Published in Drug Week, October 20th, 2006
"TWEAK is a TNF family member with pleiotropic effects on a variety of cell types, one of which is the induction of proinflammatory cytokines by synovial fibroblasts derived from rheumatoid arthritis (RA) patients. In this study, we report that the serum TWEAK level was dramatically elevated during mouse collagen-induced arthritis (CIA) and blocking TWEAK by a neutralizing mAb significantly reduced the clinical severity of CIA," scientists in the United States reported.
According to S.J. Perper and colleagues, Biogen Inc., "Histological analyses also revealed that TWEAK...
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