market Analysis - New medicines in development for diseases that affect Hispanic Americans

Market Analysis - Report evaluates potential for new products within diabetes market

Market Analysis - Report examines detailed profiles of key compounds in development for use in bipolar disorder

Market Analysis - Report examines the issues and concerns about translational medicine, how they can be addressed

Market Analysis - Report examines throughput screening in pharma research and chemical biology

Market Analysis - Report shows drug companies spend millions in first-year marketing

Market Analysis - Research and Markets forecasts allergic rhinitis rates to increase to 1.8 billion individuals

Market Analysis - Research and Markets report analyzes factors driving growth of generics industry

Market Analysis - Studies suggest drug makers face tough challenges in Chinese OTC market

Marketing - Kline study to examine over-the-counter purchase patterns

Measles Vaccine - Measles vaccine is often ineffective in HIV-infected children with immune recovery after HAART

Medical Devices - Dialysis dose (Kt/V) is continuously measured using an on-line monitoring system

Medical Devices - Interventional guidance system can be compatible with x-ray and MRI

Medical Devices - Mitral annular dynamics are determined using an automated tracking method

Medicare - Three-fourths of beneficiaries enrolled in Medicare Part D are satisfied, says survey

Medicare - Wolters Kluwer study indicates Medicare Part D "doughnut hole" pushes seniors to drop meds

Melanoma - Dr. Steven O'Day announces positive results in multicenter trial of new agent against melanoma

Melanoma - Melanoma cell survival promoted by erythropoietin via phosphoinositide 3-kinase/Akt pathway

Melanoma - Melanoma lung metastasis can be blocked by targeting kinase in the B-V600E-Raf signaling cascade

Melanoma - SciClone, Sigma-Tau present encouraging interim data on malignant melanoma response trial

Menorrhagia - Menorrhagia may be caused by dysfunctional angiogenesis

Mental Health - Traumatic brain injury patients may benefit from creatine administration

Mergers & Acquisitions - AAIPharma establishes new business unit, expands clinical development operations

Mergers & Acquisitions - China Health Holding executes definitive acquisition agreement for 100% of Shaanxi MeiChen